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Saint Charles, MO Office Spaces for Lease

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38 properties
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Connected Office Suites
Updated: Sep 23
Connected Office Suites

Saint Charles, MO 63304

$430/Mo
Suite 202 measures 349 SF; Suite 203 measures 224 SF; combined area is 573 contiguous SF
Suites can be leased separately or together and connect by a private hallway
Full‑service offering includes heat, electricity, trash, Wi‑Fi, kitchenette, and conference room use
Recent updates include flooring, paint, lighting, and interior and exterior renovations
Large windows, common‑area bathrooms on each floor, and atrium seating
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Private Office Suites
Updated: Jul 22
Private Office Suites

Saint Charles, MO 63301

$500/Mo
0.23 AC lot
Suites 203 and 204 offer approximately 13' x 11' of private, lockable office space
High‑speed internet and Wi‑Fi included
24/7 secure building access with security cameras
Dedicated mailbox and business address provided
Renovated 1920 brick office building
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New Construction Retail Space
New Construction Retail Space

Saint Charles, MO 63301

$2,850/Mo
1.25 AC lot

White-box delivery offers flexible space for customized retail or office buildouts.

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Lower-Level Office Units
Lower-Level Office Units

Saint Charles, MO 63301

$667/Mo
800 sqft

Lower-level units in a retail center are identified for office, storage, or BLDR office use.

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Office Unit with Kitchenette
Office Unit with Kitchenette

Saint Charles, MO 63301

$1,400/Mo
0.16 AC lot

Compact office setup with a kitchenette, bathroom area, and a setting suited to minimal foot traffic.

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Medical Office Space with Operatories
Medical Office Space with Operatories

Saint Charles, MO 63303

$19 SF/Yr
1.59 AC lot

Clinical layout includes reception, private offices, lab rooms, storage, patient amenities, and zoned HVAC.

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Office Space Near I-70
Office Space Near I-70

190 Spring Drive, Saint Charles, MO 63303

$10 SF/Yr
7,584 sqft

7,584 SF office space with convenient highway access.

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Multi-Tenant Brick Office Building
Multi-Tenant Brick Office Building

Saint Charles, MO 63303

$12 SF/Yr
14,015 sqft

Well-maintained all-brick office building offers an updated, 1,550 SF suite with separate at-grade entrances.

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Professional Office Space
Professional Office Space

Saint Charles, MO 63303

$15 SF/Yr
11,160 sqft

Professional office space for lease with ample parking and strong exposure to Hwy 94.

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Westgate 200 Available For Lease
Westgate 200 Available For Lease

3817-3841 Millstone Parkway, Saint Charles, MO 63301

$5.95 SF/Yr
86,800 sqft

86,800 SF divisible space with office and showroom.

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Fenced Flex Space with Drive-In Doors
Fenced Flex Space with Drive-In Doors

7 Governor Dr, Saint Charles, MO 63301

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6,000 sqft

Secure, fully fenced property combines office space, storage, and drive-in access.

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HVAC-Controlled Flex Space
HVAC-Controlled Flex Space

Saint Charles, MO 63303

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2,500 sqft

Clean, temperature-controlled suite with adaptable office-warehouse functionality and three-phase power availability.

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Newly Renovated Medical Office Space
Newly Renovated Medical Office Space

Saint Charles, MO 63303

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2,698 sqft

Newly renovated two-story entrance lobby anchors office suites with conference and kitchen amenities.

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Professional Office Suite with Bullpen
Professional Office Suite with Bullpen

918-924 Hemsath Rd, Saint Charles, MO 63303

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1,560 sqft

Business-park space combines collaborative work areas with private office and support amenities.

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Second-Floor Office with 11 Offices
Second-Floor Office with 11 Offices

Saint Charles, MO 63301

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3,500 sqft

Second-floor office space above Llewelyn’s Pub with 11 offices, a bullpen area, and lot and street parking.

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Two-Story Office Building
Two-Story Office Building

Saint Charles, MO 63303

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9,200 sqft

Updated professional space offers flexible floor configurations, dedicated parking, signage, and access to multiple regional highways.

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Second-Floor Office Unit
Second-Floor Office Unit

Saint Charles, MO 63301

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675 sqft

Office suite with a private room, open workspace, kitchenette, and dedicated access.

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Retail Suite in Retail/Office Building
Retail Suite in Retail/Office Building

4500-4520 Central School Rd, Saint Charles, MO 63304

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750 sqft

750-square-foot space available across from Hollenbeck Elementary School on Central School Road.

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Suite 105 Office Suite
Suite 105 Office Suite

Saint Charles, MO 63301

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1,275 sqft

Full-service lease Suite 105 in a C-2 zoned, two-story multi-tenant office building with ample parking.

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Office Unit Near Retail
Office Unit Near Retail

Saint Charles, MO 63301

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3,000 sqft

Office space positioned near retail, restaurants, and other offices with access to nearby regional highways.

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Turn-Key Dental Office Suite
Turn-Key Dental Office Suite

Saint Charles, MO 63303

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2,880 sqft

Updated dental office with five treatment chairs, waiting and reception area, and accessible restroom plus employee shower.

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Second-Floor Office Space
Second-Floor Office Space

Saint Charles, MO 63301

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2,512 sqft

Second-floor office suite with three offices, a large bullpen area, and two single restrooms.

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Office Building with Generator Backup
Office Building with Generator Backup

2070 Little Hills Expy, Saint Charles, MO 63301

Contact for pricing
41,125 sqft 4.75 AC lot

41,125 SF office building with generator, UPS back-up, IT rooms, and 269 parking spaces.

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Private Office Units Near University
Private Office Units Near University

Saint Charles, MO 63301

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600 sqft

Private office suites include shared conference and kitchenette access, open parking, natural light, and utilities within an all-inclusive lease.

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Saint Charles, MO Office Spaces Lease Rates & Market Statistics

Browse 38 Office Spaces for lease in Saint Charles, MO on Realmo, a commercial real estate marketplace serving the Saint Charles area. The current inventory totals 296,789 square feet of properties — an average of ~7,800 SF per listing.

Asking lease rates for Office Spaces in Saint Charles start at $5.95 SF/Yr, average $11.99 SF/Yr, and reach $19 SF/Yr at the top of the market. That's a 3x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. At $11.99 SF/Yr, the local average runs 53% below Missouri's state average of $25.29 SF/Yr.

Saint Charles accounts for 49% of the 77 office spaces currently available across St. Charles County, where nearby markets include St Peters and O Fallon. By space type, the market includes 33 office units, 5 office buildings and 4 medical office space listings — office buildings typically offer the lowest entry point, while medical office space commands the highest rates.

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