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    Seneca, SC Retail Properties & Spaces for Lease

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    Clemson, SC West Union, SC Walhalla, SC
    9 results
    Seneca Retail/Office Space Available
    $1,700/Mo
    712 SF

    Seneca Retail/Office Space Available

    1109 Jennings Ave Unit A, Seneca, SC 29768

    Retail/office space for lease in Seneca, SC. Renovated and visible.

    • Located at one of the busiest intersections in Seneca, SC, offering incredible visibility.
    • Rent includes all utilities ($1,700/month).
    • Recently renovated with new lights, new paint, and concrete floors.
    • Ample parking available.
    • Lots of natural light.
    Updated: Mar 5
    View details
    Retail Space Near Clemson University
    $21 SF/Yr
    43,000 SF

    Retail Space Near Clemson University

    1085 Old Clemson Highway, Seneca, SC 29672

    End-cap retail space with drive-thru potential near Clemson University.

    • High Traffic Location: 29,900 Vehicles Per Day (VPD) on Hwy. 123.
    • Proximity to Clemson University: Only 5 minutes away.
    • Located Between Two Major Lakes: Lake Keowee and Lake Hartwell.
    • End Cap Unit: ±1,200 SF Available for Lease.
    • Drive‑Thru Potential: Suite A offers drive‑thru possibilities.
    Updated: Nov 26, 2025
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    Retail Property on Main Corridor
    $11 SF/Yr
    7,250 SF

    Retail Property on Main Corridor

    Retail property with excellent visibility and heavy traffic.

    1592 Sandifer Blvd, Seneca, SC
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    Retail Opportunity Near Walmart
    Contact for pricing

    Retail Opportunity Near Walmart

    Retail space available for lease near Walmart and hospital.

    Seneca, SC 29678
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    Retail Opportunity Near Walmart
    Contact for pricing

    Retail Opportunity Near Walmart

    Retail space available for lease, GL, or build-to-suit.

    1637 Sandifer Blvd, Seneca, SC
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    Seneca Office/Retail Space Available
    $15 SF/Yr
    4,800 SF

    Seneca Office/Retail Space Available

    Office and retail spaces for lease in Seneca, South Carolina.

    12019 North Radio Station Rd, Seneca, SC
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    Restaurant Space Near Oconee Medical
    Contact for pricing
    16,000 SF

    Restaurant Space Near Oconee Medical

    1,600 SF 2nd Gen Restaurant Space Available For Rent.

    201-273 Applewood Center Pl, Seneca, SC
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    Retail Space Near Oconee Medical
    Contact for pricing
    1,600 SF

    Retail Space Near Oconee Medical

    Retail space available near Oconee Medical Center and Clemson University.

    101 Applewood Center Pl, Seneca, SC
    View details
    Dominant Power Center For Rent
    $25 SF/Yr
    245,000 SF

    Dominant Power Center For Rent

    245,000 SF power center anchored by Belk, Hobby Lobby, etc.

    201 Applewood Center Pl, Seneca, SC 29678
    View details
    Based on your search, we've compiled 26 Potential Opportunities for your consideration. Besides 9 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 9 Properties for Sales.

    Retail properties & Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Historic Pendleton Bank Retail Space
    $3,500/Mo

    Historic Pendleton Bank Retail Space

    Renovated retail space in historic Pendleton Town Square.

    104 Exchange Street, Pendleton, SC 29670
    View details
    Downtown Clemson Retail Space Available
    $2,800/Mo

    Downtown Clemson Retail Space Available

    Retail space in downtown Clemson, formerly a coffee shop.

    382 College Avenue, Clemson, SC 29631
    View details
    Retail Space with Open Layout
    Contact for pricing

    Retail Space with Open Layout

    Retail space featuring an open layout and additional storage.

    125 N Mechanic St, Pendleton, SC 29670
    View details
    Retail/Restaurant Space Near Clemson University
    Contact for pricing
    3,500 SF

    Retail/Restaurant Space Near Clemson University

    Retail/restaurant space with dedicated parking and lake access.

