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    Seneca, SC Office Spaces for Sale

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    Newry, SC Walhalla, SC West Union, SC
    Commercial Building in Seneca, SC
    $234,900
    0.23 Acres
    Commercial Building in Seneca, SC

    615 W N 1st Street, Seneca, SC 29678

    Commercial building with open floor plan suitable for retail/office/restaurant.
    • Commercial building in Seneca with versatile potential
    • Open floor plan suitable for various business types
    • Includes a storage building
    • New HVAC unit installed in April 2026
    • Two bathrooms
    Updated: Apr 17
    View details
    Seneca Office Space For Sale
    $599,000
    2,400 SF
    Seneca Office Space For Sale

    631 By Pass 123, Seneca, SC

    Office space conveniently located off Bypass 123 in Seneca, SC.
    • Convenient location right off the 123 Bypass
    • Perfect for office, professional, or service‑based businesses
    Updated: Jun 25, 2025
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    Commercial Property on Radio Station Rd
    $250,000
    0.63 Acres
    Commercial Property on Radio Station Rd

    Commercial property with road frontage, suitable for business location.

    11081 N Radio Station Road, Seneca, SC 29678

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    Seneca Office Space For Rent
    Contact for pricing
    2,900 SF
    Seneca Office Space For Rent

    Office space in the heart of Seneca, ample parking.

    735 N Townville St, Seneca, SC

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    Land Near Clemson University
    $350,000
    6.54 Acres
    Land Near Clemson University

    Land available near Clemson University, close to lakes.

    Union Station Dr, Seneca, SC 29678

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    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 5 Active listings in Seneca, SC, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 67 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Commercial Building on Highway 28
    $579,000
    0.77 Acres
    Commercial Building on Highway 28

    Meticulously maintained commercial building with high visibility and ample parking.

    3691 Blue Ridge Boulevard, Walhalla, SC 29691

    View details
    Move-in Ready Office Space
    $349,900
    0.35 Acres
    Move-in Ready Office Space

    Well-maintained office space in established park, ideal for professionals.

    111 N Earle Street, Walhalla, SC 29691

    View details
    Versatile Mixed-Use Commercial Property
    $750,000
    0.48 Acres
    Versatile Mixed-Use Commercial Property

    Over 5,000 sq ft commercial property with residential area.

    4327 Old Mill Road, Anderson, SC 29623

    View details
    Versatile Mixed-Use Property with Residence
    $750,000
    5,000 SF
    Versatile Mixed-Use Property with Residence

    Three-level commercial property with residential area and office space.

    4327 Old Mill Rd, Anderson, SC 29621

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Lot Near Wells Highway
    $395,000
    0.99 Acres
    Commercial Lot Near Wells Highway

    0.99-acre commercial lot with high visibility and easy access.

    Corner of Wells Hwy. & Return Church Rd. Highway, Seneca, SC 29678

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    High-Traffic Commercial Land Available
    $585,000
    1.45 Acres
    High-Traffic Commercial Land Available

    1.45 acre commercial land with high visibility and accessibility.

    Destination Boulevard lot: R-1-A, Anderson, SC 29621

    View details
    High-Traffic Commercial Land Available
    $585,000
    4.61 Acres
    High-Traffic Commercial Land Available

    4.61 acres at I-85 and US 76-28 intersection.

    Destination Boulevard lot: R-1-B + R-2, Anderson, SC 29621

    View details
    Commercial Lot in Mall Park
    Contact for pricing
    0.15 Acres
    Commercial Lot in Mall Park

    Centrally located commercial lot among established businesses in Anderson, SC.

    29 Civic Center Boulevard, Anderson, SC 29625

    View details

    Off-Market Properties in Seneca, SC

    Consider similar Off-Market properties in Seneca, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    8 Accountants Cir

    8 Accountants Cir

    OFFICE BUILDING • 1,137 SF
    Value Estimation by Request
    8 Accountants Cir, Seneca, SC 29678-2670
    View details
    203 Central Park Ln

    203 Central Park Ln

    MEDICAL BUILDING • 4,578 SF
    Value Estimation
    $520,000
    203 Central Park Ln, Seneca, SC 29678-1156
    View details
    104 Wn 1st St

