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    South San Francisco, CA Commercial Real Estate for Sale

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    Lancaster, CA San Diego, CA California City, CA
    15 results
    Versatile Showroom Warehouse in Peninsula
    $1,100,000
    2,720 SF

    Versatile Showroom Warehouse in Peninsula

    1435 Huntington Avenue #C, South San Francisco, CA 94080

    Functional industrial space in South San Francisco's commercial hub.

    • Prime location in South San Francisco with quick access to Highways 101, 280, and 380.
    • Versatile space suitable for showroom, workspace, light industrial use, offices, design studios, or storage.
    • Flexible layout with approximately 1,560 sq. ft. on the ground floor and 1,160 sq. ft. loft area.
    • Functional design with a grade level roll‑up door for convenient loading and deliveries.
    • Suitable for owner‑user or investor.
    Updated: Mar 19
    View details
    Commercial Property - SOUTH SAN FRANCISCO, CA
    $48,000,000
    21,552 SF

    Commercial Property - SOUTH SAN FRANCISCO, CA

    560 Eccles AVE, South San Francisco, CA 94080

    Manufacturing properties · 21,552 SF

    • Mission‑critical biotech facility with a federal tenant, providing a secure and stable investment.
    • Purpose‑built in 2019 with specialized laboratory infrastructure including entomology and botany labs with high‑purity reverse osmosis water systems.
    • Advanced security features including Lenel card reader system, 24‑hour CCTV, shatter‑resistant blast‑mitigation windows, and fenced parking.
    • Redundant power systems with a 500kW stand‑alone diesel generator and dedicated UPS backup.
    • Streamlined logistics with 4 interior dock‑high doors and a secure devanning area for 53‑foot tractor‑trailers.
    Updated: Apr 23
    View details
    Combined Flex Space Units
    $799,000
    2,208 SF

    Combined Flex Space Units

    Combined flex space units with office and warehouse areas.

    451 Victory Avenue #4, South San Francisco, CA 94080
    View details
    South San Francisco Redevelopment Opportunity
    $2,700,000
    10,067 SF

    South San Francisco Redevelopment Opportunity

    10,067 SF automotive site with redevelopment potential.

    201 Cypress Avenue, South San Francisco, CA 94080
    View details
    Retail/Warehouse/Development Opportunity in South San Francisco
    $2,595,000
    7,603 SF

    Retail/Warehouse/Development Opportunity in South San Francisco

    Retail/warehouse property with development potential near Grand Ave.

    305 Airport Boulevard, South San Francisco, CA 94080
    View details
    Retail Space Below Luxury Condos
    $848,000
    1,216 SF

    Retail Space Below Luxury Condos

    Retail spaces available below newly constructed luxury residential condos.

    889 McLellan Dr, South San Francisco, CA
    View details
    South San Francisco Warehouse Opportunity
    Contact for pricing
    33,000 SF

    South San Francisco Warehouse Opportunity

    Value-add warehouse facility with upside potential in South San Francisco.

    1373 Lowrie Ave, South San Francisco, CA 94080
    View details
    Freestanding Office Building For Sale
    $1,699,000
    3,010 SF

    Freestanding Office Building For Sale

    Freestanding office building in South San Francisco, delivered vacant.

    161 El Camino Real, South San Francisco, CA
    View details
    South San Francisco SRO Hotel
    $3,899,999
    6,774 SF

    South San Francisco SRO Hotel

    29-room hotel near downtown South San Francisco.

    MILLER AVE, South San Francisco, CA 94080
    View details
    South San Francisco Warehouse Opportunity
    $5,000,000
    8,000 SF

    South San Francisco Warehouse Opportunity

    8,000 sqft warehouse/industrial property in South San Francisco for sale.

    435 Grand Avenue, South San Francisco, CA 94080
    View details
    South San Francisco Flex Space
    $1,250,000
    2,400 SF

    South San Francisco Flex Space

    2,400 SF flex space with mezzanine and drive-in door.

    121 S Maple Ave, South San Francisco, CA
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    Mixed-Use Property with Restaurant
    $1,298,000
    1,584 SF

    Mixed-Use Property with Restaurant

    Mixed-use property with a long-standing restaurant and residential unit.

    231 Lux Avenue, South San Francisco, CA 94080
    View details
    Functional Industrial Building For Sale
    $1,350,000
    3,930 SF

    Functional Industrial Building For Sale

    3,930 SF industrial building with flexible space and warehouse.

