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    South San Francisco, CA Office Spaces for Sale

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    San Bruno, CA Brisbane, CA Colma, CA
    6 properties
    Fully Secured High-Tech Biotech Facility
    Updated: Jul 6
    Fully Secured High-Tech Biotech Facility

    560 Eccles AVE, South San Francisco, CA 94080

    $48,000,000
    3.65 AC lot
    Premier 21,552 SF high‑tech biotech facility built in 2019 on a 3.65‑acre site
    Interior includes approx. 9,500 SF office, 4,500 SF mission‑critical lab space, and 7,000 SF warehouse/inspection zone
    Security features include Security Level II: Lenel card reader system, 24‑hour CCTV, and fenced parking with 62 assigned spaces
    Mission‑critical lab infrastructure includes 100% ducted exhaust (8 air changes/hour) and high‑purity reverse osmosis water systems
    Power backup: 500 kW stand‑alone diesel generator plus dedicated UPS backup power
    View details
    Versatile Showroom Warehouse in Peninsula
    Updated: Mar 19
    Versatile Showroom Warehouse in Peninsula

    1435 Huntington Avenue #C, South San Francisco, CA 94080

    $1,100,000
    2,720 sqft · 3.83 AC lot
    Prime location in South San Francisco with quick access to Highways 101, 280, and 380.
    Versatile space suitable for showroom, workspace, light industrial use, offices, design studios, or storage.
    Flexible layout with approximately 1,560 sq. ft. on the ground floor and 1,160 sq. ft. loft area.
    Functional design with a grade level roll‑up door for convenient loading and deliveries.
    Suitable for owner‑user or investor.
    View details
    High-Security Life Science Flex Facility
    High-Security Life Science Flex Facility

    560 Eccles Avenue, South San Francisco, CA 94080

    $48,000,000
    21,552 sqft · 3.65 AC lot

    Purpose-built 2019 lab, office, and warehouse/inspection space with advanced utilities and secured logistics for mission-critical operations.

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    South San Francisco Redevelopment Opportunity
    South San Francisco Redevelopment Opportunity

    201 Cypress Avenue, South San Francisco, CA 94080

    $2,700,000
    10,067 sqft · 0.23 AC lot

    10,067 SF automotive site with redevelopment potential.

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    Combined Flex Warehouse Office
    Combined Flex Warehouse Office

    451 Victory Avenue 5, South San Francisco, CA 94080

    $499,000

    Combined units provide office-ready space with ADA restrooms, a warehouse plus mezzanine storage, and two second-floor access points.

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    South San Francisco Industrial Warehouse
    South San Francisco Industrial Warehouse

    253 E Harris Ave, South San Francisco, CA 94080

    $6,625,000
    19,800 sqft

    Well-maintained 19,800 SF industrial warehouse in prime location.

    View details
    Based on your search, we've compiled 80 Potential Opportunities for your consideration. Besides 6 Active listings in South San Francisco, CA, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 66 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Ground-Floor Commercial Condo
    Ground-Floor Commercial Condo

    5020 Mission Street Unit 1, San Francisco, CA 94112

    $399,900
    831 sqft · 0.02 AC lot

    Flexible ground-floor unit with open layout, set in an NC-3 zone and supported by established monthly HOA dues.

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    Mixed-Use Duplex with Office Unit
    Mixed-Use Duplex with Office Unit

    5480 Mission ST, San Francisco, CA 94112

    $999,000
    2,500 sqft · 0.05 AC lot

    Duplex offers a 2 bed/2 bath residence plus an additional office-style unit under NC2 zoning.

    View details
    Move-In Ready Office Space
    Move-In Ready Office Space

    851 Burlway Rd, Burlingame, CA

    Contact for pricing
    2,858 sqft · 1.87 AC lot

    Office suites available near SFO with Bay and City views.

    View details
    Two-Story Office and Warehouse Campus
    Two-Story Office and Warehouse Campus

    831-839 Mitten Rd, Burlingame, CA 94010

    Contact for pricing
    540 sqft

    Two-story campus combines office space with a standalone warehouse, plus EV charging and abundant natural light.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Prime Corner Lot in Burlingame
    Prime Corner Lot in Burlingame

    Hillsborough, CA 94010

    $11,500,000
    11,000 sqft · 0.65 AC lot

    Iconic building site with development potential near downtown.

    View details
    El Sobrante Land Opportunity
    El Sobrante Land Opportunity

    425 Appian Way, El Sobrante, CA 94803

    $1,350,000
    10,000 sqft

    Commercial land available off San Pablo Dam Road.

    View details
    Vallejo Commercial Land For Sale
    Vallejo Commercial Land For Sale

    1401 Sonoma Boulevard, Vallejo, CA 94590

    $1,495,000

    Commercial land available for sale in Vallejo, California.

    View details
    Commercial Parcel in Livermore Hub
    Commercial Parcel in Livermore Hub

    2901 Las Positas Road, Livermore, CA 94551

    $1,900,000
    0.93 AC lot

    Prime commercial land in established retail and service hub.

