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    South San Francisco, CA Office Spaces for Sale

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    San Bruno, CA Brisbane, CA Colma, CA
    High-Tech Biotech Facility For Sale
    $48,000,000
    21,552 SF
    High-Tech Biotech Facility For Sale

    South San Francisco, 94080

    Premier 21,552 SF high-tech facility in South San Francisco.
    • Fully secured, mission‑critical biotech facility with a federal tenant, providing stable income.
    • Purpose‑built in 2019 with specialized laboratory infrastructure, including entomology and botany labs with advanced features.
    • Redundant systems: 500kW stand‑alone diesel generator and UPS backup power for operational continuity.
    • Advanced security features: Lenel card reader system, 24‑hour CCTV, shatter‑resistant blast‑mitigation windows.
    • Strategic location in the heart of the global biotech cluster with immediate access to major transit corridors.
    Updated: May 20
    View details
    Versatile Showroom Warehouse in Peninsula
    $1,100,000
    2,720 SF
    Versatile Showroom Warehouse in Peninsula

    1435 Huntington Avenue #C, South San Francisco, CA 94080

    Functional industrial space in South San Francisco's commercial hub.
    • Prime location in South San Francisco with quick access to Highways 101, 280, and 380.
    • Versatile space suitable for showroom, workspace, light industrial use, offices, design studios, or storage.
    • Flexible layout with approximately 1,560 sq. ft. on the ground floor and 1,160 sq. ft. loft area.
    • Functional design with a grade level roll‑up door for convenient loading and deliveries.
    • Suitable for owner‑user or investor.
    Updated: Mar 19
    View details
    Combined Flex Space Units
    $799,000
    2,208 SF
    Combined Flex Space Units

    Combined flex space units with office and warehouse areas.

    451 Victory Avenue #4, South San Francisco, CA 94080

    View details
    South San Francisco Redevelopment Opportunity
    $2,700,000
    10,067 SF
    South San Francisco Redevelopment Opportunity

    10,067 SF automotive site with redevelopment potential.

    201 Cypress Avenue, South San Francisco, CA 94080

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    Freestanding Office Building For Sale
    $1,699,000
    3,010 SF
    Freestanding Office Building For Sale

    Freestanding office building in South San Francisco, delivered vacant.

    161 El Camino Real, South San Francisco, CA

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    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 5 Active listings in South San Francisco, CA, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 67 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Mixed-Use Property in San Francisco
    $1,200,000
    3,075 SF
    Mixed-Use Property in San Francisco

    Mixed-use property with retail and residential units in prime location.

    San Francisco, 94112

    View details
    Visible Office Building Near BART
    $8,188,000
    21,735 SF
    Visible Office Building Near BART

    Office building with high visibility and flexible floor plan.

    1300 El Camino Real, Colma, CA

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    Office Space on El Camino
    Contact for pricing
    Office Space on El Camino

    Office space for sale with great visibility and access.

    Colma, CA 94014

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    Commercial Property on Corner Location
    $2,199,000
    7,110 SF
    Commercial Property on Corner Location

    Two-unit commercial property with high ceilings and abundant natural light.

    4-8 Persia Ave, San Francisco, CA

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Corner Lot in Burlingame
    $11,500,000
    11,000 SF
    Prime Corner Lot in Burlingame

    Iconic building site with development potential near downtown.

    2 Park Road, Burlingame, CA 94010

    View details
    El Sobrante Land Opportunity
    $1,350,000
    10,000 SF
    El Sobrante Land Opportunity

    Commercial land available off San Pablo Dam Road.

    425 Appian Way, El Sobrante, CA 94803

    View details
    Vallejo Commercial Land For Sale
    $1,495,000
    Vallejo Commercial Land For Sale

    Commercial land available for sale in Vallejo, California.

    1401 Sonoma Boulevard, Vallejo, CA 94590

    View details
    Commercial Land in Downtown San Jose
    $1,900,000
    7,008 SF
    Commercial Land in Downtown San Jose

    Prime commercial land in a rapidly growing San Jose location.

    San Jose, 95112

    View details

    Off-Market Properties in South San Francisco, CA

    Consider similar Off-Market properties in South San Francisco, CA. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    163 Harris Ave

    163 Harris Ave

    OFFICE BUILDING (MULTI-STORY) • 0.35 Acres
    Value Estimation by Request
    163 Harris Ave, South San Francisco, CA 94080-6008
    View details
    323 Miller Ave, Unit 329

    323 Miller Ave, Unit 329

    PROFESSIONAL BUILDING • 0.18 Acres
    Value Estimation by Request
    323 Miller Ave, South San Francisco, CA 94080-3725
    View details
    1405 Huntington Ave

    1405 Huntington Ave

    PROFESSIONAL BUILDING • 0.04 Acres
    Value Estimation
    $815,000
    1405 Huntington Ave, South San Francisco, CA 94080-5988
    View details
    1475 Huntington Ave

