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St Joseph, MO Office Spaces for Lease

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Found 30 office space listings for lease in St Joseph, MO, averaging $18/SF/YR. Use lease type data to compare options faster.
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Flex Space with Warehouse
Updated: May 22
Flex Space with Warehouse

4402 S 40th Street, St Joseph, MO 64503

$7,000/Mo
1.31 AC lot
Flex suite with finished offices and warehouse space
16- to 18‑foot clear warehouse height
14‑foot overhead door
M‑1 zoning
Private office with dedicated restroom overlooking shop area
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Office Units with Shared Amenities
Updated: Jun 12
Office Units with Shared Amenities

1203 N 6th Street, St Joseph, MO 64501

$500/Mo
0.72 AC lot
Two private offices plus a dedicated storage area
Shared kitchen, break room, conference areas, and large open workspace
Dedicated parking in an on‑site parking lot
Full‑service gross lease includes janitorial services
C‑1 zoning
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Flexible Office Building
Flexible Office Building

1602 N Woodbine Road, St Joseph, MO 64506

Triple net (NNN)
$14 SF/Yr
9,420 sqft  Built 1994  1.43 acres
Road access

C-3-zoned office property with parking and a layout that supports single-user or multi-suite occupancy.

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Medical Office Space with Shared Entrance Options
Medical Office Space with Shared Entrance Options

2301 S 22nd St, Saint Joseph, MO 64505

$15 SF/Yr
1,280 sqft

An approximately 1,280-square-foot suite sits within a healthcare-related facility with parking and flexible access arrangements.

Shared or separate entrance options  Ample parking
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Retail Space with Pole Sign
Retail Space with Pole Sign

3007 S Belt Highway, St Joseph, MO 64503

$13 SF/Yr
1,273 sqft  Built 2000

C-3-zoned commercial space offers office and retail functionality with on-site parking and water availability.

Restroom  Breakroom  Large open area
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Downtown Mixed-Use Property
Downtown Mixed-Use Property

621 Francis Street, St Joseph, MO 64501

$1,850/Mo
Built 1930  0.07 acres

C3-Com zoning with water available and parking options at the property.

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Downtown Office Suite
Downtown Office Suite

625 Francis Street, St Joseph, MO 64501

$1,250/Mo
Built 1930  0.5 acres  stone facade
4 private offices  1 meeting room

Configured with private offices, a lobby, conference room, restroom, and large corner windows.

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Storefront Retail Space
Storefront Retail Space

518 Felix St, Saint Joseph, MO 64501

$3,000/Mo
5,000 sqft  Ground

Main-floor commercial space includes display cases, private offices, conference rooms, and a kitchen/break area.

High speed internet  Kitchen/break area  Reception area  Conference rooms
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Downtown Office Unit
Downtown Office Unit

216 1/2 N 7th Street, St Joseph, MO 64501

$500/Mo
1 space  800 sqft  0.02 acres

Compact office setting with C-3 zoning, water availability, and on-street parking in central St. Joseph.

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Downtown Flex Space
Downtown Flex Space

210 N 7th Street, St Joseph, MO 64501

$1,350/Mo
Built 1930

C-3-zoned commercial space with office, retail, and storage use possibilities plus garage, lot, and on-street parking options.

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Multi-Office Office Suite
Multi-Office Office Suite

3110 Suite 203, Karnes Road, St Joseph, MO 64506

Gross
$3,500/Mo
9–15 people  2,386 sqft  Built 1984
Highway access

A reception area, elevator access, and paved parking support day-to-day office operations.

Welcoming reception area  Fully ADA compliant  Paved parking lot
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Medical Office Space with Exam Rooms
Medical Office Space with Exam Rooms

3725 A Gene Field Road, St Joseph, MO 64506

$1,700/Mo
Built 1997  0.79 acres
Highway access

Medical office layout with reception, private office, exam rooms, breakroom, and on-site parking near the Belt Highway.

