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South San Francisco, CA Office Spaces for Lease

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Cost-Efficient Office Space at CA, South San Francisco - Spaces Oyster Point. Contact us today to book a tour!
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Biotech Lab and Office Suite
Updated: Jun 5
Biotech Lab and Office Suite

1 Tower Pl, South San Francisco, CA 94080

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14,674 sqft
Flex suite configured for biology lab and tissue culture use
Includes a tissue culture suite and associated lab space
Features (1) 6FT fume hood and house gases
Lab support includes Vac & CDA
Break room plus (2) conference rooms and (3) private offices
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Two-Story Flex Space with Elevator
Updated: Apr 16
Two-Story Flex Space with Elevator

453-467 Forbes Boulevard, South San Francisco, CA 94080

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3,786 sqft
Warehouse area of 119,798 SF
22–24’ clear height
Two‑story building with elevator
New office buildout with high‑end finishes
Renovated lobby and common areas
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Laboratory Office Building
Laboratory Office Building

285 E Grand Ave, South San Francisco, CA 94080

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65,764 sqft

Fully integrated biology, tissue culture, chemistry, and vivarium lab space with large suite and floor configurations.

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Distribution Center with HVAC Office
Distribution Center with HVAC Office

275 South Maple Avenue, South San Francisco, CA 94080

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70,000 sqft

Sprinklered distribution facility with dedicated offices, conference space, and warehouse racking.

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Office Space Walking Distance to Caltrain
Office Space Walking Distance to Caltrain

South San Francisco, CA 94080

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5,283 sqft

Office space in the South San Francisco life science cluster with convenient Highway 101 access and walkable CalTrain access.

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Corner Flex Warehouse with Lab Potential
Corner Flex Warehouse with Lab Potential

436 N Canal St, Unit 10, South San Francisco, CA 94080

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3,710 sqft

Corner flex/warehouse condo with 1,000 sf office, central HVAC, 400-amp power, and 9 reserved spaces.

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Move-In Ready Office Lab Suite
Move-In Ready Office Lab Suite

600 Gateway Blvd, South San Francisco, CA 94080

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4,889 sqft

Plug-and-play office lab suite with access to autoclave; lab equipment is negotiable.

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Centrally Located Office Building
Centrally Located Office Building

South San Francisco, CA 94080

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9,655 sqft

Office building in the South San Francisco life science cluster with walking access to CalTrain and nearby Highway 101 access.

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Corner Office Suite with Meeting Rooms
Corner Office Suite with Meeting Rooms

1486 Huntington Ave, South San Francisco, CA 94080

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2,621 sqft

Third-floor corner office suite featuring three private offices and three meeting rooms, with elevator access and 8 parking spaces.

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Office Space Near Caltrain
Office Space Near Caltrain

601 Gateway Blvd, South San Francisco, CA 94080

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10,451 sqft

Centrally located office space in the South San Francisco life science cluster near CalTrain and Highway 101 access.

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Office Space Near CalTrain
Office Space Near CalTrain

South San Francisco, CA 94080

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14,168 sqft

Office space in the South San Francisco Life Science cluster with walking access to CalTrain and convenient Highway 101 access.

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Office Space Near Caltrain
Office Space Near Caltrain

601 Gateway Blvd, South San Francisco, CA 94080

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5,557 sqft

Centrally located office space in the South San Francisco life science cluster, with CalTrain within walking distance.

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Office Units Near Life Science Cluster
Office Units Near Life Science Cluster

South San Francisco, CA 94080

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10,208 sqft

Office units with access to restaurants, retail, fitness centers, hotels, marina amenities, public transportation, and nearby residential communities.

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Office Space Near Caltrain
Office Space Near Caltrain

South San Francisco, CA 94080

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7,107 sqft

Centrally located office option within the South San Francisco life science cluster, walkable to CalTrain.

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Office Space Near Caltrain
Office Space Near Caltrain

601 Gateway Blvd, South San Francisco, CA 94080

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2,801 sqft

Office space in the South San Francisco life science cluster with CalTrain access and nearby retail, dining, and hotels.

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Office Units Near Caltrain
Office Units Near Caltrain

South San Francisco, CA 94080

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5,469 sqft

Office units in the South San Francisco life science cluster with convenient Highway 101 access and walking distance to CalTrain.

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Office Space Near Caltrain Station
Office Space Near Caltrain Station

601 Gateway Blvd, South San Francisco, CA 94080

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1,900 sqft

Centrally located office space near the CalTrain station with convenient access to Highway 101.

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South San Francisco Office/Lab Sublease
South San Francisco Office/Lab Sublease

651 Gateway Boulevard, South San Francisco, CA 94080

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22,365 sqft

Full floor office/lab space available for sublease through July 2029.

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Class A Lab & Office
Class A Lab & Office

151 Oyster Point Boulevard, South San Francisco, CA 94080

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78,173 sqft

Sublease opportunity: 34,988 SF of Class A lab & office.

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South San Francisco Office Space
South San Francisco Office Space

1487 Huntington Ave, South San Francisco, CA 94080

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14,000 sqft

14,000 sqft office space available for rent.

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Office Units Within Walking Distance to CalTrain
Office Units Within Walking Distance to CalTrain

601 Gateway Blvd, South San Francisco, CA 94080

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1,856 sqft

Office units in the South San Francisco life science cluster with walking access to CalTrain and nearby dining, retail, and hotels.

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Office Space for Lease
Office Space for Lease

343 Oyster Point Blvd, South San Francisco, CA 94080

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17,507 sqft

Office space is available for lease at 343 Oyster Point Blvd with suite sizes ranging from 4,511 to 17,507 SF.

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South San Francisco Campus For Lease
South San Francisco Campus For Lease

385 Oyster Point Blvd, South San Francisco, CA 94080

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5,400 sqft

Three-building campus with office, industrial, and life science space.

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South San Francisco, CA Office Spaces Lease Rates & Market Statistics

Browse 60 Office Spaces for lease in South San Francisco, CA on Realmo, a commercial real estate marketplace serving the South San Francisco area. The current inventory totals 2,125,454 square feet of properties — an average of ~35,400 SF per listing.

Office Spaces lease rates in South San Francisco range from $129/Mo at the entry level to $35,812/Mo at the top of the market, averaging $17,970/Mo.

South San Francisco accounts for 4% of the 1,630 office spaces currently available across San Mateo County, where nearby markets include San Francisco and San Mateo. By space type, the market includes 34 office units and 22 office buildings.

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