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    South San Francisco, CA Commercial Real Estate for Sale

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    San Bruno, CA Brisbane, CA Colma, CA
    17 listings
    Fully Secured High-Tech Biotech Facility
    $48,000,000
    3.65 Acres
    Fully Secured High-Tech Biotech Facility

    560 Eccles AVE, South San Francisco, CA 94080

    2019-built facility with mission-critical labs, dedicated power backup, and secure dock access for large tractor-trailers.
    • Premier 21,552 SF high‑tech biotech facility built in 2019 on a 3.65‑acre site
    • Interior includes approx. 9,500 SF office, 4,500 SF mission‑critical lab space, and 7,000 SF warehouse/inspection zone
    • Security features include Security Level II: Lenel card reader system, 24‑hour CCTV, and fenced parking with 62 assigned spaces
    • Mission‑critical lab infrastructure includes 100% ducted exhaust (8 air changes/hour) and high‑purity reverse osmosis water systems
    • Power backup: 500 kW stand‑alone diesel generator plus dedicated UPS backup power
    Updated: May 20
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    Versatile Showroom Warehouse in Peninsula
    $1,100,000
    2,720 SF
    Versatile Showroom Warehouse in Peninsula

    1435 Huntington Avenue #C, South San Francisco, CA 94080

    Functional industrial space in South San Francisco's commercial hub.
    • Prime location in South San Francisco with quick access to Highways 101, 280, and 380.
    • Versatile space suitable for showroom, workspace, light industrial use, offices, design studios, or storage.
    • Flexible layout with approximately 1,560 sq. ft. on the ground floor and 1,160 sq. ft. loft area.
    • Functional design with a grade level roll‑up door for convenient loading and deliveries.
    • Suitable for owner‑user or investor.
    Updated: Mar 19
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    South San Francisco Retail Investment
    $2,630,000
    6,183 SF
    South San Francisco Retail Investment

    Retail investment opportunity in the heart of South San Francisco.

    369 Grand Ave, South San Francisco, CA 94080

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    South San Francisco Redevelopment Opportunity
    $2,700,000
    10,067 SF
    South San Francisco Redevelopment Opportunity

    10,067 SF automotive site with redevelopment potential.

    201 Cypress Avenue, South San Francisco, CA 94080

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    Retail/Warehouse/Development Opportunity in South San Francisco
    $2,595,000
    7,603 SF
    Retail/Warehouse/Development Opportunity in South San Francisco

    Retail/warehouse property with development potential near Grand Ave.

    305 Airport Boulevard, South San Francisco, CA 94080

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    Combined Flex Space Units
    $799,000
    2,208 SF
    Combined Flex Space Units

    Combined flex space units with office and warehouse areas.

    451 Victory Avenue #4, South San Francisco, CA 94080

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    Freestanding Office Building For Sale
    $1,699,000
    3,010 SF
    Freestanding Office Building For Sale

    Freestanding office building in South San Francisco, delivered vacant.

    161 El Camino Real, South San Francisco, CA

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    South San Francisco SRO Hotel
    $3,899,999
    6,774 SF
    South San Francisco SRO Hotel

    29-room hotel near downtown South San Francisco.

    MILLER AVE, South San Francisco, CA 94080

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    South San Francisco Industrial Warehouse
    $6,625,000
    19,800 SF
    South San Francisco Industrial Warehouse

    Well-maintained 19,800 SF industrial warehouse in prime location.

    253 E Harris Ave, South San Francisco, CA 94080

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    South San Francisco Flex Space
    $1,250,000
    2,400 SF
    South San Francisco Flex Space

    2,400 SF flex space with mezzanine and drive-in door.

    121 S Maple Ave, South San Francisco, CA

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    South San Francisco Warehouse Opportunity
    $5,000,000
    8,000 SF
    South San Francisco Warehouse Opportunity

    8,000 sqft warehouse/industrial property in South San Francisco for sale.

    435 Grand Avenue, South San Francisco, CA 94080

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    South San Francisco Flex Space
    $1,350,000
    3,930 SF
    South San Francisco Flex Space

    3,930 SF flex space on 5,081 SF parcel.

