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    Seneca, SC
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    Seneca, SC Retail Properties & Spaces for Lease

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    Clemson, SC West Union, SC Walhalla, SC
    6 properties
    Retail Property on Main Corridor
    Updated: Oct 21, 2025
    Retail Property on Main Corridor

    1592 Sandifer Blvd, Seneca, SC

    $11 SF/Yr
    7,250 sqft · $6,947/Mo
    Excellent visibility
    Heavy traffic counts
    Located on main corridor
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    Seneca Office/Retail Space Available
    Updated: Jun 19, 2024
    Seneca Office/Retail Space Available

    12019 North Radio Station Rd, Seneca, SC

    $15 SF/Yr
    4,800 sqft · $6,000/Mo
    Available Office/Retail Spaces
    2,000 SF Space Available (1st - C)
    1,800 SF Space Available (1st - F)
    $15.00 NNN Lease Rate for 1st - C and 1st - F
    1,000 SF Leased Space (1st - G)
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    Retail Opportunity Near Walmart
    Retail Opportunity Near Walmart

    1637 Sandifer Blvd, Seneca, SC

    Contact for pricing

    Retail space available for lease, GL, or build-to-suit.

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    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Restaurant Space Near Oconee Medical
    Restaurant Space Near Oconee Medical

    201-273 Applewood Center Pl, Seneca, SC

    Contact for pricing
    16,000 sqft

    1,600 SF 2nd Gen Restaurant Space Available For Rent.

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    Dominant Power Center For Rent
    Dominant Power Center For Rent

    201 Applewood Center Pl, Seneca, SC 29678

    $25 SF/Yr
    245,000 sqft · $510,416/Mo

    245,000 SF power center anchored by Belk, Hobby Lobby, etc.

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    Retail Space Near Oconee Medical
    Retail Space Near Oconee Medical

    101 Applewood Center Pl, Seneca, SC

    Contact for pricing
    1,600 sqft

    Retail space available near Oconee Medical Center and Clemson University.

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    Based on your search, we've compiled 24 Potential Opportunities for your consideration. Besides 6 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 10 Properties for Sales.

    Retail properties & Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Below-Boutique Retail Space
    Below-Boutique Retail Space

    382 College Avenue, Clemson, SC 29631

    $2,800/Mo

    Finished retail space below The Fizz Boutique, previously a coffee shop, available for lease.

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    Remodeled Restaurant Space on Main
    Remodeled Restaurant Space on Main

    100 -102 W Main Street, Walhalla, SC 29691

    $2,000/Mo

    Prime restaurant property in a high-traffic, growing tourist area.

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    Historic Retail Buildings on Main
    Historic Retail Buildings on Main

    214-218 E Main St, Walhalla, SC

    Contact for pricing
    6,130 sqft

    Renovated retail spaces with historic charm and modern amenities.

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    Retail/Restaurant Space Near Clemson University
    Retail/Restaurant Space Near Clemson University

    894 Tiger Blvd, Clemson, SC

    Contact for pricing
    3,500 sqft

    Retail/restaurant space with dedicated parking and lake access.

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    Similar Spaces for Sale in Seneca, SC

    Consider Similar Space for Sale. We found 10 Spaces matching your search parameters.

    Seneca Commercial Building For Sale
    Seneca Commercial Building For Sale

    518 W N 1st Street, Seneca, SC 29678

    $1,695,000
    8,000 sqft · 1.01 AC lot

    All brick/concrete building in Seneca, SC with tenant income.

    View details
    Versatile Retail and Office Building
    Versatile Retail and Office Building

    615 W N 1st Street, Seneca, SC 29678

    $214,900
    0.23 AC lot

    Open floor plan with two bathrooms, plus a side storage building and newly installed HVAC.

    View details
    Seneca Retail Building For Sale
    Seneca Retail Building For Sale

    12020 North Radio Station Road, Seneca, SC 29678

    $1,399,999
    12,000 sqft · 2.42 AC lot

    12,000 SF building with conversion potential in Seneca, SC.

    View details
    Turn-Key Restaurant Franchise Opportunity
    Turn-Key Restaurant Franchise Opportunity

    1053 By Pass 123 Bypass, Seneca, SC 29678

    $1,900,000
    0.78 AC lot

    Turn-key national franchise restaurant with real estate for sale.

    View details
    NNN Bank Building
    NNN Bank Building

    1313 Sandifer Boulevard, Seneca, SC 29678

    $2,049,000

    For sale NNN bank building with corporate ABS structure in Seneca, SC.

    View details
    Commercial Building with Open Plan
    Commercial Building with Open Plan

    615 W North 1st St, Seneca, SC 29678

    $214,900

    Own a tenant-occupied commercial building with an open floor plan, two bathrooms, and a recently installed HVAC unit.

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    Prime Commercial Acreage For Sale
    Prime Commercial Acreage For Sale

    1018 E. North 1st Street, Seneca, SC 29678

    $3,500,000
    4.33 AC lot

    4.3 acres in Seneca, SC, ideal for retail or hospitality.

    View details
    Automotive Shop Near Lake Keowee
    Automotive Shop Near Lake Keowee

    445 By Pass 123, Seneca, SC 29678

    $900,000

    10-bay automotive shop, redevelopment potential for fast food.

    View details
    Established Hibachi Restaurant for Sale
    Established Hibachi Restaurant for Sale

    1510 Blue Ridge Boulevard, Seneca, SC 29672

    $219,000

    Turnkey Hibachi restaurant with existing lease and equipment included.

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    Land Near Clemson University
    Land Near Clemson University

    Union Station Dr, Seneca, SC 29678

    $350,000
    6.54 AC lot

    Land available near Clemson University, close to lakes.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Laurens Road Commercial Land Lease
    Laurens Road Commercial Land Lease

    1012 Laurens Road, Greenville, SC 29607

    Contact for pricing
    3,500 sqft

    0.72-acre build-to-suit or ground lease opportunity on Laurens Road.

    View details
    Specialty Commercial Rental Space
    Specialty Commercial Rental Space

    106 Memorial Drive, Greer, SC 29650

    $2,200/Mo

    Commercially zoned rental property on Memorial Drive in Greer, suited for specialty uses requiring a small site.

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    Ellijay, GA Commercial Land
    Ellijay, GA Commercial Land

    4.74AC Eller Road, Ellijay, GA 30540

    $7,260/Mo

    4.74 acres of commercial land for lease in Ellijay.

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    Ellijay, GA Commercial Land
    Ellijay, GA Commercial Land

    12.86AC Highlands Hill Drive, Ellijay, GA 30540

    $17,424/Mo

    12.86 acres of commercial land for lease in Ellijay.

    View details

    Seneca, SC Retail properties & Spaces Market Trends and Statistics

    Explore Retail properties & Spaces leasing options in Seneca, SC with 6 listings featured on our commercial real estate exchange. The current inventory includes 257,762 square feet of properties with an estimated lease value of $80 SF/Yr.

    Estimated lease rates for Retail properties & Spaces in Seneca, SC begin at $11 SF/Yr, with an average of $20 SF/Yr and extend to $28 SF/Yr.
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    Most Searched ZIP Codes in Seneca, SC

    • 29678
    • 29768

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