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    Cape Girardeau, MO Office Spaces for Lease

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    Scott City, MO Jackson, MO
    20 properties
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    Renovated Downtown Storefront Property
    Updated: Jul 11
    Renovated Downtown Storefront Property

    230 N Sprigg Street, Cape Girardeau, MO 63701

    $2,500/Mo
    2,937 sqft 0.25 AC lot
    2937 square feet of renovated commercial space
    Renovations include A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, siding, and tuckpointing
    Brick construction with a flat roof
    Forced‑air heating and central air with electric cooling
    Open parking lot and road frontage on N Sprigg Street
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    Office Units with Highway Frontage
    Updated: Nov 14, 2025
    Office Units with Highway Frontage

    450 Siemers Drive, Cape Girardeau, MO 63701

    $5,642/Mo
    6,770 sqft
    6,770 square feet of office space
    Built in 1991
    Business park setting with highway and interstate frontage
    Central air conditioning with electric, natural gas, and forced‑air heating
    Driveway parking available
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    Second-Floor Office Suite
    Second-Floor Office Suite

    2027 Broadway Street, Cape Girardeau, MO 63701

    $1,958/Mo
    2.70 AC lot

    Updated second-floor suite with seven private offices, open work area, and secure 24/7 badge access.

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    Office Unit with Private Offices
    Office Unit with Private Offices

    C-1020 N Kingshighway Street, Cape Girardeau, MO 63701

    $1,200/Mo
    1,050 sqft

    Flexible suite layout includes reception, open workspace, break room, and private restroom.

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    Flexible Office Unit
    Flexible Office Unit

    1469 N Kingshighway Street, Cape Girardeau, MO 63701

    $1,128/Mo

    Commercial space with a private bathroom and owner-approved build-to-suit options.

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    Retail Suite with Pylon Signage
    Retail Suite with Pylon Signage

    3065 William St Unit 305, Cape Girardeau, MO 63703

    $1,190/Mo
    976 sqft

    Flexible commercial suite with on-site signage and access to nearby retail, office, hospitality, and dining uses.

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    Office Suite with Private Offices
    Office Suite with Private Offices

    1020 N. Kingshighway, Suite C, Cape Girardeau, MO 63701

    $1,200/Mo
    1,050 sqft

    Flexible commercial suite with reception, work areas, natural light, parking, and signage options for office or service-oriented use.

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    Flexible Office Units with Private Entrances
    Flexible Office Units with Private Entrances

    106 Farrar Drive, Cape Girardeau, MO 63703

    $2,500/Mo
    2,580 sqft

    Adaptable office suites offer open workspace, private offices, and a dedicated breakroom.

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    Executive Office Suite
    Executive Office Suite

    2a-301 Broadway St, Cape Girardeau, MO 63701

    $5,633/Mo
    2,600 sqft

    Second-floor workspace with private offices, reception, breakroom, and two restrooms.

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    Versatile Commercial Space on Kingshighway
    Versatile Commercial Space on Kingshighway

    500 N Kingshighway St, Cape Girardeau, MO 63701

    $3,650/Mo
    3,500 sqft

    3,500 SF commercial property suitable for retail, office, or service.

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    Second-Floor Office Suite
    Second-Floor Office Suite

    2b-301 Broadway St, Cape Girardeau, MO 63701

    $2,600/Mo
    1,250 sqft

    Second-floor office suite with reception, private office, conference space, and an open area for flexible work setups.

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    Downtown Office Building For Lease
    Downtown Office Building For Lease

    18 N. Main, Cape Girardeau, MO 63701

    $8,558/Mo
    13,694 sqft

    13,694 SF office building in historic downtown Cape Girardeau.

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    Corner Executive Office Unit
    Corner Executive Office Unit

    301 Broadway St, Cape Girardeau, MO 63701

    $26 SF/Yr
    2,600 sqft

    Second-floor corner suite with private offices, reception, breakroom, and two restrooms.

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    Remodeled Office Space with Amenities
    Remodeled Office Space with Amenities

    1427 Thomas Dr, Cape Girardeau, MO 63701

    $850/Mo per office
    275 sqft

    Centrally located office space with modern finishes and included amenities.