    View details

    Off-Market Properties in South San Francisco, CA

    Consider similar Off-Market properties in South San Francisco, CA. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    163 Harris Ave
    OFFICE BUILDING (MULTI-STORY)

    163 Harris Ave, South San Francisco, CA 94080-6008

    Value Estimation by Request
    0.35 AC lot
    View details
    323 Miller Ave, Unit 329
    PROFESSIONAL BUILDING

    323 Miller Ave, South San Francisco, CA 94080-3725

    Unit 329
    Value Estimation by Request
    0.18 AC lot
    View details
    1405 Huntington Ave
    PROFESSIONAL BUILDING

    1405 Huntington Ave, South San Francisco, CA 94080-5988

    $815,000
    Estimated value
    0.04 AC lot
    View details
    1475 Huntington Ave
    PROFESSIONAL BUILDING

    1475 Huntington Ave, South San Francisco, CA 94080-5990

    $1,145,000
    Estimated value
    0.03 AC lot
    View details
    1475 Huntington Ave Ste, Unit 200
    PROFESSIONAL BUILDING

    1475 Huntington Ave Ste, South San Francisco, CA 94080-5967

    Unit 200
    $530,000
    Estimated value
    1,530 sqft · 0.03 AC lot
    View details
    1241 Msn Rd
    OFFICE BUILDING (MULTI-STORY)

    1241 Msn Rd, South San Francisco, CA 94080-1397

    $1,545,000
    Estimated value
    4,561 sqft · 0.32 AC lot
    View details
    421 Grand Ave
    OFFICE BUILDING (MULTI-STORY)

    421 Grand Ave, South San Francisco, CA 94080-3635

    Value Estimation by Request
    6,629 sqft · 0.16 AC lot
    View details
    1435 Huntington Ave
    PROFESSIONAL BUILDING

    1435 Huntington Ave, South San Francisco, CA 94080-5989

    Value Estimation by Request
    3,224 sqft · 3.47 AC lot
    View details
    435 Grand Ave
    OFFICE BUILDING (MULTI-STORY)

    435 Grand Ave, South San Francisco, CA 94080-3635

    Value Estimation by Request
    0.08 AC lot
    View details
    1587 San Mateo Ave
    OFFICE BUILDING (MULTI-STORY)

    1587 San Mateo Ave, South San Francisco, CA 94080-6500

    $610,000
    Estimated value
    2.44 AC lot
    View details
    1435 Huntington Ave Ste, Unit 337
    PROFESSIONAL BUILDING

    1435 Huntington Ave Ste, South San Francisco, CA 94080-5989

    Unit 337
    $1,225,000
    Estimated value
    1,220 sqft · 0.03 AC lot
    View details
    1165 El Camino Real
    OFFICE BUILDING (MULTI-STORY)

    1165 El Camino Real, South San Francisco, CA 94080-3207

    Value Estimation by Request
    0.25 AC lot
    View details
    359 El Camino Real
    OFFICE BUILDING (MULTI-STORY)

    359 El Camino Real, South San Francisco, CA 94080-5923

    $1,385,000
    Estimated value
    16,550 sqft · 0.95 AC lot
    View details
    1265 Msn Rd
    OFFICE BUILDING (MULTI-STORY)

    1265 Msn Rd, South San Francisco, CA 94080-1397

    Value Estimation by Request
    0.26 AC lot
    View details
    1475 Huntington Ave Ste, Unit 306
    PROFESSIONAL BUILDING

    1475 Huntington Ave Ste, South San Francisco, CA 94080-5967

    Unit 306
    Value Estimation by Request
    1,125 sqft · 0.03 AC lot
    View details
    800 Dubuque Ave, Unit 890
    OFFICE BUILDING (MULTI-STORY)

    800 Dubuque Ave, South San Francisco, CA 94080-1804

    Unit 890
    $2,295,000
    Estimated value
    112,912 sqft · 5.96 AC lot
    View details
    160 Country Clb Dr
    PROFESSIONAL BUILDING

    160 Country Clb Dr, South San Francisco, CA 94080-4347

    $11,130,000
    Estimated value
    10,814 sqft · 0.47 AC lot
    View details
    2 Tower Pl
    OFFICE BUILDING (MULTI-STORY)

    2 Tower Pl, South San Francisco, CA 94080-1826

    Value Estimation by Request
    350,036 sqft · 2.91 AC lot
    View details

    South San Francisco, CA Office Spaces Market Trends and Statistics

    Explore 72 office spaces for sale in South San Francisco, CA, showcased through 6 active listings on our real estate platform. These investment opportunities span a total of 59,357 square feet of properties for sale, with an estimated market value of $60,923,000.

    Sale prices for office spaces in South San Francisco, CA start at $799,000, averaging $10,153,833, and reaching up to $48,000,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 41
    Office buildings 12
    Medical Office Space 3
    Coworking space 1

    Demographics Overview

    Population 65K
    Population Growth (5Y) -3.8%
    Median Household Income $135,966
    College Educated 26.3%

    High-Yield Neighborhoods for Investment

    Identify South San Francisco submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    94080 $15.4M

    Taxes & Financing

    Tax Rate (average for all types) 1.16%
    Property Tax per SF $7.35 per SF
    Tax Rate vs County Average 0.02 pp below county avg
    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in San Mateo County

    New Delisted

    Total CRE Inventory on Market (SF)

    Average Property Price per SF

    For-sale pricing trends across core commercial property types in San Mateo County

    Retail

    Residential Income

    Property Size Breakdown

    The majority of commercial real estate listings in South San Francisco fall within the 100,000+ square foot range.

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