    1139 Airport Boulevard, South San Francisco, CA 94080
    View details
    South San Francisco Flex Space
    $1,350,000
    3,930 SF

    South San Francisco Flex Space

    3,930 SF flex space on 5,081 SF parcel.

    Airport Boulevard, South San Francisco, CA 94080
    View details
    Mixed-Use Property in Downtown South
    $1,799,000
    2,760 SF

    Mixed-Use Property in Downtown South

    Mixed-use property in a thriving downtown location with high visibility.

    20 Linden Ave, South San Francisco, CA 94080
    View details
    Based on your search, we've compiled 1592 Potential Opportunities for your consideration. Besides 15 Active listings in South San Francisco, CA, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 1573 Off-Market properties to explore as potential leads

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    San Bruno Industrial Warehouse Opportunity
    $1,250,000
    2,500 SF

    San Bruno Industrial Warehouse Opportunity

    2,500 sq ft San Bruno warehouse for sale.

    1141 San Mateo Avenue, San Bruno, CA 94066
    View details
    Industrial Building Near Transportation Hub
    $995,000
    2,500 SF

    Industrial Building Near Transportation Hub

    2,500 SF industrial building, available April 2026, near highways.

    1125 San Mateo Ave, San Bruno, CA 94066
    View details
    Mixed-Use Building in Downtown Brisbane
    $799,000
    1,800 SF

    Mixed-Use Building in Downtown Brisbane

    Mixed-use commercial building with high visibility and street parking.

    45 Visitacion Avenue, Brisbane, CA 94005
    View details
    Mixed-Use Building Under Construction
    $3,800,000
    4,200 SF

    Mixed-Use Building Under Construction

    Live, work, or rent in this mixed-use building!

    18 Visitacion Avenue, Brisbane, CA 94005
    View details

    Explore Off-Market Properties in South San Francisco, CA

    Consider similar Off-Market properties in South San Francisco, CA. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1409 San Mateo Ave

    1409 San Mateo Ave

    WAREHOUSE, STORAGE • 8,000 SF
    Value Estimation
    $845,000
    1409 San Mateo Ave, South San Francisco, CA 94080-6504
    View details
    651 Gtwy Blvd

    651 Gtwy Blvd

    CANNERY • 321,315 SF
    Value Estimation
    $1,210,000
    651 Gtwy Blvd, South San Francisco, CA 94080-7055
    View details
    133 Hickey Blvd

    133 Hickey Blvd

    REGIONAL SHOPPING CENTER, MALL • 19,392 SF
    Value Estimation
    $5,680,000
    133 Hickey Blvd, South San Francisco, CA 94080-1145
    View details
    141 Hickey Blvd

    141 Hickey Blvd

    REGIONAL SHOPPING CENTER, MALL • 0.41 Acres
    Value Estimation by Request
    141 Hickey Blvd, South San Francisco, CA 94080-1145
    View details
    113 Hickey Blvd

    113 Hickey Blvd

    REGIONAL SHOPPING CENTER, MALL • 24,309 SF
    Value Estimation
    $6,830,000
    113 Hickey Blvd, South San Francisco, CA 94080-1145
    View details
    324 Pne Ave

    324 Pne Ave

    APARTMENT HOUSE (5+ UNITS) • 6,896 SF
    Value Estimation
    $2,510,000
    324 Pne Ave, South San Francisco, CA 94080-2976
    View details
    100 Utah Ave

    100 Utah Ave

    MANUFACTURING (LIGHT) • 117,590 SF
    Value Estimation
    $29,370,000
    100 Utah Ave, South San Francisco, CA 94080-6710
    View details
    2228 Westborough Blvd

    2228 Westborough Blvd

    RETAIL STORES (PERSONAL SERVICES) • 4.47 Acres
    Value Estimation
    $510,000
    2228 Westborough Blvd, South San Francisco, CA 94080-5405
    View details
    105 Rockwood Dr

    105 Rockwood Dr

    RETAIL STORES (PERSONAL SERVICES) • 2,254 SF
    Value Estimation by Request
    105 Rockwood Dr, South San Francisco, CA 94080-5741
    View details

    South San Francisco, CA Commercial Real Estate Investment Opportunities Market Analysis

    Explore 1588 commercial real estate for sale in South San Francisco, CA, showcased through 15 active listings on our real estate platform. These investment opportunities span a total of 77,754 square feet of properties for sale, with an estimated market value of $73,687,999.

    Sale prices for business properties in South San Francisco, CA start at $799,000, averaging $5,263,428, and reaching up to $48,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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