Cameron County, TX Office Spaces for Rent & Lease

Updated: Sep 24

Second-Floor Medical Office Space

1204 E Los Ebanos Blvd., Brownsville, TX 78520

$4,500/Mo

3,437 sqft

3,437 square feet of second‑floor medical office space
On‑site parking
First‑floor medical occupancy
Zoned C
Building constructed in 1983

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Updated: Dec 5, 2025

Office Unit Near Expressway

2312 S Expressway 83, Harlingen, TX 78552

$1,200/Mo

1,190 sqft 1.73 AC lot

1,190 square feet of office space
Just off Expressway 83 in Harlingen
Accessible approach with ramp
Built in 2007
Property encompasses 1.7342 acres

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Corner Office Unit with Consultation Rooms

5636 SOUTHMOST RD., Brownsville, TX 78521

Contact for pricing

3,500 sqft 1.07 AC lot

Configured with reception, lobby, private rooms, records space, and accessible restrooms.

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Corner Office Building with Conference Rooms

1002 E Taylor St, Brownsville, TX 78520

$2,900/Mo

3,372 sqft

Professional office property with private work areas, meeting rooms, support spaces, and a convenient downtown-adjacent setting.

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Multi-Suite Office Units

4405 Padre Blvd., South Padre Island, TX 78597

$8,000/Mo

3,360 sqft 62.60 AC lot

Flexible office layout with reception, meeting rooms, kitchen, restroom, and customer and employee parking.

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Corner Office Unit with Bus Access

5636 SOUTHMOST RD., Brownsville, TX 78521

Contact for pricing

1,000 sqft 1.07 AC lot

Flexible office suite suited to medical, dental, and professional office uses.

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Office Unit Near Police Department

1104 E 7TH ST., Brownsville, TX 78520

Contact for pricing

900 sqft 12.00 AC lot

The 900-square-foot office dates to 1981 and is positioned across from the Brownsville Police Department.

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Office Unit with Dual Access

1300 E Harrison Ave, Harlingen, TX 78550

$5,000/Mo

4,070 sqft

Former medical-office configuration with professional, medical, and commercial use potential.

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Remodeled Retail Space

2495 BOCA CHICA BLVD., Brownsville, TX 78521

Contact for pricing

1,376 sqft 0.12 AC lot

Updated commercial unit on a commercial corridor is suited to retail, professional office, medical, beauty, and service businesses.

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Flex Suite with Warehouse

1501 N 28TH ST., Harlingen, TX 78550

Contact for pricing

2,000 sqft 1.43 AC lot

North Harlingen commercial space combines organized office functions with storage capacity and on-site parking.

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Professional Office Units

A-1911 Lubbock St, Harlingen, TX 78550

$3,500/Mo

2,500 sqft

Office space near Valley Baptist Medical Center with paved off-street parking and flexible professional-use potential.

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Gallery Walk Retail Space

FM 802, Brownsville, TX 78526

$2,107/Mo

980 sqft 0.24 AC lot

Retail space supporting office, medical, restaurant, spa, and clothing-related uses within a commercial setting.

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New Retail Space at Gallery Walk

FM 802, Brownsville, TX 78526

$2,107/Mo

980 sqft 0.24 AC lot

2024-built commercial space with C zoning and multiple stated retail and service use possibilities.

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Medical Office with Exam Rooms

2014 Pease St., Harlingen, TX 78550

$4,500/Mo

3,844 sqft

Configured healthcare space with patient reception, clinical rooms, laboratory area, and dedicated parking.

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Flexible-Use Retail Space

FM 802, Brownsville, TX 78526

$1,957/Mo

910 sqft 0.24 AC lot

Built in 2024 and zoned C, the property supports office, medical, restaurant, spa, and clothing retail uses.

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Retail Space in New Construction

FM 802, Brownsville, TX 78526

$1,957/Mo

910 sqft 0.24 AC lot

C-zoned commercial space supports office, medical, restaurant, spa, and retail uses.

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Freestanding Flex Space with Drive-Through

17745 W Expressway 83, Harlingen, TX 78555

$3,000/Mo

3,473 sqft

Mixed office and service layout with a gated yard and oversized overhead doors.

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Office Unit with Pylon Signage

1720 E HARRISON AVE., Harlingen, TX 78550

Contact for pricing

1,600 sqft 0.34 AC lot

Configured with reception, conference space, private offices, break room, storage, and ADA restrooms.

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Mixed-Use Building with Apartment

900 E Levee St., Brownsville, TX 78520

$2,500/Mo

4,129 sqft

Retail and warehouse space is paired with an upstairs residential unit and separate street access.

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Multi-Suite Office Property

2805 & 2809 S EXPRESSWAY 83, Harlingen, TX 78550

Contact for pricing

1.41 AC lot

Flexible professional space offers private offices, clinical-support areas, conference rooms, and dedicated IT infrastructure.

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Medical Office Suite with Drive-Through

707 W Sesame Dr Unit B, Harlingen, TX 78550

$2,375/Mo

1,500 sqft

Flexible professional suite with an open work area, private office, conference space, and rear workroom.

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Office Unit with Pylon Signage

1720 E HARRISON AVE., Harlingen, TX 78550

Contact for pricing

700 sqft 0.34 AC lot

Reception area, private office, and ADA restroom support a compact professional layout.

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Live-Work Space with Loft

31220 State Highway 100, Los Fresnos, TX 78566

$2,800/Mo

1,728 sqft

A two-level layout combines a kitchen, sink-equipped loft, and rooms suited to office or residential use.

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Office Suites Near Medical Centers

1514 S 77 SUNSHINE STRIP, Harlingen, TX 78550

$1.00 SF/Yr

1,000 sqft 10.98 AC lot

Flexible configurations support medical, retail, sales, and office users.

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Cameron County, TX Office Spaces Market Trends and Statistics

Explore Office Spaces leasing options in Cameron County, TX with 68 listings featured on our commercial real estate exchange. The current inventory includes 353,958 square feet of properties with an estimated lease value of $664.79.

Estimated lease rates for Office Spaces in Cameron County, TX begin at $2.88 SF/Yr, with an average of $17.49 SF/Yr and extend to $73.49 SF/Yr.

Featured Cameron County Real Estate Agencies

Realmo connects you with licensed Cameron County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

Keller Williams Lower Rio Grande Valley

1713 E Tyler Ste A Harlingen, TX 78550

Phone: 19564238877

Harlingen Homes

1201 E Harrison Ave Harlingen, TX 78550

Phone: 19564235300