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    Florence County, SC Mixed-use Properties for Sale

    6 results
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    Florence Commercial Lot For Sale
    $1,500,000
    4.02 Acres

    Florence Commercial Lot For Sale

    1714 2Nd Loop Rd, Florence, SC 29501

    4.02 acre mixed-use lot with high visibility in Florence, SC.

    • 260' of road frontage on 2nd Loop Road offers high visibility.
    • Zoned Mixed‑Use allows for a wide range of commercial and community‑oriented uses.
    • Permitted uses include schools, churches, retail, offices, restaurants, and hotels.
    • Conditional approval for multi‑family, live/work units, and other diverse uses.
    • Ideal location for businesses seeking high traffic and accessibility.
    Updated: Oct 24, 2025
    View details
    Florence Mixed-Use Investment Opportunity
    $500,000
    1.38 Acres

    Florence Mixed-Use Investment Opportunity

    0 Sc-327, Florence, SC 29506

    High-traffic SC-327 Retail & Restaurant Space

    • 1.38‑acre mixed‑use lot in Florence, SC, on US Hwy 327, priced at $500,000.
    • High‑visibility location adjacent to a RaceWay gas station.
    • Zoned for restaurant and pharmacy/drug store uses.
    • High traffic counts due to prime highway location.
    • Adjacent 1.38‑acre lots also available.
    Updated: Dec 11, 2024
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    Hwy 327 Mixed-Use Investment Opportunity
    $500,000
    1.38 Acres

    Hwy 327 Mixed-Use Investment Opportunity

    High-traffic Florence, SC retail center. Excellent visibility.

    0 Sc-327, Florence, SC 29506
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    Florence, SC Hwy 76 Commercial Land
    $1,750,000
    10.55 Acres

    Florence, SC Hwy 76 Commercial Land

    10.55 Acres, Mixed-Use Development Potential

    0 Us-76, Florence, SC 29506
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    High-Traffic Florence Mixed-Use Property
    $975,000
    36.58 Acres

    High-Traffic Florence Mixed-Use Property

    Prime US-76 location, multi-use potential.

    0 Palmetto St, Florence, SC 29506
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    High-Traffic Mixed-Use Florence SC
    $3,750,000
    105.44 Acres

    High-Traffic Mixed-Use Florence SC

    105 Acres, Multi-Use Investment Opportunity

    0 Williston Rd, Florence, SC 29506
    View details
    Based on your search, we've compiled 50 Potential Opportunities for your consideration. Besides 6 Active listings in Florence County, SC, we suggest exploring several alternatives: similar 44 Off-Market properties to explore as potential leads

    Explore Off-Market Properties in Florence County, SC

    Consider similar Off-Market properties in Florence County, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    520 Ham Rd

    520 Ham Rd

    OFFICE/RESIDENTIAL (MIXED USE)
    Value Estimation by Request
    520 Ham Rd, Timmonsville, SC 29161-7792
    View details
    Main St

    Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 1.28 Acres
    Value Estimation by Request
    Main St, Timmonsville, SC 29161
    View details
    208 Saunders St

    208 Saunders St

    OFFICE/RESIDENTIAL (MIXED USE) • 768 SF
    Value Estimation by Request
    208 Saunders St, Florence, SC 29501-2814
    View details
    130 Dargan St

    130 Dargan St

    Individual retail properties • 6,520 SF
    Value Estimation by Request
    130 Dargan St, Florence, SC 29506
    View details
    1501 Palmetto St

    1501 Palmetto St

    OFFICE/RESIDENTIAL (MIXED USE) • 1,912 SF
    Value Estimation by Request
    1501 Palmetto St, Florence, SC 29501-4131
    View details
    2702 Irby St

    2702 Irby St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,541 SF
    Value Estimation by Request
    2702 Irby St, Florence, SC 29505-3434
    View details
    Palmetto St

    Palmetto St

    Multifamily properties • 36.58 Acres
    Value Estimation by Request
    0 Palmetto St, Florence, SC 29506
    View details
    1388 Blackwell Ml Rd

    1388 Blackwell Ml Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 2,340 SF
    Value Estimation by Request
    1388 Blackwell Ml Rd, Johnsonville, SC 29555-6224
    View details
    State Hwy 51

    State Hwy 51

    OFFICE/RESIDENTIAL (MIXED USE) • 1,236 SF
    Value Estimation by Request
    State Hwy 51, Effingham, SC 29541
    View details
    109 Lynch Rd

    109 Lynch Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 2,943 SF
    Value Estimation by Request
    109 Lynch Rd, Coward, SC 29530
    View details
    1257 Sumter St, Unit 9

    1257 Sumter St, Unit 9

    OFFICE/RESIDENTIAL (MIXED USE) • 672 SF
    Value Estimation by Request
    1257 Sumter St, Florence, SC 29501-2209
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    245 Moore St

    245 Moore St

    OFFICE/RESIDENTIAL (MIXED USE) • 0.37 Acres
    Value Estimation by Request
    245 Moore St, Lake City, SC 29560-2532
    View details
    110 Myrtle Bch Hwy

    110 Myrtle Bch Hwy

    OFFICE/RESIDENTIAL (MIXED USE) • 2,186 SF
    Value Estimation by Request
    110 Myrtle Bch Hwy, Lake City, SC 29560-4504
    View details
    1459 Palmetto St

    1459 Palmetto St

    OFFICE/RESIDENTIAL (MIXED USE) • 1,519 SF
    Value Estimation by Request
    1459 Palmetto St, Florence, SC 29501-4173
    View details
    1512 Palmetto St

    1512 Palmetto St

    OFFICE/RESIDENTIAL (MIXED USE) • 1,780 SF
    Value Estimation by Request
    1512 Palmetto St, Florence, SC 29501-4132
    View details
    174 Ron Mcnair Blvd

    174 Ron Mcnair Blvd

    OFFICE/RESIDENTIAL (MIXED USE) • 1,024 SF
    Value Estimation by Request
    174 Ron Mcnair Blvd, Lake City, SC 29560-3260
    View details
    Us-76

    Us-76

    Lifestyle centers • 10.55 Acres
    Value Estimation by Request
    0 Us-76, Florence, SC 29506
    View details
    Sc-327

    Sc-327

    Lifestyle centers • 1.38 Acres
    Value Estimation by Request
    0 Sc-327, Florence, SC 29506
    View details

    Florence County, SC Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 50 mixed-use properties for sale in Florence County, SC, showcased through 6 active listings on our real estate platform. These investment opportunities span a total of 7,598,805 square feet of properties for sale, with an estimated market value of $11,265,000.

    Sale prices for multi use buildings in Florence County, SC start at $65,000, averaging $662,647, and reaching up to $3,750,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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