South San Francisco, CA Commercial Real Estate for Sale

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Versatile Showroom Warehouse in Peninsula
Updated: Mar 19
Versatile Showroom Warehouse in Peninsula

1435 Huntington Avenue #C, South San Francisco, CA 94080

$1,100,000
2,720 sqft 3.83 AC lot
Prime location in South San Francisco with quick access to Highways 101, 280, and 380.
Versatile space suitable for showroom, workspace, light industrial use, offices, design studios, or storage.
Flexible layout with approximately 1,560 sq. ft. on the ground floor and 1,160 sq. ft. loft area.
Functional design with a grade level roll‑up door for convenient loading and deliveries.
Suitable for owner‑user or investor.
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1435 Huntington Avenue #C, South San Francisco, CA 94080

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Fully Secured Biotech Lab Facility
Updated: Jul 6
Fully Secured Biotech Lab Facility

560 Eccles AVE, South San Francisco, CA 94080

$48,000,000
3.65 AC lot
21,552 SF mission‑critical biotech facility built in 2019 on a 3.65‑acre site with fully secured access
Interior includes approx. 9,500 SF professional office, 4,500 SF mission‑critical lab space, and 7,000 SF warehouse/inspection zone
Lab build‑out features multiple entomology and botany labs with phenolic resin countertops plus high‑purity reverse osmosis water systems
100% ducted exhaust rated at 8 air changes per hour
Power and backup include a 500kW stand‑alone diesel generator and dedicated UPS backup power
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High-Security Life Science Flex Facility
High-Security Life Science Flex Facility

560 Eccles Avenue, South San Francisco, CA 94080

$48,000,000
21,552 sqft 3.65 AC lot

Purpose-built 2019 lab, office, and warehouse/inspection space with advanced utilities and secured logistics for mission-critical operations.

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South San Francisco Redevelopment Opportunity
South San Francisco Redevelopment Opportunity

201 Cypress Avenue, South San Francisco, CA 94080

$2,700,000
10,067 sqft 0.23 AC lot

10,067 SF automotive site with redevelopment potential.

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Downtown Transit Core Office Building
Downtown Transit Core Office Building

201 Baden Avenue, South San Francisco, CA 94080

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12,164 sqft 0.30 AC lot

Mid-century office building on a Downtown Transit Core site with permitted medical, retail, and residential uses.

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South San Francisco Retail Investment
South San Francisco Retail Investment

369 Grand Ave, South San Francisco, CA 94080

Contact for pricing
6,183 sqft 0.16 AC lot

Retail investment opportunity in the heart of South San Francisco.

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South San Francisco Industrial Warehouse
South San Francisco Industrial Warehouse

253 E Harris Ave, South San Francisco, CA 94080

$6,625,000
19,800 sqft

Well-maintained 19,800 SF industrial warehouse in prime location.

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South San Francisco Flex Space
South San Francisco Flex Space

Airport Boulevard, South San Francisco, CA 94080

$1,350,000
3,930 sqft 0.11 AC lot

3,930 SF flex space on 5,081 SF parcel.

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Mixed-Use Potential Office/Retail Building
Mixed-Use Potential Office/Retail Building

201 Baden Ave, South San Francisco, CA 94080

Contact for pricing
12,164 sqft 0.30 AC lot

Two-frontage, two-story office and retail building with an additional usable tower and on-site parking.

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Mixed-Use Property with Restaurant
Mixed-Use Property with Restaurant

231 Lux Avenue, South San Francisco, CA 94080

$1,298,000
1,584 sqft

Mixed-use property with a long-standing restaurant and residential unit.

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Functional Industrial Building For Sale
Functional Industrial Building For Sale

1139 Airport Boulevard, South San Francisco, CA 94080

$1,350,000
3,930 sqft

3,930 SF industrial building with flexible space and warehouse.

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Industrial Space Available For Lease
Industrial Space Available For Lease

171 Beacon Street, South San Francisco, CA 94080

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8,500 sqft

Industrial property featuring 8,500 square feet available for lease.

