Seneca, SC Retail properties & Spaces for Rent & Lease

Updated: Jul 27

Retail Storefront in Shopping Center

1640 Sandifer Boulevard, Seneca, SC 29678

Contact for pricing

2,550 sqft

Commercial zoning
About 130 ft of frontage on Sandifer Blvd.
Located at a signalized shopping center entrance
Good visibility from Sandifer Blvd.
Walmart Supercenter averages over 222,000 monthly visitors

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Updated: Oct 21, 2025

Retail Space with Excellent Signage Visibility

1592 Sandifer Blvd, Seneca, SC 29678

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7,250 sqft

7,250 SF retail space
Excellent signage and visibility
Located in the main retail corridor
23,500+ VPD on Sandifer Blvd
1592 Sandifer Blvd, Seneca, SC 29678

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Retail Redevelopment Site

1637 Sandifer Blvd, Seneca, SC 29678

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1.83 AC lot

Freestanding retail site with full access along Sandifer Blvd and cross access to Stop-A-Minit.

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Dominant Power Center For Rent

201 Applewood Center Pl, Seneca, SC 29678

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245,000 sqft

245,000 SF power center anchored by Belk, Hobby Lobby, etc.

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Based on your search, we've compiled 19 Potential Opportunities for your consideration. Besides 4 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 11 Properties for Sales.

Retail properties & Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Open-Concept Retail Space

117-125 N Mechanic St, Pendleton, SC 29670

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1,405 sqft

Managed retail space with an open layout, restroom, and optional additional storage.

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Retail Space with Open Layout

125 North Mechanic Street, Pendleton, SC 29670

$19 SF/Yr

Retail space featuring an open layout and additional storage.

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Downtown Retail Space

382 College Avenue, Clemson, SC 29631

$2,800/Mo

Finished commercial interior with tile flooring, central HVAC, and electric heating and cooling.

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Retail Suite with Open Layout

1067 Tiger Blvd, Clemson, SC 29631

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1,300 sqft

1,300 SF retail suite offers a wide-open sales area, rear storage, and two single-stall restrooms.

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Similar Spaces for Sale in Seneca, SC

Consider Similar Space for Sale. We found 11 Spaces matching your search parameters.

Downtown Retail Building with Two Units

319 Main Street, Seneca, SC 29678

$1,500,000

5,500 sqft 0.24 AC lot

Two fully heated and air-conditioned retail units with private entrances and restrooms, plus street-to-street rear access.

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Seneca Commercial Building For Sale

518 W N 1st Street, Seneca, SC 29678

$1,695,000

8,000 sqft 1.01 AC lot

All brick/concrete building in Seneca, SC with tenant income.

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Downtown Mixed-Use Commercial Building

110 E North 1st St, Seneca, SC 29678

$429,943

5,000 sqft

Two-level commercial building with a prominent street-front location and 2,500 sq ft per floor for flexible uses.

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Unrestricted Development Retail Site

8095 Keowee School Rd, Seneca, SC 29672

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2,500 sqft 6.48 AC lot

Unrestricted commercial property with a 2,500 sq ft building, commercial kitchen, outbuildings, two ponds, and water/power access.

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Retail Shopping Center with Parking

810 E Main St, Seneca, SC 29630

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19,297 sqft 3.00 AC lot

Built in 2009, this shopping center offers 69 parking spaces and includes two available retail units.

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Storefront Retail Building with Storage

615 W N 1st Street, Seneca, SC 29678

$199,900

0.23 AC lot

Open commercial layout with two bathrooms, side storage, and General Commercial zoning in Seneca.

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Seneca Retail Building For Sale

12020 N Radio Station Rd, Seneca, SC 29678

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12,000 sqft 2.42 AC lot

12,000 SF building with conversion potential in Seneca, SC.

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NNN Bank Building

1313 Sandifer Boulevard, Seneca, SC 29678

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For sale NNN bank building with corporate ABS structure in Seneca, SC.

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ALDI-Anchored Regional Shopping Center

13300 Clemson Blvd, Seneca, SC 29678

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Regional shopping center anchored by ALDI, drawing over 2.5 million annual visits and featuring 8.2 years WALT.

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Land Near Clemson University

Union Station Dr, Seneca, SC 29678

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6.54 AC lot

Land available near Clemson University, close to lakes.

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Established Hibachi Restaurant for Sale

1510 Blue Ridge Boulevard, Seneca, SC 29672

$219,000

Turnkey Hibachi restaurant with existing lease and equipment included.

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