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    South San Francisco, CA Commercial Real Estate for Lease

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    Cost-Efficient Office Space at CA, South San Francisco - Spaces Oyster Point. Contact us today to book a tour!
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    Warehouse Space with Loading Docks
    Updated: Jan 24, 2025
    Warehouse Space with Loading Docks

    253 E Harris Ave, South San Francisco, CA 94080

    $33,000/Mo
    19,800 sqft 0.46 AC lot
    19,800 square feet of warehouse space
    Two warehouse condos with two APNs
    Two loading docks plus one on‑grade level door
    19‑foot clear ceiling height and 12 parking spaces
    4,000‑amp main panel at 480/227 volts
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    Retail Space with Floor Drains
    Updated: Aug 20
    Retail Space with Floor Drains

    324-328 Grand Ave, South San Francisco, CA 94080

    $3,650/Mo
    3,650 sqft
    Two retail units with available configurations from 500 to 3,150 SF
    3,650 SF property with separately metered spaces
    Floor drains installed in the retail units
    Refrigeration may be available
    One covered parking spot may be available
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    Office Unit With Reception Area
    Office Unit With Reception Area

    363 El Camino Real, South San Francisco, CA 94080

    $3,200/Mo

    Bright workspace includes multiple private rooms and a dedicated entry area.

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    Biotech Lab and Office Suite
    Biotech Lab and Office Suite

    1 Tower Pl, South San Francisco, CA 94080

    Contact for pricing
    14,674 sqft

    Flex suite configured as a biology lab and tissue culture space with office areas and multiple conference rooms.

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    Laboratory Office Building
    Laboratory Office Building

    285 E Grand Ave, South San Francisco, CA 94080

    Contact for pricing
    65,764 sqft

    Fully integrated biology, tissue culture, chemistry, and vivarium lab space with large suite and floor configurations.

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    South San Francisco Industrial Space
    South San Francisco Industrial Space

    930 Linden Avenue, South San Francisco, CA 94080

    $19,700/Mo
    9,975 sqft

    Industrial space for lease in South San Francisco, California.

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    Freestanding Industrial Warehouse
    Freestanding Industrial Warehouse

    100 Utah Avenue, South San Francisco, CA 94080

    Contact for pricing
    120,345 sqft

    Large warehouse and office facility with dock access, secured truck staging, yard space, and installed electric vehicle charging infrastructure.

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    Warehouse Space in Two Configurations
    Warehouse Space in Two Configurations

    361 Swift Ave, South San Francisco, CA 94080

    Contact for pricing
    10,758 sqft

    Industrial warehouse availability offers two separate space options in South San Francisco.

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    Move-In Ready Office Lab Suite
    Move-In Ready Office Lab Suite

    600 Gateway Blvd, South San Francisco, CA 94080

    Contact for pricing
    4,889 sqft

    Plug-and-play office lab suite with access to autoclave; lab equipment is negotiable.

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    Distribution Center with HVAC Office
    Distribution Center with HVAC Office

    275 South Maple Avenue, South San Francisco, CA 94080

    Contact for pricing
    70,000 sqft

    Sprinklered distribution facility with dedicated offices, conference space, and warehouse racking.

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    Office Space Near Caltrain
    Office Space Near Caltrain

    601 Gateway Blvd, South San Francisco, CA 94080

    Contact for pricing
    5,557 sqft

    Centrally located office space in the South San Francisco life science cluster, with CalTrain within walking distance.

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    Corner Flex Warehouse with Lab Potential
    Corner Flex Warehouse with Lab Potential

    436 N Canal St, Unit 10, South San Francisco, CA 94080

    Contact for pricing
    3,710 sqft

    Corner flex/warehouse condo with 1,000 sf office, central HVAC, 400-amp power, and 9 reserved spaces.

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    Partially Built-Out Office and Flex Space
    Partially Built-Out Office and Flex Space

    1 Tower Place, South San Francisco, CA 94080

    Contact for pricing
    18,748 sqft

    For lease with approximately half of the office area already built out, supporting a range of business layouts.

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    Corner Office Suite with Meeting Rooms
    Corner Office Suite with Meeting Rooms

    1486 Huntington Ave, South San Francisco, CA 94080

    Contact for pricing
    2,621 sqft

    Third-floor corner office suite featuring three private offices and three meeting rooms, with elevator access and 8 parking spaces.

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    Insulated Flex Warehouse with Offices
    Insulated Flex Warehouse with Offices

    140 Beacon St, South San Francisco, CA 94080

    Contact for pricing
    24,000 sqft

    Insulated, fully sprinklered warehouse with office space, skylights, and multiple grade-level doors for flexible operations.

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    U-Shaped Retail Space
    U-Shaped Retail Space

    2288 Westborough Blvd, South San Francisco, CA 94080

    Contact for pricing
    1,419 sqft

    Commercial premises available for lease at 2288 Westborough Blvd in South San Francisco.

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    Office Suite Sublease with Amenities
    Office Suite Sublease with Amenities

    400 Oyster Point Blvd, Suite 335, South San Francisco, CA 94080

    $43.92 SF/Yr

    Office sublease in the Oyster Point business district with EV charging and fitness center amenities.

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    Flex Space with Biology Lab
    Flex Space with Biology Lab

    2 Tower Pl, South San Francisco, CA 94080

    Contact for pricing
    19,608 sqft

    Flex space built for lab use with a 6FT fume hood, house gases, and multiple private offices and conference rooms.

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    Retail Storefront with Open Floor Plan
    Retail Storefront with Open Floor Plan

    South San Francisco, CA 94080

    Contact for pricing
    3,500 sqft

    Retail storefront offering an open floor plan and 10 rear parking spaces near Grand Ave and the 101 freeway.

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    South San Francisco Office/Lab Sublease
    South San Francisco Office/Lab Sublease

    651 Gateway Boulevard, South San Francisco, CA 94080

    Contact for pricing
    22,365 sqft

    Full floor office/lab space available for sublease through July 2029.

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    Biology Lab Flex Suite
    Biology Lab Flex Suite

    2 Tower Pl, South San Francisco, CA 94080

    Contact for pricing
    19,861 sqft

    Flex suite built for lab use with fume hoods, dedicated support rooms, and multiple private offices.

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    Class A Lab & Office
    Class A Lab & Office

    131 Oyster Point Blvd, South San Francisco, CA 94080

    Contact for pricing
    34,988 sqft

    Sublease opportunity: 34,988 SF of Class A lab & office.

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    South San Francisco Office Space
    South San Francisco Office Space

    1487 Huntington Ave, South San Francisco, CA 94080

    Contact for pricing
    14,000 sqft

    14,000 sqft office space available for rent.

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    Industrial Space for Lease
    Industrial Space for Lease

    330 Corey Way, South San Francisco, CA 94080

    Contact for pricing
    25,490 sqft

    Industrial space available for lease, suited for warehouse and light industrial use needs.

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    South San Francisco, CA Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in South San Francisco, CA with 109 listings featured on our commercial real estate exchange. The current inventory includes 3,367,731 square feet of properties with an estimated lease value of $181.27.

    Estimated lease rates for Commercial real estate in South San Francisco, CA begin at $7.25 SF/Yr, with an average of $25.90 SF/Yr and extend to $43.92 SF/Yr.
    South San Francisco, CA CRE market trends — vacancy, lease rates and price per SF, updated monthly
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