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    Florence County, SC Office Buildings for Sale

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    Pamplico Highway Commercial Opportunity
    $229,900
    0.80 Acres

    Pamplico Highway Commercial Opportunity

    1424 Pamplico Hwy, Florence, SC 29505

    Commercial lot on heavily traveled Pamplico Highway with multiple driveways.

    • High‑traffic location on Pamplico Highway
    • Four driveways providing easy access
    • Suitable for retail or commercial development
    • Existing house usable as an office
    • Road frontage
    Updated: Aug 14, 2025
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    Florence Office Building For Sale
    $1,500,000
    7,517 SF

    Florence Office Building For Sale

    1706 2Nd Loop Rd, Florence, SC 29501

    Office building with 7,517 square feet of space in Florence.

    • Handicap access: accessible approach with ramp.
    • Features office(s) and reception area.
    • Kitchen facility available.
    • Private restrooms.
    • Central heating and central air.
    Updated: Oct 24, 2025
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    Stand-Alone Office Building For Sale
    $250,000
    1,722 SF

    Stand-Alone Office Building For Sale

    Stand-alone office building with immediate occupancy in Lake City, SC.

    215 John St, Lake City, SC 29560
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    Downtown Florence Business Technology Center
    $12,000,000
    119,567 SF

    Downtown Florence Business Technology Center

    Office building in downtown Florence with investment and value-add potential.

    187 E Evans St, Florence, SC 29506
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    Based on your search, we've compiled 492 Potential Opportunities for your consideration. Besides 4 Active listings in Florence County, SC, we suggest exploring several alternatives: similar 486 Off-Market properties to explore as potential leads, plus 2 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Florence Commercial Lot For Sale
    $1,500,000
    4.02 Acres

    Florence Commercial Lot For Sale

    4.02 acre mixed-use lot with high visibility in Florence, SC.

    1714 2Nd Loop Rd, Florence, SC 29501
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    Florence Commercial Land For Sale
    $49,900
    0.17 Acres

    Florence Commercial Land For Sale

    Versatile B-6 zoned property with commercial and redevelopment potential.

    720 S Barringer St, Florence, SC 29506
    View details

    Explore Off-Market Properties in Florence County, SC

    Consider similar Off-Market properties in Florence County, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    215 3rd Loop Rd

    215 3rd Loop Rd

    OFFICE BUILDING • 10,709 SF
    Value Estimation by Request
    215 3rd Loop Rd, Florence, SC 29505-4717
    View details
    151 Evans St

    151 Evans St

    OFFICE BUILDING • 14,829 SF
    Value Estimation by Request
    151 Evans St, Florence, SC 29501-3425
    View details
    142 Dargan St

    142 Dargan St

    OFFICE BUILDING • 6,255 SF
    Value Estimation by Request
    142 Dargan St, Florence, SC 29506-2500
    View details
    Lake

    Lake

    OFFICE BUILDING • 2,000 SF
    Value Estimation
    $210,000
    Lake, City, SC 29560
    View details
    255 Warley St

    255 Warley St

    OFFICE BUILDING • 3,590 SF
    Value Estimation by Request
    255 Warley St, Florence, SC 29501-4444
    View details
    520 Palmetto St

    520 Palmetto St

    OFFICE BUILDING • 1,897 SF
    Value Estimation
    $275,000
    520 Palmetto St, Florence, SC 29501-4428
    View details
    1702 Irby St

    1702 Irby St

    OFFICE BUILDING • 1,280 SF
    Value Estimation
    $830,000
    1702 Irby St, Florence, SC 29505-3412
    View details
    2405 Palmetto St

    2405 Palmetto St

    OFFICE BUILDING • 1,501 SF
    Value Estimation by Request
    2405 Palmetto St, Florence, SC 29506-3602
    View details
    1217 Pamplico Hwy

    1217 Pamplico Hwy

    OFFICE BUILDING • 1,664 SF
    Value Estimation
    $100,000
    1217 Pamplico Hwy, Florence, SC 29505-6134
    View details
    150 Dargan St

    150 Dargan St

    OFFICE BUILDING • 11,182 SF
    Value Estimation
    $205,000
    150 Dargan St, Florence, SC 29506-2590
    View details
    114 Seaboard Ave

    114 Seaboard Ave

    OFFICE BUILDING • 992 SF
    Value Estimation
    $70,000
    114 Seaboard Ave, Johnsonville, SC 29555
    View details
    1311 National Cemetery Rd

    1311 National Cemetery Rd

    OFFICE BUILDING • 2,400 SF
    Value Estimation by Request
    1311 National Cemetery Rd, Florence, SC 29506-3248
    View details
    1000 Evans St

    1000 Evans St

    OFFICE BUILDING • 2,668 SF
    Value Estimation
    $275,000
    1000 Evans St, Florence, SC 29501-3318
    View details
    2802 Pamplico Hwy

    2802 Pamplico Hwy

    OFFICE BUILDING • 3,150 SF
    Value Estimation by Request
    2802 Pamplico Hwy, Florence, SC 29505-7525
    View details
    Florence, SC 29505

    Florence, SC 29505

    OFFICE BUILDING • 7,500 SF
    Value Estimation by Request
    Florence, SC 29505
    View details
    511 Evans St

    511 Evans St

    OFFICE BUILDING • 1,250 SF
    Value Estimation by Request
    511 Evans St, Florence, SC 29501-3407
    View details
    1457 Evans St

    1457 Evans St

    OFFICE BUILDING • 1,473 SF
    Value Estimation
    $125,000
    1457 Evans St, Florence, SC 29501-3390
    View details
    134 Church St

    134 Church St

    OFFICE BUILDING • 2,092 SF
    Value Estimation by Request
    134 Church St, Lake City, SC 29560-2658
    View details
    156 Broadway St

    156 Broadway St

    OFFICE BUILDING • 1,774 SF
    Value Estimation by Request
    156 Broadway St, Johnsonville, SC 29555
    View details
    436 Georgetown Hwy

    436 Georgetown Hwy

    OFFICE BUILDING • 3,544 SF
    Value Estimation by Request
    436 Georgetown Hwy, Johnsonville, SC 29555-8084
    View details

    Florence County, SC Office Buildings Investment Opportunities Market Analysis

    Explore 490 office buildings for sale in Florence County, SC, showcased through 4 active listings on our real estate platform. These investment opportunities span a total of 13,962,200 square feet of properties for sale, with an estimated market value of $121,744,900.

    Prices for office properties in Florence County, SC start at $50,000, averaging $568,901, and reaching up to $15,640,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you have the most current data.

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