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    Remodeled Office Space with Amenities
    Remodeled Office Space with Amenities

    1427 Thomas Dr, Cape Girardeau, MO 63701

    $850/Mo per office
    279 sqft

    Centrally located office space with modern finishes and included amenities.

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    Office Units with Private Offices
    Office Units with Private Offices

    C-760 S Kingshighway, Cape Girardeau, MO

    $4,995/Mo

    Flexible office layout combines open work areas with enclosed offices and convenient customer parking.

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    Restaurant-Ready Office/Retail Suite
    Restaurant-Ready Office/Retail Suite

    820 N Sprigg St, Cape Girardeau, MO 63701

    Contact for pricing
    3,000 sqft

    Suite 1 offers an open layout and existing restaurant infrastructure with street visibility across from Towers Hall.

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    Ground-Floor Office Suite
    Ground-Floor Office Suite

    3065 William St Unit 202, Cape Girardeau, MO 63703

    $1,285/Mo

    Office suite with prominent building and pylon signage, plus convenient off-street parking.

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    Spacious Office Space For Rent
    Spacious Office Space For Rent

    301 South Broadview Street, Cape Girardeau, MO 63703

    Contact for pricing
    15,100 sqft

    15,100 SF office space near dining and shopping.

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    Brand New Office/Retail Center
    Brand New Office/Retail Center

    440 S Mt Auburn Rd, Cape Girardeau, MO 63703

    Contact for pricing

    Brand new office and retail center offering suites starting at 1,088 sf.

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    Based on your search, we've compiled 39 Potential Opportunities for your consideration. Besides 20 Active listings in Cape Girardeau, MO, we suggest exploring alternatives. Similar 19 Properties for Sales.

    Similar Spaces for Sale in Cape Girardeau, MO

    Consider Similar Space for Sale. We found 19 Spaces matching your search parameters.

    Renovated Office Building
    Renovated Office Building

    230 N Sprigg Street, Cape Girardeau, MO 63701

    $239,900
    2,937 sqft 0.25 AC lot

    Brick commercial property with central air, public utilities, and open-lot parking near downtown activity.

    View details
    Downtown Office Building For Sale
    Downtown Office Building For Sale

    18 N. Main, Cape Girardeau, MO 63701

    $899,900
    13,694 sqft

    13,694 SF office building in historic downtown Cape Girardeau.

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    Renovated Mid-Century Office Building
    Renovated Mid-Century Office Building

    429 N Broadview St, Cape Girardeau, MO 63701

    $1,690,000
    10,000 sqft

    Updated office building with multiple private offices, conference rooms, and an event space with bar and projection screen.

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    Cape Girardeau Medical Office Building
    Cape Girardeau Medical Office Building

    62 Doctors Park, Cape Girardeau, MO 63703

    $270,000
    2,546 sqft 0.43 AC lot

    2,546 SF medical office building in a thriving complex.

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    Cape Girardeau, MO Office Spaces Lease Rates & Market Statistics

    Browse 20 Office Spaces for lease in Cape Girardeau, MO on Realmo, a commercial real estate marketplace serving the Cape Girardeau area. The current inventory totals 57,661 square feet of properties — an average of ~2,900 SF per listing.

    Office Spaces lease rates in Cape Girardeau range from $7.50 SF/Yr at the entry level to $26 SF/Yr at the top of the market, averaging $15.53 SF/Yr. That's a 3x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $15.53 SF/Yr is 38% below the Missouri state average of $25.11 SF/Yr.

    Cape Girardeau accounts for 95% of the 21 office spaces currently available across Cape Girardeau County, where a nearby market includes Jackson.

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    Most Searched ZIP Codes in Cape Girardeau, MO

    • 63701
    • 63703

    Featured Cape Girardeau Real Estate Agencies

    Realmo connects you with licensed Cape Girardeau CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Edge Realty
    2511 Independence St, Ste 100 Cape Girardeau, MO 63703
    Phone: 15733358111
    www.capeareahomes.com

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