    1475 Huntington Ave

    PROFESSIONAL BUILDING • 0.03 Acres
    Value Estimation
    $1,145,000
    1475 Huntington Ave, South San Francisco, CA 94080-5990
    View details
    1475 Huntington Ave Ste, Unit 200

    1475 Huntington Ave Ste, Unit 200

    PROFESSIONAL BUILDING • 1,530 SF
    Value Estimation
    $530,000
    1475 Huntington Ave Ste, South San Francisco, CA 94080-5967
    View details
    1241 Msn Rd

    1241 Msn Rd

    OFFICE BUILDING (MULTI-STORY) • 4,561 SF
    Value Estimation
    $1,545,000
    1241 Msn Rd, South San Francisco, CA 94080-1397
    View details
    421 Grand Ave

    421 Grand Ave

    OFFICE BUILDING (MULTI-STORY) • 6,629 SF
    Value Estimation by Request
    421 Grand Ave, South San Francisco, CA 94080-3635
    View details
    1435 Huntington Ave

    1435 Huntington Ave

    PROFESSIONAL BUILDING • 3,224 SF
    Value Estimation by Request
    1435 Huntington Ave, South San Francisco, CA 94080-5989
    View details
    435 Grand Ave

    435 Grand Ave

    OFFICE BUILDING (MULTI-STORY) • 0.08 Acres
    Value Estimation by Request
    435 Grand Ave, South San Francisco, CA 94080-3635
    View details
    1587 San Mateo Ave

    1587 San Mateo Ave

    OFFICE BUILDING (MULTI-STORY) • 2.44 Acres
    Value Estimation
    $610,000
    1587 San Mateo Ave, South San Francisco, CA 94080-6500
    View details
    1435 Huntington Ave Ste, Unit 337

    1435 Huntington Ave Ste, Unit 337

    PROFESSIONAL BUILDING • 1,220 SF
    Value Estimation
    $1,225,000
    1435 Huntington Ave Ste, South San Francisco, CA 94080-5989
    View details
    1165 El Camino Real

    1165 El Camino Real

    OFFICE BUILDING (MULTI-STORY) • 0.25 Acres
    Value Estimation by Request
    1165 El Camino Real, South San Francisco, CA 94080-3207
    View details
    359 El Camino Real

    359 El Camino Real

    OFFICE BUILDING (MULTI-STORY) • 16,550 SF
    Value Estimation
    $1,385,000
    359 El Camino Real, South San Francisco, CA 94080-5923
    View details
    1265 Msn Rd

    1265 Msn Rd

    OFFICE BUILDING (MULTI-STORY) • 0.26 Acres
    Value Estimation by Request
    1265 Msn Rd, South San Francisco, CA 94080-1397
    View details
    1475 Huntington Ave Ste, Unit 306

    1475 Huntington Ave Ste, Unit 306

    PROFESSIONAL BUILDING • 1,125 SF
    Value Estimation by Request
    1475 Huntington Ave Ste, South San Francisco, CA 94080-5967
    View details
    800 Dubuque Ave, Unit 890

    800 Dubuque Ave, Unit 890

    OFFICE BUILDING (MULTI-STORY) • 112,912 SF
    Value Estimation
    $2,295,000
    800 Dubuque Ave, South San Francisco, CA 94080-1804
    View details
    160 Country Clb Dr

    160 Country Clb Dr

    PROFESSIONAL BUILDING • 10,814 SF
    Value Estimation
    $11,130,000
    160 Country Clb Dr, South San Francisco, CA 94080-4347
    View details
    2 Tower Pl

    2 Tower Pl

    OFFICE BUILDING (MULTI-STORY) • 350,036 SF
    Value Estimation by Request
    2 Tower Pl, South San Francisco, CA 94080-1826
    View details
    Airport Blvd

    Airport Blvd

    OFFICE BUILDING (MULTI-STORY) • 2.69 Acres
    Value Estimation by Request
    Airport Blvd, South San Francisco, CA 94080
    View details

    South San Francisco, CA Office Spaces Investment Opportunities Market Analysis

    Explore 72 office spaces for sale in South San Francisco, CA, showcased through 5 active listings on our real estate platform. These investment opportunities span a total of 39,557 square feet of properties for sale, with an estimated market value of $54,298,000.

    Sale prices for office spaces in South San Francisco, CA start at $799,000, averaging $10,859,600, and reaching up to $48,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

    List
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    Top Commercial Asset Segments

    Office Units 40
    Office buildings 8
    Medical Office Space 3
    Coworking space 1

    Property Size Breakdown

    The majority of commercial real estate listings in South San Francisco fall within the 100,000+ square foot range.

    Demographics Overview

    Population 65K
    Population Growth (5Y) -3.8%
    Median Household Income $135,966
    College Educated 26.3%

    High-Yield Neighborhoods for Strategic Investment

    Identify South San Francisco submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    94080 $10.9M

    Taxes & Financing

    Tax Rate (average for all types) 1.16%
    Property Tax per SF $7.35 per sq ft
    Tax Rate vs County Average 0.02 pp below county avg
    Average Loan-to-Value 65.0%

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