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    Cape Girardeau County, MO Office Properties & Spaces for Lease

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    Saint Louis, MO Louis, MO Kansas City, MO
    14 results
    Office Suite in Cape Girardeau
    $5,641 /Mo
    6,770 SF

    Office Suite in Cape Girardeau

    450 Siemers Drive, Cape Girardeau, MO 63701

    Office suite with high visibility and traffic in Cape Girardeau.

    • Turn‑key ready office suite
    • High visibility and high traffic location
    • Highway/Interstate frontage
    • Heating: Forced Air, Natural Gas, Solar
    • Cooling: Central Air, Electric
    Updated: Nov 14, 2025
    View details
    Renovated Commercial Space For Lease
    $2,500 /Mo
    2,937 SF

    Renovated Commercial Space For Lease

    230 N Sprigg Street, Cape Girardeau, MO 63701

    Renovated commercial space with high visibility in a prime location.

    • Prime location with high traffic and road frontage on N Sprigg St, offering excellent visibility in the Business District.
    • Almost 3000 sq ft of renovated space suitable for multiple offices or service providers.
    • Completely renovated with brand new A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, and siding.
    • Significant rental income potential.
    • Located downtown, in the midst of exciting activities.
    Updated: Jun 30, 2025
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    Historic Art Deco Landmark Space
    $2,900 /Mo

    Historic Art Deco Landmark Space

    Restored historic building in downtown Cape Girardeau's commercial district.

    824 Broadway St, Cape Girardeau, MO 63701
    View details
    Remodeled Office Space with Amenities
    $850 /Mo
    275 SF

    Remodeled Office Space with Amenities

    Centrally located office space with modern finishes and included amenities.

    1427 Thomas Dr, Cape Girardeau, MO 63701
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    Remodeled Office Space with Amenities
    $850 /Mo
    279 SF

    Remodeled Office Space with Amenities

    Centrally located office space with modern finishes and included amenities.

    1427 Thomas Dr, Cape Girardeau, MO 63701
    View details
    Downtown Office Building For Lease
    $8,558 /Mo
    13,694 SF

    Downtown Office Building For Lease

    13,694 SF office building in historic downtown Cape Girardeau.

    18 N. Main, Cape Girardeau, MO 63701
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    Professional Office Building For Rent
    $1,100 /Mo
    1,218 SF

    Professional Office Building For Rent

    1,218 SF professional office building in good location.

    720 Forest Ave, Cape Girardeau, MO 63701
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    Spacious Office Space in Jackson
    $5,096 /Mo
    4,368 SF

    Spacious Office Space in Jackson

    4,368 SF office space with ample parking in Jackson.

    1600 S Hope St, Jackson, MO 63755
    View details
    600 SF Commercial Storage Space
    $400 /Mo
    600 SF

    600 SF Commercial Storage Space

    Commercial space ideal for off-site storage with drive-in door.

    2222 Kingsway Dr, Suite C, Cape Girardeau, MO 63701
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    Spacious Office Space For Rent
    Contact for pricing
    15,100 SF

    Spacious Office Space For Rent

    15,100 SF office space near dining and shopping.

    301 South Broadview Street, Cape Girardeau, MO 63703
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    Prime Retail/Office Space Available
    Contact for pricing
    2,300 SF

    Prime Retail/Office Space Available

    New 2,300 SF space ideal for retail or office.

    3465 William, Cape Girardeau, MO 63703
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    Retail Storefront with Office Space
    Contact for pricing
    1,275 SF

    Retail Storefront with Office Space

    Downtown retail storefront with office space for rent.

    221 Merriwether Street, Cape Girardeau, MO 63703
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    Remodeled Office Building For Lease
    Contact for pricing
    8,200 SF

    Remodeled Office Building For Lease

    Move-in ready, remodeled office building with modern stylish space.

    1427 Thomas Dr, Cape Girardeau, MO 63701
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    Commercial Space For Lease
    Contact for pricing

    Commercial Space For Lease

    Commercial space available for lease at 3049 William St.