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Downtown Office Unit
Downtown Office Unit

214 N 7th Street, St Joseph, MO 64501

$350/Mo
1 space  500 sqft  Built 1930  0.01 acres

C-3-zoned office unit with on-street parking in downtown St. Joseph.

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Executive Office Suite with Elevator
Executive Office Suite with Elevator

3110 Suite 201 Karnes Road, St Joseph, MO 64506

Gross
$1,850/Mo
3–6 people  900 sqft

Professional office suite within an ADA-accessible executive building with elevator service and ample on-site parking.

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Newly Built Office Units
Newly Built Office Units

3820 Faraon Street, St Joseph, MO 64506

$17 SF/Yr
1 space  3,400 sqft  Built 2024  9.6 acres

Lower-floor office space with parking is available within a 2024 building.

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Office Campus with Parking
Office Campus with Parking

4802 Mitchell Avenue, St Joseph, MO 64507

$24 SF/Yr
Built 1990  27.66 acres
Public transit  Highway access

Office campus with customizable floor plans, parking, and access to nearby highways and public transportation.

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Medical Office Building
Medical Office Building

20994 State Route K, Saint Joseph, MO 64505

Contact for pricing
10,288 sqft  3.2 acres

Commercial building on 3.20 acres with paved parking, two entrances, and a full-service veterinary clinic setup.

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Executive Office Suites
Executive Office Suites

2911 S Belt Highway, St Joseph, MO 64503

Full service
$25 SF/Yr
435–585 sqft  Built 2000  1.83 acres
2 private offices  Highway access

Two-room office configurations with full-service utilities and janitorial coverage support small professional practices.

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Office Suite with Private Offices
Office Suite with Private Offices

Ste-203-3110 Suite 203 Karnes Rd, Saint Joseph, MO 64505

$3,500/Mo
9–15 people  2,386 sqft
Highway access

Office suite with multiple private offices, a large open area, and ADA-compliant access within a reception-equipped building.

Reception area  Elevator access  Fully ADA compliant  Paved parking lot
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Office Unit with Private Restroom
Office Unit with Private Restroom

2911 A S BELT Highway, St Joseph, MO 64503

$12 SF/Yr
1 space  1,596 sqft  Built 2000  1.83 acres

C-3-zoned office space with on-site parking, building signage, and water available.

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Move-in Ready Office in Historic Building
Move-in Ready Office in Historic Building

Saint Joseph, MO 64506

Modified gross
Contact for pricing
1 person  128 sqft  Built 1919

Single office space available in renovated historic Green Acres Building.

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Modern Office Unit with Open Layout
Modern Office Unit with Open Layout

1211 N Belt Highway, St Joseph, MO 64506

Full service
$28 SF/Yr
1 space  845 sqft  Built 2008  1.46 acres
Highway access + Road access

Open-plan office space in a multi-use development with utilities and janitorial service included.

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Office Units
Office Units

201 S 8th St, St Joseph, MO 64501

Contact for pricing
64–107 people  16,110 sqft

Office space is available at 201 S 8th St in St. Joseph, Missouri.

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Office Unit Near Belt Highway
Office Unit Near Belt Highway

3709 Suite E N Belt Highway, St Joseph, MO 64506

$13 SF/Yr
1 space  520 sqft  3.15 acres
Highway access

Compact office space with on-site parking and water availability.

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St Joseph, MO Office Spaces Lease Rates & Market Statistics

Explore 30 Office Spaces for lease in St Joseph, MO on Realmo, a commercial real estate exchange covering the St Joseph area. The current inventory totals 92,390 square feet of properties — an average of ~3,100 SF per listing.

Asking lease rates for Office Spaces in St Joseph start at $7.20 SF/Yr, average $17.82 SF/Yr, and reach $28 SF/Yr at the top of the market. That's a 4x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $17.82 SF/Yr is 22% below the Missouri state average of $22.89 SF/Yr.

Within Buchanan County, most St Joseph office spaces listings are located in and around Saint Joseph, with additional options across the city. By space type, the market includes 26 office units, 4 medical office space listings and 3 office buildings — medical office space options typically offer the lowest entry point, while office buildings command the highest rates.

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