Seneca, SC Office Spaces for Lease

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Clemson, SC Westminster, SC Walhalla, SC Pendleton, SC Anderson, SC Central, SC Salem, SC Fair Play, SC

7 properties

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Updated: Aug 15

Flex Space with Showroom

879 By Pass 123 Highway Includes 710 Seneca Dr, Seneca, SC 29678

$4,000/Mo

3,264 sqft

Two buildings provide 4,704 SF of combined commercial space
1,440 SF building includes showroom, office, break room, and two bathrooms
3,264 SF Service/Garage Industrial building supports service‑oriented use
169 feet of road frontage along US By Pass 123
Located at the traffic light intersection of Mountain View Drive and Seneca Drive

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Updated: Aug 6

Upper-Level Office Unit

205 Stork Way Upper Unit, Seneca, SC 29678

$1,300/Mo

1,800 sqft

1800+ SF upper‑level office unit
Separate entry door accessed from the stairway
Open floor plan with cubicles allowed
Kitchenette or break room and full bathroom
New luxury vinyl plank flooring and closet storage

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Main Corridor Office Suite

114 Nimmons Circle, Seneca, SC 29678

$1,600/Mo

1,500 sqft

Bottom-floor office suite with multiple offices, conference room, reception, two restrooms, and storage, with front parking and signage.

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Office Units With Suite Options

402 Cane Creek Landing Road, Seneca, SC 29672

$26.26-$74.38 SF/Yr

Flexible leasing includes private offices, floor suites, and full-building occupancy with shared conference and reception areas.

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Built-Out Medical Office Suite

205 Central Park Ln, Seneca, SC 29678

$17.50 SF/Yr

Fully built-out suite with clinical rooms, reception, conference space, and staff amenities.

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Furnished Office Unit

10 Accountants Circle, Seneca, SC 29678

Contact for pricing

Professional suite with nearby restroom, break room access, parking, and optional office furnishings.

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Second-Floor Office Suite with Balcony

202-1510 Blue Ridge Blvd, Seneca, SC 29672

$3,000/Mo

Second-floor suite with five private offices, a kitchen area, and two private bathrooms, plus shared lobby access and a balcony.

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Based on your search, we've compiled 26 Potential Opportunities for your consideration. Besides 7 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 15 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Historic Mixed-Use Space

102 Exchange Street Basement, Pendleton, SC 29670

$3,100/Mo

Basement commercial space offered as a shell for tenant upfit.

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First-Floor Retail and Office Suites

125 Anderson Highway, Clemson, SC 29631

$25 SF/Yr

Three first-floor suites are available inside a 150-room, 500-bed student housing community on a high-traffic Clemson corridor.

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Private Office Unit

106 Earle St, Clemson, SC 29631

Contact for pricing

Two work areas, storage, a private bathroom, and utilities support flexible day-to-day operations.

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Historic Corner Storefront Building

102 Exchange Street, Pendleton, SC 29670

$3,100/Mo

Corner-positioned commercial space offers shell delivery and tenant-directed upfit in a restored early-20th-century building.

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Similar Spaces for Sale in Seneca, SC

Consider Similar Space for Sale. We found 15 Spaces matching your search parameters.

Mixed-Use Property With Two Buildings

879 By Pass 123 Highway, includes 710 Seneca Drive, Seneca, SC 29678

$677,000

3,264 sqft

Two-building commercial offering with retail, office, and industrial improvements along an established Seneca business corridor.

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Five-Office Professional Office Suite

C-528 By Pass 123, Seneca, SC 29678

$375,000

1,290 sqft

Move-in-ready workspace includes reception, kitchenette, and an ADA-accessible restroom.

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Professional Office Suite

528 ByPass 123, Seneca, SC 29678

$375,000

1,290 sqft

Flexible professional workspace with private offices, reception, kitchenette, and an ADA-accessible restroom.

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Medical Office Building

685 S. Oak Street, Seneca, SC 29678

Contact for pricing

4,200 sqft

Established medical office property with a lease renewal option and convenient access to Seneca, Clemson, and US-123.

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Office Unit with Private Offices

1510 Blue Ridge Boulevard #103, Seneca, SC 29672

$399,999

Professional suite includes reception space, enclosed offices, restrooms, and a rear exit for additional access.

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Corner Office Unit with Private Offices

103-1510 Blue Ridge Blvd, Seneca, SC 29672

$399,999

Main-level space offers reception, three enclosed rooms, two restrooms, and a rear exit.

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Upper-Level Office Unit

205 Stork Way, Upper Unit, Seneca, SC 29678

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Flexible office layout with private entry, kitchenette, full bathroom, storage, and access to a paved parking area.

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Freestanding Office Building

631 By Pass 123, Seneca, SC 29678

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For sale office building at 631 By Pass 123, offering a straightforward setup for professional tenants.

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Office Building with Private Offices

735 N Townville St, Seneca, SC 29678

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Professional office property with reception space, multiple private rooms, and on-site parking.

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Commercial

Tract 18/19 S Walnut Street, Seneca, SC 29678

$265,000

Live-work space

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Commercial Land with Existing Building

11081 N Radio Station Road, Seneca, SC 29678

$217,000

0.63 AC lot

Road-front commercial parcel with a 1973 structure, block construction, concrete flooring, and propane utility service.

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Renovated Church Facility

936 S Depot St, Seneca, SC 29678

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Renovated commercial building includes offices, classroom or living areas, event space, kitchen, and multiple restrooms.

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Downtown Office Building

950 West North 1st Street, Seneca, SC 29678

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Office building with ample interior and exterior space and street visibility in downtown Seneca.

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Medical Office with Storage

2 Leas Courtyard, Seneca, SC 29672

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Former medical office with examination rooms, private entry, administrative areas, and adaptable storage space.

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Land Near Clemson University

Union Station Dr, Seneca, SC 29678

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6.54 AC lot

Land available near Clemson University, close to lakes.

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Seneca, SC Office Spaces Lease Rates & Market Statistics

Explore 7 Office Spaces for lease in Seneca, SC on Realmo, a commercial real estate exchange covering the Seneca area. The current inventory totals 6,564 square feet of properties.

Asking lease rates for Office Spaces in Seneca start at $8.67 SF/Yr, average $25.72 SF/Yr, and reach $74.38 SF/Yr at the top of the market. That's a 9x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $25.72 SF/Yr, the local average runs 9% above South Carolina's state average of $23.70 SF/Yr.

Seneca accounts for 100% of the 7 office spaces currently available across Oconee County.

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