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    South San Francisco, CA Office Spaces for Sale

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    San Bruno, CA Brisbane, CA Pacifica, CA Daly City, CA Colma, CA Millbrae, CA San Francisco, CA Burlingame, CA
    South San Francisco Redevelopment Opportunity
    Updated: Oct 6, 2025
    South San Francisco Redevelopment Opportunity

    201 Cypress Avenue, South San Francisco, CA 94080

    $2,700,000
    10,067 sqft 0.23 AC lot
    10,067 SF redevelopment site in South San Francisco's Downtown/Caltrain Station Area.
    Zoned Downtown Transit Core (DTC) allowing high‑density mixed‑use development (residential, office, life science, retail).
    Immediate flexibility for redevelopment or repositioning due to month‑to‑month leases.
    Environmental remediation completed (USTs removed, Phase III closed).
    Generous height and floor area ratio allowances** with no minimum residential parking requirements.
    View details
    Downtown Transit Core Office Building
    Updated: May 11
    Downtown Transit Core Office Building

    201 Baden Avenue, South San Francisco, CA 94080

    Contact for pricing
    12,164 sqft 0.30 AC lot
    Built in 1950, ±12,164 SF building on a ±13,003 SF lot at 201 Baden Ave in Downtown South San Francisco
    Downtown Transit Core (DTC) zoning on a transit‑oriented development site near the Caltrain Station
    Permitted uses include multiple‑unit/senior citizen residential and retail general sales & grocery stores
    Also permitted: business/professional/medical/dental offices, plus full service & quick service restaurants and coffee shops/cafes
    Listed price: $2,700,000 (±$222/SF)
    View details
    Mixed-Use Potential Office/Retail Building
    Mixed-Use Potential Office/Retail Building

    201 Baden Ave, South San Francisco, CA 94080

    Contact for pricing
    12,164 sqft 0.30 AC lot

    Two-frontage, two-story office and retail building with an additional usable tower and on-site parking.

    View details
    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Based on your search, we've compiled 77 Potential Opportunities for your consideration. Besides 3 Active listings in South San Francisco, CA, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 69 Off-Market properties to explore as potential leads, plus 1 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Freestanding Medical/Service Building
    Freestanding Medical/Service Building

    5601 Mission Street, San Francisco, CA 94112

    $899,900
    1,950 sqft

    Vacant freestanding building on a high-visibility corner at 5601 Mission Street, delivered for immediate occupancy.

    View details
    Office-Flex Building with Roll-Up Doors
    Office-Flex Building with Roll-Up Doors

    838 Mitten Road, Burlingame, CA 94010

    Contact for pricing
    13,552 sqft

    Move-in ready office and warehouse space zoned innovative industrial with gated parking and fully sprinklered interior.

    View details
    Flex Office with Rear Warehouse
    Flex Office with Rear Warehouse

    838 Mitten Rd, Burlingame, CA 94010

    Contact for pricing
    13,451 sqft

    Move-in ready office space with a clean rear warehouse, configured as 11,189 SF office and 2,262 SF warehouse.

    View details
    Duplex With Office Unit
    Duplex With Office Unit

    5480 Mission ST, San Francisco, CA 94112

    $999,000

    Two-unit property pairs a two-bedroom residence with flexible space for office or business use.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Entitled Mixed-Use Development Opportunity
    Entitled Mixed-Use Development Opportunity

    25A Orinda Way, Orinda, CA 94563

    Contact for pricing

    Permit-ready mixed-use development site in downtown Orinda.

    View details

    Off-Market Properties in South San Francisco, CA

    Consider similar Off-Market properties in South San Francisco, CA. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    163 Harris Ave
    OFFICE BUILDING (MULTI-STORY)

    163 Harris Ave, South San Francisco, CA 94080-6008

    $385,000
    Estimated value
    0.35 AC lot
    View details
    323 Miller Ave, Unit 329
    PROFESSIONAL BUILDING

    323 Miller Ave, South San Francisco, CA 94080-3725

    Unit 329
    $365,000
    Estimated value
    0.18 AC lot
    View details
    1405 Huntington Ave
    PROFESSIONAL BUILDING

    1405 Huntington Ave, South San Francisco, CA 94080-5988

    $815,000
    Estimated value
    0.04 AC lot
    View details
    1475 Huntington Ave
    PROFESSIONAL BUILDING

    1475 Huntington Ave, South San Francisco, CA 94080-5990

    $1,205,000
    Estimated value
    0.03 AC lot
    View details
    1475 Huntington Ave Ste, Unit 200
    PROFESSIONAL BUILDING

    1475 Huntington Ave Ste, South San Francisco, CA 94080-5967

    Unit 200
    $575,000
    Estimated value
    1,530 sqft 0.03 AC lot
    View details
    1241 Msn Rd
    OFFICE BUILDING (MULTI-STORY)

