Independence, MO Office Spaces for Lease

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Kansas City, MO Raytown, MO Lees Summit, MO Liberty, MO Blue Springs, MO Claycomo, MO Gladstone, MO North Kansas City, MO

12 properties

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Updated: Apr 18

Renovated Medical Office Space

3916 S Lynn Court, Independence, MO 64055

$10 SF/Yr

0.36 AC lot

Second‑floor office and laboratory space
Recent paint and flooring improvements
Suitable for dental or medical use
0.36‑acre site in Independence, MO
B zoning

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Updated: Apr 13

Office and Retail Suite

18920 E Valley View, unit H Parkway, Independence, MO 64055

$18 SF/Yr

Office/retail space across the street from a big box store (current use: tax service company).
Interior includes reception/waiting area, large conference room, open work area, breakroom, and bathroom.
Parking available in a parking lot.
Utilities include water available.
Available June 1, 2026.

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Medical Clinic in Office Building

300 N Osage St, Independence, MO 64050

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5,270 sqft

Move-in ready second-floor medical clinic offers 13 exam rooms, lab space, and private offices in a well-maintained building.

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Office Building with Fenced and Gated Parking

4609 S Norfleet Rd, Independence, MO 64055

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8,000 sqft 0.20 AC lot

Fenced and gated 1/5-acre parking lot with separate gas and electric by floor and a 13-year-old roof.

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Office Space for Lease

301 W Lexington Ave, Independence, MO 64050

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969 sqft

Office space available for lease in Independence, Missouri.

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Office-Retail Space with Conference Room

18920 E Valley View, Independence, MO 64055

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Office and retail space includes a reception area, large conference room, open work area, and breakroom.

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Office Suite with Penthouse Patio

14401 E 42nd St S, Independence, MO 64055

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3,087 sqft

Office space features elevators, restrooms, and conference rooms, plus a penthouse level with private patio.

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Medical Office Space with Exam Rooms

3800 S Elizabeth St, Independence, MO 64057

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2,700 sqft

Previously built-out medical office includes six rooms suitable for exam rooms or private offices.

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Medical Office Space with Exam Rooms

3800 S Elizabeth St, Independence, MO 64057

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1,200 sqft

Suite with six exam room or private office options, plus restroom and storage space.

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Office Space with Elevator

14405 E 42nd St S, Independence, MO 64055

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2,283 sqft

Full-service lease office suite with shared common amenities, breakroom, and conference rooms across multiple floors.

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Office Building with Private Suites

14401 E 42nd St S, Independence, MO 64055

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10,195 sqft

Office building featuring private suites and restrooms available for lease.

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Prime Location in Independence, Missouri

18777 East 39th St S, Independence, MO 64057

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Strategically located at the crossroads of I-70 and I-470.

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Based on your search, we've compiled 38 Potential Opportunities for your consideration. Besides 12 Active listings in Independence, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 22 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Light Industrial Flex Office

6103 Arlington Ave, Raytown, MO 64133

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6,000 sqft

One 6,000 SF light industrial space is available and can be divided into three separate areas.

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Office Space with Flexible Sublease Terms

9201 E 63rd St, Raytown, MO 64133

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10,000 sqft

Approximately 10,000 SF office space with a mix of open areas and office buildout for flexible sublease terms.

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Medical Office Space Available

Lees Summit, MO 64064

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4,350 sqft

Class A medical office space for lease with exam rooms.

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High-Quality Office Space Available

Lees Summit, MO 64064

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AAA office space suitable for medical or professional services.

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Similar Spaces for Sale in Independence, MO

Consider Similar Space for Sale. We found 22 Spaces matching your search parameters.

Medical Office Building with Courtyard

20101 E Jackson Drive, Independence, MO 64057

$3,100,000

16,086 sqft

Brick single-story building with an interior courtyard, active medical tenants, and a vacant space available for owner occupancy.

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Office Unit with On-Site Parking

2701 Blue Ridge Boulevard, Independence, MO 64052

$149,900

0.44 AC lot

C-1-zoned office property with basement access, storage, and a paved parking area for small commercial operations.

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Single-Story Office Building

20101 E JACKSON Drive, Independence, MO 64057

$3,100,000

1.60 AC lot

C-2-zoned office property with medical service occupancy, available space, and direct visibility from I-70.

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Renovated Multi-Story Office Building

201 E PARTRIDGE AVE, Independence, MO 64055

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15,626 sqft 1.26 AC lot

Renovated office property combines leased occupancy with shell space and a Class A floor ready for occupancy.

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Remodeled Office Building

705 E 23rd Street S, Independence, MO 64055

$249,000

0.09 AC lot

C3-zoned office property with private offices, rear parking, garage storage, and updated building systems.

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Two-Story Office Building Suites

4212 South Hocker Drive, Independence, MO 64055

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10,080 sqft

Two-story office building offers private suite entrances and TI availability for credit tenants.

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Renovated Commercial Space, High-Traffic Location

625 West 23rd St S, Independence, MO 64055

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480 sqft

Move-in ready, renovated commercial space suitable for various business opportunities.

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Office Building with Newer Roof

120 S Liberty Street, Independence, MO 64050

$1,150,000

0.30 AC lot

C-2 zoning, an on-site parking lot, and a downtown setting support professional and community-oriented uses.

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Office Building

2311 Redwood Avenue, Independence, MO 64057

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9,212 sqft

The building dates to 1985 and is positioned at 2311 Redwood Avenue.

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Medical Office Conversion Opportunity

13717-13723 E 39th St S, Independence, MO 64055

$365,000

Former veterinary suite with reception, private offices, exam/treatment rooms, and extensive plumbing, ready for updates.

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Fully Renovated Office-Retail Building

307 East 23rd Street South, Independence, MO 64055

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1,164 sqft

Stand-alone, fully renovated building with multiple office areas, kitchen/break space, restrooms, and off-street parking.

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Office Space with Private Restroom

14405 E 42nd St S, Independence, MO

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1,361 sqft 1.58 AC lot

Office space featuring private offices, restroom, and designated storage.

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Independence, MO Office Spaces Market Trends and Statistics

Explore Office Spaces leasing options in Independence, MO with 12 listings featured on our commercial real estate exchange. The current inventory includes 33,704 square feet of properties with an estimated lease value of $28.

Estimated lease rates for Office Spaces in Independence, MO begin at $10 SF/Yr, with an average of $14 SF/Yr and extend to $18 SF/Yr.

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