Missouri Office Spaces for Rent & Lease

Updated: Jul 11

Renovated Office Building with Central Air

230 N Sprigg Street, Cape Girardeau, MO 63701

$2,500/Mo

2,937 sqft

Approximately 2,937 SF renovated office space
0.252‑acre lot with road frontage on N Sprigg St
Brand‑new A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, siding, and newly tuckpointed
Brick building with forced‑air heating and central air (electric cooling)
Parking lot with open parking

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Updated: Jun 29

Modern Office Space with Large Windows

2613 S Main Street, Joplin, MO 64804

$12 SF/Yr

5,000 sqft

Commercial office space with large windows and a clear span layout
Central heating and central air conditioning (central air)
Metal roof
Includes two restrooms
Accessible by elevator or stairs

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Newly Constructed Retail White Box

13225 Jay Drive, Neosho, MO 64850

$12 SF/Yr

1,600 sqft

New retail white box with central air, central electric heat, and two restrooms, with dedicated on-site parking.

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Flexible Church-Built Retail/Office Space

25 Winfield Manor Dr, Winfield, MO 63389

$1,200/Mo

6,000 sqft

A 6,000± SF suite with existing church buildout and flexible layout in Winfield Plaza.

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Office Suite for Lease

13221 Jay Drive Suite C, Neosho, MO 64850

$12 SF/Yr

1,400 sqft

Office suite with tenant-paid utilities and a minimum one-year lease term in a C-3 zoned commercial setting.

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Office Suite with Conference Space

110 W Spring Street, Neosho, MO 64850

$500/Mo

190 sqft

Flexible office room with conference space and shared restroom, with utilities and Wi‑Fi included.

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Second-Level Office Suite

3570 Osage Beach Parkway, Osage Beach, MO 65065

$1,500/Mo

1,480 sqft

Second-floor office suite with private offices, conference room, kitchenette, and reception for professional use.

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Retail-Office Space with Highway Exposure

12440 Lusher Road, Saint Louis, MO 63138

$12 SF/Yr

6,975 sqft

Retail/office building on major roadways with direct in-front Metro Transit access and strong Highway 367 traffic exposure.

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Class A Office Suite Cluster

7115 E 24th Street, Joplin, MO 64804

$2,500/Mo

1,450 sqft

Three adjoining office suites are available with open collaboration space and private offices in a professional building.

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One-Level Office Suite with Meeting Area

5513 Osage Beach Parkway, Osage Beach, MO 65065

$1,986/Mo

2,040 sqft

One-level office suite with private offices and a large meeting area in Lakeshore Plaza near key local destinations.

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Office Space with Private Entrance

2117-2121 S Brentwood Blvd, Saint Louis, MO 63144

$20 SF/Yr

3,418 sqft

Two-level office suite offers private entrance, multiple offices, and built-in kitchen and breakroom areas.

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Creative Office Space with Podcast Studio

702 S Main Street, Joplin, MO 64801

$12 SF/Yr

10,000 sqft

Creative office space with expansive open floor plans, refinished hardwood floors, and access to a shared podcast and event area.

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Remodeled First-Floor Office Suite

2650 E 32nd Street, Joplin, MO 64804

$12 SF/Yr

3,300 sqft

First-floor office suite with four private offices, two in-suite restrooms, two open areas, flex rooms, and storage closets.

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Two-Level Office Suite with Parking

222 E Water St, Springfield, MO 65806

$14.50 SF/Yr

5,240 sqft

Flexible two-level layout with executive offices, conference space, and abundant natural light plus ample private parking.

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Industrial Flex Space with Multiple Doors

602 S Michigan, Joplin, MO 64801

$6 SF/Yr

9,400 sqft

Flex building in M-2 zoning with private offices, restroom, warehouse, and multiple loading doors.

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Renovated Historic Office Suite

112 S Main Street, Joplin, MO 64801

$400/Mo

172 sqft

Renovated downtown office suite with secure high-speed internet, modern systems, and shared conference space.

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Office Suite with Private Offices

1001 Craig Rd, Suite 200, Saint Louis, MO 63146

$13 SF/Yr

8,553 sqft

Well-appointed office suite with multiple private offices, training rooms, and conference rooms available for sublease.

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Flexible Office/Retail Suite

1090 S Neosho Boulevard, Neosho, MO 64850

$8 SF/Yr

1,250 sqft

Suite includes a large open space and two restrooms, with client-friendly parking and high-traffic access.

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Office Suites with Courtyard

2388 Schuetz Rd, Maryland Heights, MO 63146

$16 SF/Yr

4,679 sqft

Professionally managed office building offering multiple suites, long window lines, and ample parking for flexible tenant needs.

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Creative Office Space with Corner Access

702 S Main Street, Joplin, MO 64801

$12 SF/Yr

5,000 sqft

Corner office space with open floor plans and shared first-floor amenity access, including a podcast studio and event space.

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Renovated Mixed-Use Building

7714 S Broadway, St, Louis, MO 63111

$400/Mo

6,000 sqft

Completely rebuilt 2019 mixed-use building with offices, conference room, open retail space, and 20-space concrete parking lot.

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Office Suite with Road Frontage

1313 W 16th, Suite 500 Street, Sedalia, MO 65301

$650/Mo

347 sqft

Office suite with excellent road frontage and utilities included for streamlined occupancy.

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Versatile Retail or Office Space

4310 Madison Ave, Kansas City, MO 64111

$14 SF/Yr

7,500 sqft

Newly renovated interior with high visibility, natural light, and private off-street parking for flexible retail, office, or restaurant use.

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Single-Story Office Building with Multiple Entrances

2001 S Empire Avenue, Joplin, MO 64804

$4,000/Mo

3,090 sqft

Single-story office building with eight private offices, two half baths, and three exterior entrances plus rear parking.

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Missouri Office Spaces Market Trends and Statistics

Explore Office Spaces leasing options in Missouri with 1522 listings featured on our commercial real estate exchange. The current inventory includes 4,479,071 square feet of properties with an estimated lease value of $5,038 /Mo.

Estimated lease rates for Office Spaces in Missouri begin at $0.56 SF/Yr, with an average of $19.45 SF/Yr and extend to $250 SF/Yr.