Seneca, SC Commercial real estate for sale

Updated: Jul 10

Unrestricted Subdividable Land Parcel

12051 N Radio Station Road, Seneca, SC 29678

$799,900

22.18 AC lot

Unrestricted general use 22 +/- acres
Public water available
Currently taxed at agricultural rate
Subdividable
Located between Sandifer Blvd and Wells highway, about 5 minutes to downtown and Ram Cat Alley

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Updated: Jun 30

Two-Lot Live-Work Development Land

Tract 18/19 S Walnut Street, Seneca, SC 29678

$265,000

2.20 AC lot

Unique 2‑lot package on S. Walnut St: 1.49‑acre residential lot plus a .71‑acre tract next door.
Tract 18 is zoned residential; tract 19 is zoned commercial (buyer to confirm rezoning availability if desired).
Tract 18 utilities include power setup, water, and two septic systems (public remarks also reference “Tract 18 with 149 acres”—verify).
Owner will not separate the tracts—purchase includes both lots.
Location is less than 5 minutes from downtown Seneca’s retail/dining district and a short hop to Clemson University.

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Brick Flex Building

518 W N 1st Street, Seneca, SC 29678

$1,695,000

1.01 AC lot

All-brick and concrete flex property with existing tenants and additional space for occupancy or leasing.

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Dual-Storefront Restaurant Property

124 And 118 N Townville Street Ye Ole Restaurant, Seneca, SC 29678

$799,000

5,772 sqft

Two storefront spaces provide restaurant, confectionery, and banquet-room functionality for food and event operations.

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Unrestricted Agricultural Land

12051 N Radio Station Road, Seneca, SC 29678

$799,900

22.18 AC lot

Unrestricted acreage with agricultural tax treatment and stated potential for agricultural, residential, multifamily, or commercial use.

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Agricultural Land with Road Frontage

170 Singing Pines Road, Seneca, SC 29678

$299,765

6.71 AC lot

Agricultural parcel with public water access and possible subdivision eligibility, subject to verification and applicable restrictions.

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Commercial Land with Existing Building

11081 N Radio Station Road, Seneca, SC 29678

$217,000

0.63 AC lot

Road-front commercial parcel with a 1973 structure, block construction, concrete flooring, and propane utility service.

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Downtown Retail Building with Two Units

319 Main Street, Seneca, SC 29678

$1,500,000

5,500 sqft 0.24 AC lot

Two fully heated and air-conditioned retail units with private entrances and restrooms, plus street-to-street rear access.

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Commercial Land with Highway Frontage

1.8 Acres Rochester Highway, Seneca, SC 29672

$699,000

1.80 AC lot

Unrestricted commercial land near Publix, Ingles, and DG, positioned by established highway routes.

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Hibachi Restaurant Lease Opportunity

1510 Blue Ridge Boulevard, Seneca, SC 29672

$219,000

Existing restaurant operation offered with equipment, décor, and lease rights included.

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Two-Story Storefront Property

110 E N 1st Street, Seneca, SC 29678

$429,943

5,000 sqft

Downtown setting near shops, restaurants, and community events.

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Five-Office Professional Office Suite

C-528 By Pass 123, Seneca, SC 29678

$375,000

1,290 sqft

Move-in-ready workspace includes reception, kitchenette, and an ADA-accessible restroom.

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Professional Office Suite

528 ByPass 123, Seneca, SC 29678

$375,000

1,290 sqft

Flexible professional workspace with private offices, reception, kitchenette, and an ADA-accessible restroom.

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Updated Self-Service Car Wash

1469 Blue Ridge Boulevard 1471 Blue Ridge Blvd, Seneca, SC 29672

$895,000

0.58 AC lot

Automotive property with a customer waiting office, support buildings, and covered maintenance storage across a commercial site.

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Downtown Mixed-Use Commercial Building

110 E North 1st St, Seneca, SC 29678

$429,943

5,000 sqft

Two-level commercial building with a prominent street-front location and 2,500 sq ft per floor for flexible uses.

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Medical Office Building

685 S. Oak Street, Seneca, SC 29678

Contact for pricing

4,200 sqft

Established medical office property with a lease renewal option and convenient access to Seneca, Clemson, and US-123.

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Commercial Land on Clemson Boulevard

10149 And 10161 Clemson Boulevard, Seneca, SC 29678

$1,200,000

3.94 AC lot

3.94 acres of commercial land with road frontage.

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Ambulatory Surgery Center and Medical Office

457 E Bypass 123 Building D, Seneca, SC 29678

Contact for pricing

10,421 sqft

Medicare-certified ambulatory surgery center with two laminar flow operating rooms and shared campus medical office building.

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Mixed-Use Property with Detached Workshop

10695 Clemson Boulevard, Seneca, SC 29678

$789,000

Unrestricted acreage combines residential space, storage improvements, utility access, and flexibility for business operations.

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Commercial Land with Existing Structure

298 By Pass 123, Seneca, SC 29678

$650,000

An existing commercial building and a surveyed tract front the Bypass 123 corridor in Seneca.

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Corner Commercial Land with Building

10732 Clemson Boulevard, Seneca, SC 29672

$550,000

Corner commercial land includes an existing brick building with open-shell interiors and access from Clemson Boulevard.

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Office Unit with Private Offices

1510 Blue Ridge Boulevard #103, Seneca, SC 29672

$399,999

Professional suite includes reception space, enclosed offices, restrooms, and a rear exit for additional access.

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Corner Office Unit with Private Offices

103-1510 Blue Ridge Blvd, Seneca, SC 29672

$399,999

Main-level space offers reception, three enclosed rooms, two restrooms, and a rear exit.

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Brick Concrete Warehouse Flex Building

518 W North 1st Street, Seneca, SC 29678

$1,695,000

All-brick warehouse flex space with 16-foot ceilings and existing tenants, offering room for another tenant or owner-occupancy.

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Neighborhood	Average Price
29672	$561.4K
29678	$624.7K