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Cameron County, TX Office Spaces for Sale

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Medical Office Space with Residential Unit
Updated: Jun 24
Medical Office Space with Residential Unit

1801-1805 E HARRISON AVE., Harlingen, TX 78550

$350,000
3,465 sqft 0.30 AC lot
0.2984‑acre parcel with 3,465 SF medical office space
Duplex‑style layout with dedicated office wing plus separate apartment‑style living space
Currently operating as a chiropractic office; previously home to a title company
Office includes reception/waiting, front desk, private office, and two treatment rooms with floor‑to‑ceiling picture windows
Residential side offers large living area, kitchen, bedroom, and full bathroom
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1801-1805 E HARRISON AVE., HARLINGEN, TX 78550

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Multi-Use Industrial Property with Yard
Updated: Jun 10
Multi-Use Industrial Property with Yard

901 S Williams Road S, San Benito, TX 78586

$740,000
6,125 sqft 0.95 AC lot
0.9525‑acre corner lot with dual street frontage on S Williams Rd and Amistad
High‑clearance open bay warehouse with two roll‑up doors plus covered drive‑through bay
Ground‑floor office suite with two offices, built‑in cabinetry, recessed lighting, and kitchenette
Extensive paved yard space for equipment, fleet, or storage; fully fenced with electric gated access
Two residential units upstairs with high ceilings, full kitchen with granite countertops, interior laundry, and multiple bathrooms
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Medical Office and Care Facility
Medical Office and Care Facility

1100 W TYLER AVE., Harlingen, TX 78550

$769,000
5,161 sqft 0.48 AC lot

Turn-key healthcare-oriented building with multiple exam, procedure, and patient-ready rooms.

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Brick Office Building with Central HVAC
Brick Office Building with Central HVAC

1436 E 13th Street, Brownsville, TX 78520

$185,000
1,500 sqft 0.13 AC lot

Brick office building with central heating and central air, plus a metal roof and electric water heater.

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Condominium Office with Parking
Condominium Office with Parking

1906 Tyler Avenue, Suite B, Harlingen, TX 78550

$775,000
6,400 sqft

A well-maintained office condominium offering 2,750 SF for lease or owner-occupancy with ample parking.

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Highway Office Building
Highway Office Building

505 E Highway 100, Port Isabel, TX 78578

$598,999
3,080 sqft 0.11 AC lot

Commercial office asset positioned directly along Highway 100 in Port Isabel with C zoning.

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Retail Space Near Downtown
Retail Space Near Downtown

605 E TYLER AVE., Harlingen, TX 78550

$185,000
1,272 sqft 0.16 AC lot

Built in 2002, the property is positioned for retail or office occupancy along E Tyler Ave.

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Multi-Tenant Medical Retail Center
Multi-Tenant Medical Retail Center

3777 Frontage Rd, Brownsville, TX 78520

$3,800,000
10,563 sqft 1.08 AC lot

Las Palmas Plaza is a 2017 multi-tenant center anchored by healthcare-oriented tenants on NNN lease structures.

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Medical Office with Surgical Suite
Medical Office with Surgical Suite

1649 SAM HOUSTON, Harlingen, TX 78550

$349,995
3,092 sqft 0.28 AC lot

Full medical office about 3,092 sq. ft. one block from Valley Baptist Medical Center, featuring a dedicated surgical suite.

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Remodeled Medical Office Building
Remodeled Medical Office Building

1024 E Los Ebanos Blvd., Brownsville, TX 78520

$1,999,999
10,441 sqft 1.06 AC lot

Two-story commercial space offers flexible medical and professional office configurations with parking and access to major roadways.

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Multi-Tenant Office Building
Multi-Tenant Office Building

142 Paredes Line Road, Brownsville, TX 78521

$1,200,000
6,600 sqft

Multi-tenant office building with 7 suites, including one suite divided into 5 rental spaces.

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Freestanding Flex Building with Drive-Through
Freestanding Flex Building with Drive-Through

17745 W EXPRESSWAY 83, Harlingen, TX 78555

$325,000
3,473 sqft 0.20 AC lot

The layout combines office space with a shop area for vehicle passage and oversized overhead doors.

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Two-Story Mixed-Use Property
Two-Story Mixed-Use Property

901 S WILLIAMS AVE., San Benito, TX 78586

$740,000
4,375 sqft 0.95 AC lot

Corner-lot commercial property combines office, warehouse, paved yard, and residential space within a fully secured site.

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Remodeled Medical Center For Sale
Remodeled Medical Center For Sale

1024 E Los Ebanos Blvd, Brownsville, TX 78520

$1,999,999
10,441 sqft 1.00 AC lot

Two-story medical building in established medical district with flexible space.

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Office Units Near Hospital
Office Units Near Hospital

2701 S SUNSHINE STRIP, Harlingen, TX 78550

$1,350,000
14,400 sqft 1.38 AC lot

Corner-lot office property with substantial parking and proximity to Valley Baptist Hospital.

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Flex Space with Warehouse and Office
Flex Space with Warehouse and Office

705 W JACKSON AVE., Harlingen, TX 78550

$189,900
0.16 AC lot

The property combines warehouse areas with dedicated office space for varied commercial operations.

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Flex Space With Two Warehouses
Flex Space With Two Warehouses

705 W Jackson St, Harlingen, TX 78550

$189,900
3,098 sqft

Combines warehouse areas with office space for a flexible commercial layout.

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Corner Flex Building with Storefront
Corner Flex Building with Storefront

925 77 SUNSHINE STRIP, Harlingen, TX 78550

$365,000
2,200 sqft

The building combines retail frontage with offices and rear warehouse space.

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Versatile Commercial Space
Versatile Commercial Space

1502 N 77 Sunshine Strip, Harlingen, TX 78550

$950,000
10,800 sqft

Large commercial suite near Harlingen High School, with strong signage opportunities and flexible space for multiple business uses.

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Turnkey Medical Office Building
Turnkey Medical Office Building

1100 W TYLER AVE., Harlingen, TX 78550

$769,000
5,161 sqft

Turnkey medical office layout with multiple patient rooms, procedure room, waiting/reception areas, and lab rooms.

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Professional Office Unit
Professional Office Unit

1906 E Tyler Ave. Unit G, Harlingen, TX 78550

$415,000
3,000 sqft

Multi-room office configuration within a gated business community, with dedicated areas for meetings, reception, technology, and staff support.

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Downtown Office Building Suite
Downtown Office Building Suite

625 N SAM HOUSTON BLVD., San Benito, TX 78586

$209,000
1,638 sqft

Well-preserved office building with two mirror-image units, reception areas, private rooms, and separate HVAC and water heating.

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Commercial Office and Sales Building
Commercial Office and Sales Building

1140 E Alton Gloor Boulevard, Brownsville, TX 78526

$2,500,000
4,557 sqft 2.62 AC lot

A 4,557 sq. ft. office and sales building on a level 2.62-acre site with extensive paved, lighted parking.

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Highly Visible Office Building
Highly Visible Office Building

1600 UNIVERSITY BLVD., Brownsville, TX 78520

$1,200,000
0.61 AC lot

Prominent University Blvd frontage and convenient access make this office property a strong fit for owner-occupants or flexible reuses.

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Cameron County, TX Office Spaces Market Trends and Statistics

Explore 83 office spaces for sale in Cameron County, TX, showcased through 83 active listings on our real estate platform. These investment opportunities span a total of 680,205 square feet of properties for sale, with an estimated market value of $28,800,792.

Sale prices for office spaces in Cameron County, TX start at $175,000, averaging $847,082, and reaching up to $3,800,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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