Advertise
    Cape Girardeau, MO
    Office

    Cape Girardeau, MO Office Spaces for Lease

    Notify Me
    List
    Map
    Scott City, MO Jackson, MO Anna, IL
    22 properties
    Sort:
    Renovated Downtown Storefront Property
    Updated: Jul 11
    Renovated Downtown Storefront Property

    230 N Sprigg Street, Cape Girardeau, MO 63701

    $2,500/Mo
    2,937 sqft 0.25 AC lot
    2937 square feet of renovated commercial space
    Renovations include A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, siding, and tuckpointing
    Brick construction with a flat roof
    Forced‑air heating and central air with electric cooling
    Open parking lot and road frontage on N Sprigg Street
    View details
    Office Units with Highway Frontage
    Updated: Nov 14, 2025
    Office Units with Highway Frontage

    450 Siemers Drive, Cape Girardeau, MO 63701

    $5,642/Mo
    6,770 sqft
    6,770 square feet of office space
    Built in 1991
    Business park setting with highway and interstate frontage
    Central air conditioning with electric, natural gas, and forced‑air heating
    Driveway parking available
    View details
    Office Unit with Garage
    Office Unit with Garage

    1000 Kingsway Drive, Cape Girardeau, MO 63701

    $2,348/Mo
    0.63 AC lot

    The lease is structured as NNN, with terms to be negotiated.

    View details
    Restaurant-Ready Office/Retail Suite
    Restaurant-Ready Office/Retail Suite

    820 N Sprigg St - Suites 3-4, Cape Girardeau, MO 63701

    $18 SF/Yr
    3,000 sqft

    Suite 1 offers an open layout and existing restaurant infrastructure with street visibility across from Towers Hall.

    View details
    Office Unit with Garage
    Office Unit with Garage

    1000 Kingsway Drive, Cape Girardeau, MO 63701

    $1,885/Mo
    0.63 AC lot

    The lease is structured as NNN, with terms to be negotiated.

    View details
    Updated Office Suite
    Updated Office Suite

    2027 Broadway Street, Cape Girardeau, MO 63701

    $1,958/Mo
    2.70 AC lot

    Second-floor workspace offers private offices, open collaboration space, a kitchenette, and secure badge access.

    View details
    Flexible Office Unit
    Flexible Office Unit

    1469 N Kingshighway Street, Cape Girardeau, MO 63701

    $1,128/Mo

    Adaptable commercial unit with private bathroom and expansion potential for office or service uses.

    View details
    Office Unit with Private Offices
    Office Unit with Private Offices

    C-1020 N Kingshighway Street, Cape Girardeau, MO 63701

    $1,200/Mo
    1,050 sqft

    Flexible suite layout includes reception, open workspace, break room, and private restroom.

    View details
    Retail Suite with Pylon Signage
    Retail Suite with Pylon Signage

    3065 William St Unit 202, Cape Girardeau, MO 63703

    $1,285/Mo
    976 sqft

    Flexible commercial suite with on-site signage and access to nearby retail, office, hospitality, and dining uses.

    View details
    Office Suite with Private Offices
    Office Suite with Private Offices

    1020 N. Kingshighway, Suite C, Cape Girardeau, MO 63701

    $1,200/Mo
    1,050 sqft

    Flexible commercial suite with reception, work areas, natural light, parking, and signage options for office or service-oriented use.

    View details
    Executive Office Suite
    Executive Office Suite

    2a-301 Broadway St, Cape Girardeau, MO 63701

    $5,633/Mo
    2,600 sqft

    Second-floor workspace with private offices, reception, breakroom, and two restrooms.

    View details
    Corner Executive Office Unit
    Corner Executive Office Unit

    301 Broadway St, Cape Girardeau, MO 63701

    $2,708/Mo
    2,600 sqft

    Second-floor corner suite with private offices, reception, breakroom, and two restrooms.

    View details
    Versatile Commercial Space on Kingshighway
    Versatile Commercial Space on Kingshighway

    500 N Kingshighway St, Cape Girardeau, MO 63701

    $3,650/Mo
    3,500 sqft

    3,500 SF commercial property suitable for retail, office, or service.

