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    Florence County, SC Mixed-use Properties for Sale

    9 results
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    Florence Commercial Lot For Sale
    $1,500,000
    4.02 Acres

    Florence Commercial Lot For Sale

    1714 Second Loop Rd., Florence, SC 29501

    4.02 acre mixed-use lot with high visibility in Florence, SC.

    • 260' of road frontage on 2nd Loop Road offers high visibility.
    • Zoned Mixed‑Use allows for a wide range of commercial and community‑oriented uses.
    • Permitted uses include schools, churches, retail, offices, restaurants, and hotels.
    • Conditional approval for multi‑family, live/work units, and other diverse uses.
    • Ideal location for businesses seeking high traffic and accessibility.
    Updated: Feb 5, 2025
    View details
    Mixed-Use Property in Great Location
    $429,000
    3,764 SF

    Mixed-Use Property in Great Location

    605 S Dargan St, Florence, SC 29506

    Mixed-use property, previously commercial, next to medical staffing business.

    • Great Location!
    • Previously used for commercial purposes.
    • Located next door to a medical staffing business.
    • Currently occupied as a home by owner.
    • Year Built: 1930.
    Updated: Mar 11
    View details
    Downtown Lake City Commercial Building
    $199,000
    2,500 SF

    Downtown Lake City Commercial Building

    2,500 sq ft commercial building in downtown Lake City.

    112 E Main St, Lake City, SC 29560
    View details
    Versatile Commercial Parcel Near Downtown
    $499,900
    67,518 SF

    Versatile Commercial Parcel Near Downtown

    Office, showroom, and warehouse space less than one mile from Downtown.

    121 N Lawson St, Florence, SC 29501
    View details
    Evans Street Commercial Redevelopment Opportunity
    $79,000
    1,200 SF

    Evans Street Commercial Redevelopment Opportunity

    Standalone building on Evans Street with redevelopment potential.

    617 W Evans St, Florence, SC 29501
    View details
    Mixed-Use Investment Property
    $275,000
    4,740 SF

    Mixed-Use Investment Property

    4740 SF mixed-use property with three rental units.

    1701 Pamplico Hwy, Florence, SC 29505
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    Johnsonville Investment Opportunity
    Contact for pricing

    Johnsonville Investment Opportunity

    Prime property in Johnsonville, SC, with development potential.

    212 Maple Street, Johnsonville, SC 29555
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    Land with Highway Access
    $3,750,000

    Land with Highway Access

    Land with high traffic, accessibility, and visibility.

    N Williston Rd, Florence, SC 29506
    View details
    US Hwy 76 Frontage Land
    $2,000,000

    US Hwy 76 Frontage Land

    Commercial land with high visibility and accessibility on US Hwy 76.

    US-76, Florence, SC 29506
    View details
    Based on your search, we've compiled 57 Potential Opportunities for your consideration. Besides 9 Active listings in Florence County, SC, we suggest exploring several alternatives: similar 44 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Florence Area Investment Opportunity
    Contact for pricing

    Florence Area Investment Opportunity

    Prime land in Florence, SC, near National Cemetery.

    5723 E National Cemetery Rd, Florence, SC 29506
    View details
    Latta Acreage with Development Potential
    $45,000
    3.88 Acres

    Latta Acreage with Development Potential

    3.88 acres in Latta, SC, suitable for various development projects.

    TBD W Rice Street, Latta, SC 29565
    View details
    Hartsville Commercial Land Opportunity
    $199,999
    11.47 Acres

    Hartsville Commercial Land Opportunity

    Prime commercial land near city with utilities and versatile zoning.

    1403 S Fifth Street, Hartsville, SC 29550
    View details
    Conway Commercial Development Opportunity
    $3,200,000
    6.77 Acres

    Conway Commercial Development Opportunity

    Prime 6.77-acre commercial development tract in Conway, South Carolina.

    TBD Church St., Conway, SC 29527
    View details

    Explore Off-Market Properties in Florence County, SC

    Consider similar Off-Market properties in Florence County, SC. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    1505 Palmetto St

    1505 Palmetto St

    OFFICE/RESIDENTIAL (MIXED USE) • 1,057 SF
    Value Estimation by Request
    1505 Palmetto St, Florence, SC 29501-4131
    View details
    1388 Blackwell Ml Rd

    1388 Blackwell Ml Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 2,340 SF
    Value Estimation by Request
    1388 Blackwell Ml Rd, Johnsonville, SC 29555-6224
    View details
    1459 Palmetto St

    1459 Palmetto St

    OFFICE/RESIDENTIAL (MIXED USE) • 1,519 SF
    Value Estimation by Request
    1459 Palmetto St, Florence, SC 29501-4173
    View details
    245 Moore St

    245 Moore St

    OFFICE/RESIDENTIAL (MIXED USE) • 0.37 Acres
    Value Estimation by Request
    245 Moore St, Lake City, SC 29560-2532
    View details
    Main St

    Main St

    OFFICE/RESIDENTIAL (MIXED USE) • 1.28 Acres
    Value Estimation by Request
    Main St, Timmonsville, SC 29161
    View details
    119 Thomas St

    119 Thomas St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,613 SF
    Value Estimation by Request
    119 Thomas St, Lake City, SC 29560-2638
    View details
    209 Mclendon St

    209 Mclendon St

    OFFICE/RESIDENTIAL (MIXED USE) • 1,352 SF
    Value Estimation by Request
    209 Mclendon St, Timmonsville, SC 29161-1913
    View details
    101 Kershaw St

    101 Kershaw St

    OFFICE/RESIDENTIAL (MIXED USE) • 33,345 SF
    Value Estimation
    $795,000
    101 Kershaw St, Timmonsville, SC 29161-1425
    View details
    2702 Irby St

    2702 Irby St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,541 SF
    Value Estimation by Request
    2702 Irby St, Florence, SC 29505-3434
    View details
    501 Ron Mcnair Blvd

    501 Ron Mcnair Blvd

    OFFICE/RESIDENTIAL (MIXED USE) • 1,155 SF
    Value Estimation by Request
    501 Ron Mcnair Blvd, Lake City, SC 29560-3820
    View details
    174 Ron Mcnair Blvd

    174 Ron Mcnair Blvd

    OFFICE/RESIDENTIAL (MIXED USE) • 1,024 SF
    Value Estimation by Request
    174 Ron Mcnair Blvd, Lake City, SC 29560-3260
    View details
    Runway Dr

    Runway Dr

    OFFICE/RESIDENTIAL (MIXED USE) • 1.00 Acre
    Value Estimation by Request
    Runway Dr, Timmonsville, SC 29161
    View details
    546 Church St

    546 Church St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,862 SF
    Value Estimation by Request
    546 Church St, Lake City, SC 29560-3817
    View details
    1506 Palmetto St

    1506 Palmetto St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,978 SF
    Value Estimation by Request
    1506 Palmetto St, Florence, SC 29501-4132
    View details
    1107 Evans St

    1107 Evans St

    OFFICE/RESIDENTIAL (MIXED USE) • 2,216 SF
    Value Estimation by Request
    1107 Evans St, Florence, SC 29506-2739
    View details

    Florence County, SC Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 53 mixed-use properties for sale in Florence County, SC, showcased through 9 active listings on our real estate platform. These investment opportunities span a total of 832,630 square feet of properties for sale, with an estimated market value of $3,790,000.

    Sale prices for multi use buildings in Florence County, SC start at $65,000, averaging $315,833, and reaching up to $1,500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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