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Leased Warehouse with Dock-High Doors
Leased Warehouse with Dock-High Doors

South San Francisco, CA 94080

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211,259 sqft

Single-tenant warehouse leased to FedEx with 45 dock-high doors and 18 to 26 clear heights.

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Storefront Retail Property
Storefront Retail Property

435 Grand Avenue, South San Francisco, CA 94080

$3,950,000

For-sale storefront retail property at 435 Grand Avenue, suited for businesses seeking a street-facing retail presence.

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Combined Flex Warehouse Office
Combined Flex Warehouse Office

451 Victory Avenue 5, South San Francisco, CA 94080

$499,000

Combined units provide office-ready space with ADA restrooms, a warehouse plus mezzanine storage, and two second-floor access points.

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Combined Flex Office/Warehouse Suite
Combined Flex Office/Warehouse Suite

4-451 Victory Ave, South San Francisco, CA 94080

$499,000

Combined Unit 4 and 5 offer ground-floor offices, ADA restrooms, and second-floor office and work space with warehouse access.

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Retail Space Below Luxury Condos
Retail Space Below Luxury Condos

889 McLellan Dr, South San Francisco, CA

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1,216 sqft 0.40 AC lot

Retail spaces available below newly constructed luxury residential condos.

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Retail Storefront Below Condos
Retail Storefront Below Condos

889 McLellan Dr, South San Francisco, CA 94080

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1,293 sqft

Retail units are available in multiple sizes within a storefront level directly beneath newly constructed luxury residences.

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Office Building
Office Building

267 E Harris Avenue, South San Francisco, CA 94080

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7,480 sqft

Office building offered for sale with 7,480 SF of space.

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Retail/Warehouse Block Building
Retail/Warehouse Block Building

305 Airport Boulevard, South San Francisco, CA 94080

$2,495,000

Block-spanning retail and warehouse space with roll-up access on two streets and room for offices and storage.

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Industrial Warehouse Condo Suite
Industrial Warehouse Condo Suite

432 N Canal St, South San Francisco, CA 94080

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Industrial warehouse condo unit in a multi-suite building, with an option to be sold with Suite 4.

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Based on your search, we've compiled Potential Opportunities for your consideration. Besides 21 Active Listings in South San Francisco, CA, we suggest to view alternatives - similar 51 Off-Market properties to explore as potential leads.

Off-Market Properties in South San Francisco, CA

Consider similar Off-Market properties in South San Francisco, CA. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

1409 San Mateo Ave
WAREHOUSE, STORAGE

1409 San Mateo Ave, South San Francisco, CA 94080-6504

$845,000
Estimated value
8,000 sqft 0.31 AC lot
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651 Gtwy Blvd
CANNERY

651 Gtwy Blvd, South San Francisco, CA 94080-7055

$1,210,000
Estimated value
321,315 sqft 6.18 AC lot
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133 Hickey Blvd
REGIONAL SHOPPING CENTER, MALL

133 Hickey Blvd, South San Francisco, CA 94080-1145

$5,680,000
Estimated value
19,392 sqft 2.23 AC lot
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South San Francisco, CA Commercial Real Estate Market Trends and Statistics

Explore 72 commercial real estate for sale in South San Francisco, CA, showcased through 21 active listings on our real estate platform. These investment opportunities span a total of 323,842 square feet of properties for sale, with an estimated market value of $117,866,000.

Sale prices for business properties in South San Francisco, CA start at $499,000, averaging $9,822,166, and reaching up to $48,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Demographics Overview

Population 65K
Population Growth (5Y) -3.8%
Median Household Income $135,966
College Educated 26.3%

High-Yield Neighborhoods for Investment

Identify South San Francisco submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood Average Price
94080 $7.6M

Taxes & Financing

Tax Rate (average for all types) 1.16%
Property Tax per SF $7.35 per SF
Tax Rate vs County Average 0.02 pp below county avg
Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in San Mateo County

New Delisted

Total CRE Inventory on Market (SF)

Average Property Price per SF

For-sale pricing trends across core commercial property types in San Mateo County

Retail

Residential Income

Property Size Breakdown

The majority of commercial real estate listings in South San Francisco fall within the 50,000 to 100,000 square foot range.

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