    View details
    Second-Floor Office Suite
    Second-Floor Office Suite

    2b-301 Broadway St, Cape Girardeau, MO 63701

    $2,600/Mo
    1,250 sqft

    Second-floor office suite with reception, private office, conference space, and an open area for flexible work setups.

    View details
    Downtown Office Building For Lease
    Downtown Office Building For Lease

    18 N. Main, Cape Girardeau, MO 63701

    $8,558/Mo
    13,694 sqft

    13,694 SF office building in historic downtown Cape Girardeau.

    View details
    Remodeled Office Space with Amenities
    Remodeled Office Space with Amenities

    1427 Thomas Dr, Cape Girardeau, MO 63701

    $850/Mo per office
    275 sqft

    Centrally located office space with modern finishes and included amenities.

    View details
    Remodeled Office Space with Amenities
    Remodeled Office Space with Amenities

    1427 Thomas Dr, Cape Girardeau, MO 63701

    $850/Mo per office
    279 sqft

    Centrally located office space with modern finishes and included amenities.

    View details
    Flex Space With Climate-Controlled Warehouse
    Flex Space With Climate-Controlled Warehouse

    H-760 S Kingshighway, Cape Girardeau, MO

    $4,500/Mo

    Versatile commercial space combines offices, showroom area, and climate-controlled warehouse functionality.

    View details
    Office Units with Private Offices
    Office Units with Private Offices

    C-760 S Kingshighway, Cape Girardeau, MO

    $4,995/Mo

    Flexible office layout combines open work areas with enclosed offices and convenient customer parking.

    View details
    Flexible Office Unit
    Flexible Office Unit

    2905 Independence Street Suite D, Cape Girardeau, MO 63703

    $800/Mo

    Professional suite with reception space, private rooms, a bathroom, and dedicated storage.

    View details
    Brand New Office/Retail Center
    Brand New Office/Retail Center

    440 S Mount Auburn Rd Unit 102, Cape Girardeau, MO 63703

    $2,466/Mo

    Brand new office and retail center offering suites starting at 1,088 sf.

    View details
    Spacious Office Space For Rent
    Spacious Office Space For Rent

    301 South Broadview Street, Cape Girardeau, MO 63703

    Contact for pricing
    15,100 sqft

    15,100 SF office space near dining and shopping.

    View details
    Based on your search, we've compiled 42 Potential Opportunities for your consideration. Besides 22 Active listings in Cape Girardeau, MO, we suggest exploring alternatives. Similar 20 Properties for Sales.

    Similar Spaces for Sale in Cape Girardeau, MO

    Consider Similar Space for Sale. We found 20 Spaces matching your search parameters.

    Renovated Mid-Century Office Building
    Renovated Mid-Century Office Building

    429 N Broadview Street, Cape Girardeau, MO 63701

    $1,690,000
    10,000 sqft

    Updated office building with multiple private offices, conference rooms, and an event space with bar and projection screen.

    View details
    Two-Level Office Building For Sale
    Two-Level Office Building For Sale

    10 Doctors Park, Cape Girardeau, MO 63703

    $815,000
    9,857 sqft 0.44 AC lot

    9,857 SF office building with multiple offices and restrooms.

    View details

    Cape Girardeau, MO Office Spaces Lease Rates & Market Statistics

    Browse 22 Office Spaces for lease in Cape Girardeau, MO on Realmo, a commercial real estate marketplace serving the Cape Girardeau area. The current inventory totals 55,081 square feet of properties — an average of ~2,500 SF per listing.

    Office Spaces lease rates in Cape Girardeau range from $7.50 SF/Yr at the entry level to $26 SF/Yr at the top of the market, averaging $15.24 SF/Yr. That's a 3x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $15.24 SF/Yr is 40% below the Missouri state average of $25.45 SF/Yr.

    Cape Girardeau accounts for 100% of the 22 office spaces currently available across Cape Girardeau County.

    List
    Map

    Popular Searches in Cape Girardeau, MO

    Popular Categories

    Most Searched ZIP Codes in Cape Girardeau, MO

    • 63701
    • 63703

    Featured Cape Girardeau Real Estate Agencies

    Realmo connects you with licensed Cape Girardeau CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Edge Realty
    2511 Independence St, Ste 100 Cape Girardeau, MO 63703
    Phone: 15733358111
    www.capeareahomes.com
    Why this one?
    Saved
    Reason not saved — we won't ask again

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!