Sign Up Successful!
You now have access to more from Realmo!
    For Lease
    • For Sale
    • For Lease
    • Recently Sold
    • Property Lookup
    • Brokers
    Retail
    1
    • Retail
    • Restaurant
    • Office
    • Coworking
    • Medical Space
    • Automotive
    • Industrial
    • Warehouse
    • Flex
    Price
    Price range
    $
    $
    Size
    Property size / sq.ft.
    AI Search

    Florence, SC Retail Properties for Lease

    16 results
    List
    Map
    Versatile Commercial Space in Florence
    $5,000 / Mo
    11,390 SF

    Versatile Commercial Space in Florence

    374 Darlington St, Florence, SC 29501

    Commercial property with bay doors, ideal for automotive or warehouse.

    • Prime Downtown Florence, SC location
    • Multiple bay doors for easy access and operations
    • Versatile space suitable for automotive, warehouse, or service‑related businesses
    • Abundant open space for vehicles, equipment, or flexible use
    • Dedicated office space for administrative functions
    Updated: Oct 11, 2025
    View details
    Restaurant Space Near I-95
    $7,680 / Mo
    4,190 SF

    Restaurant Space Near I-95

    3751 W Palmetto St, Florence, SC 29501

    Restaurant space for lease with high visibility and traffic.

    • High traffic location: 36,300 vehicles daily on I‑95 and 17,800 on US‑76.
    • Excellent visibility and accessibility: Copious road frontage and two driveway entrances.
    • Ample parking available.
    • Located off I‑95 Exit 157.
    • Surrounded by established national brands.
    Updated: Aug 28, 2025
    View details
    Restaurant Space Near I-95
    $7,680 / Mo
    4,190 SF

    Restaurant Space Near I-95

    Restaurant space for lease with high visibility and traffic.

    3751 W Palmetto St, Florence, SC 29501
    View details
    Claussen Retail Center Space Available
    $12 SF/Yr
    47,905 SF

    Claussen Retail Center Space Available

    Grocery-anchored retail space in Florence, SC.

    2332 Pamplico Hwy, Florence, SC 29505
    View details
    Florence Crossing Retail Center
    $22 SF/Yr
    9,775 SF

    Florence Crossing Retail Center

    Prime Retail Space Available in Florence, SC

    100-110 Woody Jones Blvd, Florence, SC 29501
    View details
    Irby Street Retail Opportunity
    Contact for pricing
    86,324 SF

    Irby Street Retail Opportunity

    High-traffic retail space available

    1611 Irby St, Florence, SC 29505
    View details
    Logan Plaza: Prime Office Space
    Contact for pricing
    7,900 SF

    Logan Plaza: Prime Office Space

    Florence, SC Office Suites Available

    1800 2Nd Loop Rd, Florence, SC 29501
    View details
    Southside Commons Retail Space
    Contact for pricing
    37,488 SF

    Southside Commons Retail Space

    Florence, SC Retail Center - 1 Space Available

    2014 Irby St, Florence, SC 29505
    View details
    Downtown Florence Mixed-Use Gem
    $25 SF/Yr
    7,748 SF

    Downtown Florence Mixed-Use Gem

    Historic District, prime location, flexible space.

    127 Evans St, Florence, SC 29501
    View details
    Florence Mall Retail Space
    Contact for pricing
    329,345 SF

    Florence Mall Retail Space

    Prime Florence, SC retail center

    1945 Palmetto St, Florence, SC 29501
    View details
    West End District Warehouse
    $90 SF/Yr
    36,360 SF

    West End District Warehouse

    36,360 SF Warehouse, Prime Location

    2295 Hoffmeyer Rd, Florence, SC 29501
    View details
    Retail Space in Regional Destination
    $22 SF/Yr
    2,800 SF

    Retail Space in Regional Destination

    Retail space available in premier shopping center, built in 2015.

    112-120 Woody Jones Blvd, Florence, SC 29501
    View details
    Retail Space in Regional Destination
    $25 SF/Yr
    2,400 SF

    Retail Space in Regional Destination

    Retail spaces available in premier shopping destination, built in 2015.

    104 Woody Jones Blvd, Florence, SC 29501
    View details
    Retail Space in Regional Destination
    $22 SF/Yr
    4,475 SF

    Retail Space in Regional Destination

    Retail spaces available in premier shopping destination near major highways.

