Seneca, SC Office Spaces for Rent & Lease

Updated: Mar 28, 2025

Seneca Office Space For Lease

865 Old Clemson Highway, Seneca, SC 29678

$1,500/Mo

Suitable for various business types, including medical/dental offices.
Two levels with separate entrances and restrooms, offering flexible leasing options (entire building or individual floors).
Located in close proximity to Clemson and Seneca.
Lower level features 3 offices, conference room, and reception area (Lease: $1,750.00 NNN).
Upper level offers 5 offices and a reception area (Lease: $2,900.00 NNN).

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Updated: Jun 19, 2024

Seneca Office/Retail Space Available

12019 North Radio Station Rd, Seneca, SC

$15 SF/Yr

4,800 sqft

Available Office/Retail Spaces
2,000 SF Space Available (1st - C)
1,800 SF Space Available (1st - F)
$15.00 NNN Lease Rate for 1st - C and 1st - F
1,000 SF Leased Space (1st - G)

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Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center

Based on your search, we've compiled 14 Potential Opportunities for your consideration. Besides 2 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 4 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Easley Office Space Available

109 Fleetwood Dr, Easley, SC

$11 SF/Yr

3,422 sqft

Office space available for rent in Easley, South Carolina.

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Former Bank Branch with Drive-Thru

3898 Liberty Highway, Anderson, SC 29621

$18 SF/Yr

Former bank branch with drive-thru located near major retailers.

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Professional Office Space Available

341 E Beltline Blvd, Anderson, SC

Contact for pricing

3,000 sqft

Well-maintained office park near US 178/N. Main St.

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Medical Office Building For Rent

109 Fleetwood Dr, Easley, SC 29640

$11 SF/Yr

18,631 sqft

Medical office building offering approximately 18,631 square feet for lease.

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Similar Spaces for Sale in Seneca, SC

Consider Similar Space for Sale. We found 4 Spaces matching your search parameters.

General Commercial Retail/Office Building

615 W N 1st Street, Seneca, SC 29678

$199,900

0.23 AC lot

Open floor plan with two bathrooms and a side storage building, zoned General Commercial in Seneca.

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Office Building with Road Frontage

11081 N Radio Station Road, Seneca, SC 29678

$217,000

0.63 AC lot

Single-building office asset just outside Seneca city limits with substantial road frontage on Radio Station Road.

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Freestanding Office Building

631 By Pass 123, Seneca, SC 29678

Contact for pricing

For sale office building at 631 By Pass 123, offering a straightforward setup for professional tenants.

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Land Near Clemson University

Union Station Dr, Seneca, SC 29678

$350,000

6.54 AC lot

Land available near Clemson University, close to lakes.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Prime Development Opportunity in Greenville

39 Airpark Ct, Greenville, SC 29607

Contact for pricing

1.27 acre interstate-visible land for ground lease or build-to-suit.

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Commercial Land Near Interstate 40

310 Goose Creek Road, Dandridge, TN 37725

$499,900/Mo

1,860 sqft

3.96 acres with high visibility near Interstate 40.

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Commercial Land in Powder Springs

2125 Brownsville Road, Powder Springs, GA 30127

$3,000/Mo

2,690 sqft

4.5 acres of commercial land for ground lease.

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Land Lease Opportunity in Waxhaw

5325 Waxhaw Marvin Road, Waxhaw, NC 28173

$8,000/Mo

5.341-acre commercial land for lease in a high-growth area.

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