    Airport Boulevard, South San Francisco, CA 94080

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    Mixed-Use Property with Restaurant
    $1,298,000
    1,584 SF
    Mixed-Use Property with Restaurant

    Mixed-use property with a long-standing restaurant and residential unit.

    231 Lux Avenue, South San Francisco, CA 94080

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    South San Francisco Warehouse Opportunity
    Contact for pricing
    33,000 SF
    South San Francisco Warehouse Opportunity

    Value-add warehouse facility with upside potential in South San Francisco.

    1373 Lowrie Ave, South San Francisco, CA 94080

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    Retail Space Below Luxury Condos
    Contact for pricing
    1,216 SF
    Retail Space Below Luxury Condos

    Retail spaces available below newly constructed luxury residential condos.

    889 McLellan Dr, South San Francisco, CA

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    Functional Industrial Building For Sale
    $1,350,000
    3,930 SF
    Functional Industrial Building For Sale

    3,930 SF industrial building with flexible space and warehouse.

    1139 Airport Boulevard, South San Francisco, CA 94080

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    Industrial Space Available For Lease
    Contact for pricing
    8,500 SF
    Industrial Space Available For Lease

    Industrial property featuring 8,500 square feet available for lease.

    171 Beacon Street, South San Francisco, CA 94080

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    Based on your search, we've compiled Potential Opportunities for your consideration. Besides 17 Active Listings in South San Francisco, CA, we suggest to view alternatives - similar 55 Off-Market properties to explore as potential leads.

    Off-Market Properties in South San Francisco, CA

    Consider similar Off-Market properties in South San Francisco, CA. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1409 San Mateo Ave
    WAREHOUSE, STORAGE
    8,000 SF Lot: 0.31 Acres
    Estimated value
    $845,000

    1409 San Mateo Ave, South San Francisco, CA 94080-6504

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    651 Gtwy Blvd
    CANNERY
    321,315 SF Lot: 6.18 Acres

    651 Gtwy Blvd, South San Francisco, CA 94080-7055

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    133 Hickey Blvd
    REGIONAL SHOPPING CENTER, MALL
    19,392 SF Lot: 2.23 Acres
    Estimated value
    $5,680,000

    133 Hickey Blvd, South San Francisco, CA 94080-1145

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    141 Hickey Blvd
    REGIONAL SHOPPING CENTER, MALL
    Lot: 0.41 Acres
    Value Estimation by Request

    141 Hickey Blvd, South San Francisco, CA 94080-1145

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    113 Hickey Blvd
    REGIONAL SHOPPING CENTER, MALL
    24,309 SF Lot: 2.49 Acres

    113 Hickey Blvd, South San Francisco, CA 94080-1145

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    324 Pne Ave
    APARTMENT HOUSE (5+ UNITS)
    6,896 SF Lot: 0.16 Acres
    Estimated value
    $2,510,000

    324 Pne Ave, South San Francisco, CA 94080-2976

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    100 Utah Ave
    MANUFACTURING (LIGHT)
    117,590 SF Lot: 4.35 Acres
    Estimated value
    $29,370,000

    100 Utah Ave, South San Francisco, CA 94080-6710

    View details

    South San Francisco, CA Commercial Real Estate Investment Opportunities Market Analysis

    Explore 72 commercial real estate for sale in South San Francisco, CA, showcased through 17 active listings on our real estate platform. These investment opportunities span a total of 99,761 square feet of properties for sale, with an estimated market value of $80,295,999.

    Sale prices for business properties in South San Francisco, CA start at $799,000, averaging $5,735,428, and reaching up to $48,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Demographics Overview

    Population 65K
    Population Growth (5Y) -3.8%
    Median Household Income $135,966
    College Educated 26.3%

    High-Yield Neighborhoods for Investment

    Identify South San Francisco submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    94080 $2.4M

    Taxes & Financing

    Tax Rate (average for all types) 1.16%
    Property Tax per SF $7.35 per SF
    Tax Rate vs County Average 0.02 pp below county avg
    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in San Mateo County

    New Delisted

    Total CRE Inventory on Market (SF)

    Average Property Price per SF

    For-sale pricing trends across core commercial property types in San Mateo County

    Retail

    Residential Income

    Property Size Breakdown

    The majority of commercial real estate listings in South San Francisco fall within the 50,000 to 100,000 square foot range.

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