San Mateo, CA Medical Office Space for Rent & Lease

Updated: May 21, 2025

Medical/Dental Condo Suite

420 Peninsula Avenue 3, San Mateo, CA 94401

$3,500/Mo

4,000 sqft

Newly constructed medical/dental condo built in 2019
ADA‑compliant access plus a wheelchair lift
Includes a waiting area, front desk, and a private restroom
Three fully plumbed operatories, ready for equipment installation

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Updated: May 23, 2025

Medical Office Condo Suite

420 Peninsula Avenue, San Mateo, CA 94401

$3,600/Mo

4,000 sqft

2019‑built medical/dental condo with ADA‑compliant access and a wheelchair lift
Includes a private restroom
Front waiting area with front desk
Three fully plumbed operatories, ready for equipment installation

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Downtown San Mateo Office Space

101 South San Mateo Drive, San Mateo, CA 94401

Contact for pricing

2,500 sqft

Rare 2500 sqft office space in downtown San Mateo.

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Professional/Medical Office Space Available

312 N San Mateo Drive, San Mateo, CA 94401

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Professional/Medical office space for lease, near San Francisco International Airport.

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Medical Office Space Available

36 N San Mateo Dr, San Mateo, CA

Contact for pricing

1,340 sqft

Medical office space with existing dental infrastructure for lease.

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Based on your search, we've compiled 15 Potential Opportunities for your consideration. Besides 5 Active listings in San Mateo, CA, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 2 Properties for Sales.

Medical Office Space for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

South San Francisco Integrated Facility

285 East Grand Avenue, South San Francisco, CA 94080

Contact for pricing

30,000 sqft

Integrated biology, tissue culture, chemistry, and vivarium labs for rent.

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New Construction Flex Office Condos

552-560 El Camino Real, San Carlos, CA 94070

Contact for pricing

Two newly built condo-style spaces for lease with zoning flexibility for medical, office, or retail use.

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Biotech Ready Start-Up Space

130 Produce Ave, South San Francisco, CA

Contact for pricing

1,950 sqft

Biotech ready office space available for lease in South San Francisco.

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San Carlos Biotech/Lab Space

San Carlos, CA 94070

Contact for pricing

13,500 sqft

13,500 RSF biotech/lab/pharma/GMP manufacturing space available Spring 2026.

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Similar Spaces for Sale in San Mateo, CA

Consider Similar Space for Sale. We found 2 Spaces matching your search parameters.

New Medical/Dental Condo For Sale

420 Peninsula Avenue #3, San Mateo, CA 94401

$1,499,000

4,000 sqft

Newly constructed medical/dental condo on the San Mateo Burlingame border.

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Medical/Dental Condo Suite

420 Peninsula Avenue 2, San Mateo, CA 94401

$3,000,000

Newly built medical/dental condo includes a waiting room, front desk area, and three operatories with ADA restroom and lift access.

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

Commercial Land for Long-Term Lease

5538 E Paisano Drive, El Paso, TX 79905

$5,950/Mo

Lease a C4-zoned lot with easy interstate access, suited for a range of business and professional uses.

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Office Development Land For Lease

1323 Strawfloor Drive, Jonesboro, AR 72401

Contact for pricing

4,000 sqft

2.43 acres for office development with build-to-suit opportunity.

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Corner Lot on Highway 72

30472 Highway 72, Madison, AL 35756

$5,000/Mo

1,875 sqft

1.7 acre corner lot zoned for commercial, medical, residential.

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Prime Lexington Outlot Opportunity

3330 Partner Place, Lexington, KY 40503

Contact for pricing

Outlot for ground lease or build-to-suit in South Lexington.

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San Mateo, CA Medical Office Space Market Trends and Statistics

Explore Medical Office Space leasing options in San Mateo, CA with 5 listings featured on our commercial real estate exchange. The current inventory includes 8,000 square feet of properties with an estimated lease value of $21.30 SF/Yr.

Estimated lease rates for Medical Office Space in San Mateo, CA begin at $10.50 SF/Yr, with an average of $10.65 SF/Yr and extend to $10.80 SF/Yr.