Cape Girardeau County, MO Office Spaces for Rent & Lease

Updated: Nov 14, 2025

Turn-Key Office Suite

450 Siemers Drive, Cape Girardeau, MO 63701

$5,642/Mo

6,770 sqft

Office suite with solar heating, forced air heating, and natural gas
Central air and electric cooling
Driveway parking
Year built 1991
Utilities include cable available; served by public water and public sewer

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Updated: Jul 1, 2025

Renovated Office Building with Road Frontage

230 N Sprigg Street, Cape Girardeau, MO 63701

$2,500/Mo

2,937 sqft

Massive building with brick construction and flat roof
Offered for sale or lease with road frontage on N Sprigg St
Almost 3,000 sq ft of renovated space
BRAND NEW A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, siding, and newly tuckpointed
Utilities include public water and public sewer; forced air heating

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Office Space with Utilities Included

2905 E Jackson Boulevard, Jackson, MO 63755

$850/Mo

Leasing office space with a preferred three-year minimum term and all utilities included.

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Versatile Commercial Space on Kingshighway

500 N Kingshighway St, Cape Girardeau, MO 63701

$3,650/Mo

3,500 sqft

3,500 SF commercial property suitable for retail, office, or service.

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Professional Office Building For Rent

720 Forest Ave, Cape Girardeau, MO 63701

$1,100/Mo

1,218 sqft

1,218 SF professional office building in good location.

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Downtown Office Building For Lease

18 N. Main, Cape Girardeau, MO 63701

$8,558/Mo

13,694 sqft

13,694 SF office building in historic downtown Cape Girardeau.

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Spacious Office Space in Jackson

1600 S Hope St, Jackson, MO 63755

$5,096/Mo

4,368 sqft

4,368 SF office space with ample parking in Jackson.

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Remodeled Office Space with Amenities

1427 Thomas Dr, Cape Girardeau, MO 63701

$850/Mo

275 sqft

Centrally located office space with modern finishes and included amenities.

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Remodeled Office Space with Amenities

1427 Thomas Dr, Cape Girardeau, MO 63701

$850/Mo

279 sqft

Centrally located office space with modern finishes and included amenities.

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Second-Floor Office Suite

2b-301 Broadway St, Cape Girardeau, MO 63701

$2,600/Mo

1,250 sqft

Second-floor office suite with reception, private office, conference space, and an open area for flexible work setups.

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Retail and Office Storefront

211 Merriwether St, Cape Girardeau, MO 63703

$1,000/Mo

1,300 sqft

Flexible 1,300 SF storefront layout with retail frontage and included office spaces, suited for mixed-use operations.

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Office Space for Lease

2027 Broadway Street, Cape Girardeau, MO 63701

$1,958/Mo

Office space available for lease at 2027 Broadway Street in Cape Girardeau.

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Flex Space with Off-Street Parking

213 Clark Street, Cape Girardeau, MO 63701

$1,500/Mo

Flexible 1,172 SF flex space in an M-1 district, suited for day care, office, or professional service use.

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Restaurant-Ready Office/Retail Suite

820 N Sprigg St, Cape Girardeau, MO 63701

Contact for pricing

3,000 sqft

Suite 1 offers an open layout and existing restaurant infrastructure with street visibility across from Towers Hall.

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Retail Storefront with Office Space

221 Merriwether Street, Cape Girardeau, MO 63703

Contact for pricing

1,275 sqft

Downtown retail storefront with office space for rent.

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Warehouse with Drive-In Dock

211 N Spring Avenue C, Cape Girardeau, MO 63701

$6 SF/Yr

13,875 sqft

13,875 SF warehouse with office and drive-in dock.

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Office Space with Reception Area

Cape Girardeau, MO 63701

$1,000/Mo

1,200 sqft

Office space featuring reception, offices, kitchen, and bathroom.

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Based on your search, we've compiled 35 Potential Opportunities for your consideration. Besides 17 Active listings in Cape Girardeau County, MO, we suggest exploring alternatives. Similar 18 Properties for Sales.

Similar Spaces for Sale in Cape Girardeau County, MO

Consider Similar Space for Sale. We found 18 Spaces matching your search parameters.

Renovated Downtown Office and Retail Building

230 N Sprigg Street, Cape Girardeau, MO 63701

$239,900

2,937 sqft 0.25 AC lot

Renovated commercial building on a high-traffic downtown corridor, offering flexible space for offices or storefront services.

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Versatile Retail/Office Building

2357 Rust Avenue, Cape Girardeau, MO 63703

$199,900

0.57 AC lot

Clean 1,800 sq ft commercial building with adaptable interior and parking, offered for sale.

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Renovated Mid-Century Office Building

429 N Broadview Street, Cape Girardeau, MO 63701

$1,690,000

15,831 sqft

Updated office building with multiple private offices, conference rooms, and an event space with bar and projection screen.

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Flex Space with Riverfront Access

308 N Main Street, Cape Girardeau, MO 63701

$475,000

0.50 AC lot

Flexible riverfront building with multiple overhead doors, loading dock, and parking on both sides for varied commercial uses.

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Two-Level Office Building For Sale

10 Doctors Park, Cape Girardeau, MO 63703

$815,000

9,857 sqft 0.44 AC lot

9,857 SF office building with multiple offices and restrooms.

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Downtown Office Building For Sale

18 N. Main, Cape Girardeau, MO 63701

$899,900

13,694 sqft

13,694 SF office building in historic downtown Cape Girardeau.

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Multi-Level Office Building with Parking

4012 E Jackson Boulevard, Jackson, MO 63755

$249,900

0.59 AC lot

Three-level building with parking and a two-bed, one-bath unit on the third level.

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