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    Cape Girardeau, MO Office Spaces for Lease

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    Jackson, MO Scott City, MO
    15 properties
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    Turn-Key Office Suite
    Updated: Nov 14, 2025
    Turn-Key Office Suite

    450 Siemers Drive, Cape Girardeau, MO 63701

    $5,642/Mo
    6,770 sqft
    Office suite with solar heating, forced air heating, and natural gas
    Central air and electric cooling
    Driveway parking
    Year built 1991
    Utilities include cable available; served by public water and public sewer
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    Renovated Office Building with Road Frontage
    Updated: Jul 1, 2025
    Renovated Office Building with Road Frontage

    230 N Sprigg Street, Cape Girardeau, MO 63701

    $2,500/Mo
    2,937 sqft
    Massive building with brick construction and flat roof
    Offered for sale or lease with road frontage on N Sprigg St
    Almost 3,000 sq ft of renovated space
    BRAND NEW A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, siding, and newly tuckpointed
    Utilities include public water and public sewer; forced air heating
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    Versatile Commercial Space on Kingshighway
    Versatile Commercial Space on Kingshighway

    500 N Kingshighway St, Cape Girardeau, MO 63701

    $3,650/Mo
    3,500 sqft

    3,500 SF commercial property suitable for retail, office, or service.

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    Professional Office Building For Rent
    Professional Office Building For Rent

    720 Forest Ave, Cape Girardeau, MO 63701

    $1,100/Mo
    1,218 sqft

    1,218 SF professional office building in good location.

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    Downtown Office Building For Lease
    Downtown Office Building For Lease

    18 N. Main, Cape Girardeau, MO 63701

    $8,558/Mo
    13,694 sqft

    13,694 SF office building in historic downtown Cape Girardeau.

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    Remodeled Office Space with Amenities
    Remodeled Office Space with Amenities

    1427 Thomas Dr, Cape Girardeau, MO 63701

    $850/Mo
    275 sqft

    Centrally located office space with modern finishes and included amenities.

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    Remodeled Office Space with Amenities
    Remodeled Office Space with Amenities

    1427 Thomas Dr, Cape Girardeau, MO 63701

    $850/Mo
    279 sqft

    Centrally located office space with modern finishes and included amenities.

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    Second-Floor Office Suite
    Second-Floor Office Suite

    2b-301 Broadway St, Cape Girardeau, MO 63701

    $2,600/Mo
    1,250 sqft

    Second-floor office suite with reception, private office, conference space, and an open area for flexible work setups.

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    Retail and Office Storefront
    Retail and Office Storefront

    211 Merriwether St, Cape Girardeau, MO 63703

    $1,000/Mo
    1,300 sqft

    Flexible 1,300 SF storefront layout with retail frontage and included office spaces, suited for mixed-use operations.

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    Office Space for Lease
    Office Space for Lease

    2027 Broadway Street, Cape Girardeau, MO 63701

    $1,958/Mo

    Office space available for lease at 2027 Broadway Street in Cape Girardeau.

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    Flex Space with Off-Street Parking
    Flex Space with Off-Street Parking

    213 Clark Street, Cape Girardeau, MO 63701

    $1,500/Mo

    Flexible 1,172 SF flex space in an M-1 district, suited for day care, office, or professional service use.

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    Restaurant-Ready Office/Retail Suite
    Restaurant-Ready Office/Retail Suite

    820 N Sprigg St, Cape Girardeau, MO 63701

    Contact for pricing
    3,000 sqft

    Suite 1 offers an open layout and existing restaurant infrastructure with street visibility across from Towers Hall.

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    Retail Storefront with Office Space
    Retail Storefront with Office Space

    221 Merriwether Street, Cape Girardeau, MO 63703

    Contact for pricing
    1,275 sqft

    Downtown retail storefront with office space for rent.

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    Warehouse with Drive-In Dock
    Warehouse with Drive-In Dock

    211 N Spring Avenue C, Cape Girardeau, MO 63701

    $6 SF/Yr
    13,875 sqft

    13,875 SF warehouse with office and drive-in dock.

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    Office Space with Reception Area
    Office Space with Reception Area

    Cape Girardeau, MO 63701

    $1,000/Mo
    1,200 sqft

    Office space featuring reception, offices, kitchen, and bathroom.

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    Based on your search, we've compiled 38 Potential Opportunities for your consideration. Besides 15 Active listings in Cape Girardeau, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 15 Properties for Sales.

    Office Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Office Space with Utilities Included
    Office Space with Utilities Included

    2905 E Jackson Boulevard, Jackson, MO 63755

    $850/Mo

    Leasing office space with a preferred three-year minimum term and all utilities included.