    894 Tiger Blvd, Clemson, SC
    View details

    Similar Spaces for Sale in Seneca, SC

    Consider Similar Space for Sale. We found 9 Spaces matching your search parameters.

    Seneca Retail/Warehouse Opportunity
    $1,800,000
    1.01 Acres

    Seneca Retail/Warehouse Opportunity

    All brick/concrete building with existing tenants and expansion potential.

    518 W N 1st Street, Seneca, SC 29678
    View details
    Commercial Building in Seneca, SC
    $234,900
    0.23 Acres

    Commercial Building in Seneca, SC

    Commercial building with open floor plan suitable for retail/office/restaurant.

    615 W N 1st Street, Seneca, SC 29678
    View details
    Turn-Key Restaurant Franchise Opportunity
    $1,900,000
    0.78 Acres

    Turn-Key Restaurant Franchise Opportunity

    Turn-key national franchise restaurant with real estate for sale.

    1053 By Pass 123 Bypass, Seneca, SC 29678
    View details
    Seneca Retail Building For Sale
    $1,399,999
    12,000 SF

    Seneca Retail Building For Sale

    12,000 SF building with conversion potential in Seneca, SC.

    12020 North Radio Station Road, Seneca, SC 29678
    View details
    Prime Commercial Acreage For Sale
    $3,500,000
    4.33 Acres

    Prime Commercial Acreage For Sale

    4.3 acres in Seneca, SC, ideal for retail or hospitality.

    1018 E. North 1st Street, Seneca, SC 29678
    View details
    Seneca Retail Building For Sale
    $1,399,999
    12,000 SF

    Seneca Retail Building For Sale

    12,000 SF building with conversion potential in Seneca, SC.

    12020 N Radio Station Rd, Seneca, SC 29678
    View details
    Automotive Shop Near Lake Keowee
    $900,000

    Automotive Shop Near Lake Keowee

    10-bay automotive shop, redevelopment potential for fast food.

    445 By Pass 123, Seneca, SC 29678
    View details
    Established Hibachi Restaurant for Sale
    $219,000

    Established Hibachi Restaurant for Sale

    Turnkey Hibachi restaurant with existing lease and equipment included.

    1510 Blue Ridge Boulevard, Seneca, SC 29672
    View details
    Land Near Clemson University
    $350,000
    6.54 Acres

    Land Near Clemson University

    Land available near Clemson University, close to lakes.

    Union Station Dr, Seneca, SC 29678
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Laurens Road Commercial Land Lease
    Contact for pricing
    3,500 SF

    Laurens Road Commercial Land Lease

    0.72-acre build-to-suit or ground lease opportunity on Laurens Road.

    1012 Laurens Road, Greenville, SC 29607
    View details
    Ellijay, GA Commercial Land
    $7,260/Mo

    Ellijay, GA Commercial Land

    4.74 acres of commercial land for lease in Ellijay.

    4.74AC Eller Road, Ellijay, GA 30540
    View details
    Ellijay, GA Commercial Land
    $17,424/Mo

    Ellijay, GA Commercial Land

    12.86 acres of commercial land for lease in Ellijay.

    12.86AC Highlands Hill Drive, Ellijay, GA 30540
    View details
    Commercial Land on Winfield Dunn
    $8,000/Mo

    Commercial Land on Winfield Dunn

    Prime commercial property with high traffic count available for lease.

    332 Old Douglas Dam Road, Sevierville, TN 37876
    View details

    Seneca, SC Retail properties & Spaces Leasing Opportunities Market Analysis

    Explore Retail properties & Spaces leasing options in Seneca, SC with 9 listings featured on our commercial real estate exchange. The current inventory includes 55,762 square feet of properties with an estimated lease value of $76 SF/Yr.

    Estimated lease rates for Retail properties & Spaces in Seneca, SC begin at $11 SF/Yr, with an average of $19 SF/Yr and extend to $28 SF/Yr.
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    Most Searched ZIP Codes in Seneca, SC

    • 29678
    • 29672
    • 29768

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