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    South San Francisco, CA Office Spaces for Lease

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    43 properties
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    CA, South San Francisco - Spaces Oyster Point
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    Insulated Flex Warehouse with Offices
    Updated: Jun 8
    Insulated Flex Warehouse with Offices

    140 Beacon St, South San Francisco, CA 94080

    Contact for pricing
    24,000 sqft
    ±24,000 SF total with flexible layout (can be divisible): ±14,000 SF office and ±20,000 SF warehouse
    Excellent Hwy 101 frontage with building signage available
    Insulated warehouse with skylights and fully sprinklered system
    15' clear height with 3 grade‑level doors; dock loading possible (owner‑retrofitted)
    Power available: 800 amps, 480V 3‑phase; plus 200 amps, 220V
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    Functional Lab/Office Space Available
    Updated: Apr 15
    Functional Lab/Office Space Available

    600 Gateway Blvd, South San Francisco, CA 94080

    Contact for pricing
    8,711 sqft
    Prime location with easy Hwy 101 access
    Walking distance to SSF Caltrain station and shuttle to BART and ferry
    Highly functional lab/office space
    Strong MEP systems for various lab/office uses
    New facade and lobby
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    South San Francisco Industrial Building
    South San Francisco Industrial Building

    250 Hillside Boulevard, South San Francisco, CA 94080

    Contact for pricing
    29,800 sqft

    Freestanding industrial building with office/lab space for rent.

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    Corner Flex Warehouse with Lab Potential
    Corner Flex Warehouse with Lab Potential

    436 North Canal Street, South San Francisco, CA 94080

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    3,710 sqft

    Corner flex/warehouse condo with 1,000 sf office, central HVAC, 400-amp power, and 9 reserved spaces.

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    Partially Built-Out Office and Flex Space
    Partially Built-Out Office and Flex Space

    1 Tower Pl, South San Francisco, CA 94080

    Contact for pricing
    31,500 sqft

    For lease with approximately half of the office area already built out, supporting a range of business layouts.

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    South San Francisco Office/Lab Sublease
    South San Francisco Office/Lab Sublease

    651 Gateway Boulevard, South San Francisco, CA 94080

    Contact for pricing
    22,365 sqft

    Full floor office/lab space available for sublease through July 2029.

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    Class A Lab & Office
    Class A Lab & Office

    131 Oyster Point Blvd, South San Francisco, CA 94080

    Contact for pricing
    34,988 sqft

    Sublease opportunity: 34,988 SF of Class A lab & office.

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    South San Francisco Office Space
    South San Francisco Office Space

    1487 Huntington Ave, South San Francisco, CA 94080

    Contact for pricing
    14,000 sqft

    14,000 sqft office space available for rent.

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    Plug & Play Office Sublease
    Plug & Play Office Sublease

    111 Oyster Point Blvd, South San Francisco, CA 94080

    Contact for pricing
    29,711 sqft

    Sublease available with premier finishes and included furniture.

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    Office Space in South San Francisco
    Office Space in South San Francisco

    South San Francisco, CA 94080

    Contact for pricing
    58,446 sqft

    58,446 SF office space available for lease.

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    South San Francisco Office Space
    South San Francisco Office Space

    453-467 Forbes Blvd, South San Francisco, CA 94080

    Contact for pricing
    40,606 sqft

    Office building with 40,606 square feet available for rent.

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    Office Space For Rent
    Office Space For Rent

    South San Francisco, CA 94080

    $27 SF/Yr

    Office space available for rent in South San Francisco.

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    South San Francisco Integrated Facility
    South San Francisco Integrated Facility

    285 East Grand Avenue, South San Francisco, CA 94080

    Contact for pricing
    30,000 sqft

    Integrated biology, tissue culture, chemistry, and vivarium labs for rent.

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    Life Science Campus for Rent
    Life Science Campus for Rent

    180 El Camino Real, South San Francisco, CA 94080

    Contact for pricing
    300,000 sqft

    Vibrant campus with amenities near Biotech Bay Area corridor.

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    South San Francisco Office Space
    South San Francisco Office Space

    701 Gateway Blvd, South San Francisco, CA

    Contact for pricing
    29,470 sqft

    LEED Gold certified office space with excellent transportation access.

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    Purpose-Built Lab Building For Rent
    Purpose-Built Lab Building For Rent

    233 East Grand Avenue, South San Francisco, CA 94080

    Contact for pricing
    32,000 sqft

    Lab building with cafe, fitness center, and courtyard.

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    South San Francisco Office Space
    South San Francisco Office Space

    5000 Shoreline Court, South San Francisco, CA 94080

    Contact for pricing
    73,216 sqft

    Office space for rent in South San Francisco life science hub.

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    South San Francisco Office/Lab Space
    South San Francisco Office/Lab Space

    180 Kimball Way & 442 Littlefield Ave, South San Francisco, CA 94080

    Contact for pricing
    85,140 sqft

    Office and laboratory spaces in South San Francisco.

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    South San Francisco Life Science Campus
    South San Francisco Life Science Campus

    East Grand Ave & Harbor Way, South San Francisco, CA 94080

    Contact for pricing
    226,763 sqft

    Class A life science campus in South San Francisco.

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    Class A Office Building
    Class A Office Building

    6000 Shoreline Court, South San Francisco, CA 94080

    Contact for pricing
    31,321 sqft

    Class A office building in South San Francisco life science market.

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    South San Francisco Office Space
    South San Francisco Office Space

    490 Forbes Boulevard, South San Francisco, CA 94080

    Contact for pricing
    107,175 sqft

    Move-in ready office suites available in South San Francisco.

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    South San Francisco Office Space
    South San Francisco Office Space

    90 S Spruce Ave, South San Francisco, CA

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    979 sqft

    Second floor office space available for rent in South San Francisco.

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    South San Francisco Office Space
    South San Francisco Office Space

    4000 Shoreline Court, South San Francisco, CA 94080

    Contact for pricing
    24,581 sqft

    Office and medical space available for lease in South San Francisco.

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    South San Francisco R&D Lab
    South San Francisco R&D Lab

    180 Kimball Way, South San Francisco, CA

    Contact for pricing
    49,838 sqft

    R&D lab with freezer rooms, offices, and conference rooms.

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    South San Francisco, CA Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in South San Francisco, CA with 43 listings featured on our commercial real estate exchange. The current inventory includes 1,713 square feet of properties with an estimated lease value of $140.73 SF/Yr.

    Estimated lease rates for Office Spaces in South San Francisco, CA begin at $140.73 SF/Yr, with an average of $140.73 SF/Yr and extend to $140.73 SF/Yr.
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