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    Seneca, SC Office Spaces for Lease

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    7 properties
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    Flex Space with Showroom
    Updated: Aug 15
    Flex Space with Showroom

    879 By Pass 123 Highway Includes 710 Seneca Dr, Seneca, SC 29678

    $2,000/Mo
    3,264 sqft
    Two buildings provide 4,704 SF of combined commercial space
    1,440 SF building includes showroom, office, break room, and two bathrooms
    3,264 SF Service/Garage Industrial building supports service‑oriented use
    169 feet of road frontage along US By Pass 123
    Located at the traffic light intersection of Mountain View Drive and Seneca Drive
    View details
    Upper-Level Office Unit
    Updated: Aug 6
    Upper-Level Office Unit

    205 Stork Way Upper Unit, Seneca, SC 29678

    $1,300/Mo
    1,800 sqft
    1800+ SF upper‑level office unit
    Separate entry door accessed from the stairway
    Open floor plan with cubicles allowed
    Kitchenette or break room and full bathroom
    New luxury vinyl plank flooring and closet storage
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    Main Corridor Office Suite
    Main Corridor Office Suite

    114 Nimmons Circle, Seneca, SC 29678

    $1,600/Mo
    1,500 sqft

    Bottom-floor office suite with multiple offices, conference room, reception, two restrooms, and storage, with front parking and signage.

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    Office Units With Suite Options
    Office Units With Suite Options

    402 Cane Creek Landing Road, Seneca, SC 29672

    $26.26-$74.38 SF/Yr

    Flexible leasing includes private offices, floor suites, and full-building occupancy with shared conference and reception areas.

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    Built-Out Medical Office Suite
    Built-Out Medical Office Suite

    205 Central Park Ln, Seneca, SC 29678

    $17.50 SF/Yr

    Fully built-out suite with clinical rooms, reception, conference space, and staff amenities.

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    Furnished Office Unit
    Furnished Office Unit

    10 Accountants Circle, Seneca, SC 29678

    Contact for pricing

    Professional suite with nearby restroom, break room access, parking, and optional office furnishings.

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    Second-Floor Office Suite with Balcony
    Second-Floor Office Suite with Balcony

    202-1510 Blue Ridge Blvd, Seneca, SC 29672

    $3,000/Mo

    Second-floor suite with five private offices, a kitchen area, and two private bathrooms, plus shared lobby access and a balcony.

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    Based on your search, we've compiled 23 Potential Opportunities for your consideration. Besides 7 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 12 Properties for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Historic Mixed-Use Space
    Historic Mixed-Use Space

    102 Exchange Street Basement, Pendleton, SC 29670

    $3,100/Mo

    Basement commercial space offered as a shell for tenant upfit.

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    Multi-Building Flex Space
    Multi-Building Flex Space

    245 Welpine Rd, Pendleton, SC 29670

    Contact for pricing
    4,000 sqft 4.00 AC lot

    Commercial property combines front-facing office space with several warehouse buildings and two access points.

    View details
    First-Floor Retail and Office Suites
    First-Floor Retail and Office Suites

    125 Anderson Highway, Clemson, SC 29631

    $25 SF/Yr

    Three first-floor suites are available inside a 150-room, 500-bed student housing community on a high-traffic Clemson corridor.

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    Private Office Unit
    Private Office Unit

    106 Earle St, Clemson, SC 29631

    Contact for pricing

    Two work areas, storage, a private bathroom, and utilities support flexible day-to-day operations.

    View details

    Similar Spaces for Sale in Seneca, SC

    Consider Similar Space for Sale. We found 12 Spaces matching your search parameters.

    Five-Office Professional Office Suite
    Five-Office Professional Office Suite

    C-528 By Pass 123, Seneca, SC 29678

    $375,000
    1,290 sqft

    Move-in-ready workspace includes reception, kitchenette, and an ADA-accessible restroom.

    View details
    Professional Office Suite
    Professional Office Suite

    528 ByPass 123, Seneca, SC 29678

    $375,000
    1,290 sqft

    Flexible professional workspace with private offices, reception, kitchenette, and an ADA-accessible restroom.

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    Medical Office Building
    Medical Office Building

    685 S. Oak Street, Seneca, SC 29678

    Contact for pricing
    4,200 sqft

    Established medical office property with a lease renewal option and convenient access to Seneca, Clemson, and US-123.

    View details
    Mixed-Use Property with Detached Workshop
    Mixed-Use Property with Detached Workshop

    10695 Clemson Boulevard, Seneca, SC 29678

    $789,000

    Unrestricted acreage combines residential space, storage improvements, utility access, and flexibility for business operations.

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    Office Unit with Private Offices
    Office Unit with Private Offices

    1510 Blue Ridge Boulevard #103, Seneca, SC 29672

    $399,999

    Professional suite includes reception space, enclosed offices, restrooms, and a rear exit for additional access.

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    Corner Office Unit with Private Offices
    Corner Office Unit with Private Offices

    103-1510 Blue Ridge Blvd, Seneca, SC 29672

    $399,999

    Main-level space offers reception, three enclosed rooms, two restrooms, and a rear exit.

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    Renovated Two-Story Office Building
    Renovated Two-Story Office Building

    402 Cane Creek Landing Road, Seneca, SC 29672

    Contact for pricing

    Renovated office property with private offices near the Lake Keowee waterfront.

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    Upper-Level Office Unit
    Upper-Level Office Unit

    205 Stork Way, Upper Unit, Seneca, SC 29678

    Contact for pricing

    Flexible office layout with private entry, kitchenette, full bathroom, storage, and access to a paved parking area.

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    Freestanding Office Building
    Freestanding Office Building

    631 By Pass 123, Seneca, SC 29678

    Contact for pricing

    For sale office building at 631 By Pass 123, offering a straightforward setup for professional tenants.

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    Commercial
    Commercial

    Tract 18/19 S Walnut Street, Seneca, SC 29678

    $265,000

    Live-work space

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    Commercial Land with Existing Building
    Commercial Land with Existing Building

    11081 N Radio Station Road, Seneca, SC 29678

    $217,000
    0.63 AC lot

    Road-front commercial parcel with a 1973 structure, block construction, concrete flooring, and propane utility service.

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    Land Near Clemson University
    Land Near Clemson University

    Union Station Dr, Seneca, SC 29678

    Contact for pricing
    6.54 AC lot

    Land available near Clemson University, close to lakes.

    View details

    Seneca, SC Office Spaces Lease Rates & Market Statistics

    Explore 7 Office Spaces for lease in Seneca, SC on Realmo, a commercial real estate exchange covering the Seneca area. The current inventory totals 6,564 square feet of properties.

    Asking lease rates for Office Spaces in Seneca start at $7.35 SF/Yr, average $24.49 SF/Yr, and reach $74.38 SF/Yr at the top of the market. That's a 10x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $24.49 SF/Yr is in line with the South Carolina state average.

    Seneca accounts for 88% of the 8 office spaces currently available across Oconee County, where a nearby market includes Westminster.

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    Most Searched ZIP Codes in Seneca, SC

    • 29678
    • 29672

    Featured Seneca Real Estate Agencies

    Realmo connects you with licensed Seneca CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Keller Williams Seneca
    455 Highway 123 Suite A Seneca, SC 29678
    Phone: 18644822700
    bc5797.yourkwoffice.com
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