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Saint Charles, MO Office Spaces for Lease

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Ground-Floor Private Office Suite 102
Updated: Jul 10
Ground-Floor Private Office Suite 102

Saint Charles, MO 63301

$1,200/Mo
Private Office Suite 102 on the ground floor
30' x 20' suite layout with three desks and one private office
Brick office building with forced‑air natural gas heat, central air, and flat roof
24/7 digital keypad access plus security cameras
Reception area and a small conference room for shared use
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Suite 201 Office Suite
Updated: Jul 15
Suite 201 Office Suite

Saint Charles, MO 63304

$800/Mo
Suite #201 available for immediate occupancy in the Arthur Bryan Building
421 sq ft office suite with new flooring, paint, and lighting
Large windows for natural light
Full‑service includes heat, electricity, trash, and Wi‑Fi
Kitchenette plus conference room use included
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New Construction Retail Space
New Construction Retail Space

Saint Charles, MO 63301

$2,850/Mo
1.25 AC lot

White-box delivery allows tenants to customize new retail or office space with flexible bay configurations.

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Move-In Ready Office Suite
Move-In Ready Office Suite

Saint Charles, MO 63304

$800/Mo
421 sqft

Full-service office suite with large windows, new finishes, kitchenette, and shared conference room access.

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Small Office Suite with Kitchenette
Small Office Suite with Kitchenette

Saint Charles, MO 63301

$1,400/Mo
0.16 AC lot

Single office suite includes a kitchenette and bathroom area with parking along Tompkins.

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Medical Office Space with Operatories
Medical Office Space with Operatories

Saint Charles, MO 63303

$19 SF/Yr
1.59 AC lot

Clinical layout includes reception, private offices, lab rooms, storage, patient amenities, and zoned HVAC.

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Office Space Near I-70
Office Space Near I-70

190 Spring Drive, Saint Charles, MO 63303

$12 SF/Yr
7,584 sqft

7,584 SF office space with convenient highway access.

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Office/Flex Building in Saint Charles
Office/Flex Building in Saint Charles

500 Fountain Lakes Blvd, Saint Charles, MO 63301

$16.50 SF/Yr
53,932 sqft

Class A office/flex building with high visibility and heavy power.

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Fenced Flex Space with Drive-In Doors
Fenced Flex Space with Drive-In Doors

7 Governor Drive, Saint Charles, MO 63301

$7,500/Mo

Secure, fully fenced property combines office space, storage, and drive-in access.

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Westgate 200 Available For Lease
Westgate 200 Available For Lease

3817-3841 Millstone Parkway, Saint Charles, MO 63301

$5.95 SF/Yr
86,800 sqft

86,800 SF divisible space with office and showroom.

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HVAC-Controlled Flex Space
HVAC-Controlled Flex Space

Saint Charles, MO 63303

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2,500 sqft

Clean, temperature-controlled suite with adaptable office-warehouse functionality and three-phase power availability.

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St. Charles Retail/Office Space
St. Charles Retail/Office Space

3910-3930 South Old Highway 94, Saint Charles, MO 63304

$22 SF/Yr
31,716 sqft

Retail and office spaces available in high-traffic St. Charles location.

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Second-Floor Office with 11 Offices
Second-Floor Office with 11 Offices

Saint Charles, MO 63301

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3,500 sqft

Second-floor office space above Llewelyn’s Pub with 11 offices, a bullpen area, and lot and street parking.

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Suite 105 Office Suite
Suite 105 Office Suite

Saint Charles, MO 63301

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1,275 sqft

Full-service lease Suite 105 in a C-2 zoned, two-story multi-tenant office building with ample parking.

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Office Unit Near Retail
Office Unit Near Retail

Saint Charles, MO 63301

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3,000 sqft

Office space positioned near retail, restaurants, and other offices with access to nearby regional highways.

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Turn-Key Dental Office Suite
Turn-Key Dental Office Suite

Saint Charles, MO 63303

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2,880 sqft

Updated dental office with five treatment chairs, waiting and reception area, and accessible restroom plus employee shower.

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Second-Floor Office Space
Second-Floor Office Space

Saint Charles, MO 63301

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2,512 sqft

Second-floor office suite with three offices, a large bullpen area, and two single restrooms.

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Office Building with Generator Backup
Office Building with Generator Backup

2070 Little Hills Expy, Saint Charles, MO 63301

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41,125 sqft 4.75 AC lot

41,125 SF office building with generator, UPS back-up, IT rooms, and 269 parking spaces.

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Move-In Ready Office Suites
Move-In Ready Office Suites

Saint Charles, MO 63304

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421 sqft

Move-in ready office suites with updated interiors, large windows, and shared conference and kitchenette access.

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Multi-Tenant Professional Office Building
Multi-Tenant Professional Office Building

Saint Charles, MO 63303

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1,250 sqft

Multi-tenant office building offering a 1,509-square-foot suite with ample on-site parking.

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Main Floor Office Suite
Main Floor Office Suite

Saint Charles, MO 63301

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2,000 sqft

Main floor office space features multiple offices, a conference room, and a large bullpen with reception and kitchenette.

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Office Space in Saint Charles
Office Space in Saint Charles

Saint Charles, MO 63303

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3,500 sqft

Single tenant office space available for rent, 3,500 SqFt.

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Divisible Office Suite
Divisible Office Suite

Saint Charles, MO 63301

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3,825 sqft

Office space with private offices and open area, divisible for flexible tenant needs in a well-maintained brick building.

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Single-Tenant Retail Space
Single-Tenant Retail Space

300 Water St, Saint Charles, MO 63301

Contact for pricing
6,500 sqft

Retail space offered as single-tenant units ranging from smaller to larger footprints.

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Saint Charles, MO Office Spaces Lease Rates & Market Statistics

Browse 40 Office Spaces for lease in Saint Charles, MO on Realmo, a commercial real estate marketplace serving the Saint Charles area. The current inventory totals 267,510 square feet of properties — an average of ~6,700 SF per listing.

Asking lease rates for Office Spaces in Saint Charles start at $5.95 SF/Yr, average $15.75 SF/Yr, and reach $22.80 SF/Yr at the top of the market. That's a 4x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $15.75 SF/Yr, the local average runs 39% below Missouri's state average of $25.79 SF/Yr.

Saint Charles accounts for 44% of the 91 office spaces currently available across St. Charles County, where nearby markets include O Fallon and St Peters. By space type, the market includes 32 office units, 7 office buildings and 3 medical office space listings — office buildings typically offer the lowest entry point, while medical office space commands the highest rates.

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