    110 Woody Jones Blvd, Florence, SC 29501
    View details
    Retail Space in Florence, SC
    Contact for pricing
    8,000 SF

    Retail Space in Florence, SC

    8,000 SF retail space available for lease.

    2600 David H Mcleod Blvd, Florence, SC 29501
    View details
    Retail Space in Florence, SC
    Contact for pricing

    Retail Space in Florence, SC

    Located at a busy intersection with high visibility and access.

    Florence, SC 29501
    View details
    Based on your search, we've compiled 38 Potential Opportunities for your consideration. Besides 16 Active listings in Florence, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 18 Properties for Sales.

    Explore Retail properties for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Retail Space Near Walmart
    $26 SF/Yr
    1,200 SF

    Retail Space Near Walmart

    Retail space available February 2026 near Walmart Supercenter.

    1211 Retail Row, Hartsville, SC 29550
    View details
    Retail Space in Hartsville, SC
    $6 SF/Yr
    14,204 SF

    Retail Space in Hartsville, SC

    Retail space available for lease in Hartsville, South Carolina.

    844 S 5Th St, Hartsville, SC 29550
    View details
    Retail Space in Marion Center
    Contact for pricing
    1,300 SF

    Retail Space in Marion Center

    Retail and restaurant opportunities available in Marion Towne Center.

    2523-2565 Us 76, Marion, SC
    View details
    Retail Space For Lease
    $4 SF/Yr
    28,000 SF

    Retail Space For Lease

    28,000 SF retail space on 4.48 AC available.

    1404 N Main St, Marion, SC 29571
    View details

    Explore Similar Spaces for Sale in Florence, SC

    Consider Similar Space for Sale. We found 18 Spaces in Nearby Locations matching your search parameters.

    Established Auto Body Business For Sale
    $1,305,000
    4,125 SF

    Established Auto Body Business For Sale

    Turn-key auto body business with equipment, client roster, and real estate.

    803 Ranch Rd, Florence, SC 29506
    View details
    Retail Property in Prime Location
    $1,389,000
    4,160 SF

    Retail Property in Prime Location

    Single-tenant net-leased The Vitamin Shoppe in Florence, SC.

    2590 David H Mcleod Blvd, Florence, SC 29501
    View details
    Historic Mixed-Use Building in Florence
    $3,000,000
    13 SF

    Historic Mixed-Use Building in Florence

    16,000 sq ft historic building in Downtown Florence for sale.

    248 W Evans St Florence, Florence, SC 29501
    View details
    Pamplico Highway Commercial Opportunity
    $229,900
    0.80 Acres

    Pamplico Highway Commercial Opportunity

    Commercial lot on heavily traveled Pamplico Highway with multiple driveways.

    1424 Pamplico Hwy, Florence, SC 29505
    View details
    Wendy's Restaurant For Sale
    Contact for pricing
    2,058 SF

    Wendy's Restaurant For Sale

    Wendy’s in Florence, South Carolina, leased for 20 years.

    4010 E Palmetto St, Florence, SC 29501
    View details
    Wendy’s Restaurant in Florence, SC
    Contact for pricing
    2,202 SF

    Wendy’s Restaurant in Florence, SC

    Wendy’s restaurant for sale on high-traffic retail corridor.

    624 S Irby St, Florence, SC 29501
    View details
    Retail Property Near Major Intersections
    Contact for pricing
    38,000 SF

    Retail Property Near Major Intersections

    Retail property with high visibility and easy access.

    2640 W Palmetto St, Florence, SC 29501
    View details
    Former Convenience Store Investment Property
    $125,000
    2,400 SF

    Former Convenience Store Investment Property

    Fixer-upper retail property with 150' frontage, great investment potential.

    1134 E Howe Springs Rd, Florence, SC 29505
    View details

    Florence, SC Retail properties Leasing Opportunities Market Analysis

    Explore Retail properties leasing options in Florence, SC with 34 listings featured on our commercial real estate exchange. The current inventory includes 5,716,509,480 square feet of properties with an estimated lease value of $267 SF/Yr.

    Estimated lease rates for Retail properties in Florence, SC begin at $5 SF/Yr, with an average of $26 SF/Yr and extend to $90 SF/Yr.
    List
    Map

    Popular Searches in Florence, SC

    Most Searched ZIP Codes in Florence, SC

    • 29501
    • 29505
    • 29506

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Create New Password
    • At least 8 characters
    • Contains both letters and numbers
    • Contains uppercase and lowercase letters
    • At most 32 characters
    • Password required
    • Password reset link has expired. Please request a new one.