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    South San Francisco, CA Office Units for Lease

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    29 properties
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    South San Francisco Industrial Building
    Updated: Mar 25
    South San Francisco Industrial Building

    250 Hillside Boulevard, South San Francisco, CA 94080

    $1.65 SF/Yr
    29,800 sqft $4,097/Mo
    Heavy Power: 1600 Amps @ 480v 3‑Phase 4w, ideal for clean technology and manufacturing
    Excellent Location: Easy access off Hwy 101, less than 1 mile from downtown SSF and Caltrain, short drive to SFO and San Francisco
    8,500 SF of Improved Office/Lab Space with an open production/manufacturing floor
    Dock‑high doors with 1 recessed loading position and 1 Grade‑level loading
    20' Clear Height
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    South San Francisco Office Space
    Updated: Nov 24, 2025
    South San Francisco Office Space

    701 Gateway Blvd, South San Francisco, CA

    $2.00 SF/Yr
    29,470 sqft $4,911/Mo
    Shuttle to BART & CalTrain
    Just 5 Miles to SFO
    Highway Access - 101
    Features 6 Conference Rooms
    LEED Certified - Gold
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    Insulated Flex Warehouse with Offices
    Insulated Flex Warehouse with Offices

    140 Beacon St, South San Francisco, CA 94080

    Contact for pricing
    24,000 sqft

    Insulated, fully sprinklered warehouse with office space, skylights, and multiple grade-level doors for flexible operations.

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    South San Francisco Office/Lab Sublease
    South San Francisco Office/Lab Sublease

    651 Gateway Boulevard, South San Francisco, CA 94080

    Contact for pricing
    22,365 sqft

    Full floor office/lab space available for sublease through July 2029.

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    South San Francisco Office Space
    South San Francisco Office Space

    220 S Spruce Ave, South San Francisco, CA

    $2.25 SF/Yr
    1,694 sqft $317.63/Mo

    Office space near transportation and airport in South San Francisco.

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    Class A Lab & Office
    Class A Lab & Office

    131 Oyster Point Blvd, South San Francisco, CA 94080

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    34,988 sqft

    Sublease opportunity: 34,988 SF of Class A lab & office.

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    Downtown Office Space Available
    Downtown Office Space Available

    301 Grand Ave, South San Francisco, CA

    $1.66 SF/Yr
    3,689 sqft $510.31/Mo

    Office space in downtown core with multiple private rooms.

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    Plug & Play Office Sublease
    Plug & Play Office Sublease

    111 Oyster Point Blvd, South San Francisco, CA 94080

    Contact for pricing
    29,711 sqft

    Sublease available with premier finishes and included furniture.

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    Life Science Campus for Rent
    Life Science Campus for Rent

    180 El Camino Real, South San Francisco, CA 94080

    Contact for pricing
    300,000 sqft

    Vibrant campus with amenities near Biotech Bay Area corridor.

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    Corner Flex Warehouse with Lab Potential
    Corner Flex Warehouse with Lab Potential

    436 North Canal Street, South San Francisco, CA 94080

    Contact for pricing
    3,710 sqft

    Corner flex/warehouse condo with 1,000 sf office, central HVAC, 400-amp power, and 9 reserved spaces.

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    Purpose-Built Lab Building For Rent
    Purpose-Built Lab Building For Rent

    233 East Grand Avenue, South San Francisco, CA 94080

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    32,000 sqft

    Lab building with cafe, fitness center, and courtyard.

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    Life Science Campus for Collaboration
    Life Science Campus for Collaboration

    101 Terminal Court, South San Francisco, CA 94080

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    South San Francisco campus with lab and office space.

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    South San Francisco Office Space
    South San Francisco Office Space

    5000 Shoreline Court, South San Francisco, CA 94080

    Contact for pricing
    73,216 sqft

    Office space for rent in South San Francisco life science hub.

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    South San Francisco Office/Lab Space
    South San Francisco Office/Lab Space

    180 Kimball Way & 442 Littlefield Ave, South San Francisco, CA 94080

    Contact for pricing
    85,140 sqft

    Office and laboratory spaces in South San Francisco.

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    South San Francisco Office Space
    South San Francisco Office Space

    490 Forbes Boulevard, South San Francisco, CA 94080

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    107,175 sqft

    Move-in ready office suites available in South San Francisco.

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    South San Francisco Office Space
    South San Francisco Office Space

    4000 Shoreline Court, South San Francisco, CA 94080

    Contact for pricing
    24,581 sqft

    Office and medical space available for lease in South San Francisco.

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    South San Francisco Office Space
    South San Francisco Office Space

    90 S Spruce Ave, South San Francisco, CA

    Contact for pricing
    979 sqft

    Second floor office space available for rent in South San Francisco.

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    South San Francisco Office Space
    South San Francisco Office Space

    331 Oyster Point Boulevard, South San Francisco, CA 94080

    Contact for pricing
    60,000 sqft

    60,000 square foot office space available for rent.

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    South San Francisco Office Space
    South San Francisco Office Space

    Utah Ave / Littlefield Ave, South San Francisco, CA 94080

    Contact for pricing
    76,082 sqft

    76,082 SF office space available for lease.

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    Oyster Point Marina Plaza Suites
    Oyster Point Marina Plaza Suites

    395 and 400 Oyster Point Boulevard, South San Francisco, CA 94080

    Contact for pricing

    Office suites with flexible floor plans and bay views.

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    South San Francisco R&D Lab
    South San Francisco R&D Lab

    180 Kimball Way, South San Francisco, CA

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    49,838 sqft

    R&D lab with freezer rooms, offices, and conference rooms.

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    South San Francisco Office Space
    South San Francisco Office Space

    South San Francisco, CA 94080

    Contact for pricing
    13,332 sqft

    13,332 SF office suite in prime location for rent.

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    South San Francisco Flex Space
    South San Francisco Flex Space

    450 E Jamie Ct, South San Francisco, CA

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    29,745 sqft

    Scalable flex space campus for life science companies.

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    South San Francisco Flex Space
    South San Francisco Flex Space

    225 Gateway Blvd, South San Francisco, CA

    Contact for pricing
    16,421 sqft

    Flex space with labs, vivarium, and convenient transit access.

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    South San Francisco, CA Office Units Market Trends and Statistics

    Explore Office Units leasing options in South San Francisco, CA with 29 listings featured on our commercial real estate exchange. The current inventory includes 64,653 square feet of properties with an estimated lease value of $7.56 SF/Yr.

    Estimated lease rates for Office Units in South San Francisco, CA begin at $1.65 SF/Yr, with an average of $1.89 SF/Yr and extend to $2.25 SF/Yr.
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