    3049 William St, Cape Girardeau, MO 63703
    View details
    Based on your search, we've compiled 45 Potential Opportunities for your consideration. Besides 14 Active listings in Cape Girardeau County, MO, we suggest exploring alternatives. Similar 27 Properties for Sales.

    Explore Similar Spaces for Sale in Cape Girardeau County, MO

    Consider Similar Space for Sale. We found 27 Spaces matching your search parameters.

    Versatile Commercial Building Near I-55
    $569,900
    3,096 SF

    Versatile Commercial Building Near I-55

    High-traffic location, built in 2017, suitable for diverse businesses.

    5598 Us Highway 61 North, Jackson, MO 63755
    View details
    Updated Office Building For Sale
    $350,000
    4,000 SF

    Updated Office Building For Sale

    Well-maintained office building with high visibility and ample parking.

    824 Independence Street, Cape Girardeau, MO 63703
    View details
    Versatile Riverfront Commercial Property
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main Street, Cape Girardeau, MO 63701
    View details
    Renovated Commercial Building in Cape Girardeau
    $239,900
    2,937 SF

    Renovated Commercial Building in Cape Girardeau

    Renovated commercial building with high visibility in a prime location.

    230 N Sprigg Street, Cape Girardeau, MO 63701
    View details
    Versatile Riverfront Commercial Property
    $475,000
    7,044 SF

    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main Street, Cape Girardeau, MO 63701
    View details
    Furnished Mixed-Use Professional Building
    $299,999
    3,210 SF

    Furnished Mixed-Use Professional Building

    Two-level, fully furnished office building in Jackson, Missouri.

    902 E Jackson Boulevard, Jackson, MO 63755
    View details
    Leased Office Building For Sale
    $500,000
    7,140 SF

    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Drive, Cape Girardeau, MO 63701
    View details
    Mixed-Use Building in Jackson, MO
    $325,000
    2,665 SF

    Mixed-Use Building in Jackson, MO

    Mixed-use property with income potential in Jackson, Missouri.

    1502 W Jackson Boulevard, Jackson, MO 63755
    View details
    Renovated 11-Bedroom Income Property
    $450,000
    4,548 SF

    Renovated 11-Bedroom Income Property

    Versatile, renovated 11-bedroom property in downtown Cape Girardeau.

    224 N Frederick Street, Cape Girardeau, MO 63701
    View details
    Versatile Commercial Property For Sale
    $295,000
    2,920 SF

    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Avenue, Cape Girardeau, MO 63701
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Collinsville Commercial Space For Lease
    $5,000 /Mo
    5,000 SF

    Collinsville Commercial Space For Lease

    Versatile commercial space in Collinsville, available immediately.

    1902 Vandalia Street, Collinsville, IL 62234
    View details
    Cleared Lot in St Clair
    $1.00 SF/Yr

    Cleared Lot in St Clair

    1.5-acre cleared lot zoned for general commercial use.

    Saint Clair, MO 63077
    View details
    Commercial Land For Lease
    $12,500 /Mo

    Commercial Land For Lease

    Prime commercial land for lease in high-traffic Rolla location.

    626 Bishop Avenue S, Rolla, MO 65401
    View details
    High-Traffic Commercial Land in Rolla
    $7,500 /Mo

    High-Traffic Commercial Land in Rolla

    0.61 acre commercial land in high-traffic area for lease.

    704 N Bishop Avenue, Rolla, MO 65401
    View details

    Cape Girardeau County, MO Office properties & Spaces Leasing Opportunities Market Analysis

    Explore Office properties & Spaces leasing options in Cape Girardeau County, MO with 14 listings featured on our commercial real estate exchange. The current inventory includes 422,836,920 square feet of properties with an estimated lease value of $20 SF/Yr.

    Estimated lease rates for Office properties & Spaces in Cape Girardeau County, MO begin at $10 SF/Yr, with an average of $10 SF/Yr and extend to $10 SF/Yr.
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    Browse Office properties & Spaces for Lease Near Cape Girardeau, MO

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