    1241 Msn Rd, South San Francisco, CA 94080-1397

    $1,545,000
    Estimated value
    4,561 sqft 0.32 AC lot
    View details
    421 Grand Ave
    OFFICE BUILDING (MULTI-STORY)

    421 Grand Ave, South San Francisco, CA 94080-3635

    $60,000
    Estimated value
    6,629 sqft 0.16 AC lot
    View details
    1435 Huntington Ave
    PROFESSIONAL BUILDING

    1435 Huntington Ave, South San Francisco, CA 94080-5989

    $400,000
    Estimated value
    3,224 sqft 3.47 AC lot
    View details
    435 Grand Ave
    OFFICE BUILDING (MULTI-STORY)

    435 Grand Ave, South San Francisco, CA 94080-3635

    $265,000
    Estimated value
    0.08 AC lot
    View details
    1587 San Mateo Ave
    OFFICE BUILDING (MULTI-STORY)

    1587 San Mateo Ave, South San Francisco, CA 94080-6500

    $570,000
    Estimated value
    2.44 AC lot
    View details
    1435 Huntington Ave Ste, Unit 337
    PROFESSIONAL BUILDING

    1435 Huntington Ave Ste, South San Francisco, CA 94080-5989

    Unit 337
    $1,180,000
    Estimated value
    1,220 sqft 0.03 AC lot
    View details
    1165 El Camino Real
    OFFICE BUILDING (MULTI-STORY)

    1165 El Camino Real, South San Francisco, CA 94080-3207

    $275,000
    Estimated value
    0.25 AC lot
    View details
    359 El Camino Real
    OFFICE BUILDING (MULTI-STORY)

    359 El Camino Real, South San Francisco, CA 94080-5923

    $1,345,000
    Estimated value
    16,550 sqft 0.95 AC lot
    View details
    1265 Msn Rd
    OFFICE BUILDING (MULTI-STORY)

    1265 Msn Rd, South San Francisco, CA 94080-1397

    $375,000
    Estimated value
    0.26 AC lot
    View details
    1475 Huntington Ave Ste, Unit 306
    PROFESSIONAL BUILDING

    1475 Huntington Ave Ste, South San Francisco, CA 94080-5967

    Unit 306
    $410,000
    Estimated value
    1,125 sqft 0.03 AC lot
    View details
    800 Dubuque Ave, Unit 890
    OFFICE BUILDING (MULTI-STORY)

    800 Dubuque Ave, South San Francisco, CA 94080-1804

    Unit 890
    $2,240,000
    Estimated value
    112,912 sqft 5.96 AC lot
    View details
    160 Country Clb Dr
    PROFESSIONAL BUILDING

    160 Country Clb Dr, South San Francisco, CA 94080-4347

    $12,235,000
    Estimated value
    10,814 sqft 0.47 AC lot
    View details
    2 Tower Pl
    OFFICE BUILDING (MULTI-STORY)

    2 Tower Pl, South San Francisco, CA 94080-1826

    Value Estimation by Request
    350,036 sqft 2.91 AC lot
    View details
    Airport Blvd
    OFFICE BUILDING (MULTI-STORY)

    Airport Blvd, South San Francisco, CA 94080

    Value Estimation by Request
    2.69 AC lot
    View details
    100 Arroyo Dr
    PROFESSIONAL BUILDING

    100 Arroyo Dr, South San Francisco, CA 94080-3194

    $1,000,000
    Estimated value
    0.14 AC lot
    View details
    681 Gtwy Blvd, Unit 685
    OFFICE BUILDING (MULTI-STORY)

    681 Gtwy Blvd, South San Francisco, CA 94080-7015

    Unit 685
    Value Estimation by Request
    126,971 sqft 3.04 AC lot
    View details

    South San Francisco, CA Office Spaces Market Trends and Statistics

    Explore 72 office spaces for sale in South San Francisco, CA, showcased through 3 active listings on our real estate platform. These investment opportunities span a total of 34,395 square feet of properties for sale, with an estimated market value of $2,700,000.

    Sale prices for office spaces in South San Francisco, CA average $2,700,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 45
    Office buildings 25
    Medical Office Space 3
    Coworking space 1

    Demographics Overview

    Population 65K
    Population Growth (5Y) -3.8%
    Median Household Income $135,966
    College Educated 26.3%

    High-Yield Neighborhoods for Investment

    Identify South San Francisco submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    94080 $13.4M

    Taxes & Financing

    Tax Rate (average for all types) 1.16%
    Property Tax per SF $7.35 per SF
    Tax Rate vs County Average 0.02 pp below county avg
    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in San Mateo County

    New Delisted

    Total CRE Inventory on Market (SF)

    Average Property Price per SF

    For-sale pricing trends across core commercial property types in San Mateo County

    Retail

    Residential Income

    Property Size Breakdown

    The majority of commercial real estate listings in South San Francisco fall within the 100,000+ square foot range.

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