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South San Francisco, CA Office Spaces for Lease

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Cost-Efficient Office Space at CA, South San Francisco - Spaces Oyster Point. Contact us today to book a tour!
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Office Unit With Reception Area
Updated: Sep 9
Office Unit With Reception Area

363 El Camino Real, South San Francisco, CA 94080

$3,200/Mo
Four offices within the unit
Separate reception area
Abundant natural light
Property built in 1963
Located at 363 El Camino Real in South San Francisco
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Biotech Lab and Office Suite
Updated: Jun 5
Biotech Lab and Office Suite

1 Tower Pl, South San Francisco, CA 94080

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14,674 sqft
Flex suite configured for biology lab and tissue culture use
Includes a tissue culture suite and associated lab space
Features (1) 6FT fume hood and house gases
Lab support includes Vac & CDA
Break room plus (2) conference rooms and (3) private offices
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Laboratory Office Building
Laboratory Office Building

285 E Grand Ave, South San Francisco, CA 94080

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65,764 sqft

Fully integrated biology, tissue culture, chemistry, and vivarium lab space with large suite and floor configurations.

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Distribution Center with HVAC Office
Distribution Center with HVAC Office

275 South Maple Avenue, South San Francisco, CA 94080

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70,000 sqft

Sprinklered distribution facility with dedicated offices, conference space, and warehouse racking.

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Corner Flex Warehouse with Lab Potential
Corner Flex Warehouse with Lab Potential

436 N Canal St, Unit 10, South San Francisco, CA 94080

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3,710 sqft

Corner flex/warehouse condo with 1,000 sf office, central HVAC, 400-amp power, and 9 reserved spaces.

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Move-In Ready Office Lab Suite
Move-In Ready Office Lab Suite

600 Gateway Blvd, South San Francisco, CA 94080

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4,889 sqft

Plug-and-play office lab suite with access to autoclave; lab equipment is negotiable.

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Corner Office Suite with Meeting Rooms
Corner Office Suite with Meeting Rooms

1486 Huntington Ave, South San Francisco, CA 94080

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2,621 sqft

Third-floor corner office suite featuring three private offices and three meeting rooms, with elevator access and 8 parking spaces.

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Office Space Near Caltrain
Office Space Near Caltrain

601 Gateway Blvd, South San Francisco, CA 94080

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5,557 sqft

Centrally located office space in the South San Francisco life science cluster, with CalTrain within walking distance.

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Partially Built-Out Office and Flex Space
Partially Built-Out Office and Flex Space

1 Tower Place, South San Francisco, CA 94080

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18,748 sqft

For lease with approximately half of the office area already built out, supporting a range of business layouts.

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South San Francisco Office/Lab Sublease
South San Francisco Office/Lab Sublease

651 Gateway Boulevard, South San Francisco, CA 94080

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22,365 sqft

Full floor office/lab space available for sublease through July 2029.

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Class A Lab & Office
Class A Lab & Office

131 Oyster Point Blvd, South San Francisco, CA 94080

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34,988 sqft

Sublease opportunity: 34,988 SF of Class A lab & office.

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South San Francisco Office Space
South San Francisco Office Space

1487 Huntington Ave, South San Francisco, CA 94080

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14,000 sqft

14,000 sqft office space available for rent.

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Office Space in South San Francisco
Office Space in South San Francisco

2 Tower Place, South San Francisco, CA 94080

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19,817 sqft

58,446 SF office space available for lease.

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South San Francisco Campus For Lease
South San Francisco Campus For Lease

385 Oyster Point Blvd, South San Francisco, CA 94080

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5,400 sqft

Three-building campus with office, industrial, and life science space.

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Life Science Campus for Collaboration
Life Science Campus for Collaboration

101 Terminal Ct, South San Francisco, CA 94080

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378,068 sqft

South San Francisco campus with lab and office space.

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Oyster Point Campus For Lease
Oyster Point Campus For Lease

389 Oyster Point Blvd, South San Francisco, CA 94080

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3,329 sqft

Three-building campus with office, industrial, and life science space.

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South San Francisco Office Space
South San Francisco Office Space

453-467 Forbes Blvd, South San Francisco, CA 94080

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40,606 sqft

Office building with 40,606 square feet available for rent.

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Move-in Ready Lab/Office Space
Move-in Ready Lab/Office Space

600 Gateway Boulevard, South San Francisco, CA 94080

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9,174 sqft

Class A lab and office space in South San Francisco.

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Bayfront Office Space Available
Bayfront Office Space Available

400 Oyster Point Blvd, South San Francisco, CA 94080

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2,314 sqft

Office space with bay views, restaurant, and fitness center.

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Class A Flex Sublease
Class A Flex Sublease

333 Oyster Point Blvd, South San Francisco, CA

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30,140 sqft 8.93 AC lot

Flexible sublease with modern amenities and highway access.

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Office Space For Rent
Office Space For Rent

South San Francisco, CA 94080

$27 SF/Yr

Office space available for rent in South San Francisco.

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Integrated Lab Office Facility
Integrated Lab Office Facility

285 E Grand Ave, South San Francisco, CA 94080

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13,000 sqft

Fully integrated biology, tissue culture, chemistry, and vivarium lab space across two floors, available July 2026.

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South San Francisco Life Science Building
South San Francisco Life Science Building

901 Gateway Boulevard, South San Francisco, CA 94080

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10,913 sqft

Three-story life science building for sublease in South San Francisco.

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South San Francisco Integrated Facility
South San Francisco Integrated Facility

285 East Grand Avenue, South San Francisco, CA 94080

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30,000 sqft

Integrated biology, tissue culture, chemistry, and vivarium labs for rent.

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South San Francisco, CA Office Spaces Lease Rates & Market Statistics

Browse 48 Office Spaces for lease in South San Francisco, CA on Realmo, a commercial real estate marketplace serving the South San Francisco area. The current inventory totals 2,012,152 square feet of properties — an average of ~41,900 SF per listing.

Office Spaces lease rates in South San Francisco range from $27 SF/Yr at the entry level to $27 SF/Yr at the top of the market, averaging $27 SF/Yr. Pricing across the market is relatively uniform, which simplifies like-for-like comparison between listings. The local average of $27 SF/Yr is 10% above the California state average of $24.61 SF/Yr.

South San Francisco accounts for 4% of the 1,260 office spaces currently available across San Mateo County, where nearby markets include San Francisco and San Mateo. By space type, the market includes 30 office units, 13 office buildings and 3 other office properties.

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