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    Jefferson County, MO Office Spaces for Lease

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    High Ridge Retail/Office Space
    Updated: Oct 30, 2025
    High Ridge Retail/Office Space

    1588-1692 Gravois Road, High Ridge, MO

    $5.50 SF/Yr
    2,000 sqft
    Visibility from high trafficked Hwy 30
    14,445 SF of vacant space
    NNN lease structure
    1,000 SF retail suites available
    1,000‑3,045 SF available contiguous
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    Wellness-Inspired Medical Office Space
    Updated: May 8
    Wellness-Inspired Medical Office Space

    C-1000 N Truman Blvd, Crystal City, MO 63019

    $1,400/Mo
    Commercial space available for lease; previously occupied by a wellness clinic
    Flexible layout suitable for professional and service‑based businesses
    Well‑suited for wellness/medical‑related services, massage therapy, counseling, tutoring, personal care, or a tattoo studio
    Ample on‑site parking for clients and staff
    Vacant and ready for immediate occupancy
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    Retail and Office Spaces Available
    Retail and Office Spaces Available

    High Ridge, MO 63049

    $5.50 SF/Yr
    57,817 sqft

    Retail and office spaces for lease in High Ridge, Missouri.

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    Move-In Ready Office Space
    Move-In Ready Office Space

    3601 Commerce Dr, Arnold, MO

    $18.71 SF/Yr
    1,104 sqft

    Recently completed office space available for rent in Arnold, MO.

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    Retail/Office Space on Seckman Road
    Retail/Office Space on Seckman Road

    2855 Seckman Rd, Imperial, MO

    $14 SF/Yr
    2,800 sqft

    2800 SF retail/office space in high-traffic area.

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    Premier Office Space in Arnold
    Premier Office Space in Arnold

    3500-3510 Jeffco Blvd, Arnold, MO

    $17 SF/Yr
    1,565 sqft

    High-end office space with convenient access to amenities.

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    Renovated Office Retail Space Available
    Renovated Office Retail Space Available

    3029, High Ridge, MO 63049

    $14 SF/Yr
    2,277 sqft

    2,277 sq ft renovated office/retail space with ample parking.

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    Festus Retail, Office, Medical Space
    Festus Retail, Office, Medical Space

    101-109 Borga Bldg, Festus, MO

    Contact for pricing
    2,250 sqft

    Two spaces available in well-maintained Festus center.

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    Former Medical Space Endcap
    Former Medical Space Endcap

    21 Walters Pl, House Springs, MO 63051

    $15 SF/Yr
    3,600 sqft

    3,600 SF endcap space suitable for retail or medical use.

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    Retail/Office Space Available
    Retail/Office Space Available

    21 Walters Place, House Springs, MO 63051

    $15 SF/Yr
    4,800 sqft

    Divisible retail/office space with highway visibility.

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    Based on your search, we've compiled 27 Potential Opportunities for your consideration. Besides 10 Active listings in Jefferson County, MO, we suggest exploring alternatives. Similar 13 Properties for Sales.

    Similar Spaces for Sale in Jefferson County, MO

    Consider Similar Space for Sale. We found 13 Spaces matching your search parameters.

    Automotive Shop and Office Building
    Automotive Shop and Office Building

    888 Commercial Boulevard, Herculaneum, MO 63048

    $1,200,000
    0.63 AC lot

    Versatile shop space with four garage bays, office area, and customer check-in for automotive or light commercial operations.

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    Commercial Land with Office Improvements
    Commercial Land with Office Improvements

    114 Main Street, Hillsboro, MO 63050

    $426,900
    2,772 sqft 0.51 AC lot

    A downtown Hillsboro commercial site with office-ready space and a kitchen area on a half-acre corner lot.

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    Mixed-Use Income Property with Apartments
    Mixed-Use Income Property with Apartments

    2801 High Ridge Boulevard, High Ridge, MO 63049

    $610,000
    0.70 AC lot

    Residential and income-generating space on High Ridge Boulevard, including apartments plus an attached office and commercial units.