    104 Wn 1st St

    OFFICE BUILDING • 5,400 SF
    Value Estimation by Request
    104 Wn 1st St, Seneca, SC 29678-3248
    View details
    Seneca, SC 29678

    Seneca, SC 29678

    MEDICAL BUILDING • 2,929 SF
    Value Estimation by Request
    Seneca, SC 29678
    View details
    693 Oak St

    693 Oak St

    MEDICAL BUILDING • 4,900 SF
    Value Estimation
    $535,000
    693 Oak St, Seneca, SC 29678-3827
    View details
    959 By Pass 123rd A Ste A

    959 By Pass 123rd A Ste A

    MEDICAL BUILDING • 13,440 SF
    Value Estimation
    $1,170,000
    959 By Pass 123rd A Ste A, Seneca, SC 29678-4706
    View details
    108 Keowee School Rd

    108 Keowee School Rd

    OFFICE BUILDING • 1,402 SF
    Value Estimation by Request
    108 Keowee School Rd, Seneca, SC 29672-6741
    View details
    Seneca, SC 29678

    Seneca, SC 29678

    OFFICE BUILDING • 1,962 SF
    Value Estimation by Request
    Seneca, SC 29678
    View details
    735 Townville St

    735 Townville St

    OFFICE BUILDING • 2,968 SF
    Value Estimation by Request
    735 Townville St, Seneca, SC 29678-2644
    View details
    528 By Pass 123rd G Ste G

    528 By Pass 123rd G Ste G

    OFFICE BUILDING • 1,616 SF
    Value Estimation by Request
    528 By Pass 123rd G Ste G, Seneca, SC 29678-0866
    View details
    2 Leas Courtyard Dr

    2 Leas Courtyard Dr

    MEDICAL BUILDING • 3,320 SF
    Value Estimation by Request
    2 Leas Courtyard Dr, Seneca, SC 29672-6660
    View details
    11 Professionals Cir

    11 Professionals Cir

    DENTAL BUILDING • 2,848 SF
    Value Estimation by Request
    11 Professionals Cir, Seneca, SC 29678-2669
    View details
    528 By Pass 123rd D Ste D

    528 By Pass 123rd D Ste D

    OFFICE BUILDING • 2,282 SF
    Value Estimation by Request
    528 By Pass 123rd D Ste D, Seneca, SC 29678-0866
    View details
    10626 Clemson Blvd

    10626 Clemson Blvd

    MEDICAL BUILDING • 13,342 SF
    Value Estimation
    $2,150,000
    10626 Clemson Blvd, Seneca, SC 29678-4526
    View details
    15575 Wls Hwy

    15575 Wls Hwy

    MEDICAL BUILDING • 9,944 SF
    Value Estimation
    $905,000
    15575 Wls Hwy, Seneca, SC 29678-1664
    View details
    14 Professionals Cir

    14 Professionals Cir

    OFFICE BUILDING • 2,830 SF
    Value Estimation by Request
    14 Professionals Cir, Seneca, SC 29678-2669
    View details
    406 En 1st St

    406 En 1st St

    OFFICE BUILDING • 1,300 SF
    Value Estimation by Request
    406 En 1st St, Seneca, SC 29678-2742
    View details
    879 By Pass 123

    879 By Pass 123

    OFFICE BUILDING • 1,440 SF
    Value Estimation by Request
    879 By Pass 123, Seneca, SC 29678-4755
    View details
    841 Wn 1st St

    841 Wn 1st St

    OFFICE BUILDING • 1,100 SF
    Value Estimation by Request
    841 Wn 1st St, Seneca, SC 29678-2528
    View details

    Seneca, SC Office Spaces Investment Opportunities Market Analysis

    Explore 72 office spaces for sale in Seneca, SC, showcased through 5 active listings on our real estate platform. These investment opportunities span a total of 2,400 square feet of properties for sale, with an estimated market value of $599,000.

    Sale prices for office spaces in Seneca, SC start at $599,000, averaging $599,000, and reaching up to $599,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Office Units 6
    Medical Office Space 1
    Office buildings 1

    Demographics Overview

    Population 36K
    Population Growth (5Y) +2.7%
    Median Household Income $62,735
    College Educated 31.9%

    High-Yield Neighborhoods for Strategic Investment

    Identify Seneca submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    29678 $280K

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