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    Cape Girardeau County, MO Office Spaces for Lease

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    Saint Louis, MO Kansas City, MO Springfield, MO
    16 results
    Office Suite in Cape Girardeau
    $5,641/Mo
    6,770 SF
    Office Suite in Cape Girardeau

    450 Siemers Drive, Cape Girardeau, MO 63701

    Office suite with high visibility and traffic in Cape Girardeau.
    • Turn‑key ready office suite
    • High visibility and high traffic location
    • Highway/Interstate frontage
    • Heating: Forced Air, Natural Gas, Solar
    • Cooling: Central Air, Electric
    Updated: Nov 14, 2025
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    Renovated Commercial Space For Lease
    $2,500/Mo
    2,937 SF
    Renovated Commercial Space For Lease

    230 N Sprigg Street, Cape Girardeau, MO 63701

    Renovated commercial space with high visibility in a prime location.
    • Prime location with high traffic and road frontage on N Sprigg St, offering excellent visibility in the Business District.
    • Almost 3000 sq ft of renovated space suitable for multiple offices or service providers.
    • Completely renovated with brand new A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, and siding.
    • Significant rental income potential.
    • Located downtown, in the midst of exciting activities.
    Updated: Jun 30, 2025
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    Flexible Restaurant/Retail/Office Suite
    $18 SF/Yr
    3,000 SF
    Flexible Restaurant/Retail/Office Suite

    Versatile suites with existing restaurant infrastructure, positioned across from Towers Hall for high student traffic.

    820 N Sprigg St - Suites 3-4, Cape Girardeau, MO 63701

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    Remodeled Office Space with Amenities
    $850/Mo
    275 SF
    Remodeled Office Space with Amenities

    Centrally located office space with modern finishes and included amenities.

    1427 Thomas Dr, Cape Girardeau, MO 63701

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    Remodeled Office Space with Amenities
    $850/Mo
    279 SF
    Remodeled Office Space with Amenities

    Centrally located office space with modern finishes and included amenities.

    1427 Thomas Dr, Cape Girardeau, MO 63701

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    Downtown Office Building For Lease
    $8,558/Mo
    13,694 SF
    Downtown Office Building For Lease

    13,694 SF office building in historic downtown Cape Girardeau.

    18 N. Main, Cape Girardeau, MO 63701

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    Professional Office Building For Rent
    $1,100/Mo
    1,218 SF
    Professional Office Building For Rent

    1,218 SF professional office building in good location.

    720 Forest Ave, Cape Girardeau, MO 63701

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    Spacious Office Space in Jackson
    $5,096/Mo
    4,368 SF
    Spacious Office Space in Jackson

    4,368 SF office space with ample parking in Jackson.

    1600 S Hope St, Jackson, MO 63755

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    600 SF Commercial Storage Space
    $400/Mo
    600 SF
    600 SF Commercial Storage Space

    Commercial space ideal for off-site storage with drive-in door.

    2222 Kingsway Dr, Suite C, Cape Girardeau, MO 63701

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    Historic Art Deco Landmark Space
    $2,900/Mo
    Historic Art Deco Landmark Space

    Restored historic building in downtown Cape Girardeau's commercial district.

    824 Broadway St, Cape Girardeau, MO 63701

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    Spacious Office Space For Rent
    Contact for pricing
    15,100 SF
    Spacious Office Space For Rent

    15,100 SF office space near dining and shopping.

    301 South Broadview Street, Cape Girardeau, MO 63703

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    Prime Retail/Office Space Available
    Contact for pricing
    2,300 SF
    Prime Retail/Office Space Available

    New 2,300 SF space ideal for retail or office.

    3465 William, Cape Girardeau, MO 63703

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    Versatile Commercial Space on Kingshighway
    Contact for pricing
    3,500 SF
    Versatile Commercial Space on Kingshighway

    3,500 SF commercial property suitable for retail, office, or service.