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    Spacious Office Space in Jackson
    Spacious Office Space in Jackson

    1600 S Hope St, Jackson, MO 63755

    $5,096/Mo
    4,368 sqft

    4,368 SF office space with ample parking in Jackson.

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    Two-Unit Flex Warehouse Facility
    Two-Unit Flex Warehouse Facility

    300 Matthews Lane, Sikeston, MO 63801

    $5,000/Mo

    Two separate warehouse units are available, including a dock-equipped front space and a back unit with offices and shop area.

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    Medical Office Space Sublease
    Medical Office Space Sublease

    1124 N Main Street, Sikeston, MO 63801

    $16.50 SF/Yr
    2,631 sqft

    2,631 SF medical office space available for sublease.

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    Similar Spaces for Sale in Cape Girardeau, MO

    Consider Similar Space for Sale. We found 15 Spaces matching your search parameters.

    Renovated Downtown Office and Retail Building
    Renovated Downtown Office and Retail Building

    230 N Sprigg Street, Cape Girardeau, MO 63701

    $239,900
    2,937 sqft 0.25 AC lot

    Renovated commercial building on a high-traffic downtown corridor, offering flexible space for offices or storefront services.

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    Versatile Retail/Office Building
    Versatile Retail/Office Building

    2357 Rust Avenue, Cape Girardeau, MO 63703

    $199,900
    0.57 AC lot

    Clean 1,800 sq ft commercial building with adaptable interior and parking, offered for sale.

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    Renovated Mid-Century Office Building
    Renovated Mid-Century Office Building

    429 N Broadview Street, Cape Girardeau, MO 63701

    $1,690,000
    15,831 sqft

    Updated office building with multiple private offices, conference rooms, and an event space with bar and projection screen.

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    Flex Space with Riverfront Access
    Flex Space with Riverfront Access

    308 N Main Street, Cape Girardeau, MO 63701

    $475,000
    0.50 AC lot

    Flexible riverfront building with multiple overhead doors, loading dock, and parking on both sides for varied commercial uses.

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    Two-Level Office Building For Sale
    Two-Level Office Building For Sale

    10 Doctors Park, Cape Girardeau, MO 63703

    $815,000
    9,857 sqft 0.44 AC lot

    9,857 SF office building with multiple offices and restrooms.

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    Downtown Office Building For Sale
    Downtown Office Building For Sale

    18 N. Main, Cape Girardeau, MO 63701

    $899,900
    13,694 sqft

    13,694 SF office building in historic downtown Cape Girardeau.

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    Updated Office Building with Parking
    Updated Office Building with Parking

    824 Independence Street, Cape Girardeau, MO 63703

    $350,000
    0.42 AC lot

    Well maintained office building on Independence Street with ample on-site parking and strong daily traffic counts.

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    Medical Office Condominiums in Building
    Medical Office Condominiums in Building

    937 Broadway Street, Cape Girardeau, MO 63701

    $99,000
    4,300 sqft

    Four commercial condominium units are located inside the historic Cape Girardeau Medical Arts building on Broadway Street.

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    Cape Girardeau Medical Office Building
    Cape Girardeau Medical Office Building

    62 Doctors Park, Cape Girardeau, MO 63703

    $270,000
    2,546 sqft 0.43 AC lot

    2,546 SF medical office building in a thriving complex.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Class A Office Suite with Bullpen
    Class A Office Suite with Bullpen

    1902 Vandalia Street, Collinsville, IL 62234

    $5,000/Mo

    Recently built office space with private offices, bullpen, and modern amenities for professional teams.

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    Office Development Land For Lease
    Office Development Land For Lease

    1323 Strawfloor Drive, Jonesboro, AR 72401

    Contact for pricing
    4,000 sqft

    2.43 acres for office development with build-to-suit opportunity.

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    Corner Lot on Highway 72
    Corner Lot on Highway 72

    30472 Highway 72, Madison, AL 35756

    $5,000/Mo
    1,875 sqft

    1.7 acre corner lot zoned for commercial, medical, residential.

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    Joplin Commercial Land For Lease
    Joplin Commercial Land For Lease

    2914&2920 E 22nd Street, Joplin, MO 64804

    $20/Mo
    5,000 sqft

    Versatile commercial land with potential for customized building.

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    Cape Girardeau, MO Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Cape Girardeau, MO with 15 listings featured on our commercial real estate exchange. The current inventory includes 46,298 square feet of properties with an estimated lease value of $174.90 SF/Yr.

    Estimated lease rates for Office Spaces in Cape Girardeau, MO begin at $6 SF/Yr, with an average of $15.90 SF/Yr and extend to $37.09 SF/Yr.
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