Seneca, SC Commercial Real Estate for Sale

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Newry, SC West Union, SC Walhalla, SC Westminster, SC Clemson, SC Townville, SC Salem, SC Central, SC

57 properties

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Updated: Jul 10

Unrestricted Subdividable Land Parcel

12051 N Radio Station Road, Seneca, SC 29678

$799,900

22.18 AC lot

Unrestricted general use 22 +/- acres
Public water available
Currently taxed at agricultural rate
Subdividable
Located between Sandifer Blvd and Wells highway, about 5 minutes to downtown and Ram Cat Alley

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Updated: Jan 7

Brick Flex Building

518 W N 1st Street, Seneca, SC 29678

$1,695,000

1.01 AC lot

Flex space building at 518 W N 1st Street, Seneca, SC 29678
All‑brick and concrete construction
Two tenants occupy close to 8000 Sqft
Over 7000 sqft remains available
16‑foot ceilings with no‑load bearing walls

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Two-Lot Live-Work Development Land

Tract 18/19 S Walnut Street, Seneca, SC 29678

$265,000

2.20 AC lot

Two adjacent lots offer flexible options for a residential build paired with a commercial storefront.

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Dual-Storefront Restaurant Property

124 And 118 N Townville Street Ye Ole Restaurant, Seneca, SC 29678

$799,000

5,772 sqft

Two storefront spaces provide restaurant, confectionery, and banquet-room functionality for food and event operations.

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Self-Storage Facility with Outdoor Storage

195 Meade Street, Seneca, SC 29672

$750,000

0.85 AC lot

Fenced property with electronic gate access and a small building offering potential office or additional storage use.

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Unrestricted Agricultural Land

12051 N Radio Station Road, Seneca, SC 29678

$799,900

22.18 AC lot

Unrestricted acreage with agricultural tax treatment and stated potential for agricultural, residential, multifamily, or commercial use.

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Agricultural Land with Road Frontage

170 Singing Pines Road, Seneca, SC 29678

$348,765

6.71 AC lot

Agricultural parcel with public water access and possible subdivision eligibility, subject to verification and applicable restrictions.

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Mixed-Use Property With Two Buildings

879 By Pass 123 Highway, includes 710 Seneca Drive, Seneca, SC 29678

$677,000

3,264 sqft

Two-building commercial offering with retail, office, and industrial improvements along an established Seneca business corridor.

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Commercial Land with Existing Building

11081 N Radio Station Road, Seneca, SC 29678

$217,000

0.63 AC lot

Road-front commercial parcel with a 1973 structure, block construction, concrete flooring, and propane utility service.

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Graded Commercial Land

Corner of Wells Hwy. & Return Church Rd. Highway, Seneca, SC 29678

$395,000

0.99 AC lot

Flat, prepared corner site suited for commercial development, ground lease, or build-to-suit planning.

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Downtown Retail Building with Two Units

319 Main Street, Seneca, SC 29678

$1,500,000

5,500 sqft 0.24 AC lot

Two fully heated and air-conditioned retail units with private entrances and restrooms, plus street-to-street rear access.

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Commercial Land with Highway Frontage

1.8 Acres Rochester Highway, Seneca, SC 29672

$699,000

1.80 AC lot

Unrestricted commercial land near Publix, Ingles, and DG, positioned by established highway routes.

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Hibachi Restaurant Lease Opportunity

1510 Blue Ridge Boulevard, Seneca, SC 29672

$219,000

Existing restaurant operation offered with equipment, décor, and lease rights included.

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Two-Story Storefront Property

110 E N 1st Street, Seneca, SC 29678

$429,943

5,000 sqft

Downtown setting near shops, restaurants, and community events.

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Five-Office Professional Office Suite

C-528 By Pass 123, Seneca, SC 29678

$375,000

1,290 sqft

Move-in-ready workspace includes reception, kitchenette, and an ADA-accessible restroom.

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Updated Self-Service Car Wash

1469 Blue Ridge Boulevard 1471 Blue Ridge Blvd, Seneca, SC 29672

$895,000

0.58 AC lot

Automotive property with a customer waiting office, support buildings, and covered maintenance storage across a commercial site.

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Professional Office Suite

528 ByPass 123, Seneca, SC 29678

$375,000

1,290 sqft

Flexible professional workspace with private offices, reception, kitchenette, and an ADA-accessible restroom.

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Downtown Mixed-Use Commercial Building

110 E North 1st St, Seneca, SC 29678

$429,943

5,000 sqft

Two-level commercial building with a prominent street-front location and 2,500 sq ft per floor for flexible uses.

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Medical Office Building

685 S. Oak Street, Seneca, SC 29678

Contact for pricing

4,200 sqft

Established medical office property with a lease renewal option and convenient access to Seneca, Clemson, and US-123.

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Ambulatory Surgery Center and Medical Office

457 E Bypass 123 Building D, Seneca, SC 29678

Contact for pricing

10,421 sqft

Medicare-certified ambulatory surgery center with two laminar flow operating rooms and shared campus medical office building.

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Office Unit with Private Offices

1510 Blue Ridge Boulevard #103, Seneca, SC 29672

$399,999

Professional suite includes reception space, enclosed offices, restrooms, and a rear exit for additional access.

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Corner Office Unit with Private Offices

103-1510 Blue Ridge Blvd, Seneca, SC 29672

$399,999

Main-level space offers reception, three enclosed rooms, two restrooms, and a rear exit.

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Unrestricted Commercial Land

12051 N Radio Station Rd, Seneca, SC 29678

$799,900

Unrestricted acreage supports agricultural, residential, multi-residential, or commercial use options.

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Former Walgreens Drug Store

1020 E North 1st St, Seneca, SC 29678

Contact for pricing

10,908 sqft

Renovated in 2018, the facility can support continued retail use or conversion to office space.

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Seneca, SC Commercial Real Estate Market Trends and Statistics

Explore 72 commercial real estate for sale in Seneca, SC, showcased through 57 active listings on our real estate platform. These investment opportunities span a total of 2,765,587 square feet of properties for sale, with an estimated market value of $22,292,914.

Sale prices for business properties in Seneca, SC start at $175,000, averaging $696,653, and reaching up to $2,250,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Demographics Overview

Population 36K

Population Growth (5Y) +2.7%

Median Household Income $62,735

College Educated 31.9%

High-Yield Neighborhoods for Investment

Identify Seneca submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
29678	$649.6K
29672	$703.3K

Listings Trend

New vs delisted commercial listings in Oconee County

New Delisted

Total CRE Inventory on Market (SF)

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