Daly City, CA Office Spaces for Rent & Lease

Updated: Nov 22, 2025

Class A Lab/Office Space

2001 Junipero Serra Boulevard, Daly City, CA 94014

$6.25 SF/Yr

47,139 sqft

Class A laboratory and office building
Large, open floor plates ideal for modern lab design
Located right off I‑280
Premier visibility
Convenient access throughout the Bay Area

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Updated: Apr 20

Class A Laboratory Office Building

2001 Junipero Serra Blvd, Daly City, CA 94014

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12,118 sqft

GENESIS – Station is a nine‑story Class A laboratory and office building in Daly City, CA.
Retrofit multi‑tenant building with large, open floor plates and suites from about 19,800 to 48,000 RSF.
Robust laboratory infrastructure systems designed for lab‑and‑office use.
Convenient access: within walking distance to Daly City BART station for commuting from North, South, and East Bay.
Located along the I‑280 corridor with visibility, and surrounded by nearby retail shops and restaurants.

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Daly City Office Space Available

323 89th Street, Daly City, CA 94015

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6,189 sqft

Full floor office space with potential for multiple tenants.

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Daly City Office Space

1655 Southgate Ave, #1st Floor, Daly City, CA 94015

$45 SF/Yr

Office space available for rent in Daly City, CA.

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Daly City Office Space Available

950 John Daly Boulevard, Daly City, CA 94015

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4,249 sqft

Office space for rent, walking distance to retail amenities.

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Multiple Office Suites For Lease

151 87th St, Daly City, CA 94015

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Four office suites are available, ranging from 180 to 600 square feet.

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Daly City Office Space Available

333 Gellert Blvd, Daly City, CA 94015

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Office suites available near Highway 280, BART, and SamTrans.

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Daly City Shopping Center Space

5-95 Southgate Ave, Daly City, CA

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2,606 sqft 0.86 AC lot

Retail space available in a large Daly City shopping center.

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Based on your search, we've compiled 13 Potential Opportunities for your consideration. Besides 8 Active listings in Daly City, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 1 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Office Space for Lease

551 Faxon Avenue, San Francisco, CA 94112

$2,800/Mo

1,400 sqft

Office units and spaces available for lease at 551 Faxon Avenue in San Francisco.

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Flex Space with Cross-Loading

240-246 Valley Dr, Brisbane, CA 94005

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79,400 sqft

Industrial flex facility combines substantial warehouse capacity with office space, loading infrastructure, and on-site parking.

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Office Suite with Private Entrance

1500 Ocean Ave, San Francisco, CA 94112

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1,800 sqft

Open office suite with skylights, all-new floors, two restrooms, and a private entrance.

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Brisbane Industrial Space Available

440 Valley Dr, Brisbane, CA 94005

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39,600 sqft

Industrial space in Brisbane with office and loading docks.

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Similar Spaces for Sale in Daly City, CA

Consider Similar Space for Sale. We found 1 Spaces matching your search parameters.

Office Building with Post Office Tenant

6025 Mission Street, Daly City, CA 94014

$998,000

C-1 Light Commercial zoning and ADA-compliant restrooms support the building’s current commercial configuration.

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Daly City, CA Office Spaces Lease Rates & Market Statistics

Browse 8 Office Spaces for lease in Daly City, CA on Realmo, a commercial real estate marketplace serving the Daly City area. The current inventory totals 72,301 square feet of properties.

Asking lease rates for Office Spaces in Daly City start at $6.25 SF/Yr, average $25.63 SF/Yr, and reach $45 SF/Yr at the top of the market. That's a 7x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $25.63 SF/Yr is in line with the California state average.

Daly City accounts for 1% of the 1,261 office spaces currently available across San Mateo County, where nearby markets include San Francisco and San Mateo.