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    Multi-Family Income Property with Office
    Multi-Family Income Property with Office

    2801 High Ridge Boulevard, High Ridge, MO 63049

    $610,000
    0.70 AC lot

    Income-generating mixed-use property on heavily traveled High Ridge Blvd., including rental apartments, an attached office, and shop spaces.

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    Commercial-Residential Land with Warehouse
    Commercial-Residential Land with Warehouse

    1545 & 1565 State Hwy Z, Pevely, MO 63070

    $750,000
    9.98 AC lot

    Nearly 10 acres in Pevely, MO, featuring a house and warehouse with electric, with floodway-limited build areas.

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    Office Building with Highway Access
    Office Building with Highway Access

    3675 W Outer Road, Arnold, MO 63010

    $1,750,000
    25,558 sqft

    Office building offering strong visibility and convenient access supported by high daily vehicle counts on nearby roadways.

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    Renovated Retail/Office Space Available
    Renovated Retail/Office Space Available

    3838 Jeffco Blvd, Arnold, MO

    $1,395,000
    538 sqft 0.99 AC lot

    9,462 SF rentable commercial space in Arnold, MO.

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    Office Unit For Sale
    Office Unit For Sale

    2380 N Truman Blvd, Crystal City, MO 63019

    $450,642
    2,564 sqft

    Office unit for sale with below market rent.

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    Commercial Property Near City Hall
    Commercial Property Near City Hall

    114 Main St, Hillsboro, MO 63050

    $426,900
    2,772 sqft 0.50 AC lot

    Updated commercial property with large lot near government buildings.

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    Commercial Property with Three Buildings
    Commercial Property with Three Buildings

    1449 Jeffco Boulevard, Arnold, MO 63010

    $279,900
    1.22 AC lot

    Three commercial buildings with versatile spaces and ample parking.

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    Commercial Property with Three Buildings
    Commercial Property with Three Buildings

    1447 Jeffco Boulevard, Arnold, MO 63010

    $279,900
    0.11 AC lot

    Commercial property featuring three buildings suitable for various businesses.

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    Professional Office Building
    Professional Office Building

    3601 Commerce Dr, Arnold, MO 63010

    $950,000

    Professional office building in the Synergy Collaborative Building with flexible layout, ample parking, and modern amenities.

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    Cedar Hill Commercial Lots
    Cedar Hill Commercial Lots

    Lake Adelle, MO 63016

    $623,400
    1.79 AC lot

    1.79 acres near Highway 30, Cedar Hill, MO

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Class A Office Suite with Bullpen
    Class A Office Suite with Bullpen

    1902 Vandalia Street, Collinsville, IL 62234

    $5,000/Mo

    Recently built office space with private offices, bullpen, and modern amenities for professional teams.

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    Office Development Land For Lease
    Office Development Land For Lease

    1323 Strawfloor Drive, Jonesboro, AR 72401

    Contact for pricing
    4,000 sqft

    2.43 acres for office development with build-to-suit opportunity.

    View details
    Joplin Commercial Land For Lease
    Joplin Commercial Land For Lease

    2914&2920 E 22nd Street, Joplin, MO 64804

    $20/Mo
    5,000 sqft

    Versatile commercial land with potential for customized building.

    View details
    Plainfield Commercial Land For Rent
    Plainfield Commercial Land For Rent

    SW corner of Rte 59 & Fraser Road, Plainfield, IL 60586

    Contact for pricing

    6.491 acre commercial land available for rent in Plainfield, IL.

    View details

    Jefferson County, MO Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Jefferson County, MO with 10 listings featured on our commercial real estate exchange. The current inventory includes 75,963 square feet of properties with an estimated lease value of $104.71 SF/Yr.

    Estimated lease rates for Office Spaces in Jefferson County, MO begin at $5.50 SF/Yr, with an average of $13.09 SF/Yr and extend to $18.71 SF/Yr.
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