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    South San Francisco, CA Office Units for Lease

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    Belmont, CA San Bruno, CA Brisbane, CA
    34 results
    Corner Office Space Available
    $2 SF/Yr
    2,621 SF

    Corner Office Space Available

    1486 Huntington Avenue, South San Francisco, CA 94080

    Prominent corner office space near transportation and shopping.

    • Excellent Location: Just off Hwy 380 and El Camino Real
    • Walking distance (0.5 miles) to San Bruno BART and Tanforan Shopping Center
    • Adjacent to new Safeway development at Discovery Station
    • Prominent corner office on the 3rd floor
    • 3 Private Offices
    Updated: Mar 25
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    South San Francisco Office/Lab Sublease
    Contact for pricing
    22,365 SF

    South San Francisco Office/Lab Sublease

    651 Gateway Boulevard, South San Francisco, CA 94080

    Full floor office/lab space available for sublease through July 2029.

    • Full floor (± 22,365 RSF) divisible office/lab space available for sublease through July 2029.
    • Prominent location on Highway 101 corridor with easy access.
    • Free shuttle service to San Francisco Airport (10 minutes away).
    • Full‑building lab conversion with new laboratory infrastructure and robust MEP systems.
    • Brand new Class A exteriors, lobby, and lab warm shell core.
    Updated: Jan 27
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    South San Francisco Industrial Building
    Contact for pricing
    29,800 SF

    South San Francisco Industrial Building

    Freestanding industrial building with office/lab space for rent.

    250 Hillside Boulevard, South San Francisco, CA 94080
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    Oyster Point Flex/Lab Space
    Contact for pricing
    10,248 SF

    Oyster Point Flex/Lab Space

    30,140 SF flex/lab space available for lease.

    333 Oyster Point Blvd, South San Francisco, CA 94080
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    South San Francisco Flex Space
    Contact for pricing
    30,491 SF

    South San Francisco Flex Space

    Flex space available for rent in South San Francisco.

    400 E Jamie Ct, South San Francisco, CA 94080
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    Class A Lab & Office
    Contact for pricing
    34,988 SF

    Class A Lab & Office

    Sublease opportunity: 34,988 SF of Class A lab & office.

    131 Oyster Point Blvd, South San Francisco, CA 94080
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    Plug & Play Office Sublease
    Contact for pricing
    29,711 SF

    Plug & Play Office Sublease

    Sublease available with premier finishes and included furniture.

    111 Oyster Point Blvd, South San Francisco, CA 94080
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    South San Francisco Office Space
    $2 SF/Yr
    1,694 SF

    South San Francisco Office Space

    Office space near transportation and airport in South San Francisco.

    220 S Spruce Ave, South San Francisco, CA
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    Downtown Office Space Available
    $1.66 SF/Yr
    3,689 SF

    Downtown Office Space Available

    Office space in downtown core with multiple private rooms.

    301 Grand Ave, South San Francisco, CA
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    Life Science Campus for Rent
    Contact for pricing
    300,000 SF

    Life Science Campus for Rent

    Vibrant campus with amenities near Biotech Bay Area corridor.

    180 El Camino Real, South San Francisco, CA 94080
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    South San Francisco Commercial Space
    Contact for pricing

    South San Francisco Commercial Space

    Commercial space available for rent in South San Francisco.

    578 Eccles Avenue, South San Francisco, CA 94080
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    South San Francisco Warehouse Space
    $33,000 SF/Yr
    19,800 SF

    South San Francisco Warehouse Space

    19,800 SF warehouse space for rent in South San Francisco.

    253 E Harris Ave, South San Francisco, CA 94080
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    South San Francisco Office Space
    $2.00 SF/Yr
    29,470 SF

    South San Francisco Office Space

    LEED Gold certified office space with excellent transportation access.

    701 Gateway Blvd, South San Francisco, CA
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    South San Francisco Office Space
    $35 SF/Yr
    1,590 SF

    South San Francisco Office Space

    Office space available for lease in South San Francisco.

    201 Grand Ave, South San Francisco, CA
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    South San Francisco Office Space
    Contact for pricing
    38,400 SF

    South San Francisco Office Space

    Office space available for lease in South San Francisco.

    1 & 2 Tower Place, South San Francisco, CA 94080
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    South San Francisco Lab Space
    Contact for pricing
    19,817 SF

    South San Francisco Lab Space

    Class A lab and office space available for sublease.

    2 Tower Place, South San Francisco, CA 94080
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    Life Science Campus for Collaboration
    Contact for pricing

    Life Science Campus for Collaboration

    South San Francisco campus with lab and office space.

    101 Terminal Court, South San Francisco, CA 94080
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    South San Francisco Office Space
    Contact for pricing
    73,216 SF

    South San Francisco Office Space

    Office space for rent in South San Francisco life science hub.

    5000 Shoreline Court, South San Francisco, CA 94080
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    South San Francisco Office/Lab Space
    Contact for pricing
    85,140 SF

    South San Francisco Office/Lab Space

    Office and laboratory spaces in South San Francisco.

    180 Kimball Way & 442 Littlefield Ave, South San Francisco, CA 94080
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    South San Francisco Office Space
    Contact for pricing
    13,332 SF

    South San Francisco Office Space

    13,332 SF office suite in prime location for rent.

    South San Francisco, CA 94080
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    South San Francisco Office Space
    Contact for pricing
    107,175 SF

    South San Francisco Office Space

    Move-in ready office suites available in South San Francisco.

    490 Forbes Boulevard, South San Francisco, CA 94080
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    South San Francisco Office Space
    $0.80 SF/Yr
    1,967 SF

    South San Francisco Office Space

    Second floor office space with abundant natural light.

    100 Produce Ave, South San Francisco, CA
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    South San Francisco Office Space
    Contact for pricing
    24,581 SF

    South San Francisco Office Space

    Office and medical space available for lease in South San Francisco.

    4000 Shoreline Court, South San Francisco, CA 94080
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    South San Francisco Office Space
    Contact for pricing
    979 SF

    South San Francisco Office Space

    Second floor office space available for rent in South San Francisco.

    90 S Spruce Ave, South San Francisco, CA
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    South San Francisco, CA Office Units Leasing Opportunities Market Analysis

    Explore Office Units leasing options in South San Francisco, CA with 34 listings featured on our commercial real estate exchange. The current inventory includes 62,781 square feet of properties with an estimated lease value of $33,046.

    Estimated lease rates for Office Units in South San Francisco, CA begin at $0.80 SF/Yr, with an average of $4,130 /Mo and extend to $33,000.
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