    500 N Kingshighway St, Cape Girardeau, MO 63701

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    Retail Storefront with Office Space
    Contact for pricing
    1,275 SF
    Retail Storefront with Office Space

    Downtown retail storefront with office space for rent.

    221 Merriwether Street, Cape Girardeau, MO 63703

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    Warehouse with Drive-In Dock
    $6 SF/Yr
    13,875 SF
    Warehouse with Drive-In Dock

    13,875 SF warehouse with office and drive-in dock.

    211 N Spring Avenue C, Cape Girardeau, MO 63701

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    Commercial Space For Lease
    Contact for pricing
    Commercial Space For Lease

    Commercial space available for lease at 3049 William St.

    3049 William St, Cape Girardeau, MO 63703

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    Based on your search, we've compiled 47 Potential Opportunities for your consideration. Besides 16 Active listings in Cape Girardeau County, MO, we suggest exploring alternatives. Similar 27 Properties for Sales.

    Similar Spaces for Sale in Cape Girardeau County, MO

    Consider Similar Space for Sale. We found 27 Spaces matching your search parameters.

    Versatile Commercial Building Near I-55
    $569,900
    3,096 SF
    Versatile Commercial Building Near I-55

    High-traffic location, built in 2017, suitable for diverse businesses.

    5598 Us Highway 61 North, Jackson, MO 63755

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    Furnished Mixed-Use Professional Building
    $184,900
    3,210 SF
    Furnished Mixed-Use Professional Building

    Two-level, fully furnished office building in Jackson, Missouri.

    902 E Jackson Boulevard, Jackson, MO 63755

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    Updated Office Building For Sale
    $350,000
    4,000 SF
    Updated Office Building For Sale

    Well-maintained office building with high visibility and ample parking.

    824 Independence Street, Cape Girardeau, MO 63703

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    Versatile Riverfront Commercial Property
    $400,000
    4,400 SF
    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main Street, Cape Girardeau, MO 63701

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    Renovated Commercial Building in Cape Girardeau
    $239,900
    2,937 SF
    Renovated Commercial Building in Cape Girardeau

    Renovated commercial building with high visibility in a prime location.

    230 N Sprigg Street, Cape Girardeau, MO 63701

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    Versatile Riverfront Commercial Property
    $475,000
    7,044 SF
    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main Street, Cape Girardeau, MO 63701

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    Versatile Commercial Property For Sale
    $295,000
    2,920 SF
    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Avenue, Cape Girardeau, MO 63701

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    Leased Office Building For Sale
    $500,000
    7,140 SF
    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Drive, Cape Girardeau, MO 63701

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Collinsville Commercial Space For Lease
    $5,000/Mo
    5,000 SF
    Collinsville Commercial Space For Lease

    Versatile commercial space in Collinsville, available immediately.

    1902 Vandalia Street, Collinsville, IL 62234

    View details
    Office Development Land For Lease
    Contact for pricing
    4,000 SF
    Office Development Land For Lease

    2.43 acres for office development with build-to-suit opportunity.

    1323 Strawfloor Drive, Jonesboro, AR 72401

    View details
    Commercial Land For Lease
    $12,500/Mo
    Commercial Land For Lease

    Prime commercial land for lease in high-traffic Rolla location.

    626 Bishop Avenue S, Rolla, MO 65401

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    High-Traffic Commercial Land in Rolla
    $7,500/Mo
    High-Traffic Commercial Land in Rolla

    0.61 acre commercial land in high-traffic area for lease.

    704 N Bishop Avenue, Rolla, MO 65401

    View details

    Cape Girardeau County, MO Office Spaces Leasing Opportunities Market Analysis

    Explore Office Spaces leasing options in Cape Girardeau County, MO with 16 listings featured on our commercial real estate exchange. The current inventory includes 44,016 square feet of properties with an estimated lease value of $140 SF/Yr.

    Estimated lease rates for Office Spaces in Cape Girardeau County, MO begin at $6 SF/Yr, with an average of $15 SF/Yr and extend to $37 SF/Yr.
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