San Antonio, TX Medical Office Space for Sale

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Updated: Feb 19, 2025

Standalone Medical Office Building

13039 Nacogdoches Road, San Antonio, TX 78217

$445,000

2,243 sqft 0.31 AC lot

2,243‑square‑foot standalone building on 0.314 acres
Three examination rooms plus operating and x‑ray rooms
Kennel room with over 15 kennels and a dedicated pet bathing area
16‑space parking lot
Kitchen includes washer, dryer, stove, sink, and microwave

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Updated: Jun 28

Net-Leased Dental Office Property

9590 Marbach Rd, San Antonio, TX 78245

$2,100,000

4,364 sqft 0.91 AC lot

4,317 SF dental property built in 2007 on a 0.91‑acre parcel with an in‑place NNN lease
Heritage Dental Group tenant: in year seven of a 10‑year lease with two additional five‑year renewal options
NNN lease includes 2% annual rent increases for consistent income growth
2017 tenant renovations; HVAC units recently replaced in 2025, reducing near‑term capital needs
Parking ratio of 7.41 per 1,000 with visibility to approx. 24,333 vehicles per day

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Professional Office Building with Waiting Area

16007 Via Shavano, San Antonio, TX 78249

$1,150,000

2,650 sqft

Turnkey 2,650-square-foot office building configured for a medical practice with private offices, waiting area, and soundproofing.

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See what stands out in Bexar County

We check every for-sale listing in the county against comparable properties across the country. Most price about where you would expect. A few are worth a second look.

We check every listing here. A few are worth a second look.

Cap Rate available after sign in

NOI available after sign in

Local Demand available after sign in

Medical Office Building

4151 Callaghan, San Antonio, TX 78228

$2,600,000

10,533 sqft

Medical office building for sale near the corner of Ingram and Callaghan in Bexar County.

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Standalone Medical Office Building

378 Las Palmas Dr, San Antonio, TX 78237

$139,900

1,802 sqft

Former dental-office layout includes exam rooms, reception, restrooms, and dedicated parking.

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Medical Office Suite with Reception

8265 Fredericksburg, San Antonio, TX 78229

$325,000

1,001 sqft

Professional office setting with a welcoming entry area, natural light, and updated finishes for patient-facing operations.

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Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center

Medical-to-Retail Conversion Building

234 San Pedro, San Antonio, TX 78205

$1,799,999

4,428 sqft

A 4,428-sf medical space with plumbing in place, located in an Opportunity Zone with C-3NA designation and nearby parking-ready lots.

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Turnkey Corner Restaurant and Apartment

603 Bandera Rd, San Antonio, TX 78228

$699,000

6,025 sqft 0.43 AC lot

Turnkey corner property with restaurant FF&E, a 1,245 SF apartment, and C-2 zoning with three access points.

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Class A Office Building

4306 De Zavala, San Antonio, TX 78249

$6,900,000

45,528 sqft

Newly completed Class A office building in 2023, zoned O-2 and suited for medical or professional office use.

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Standalone Medical Office Building

5318 Summit, San Antonio, TX 78228

$599,999

2,920 sqft 0.55 AC lot

Standalone medical office on a 0.55-acre lot with parking space and a current dental laboratory setup.

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Freestanding Mixed-Use Building

7870 Broadway Building C, San Antonio, TX 78209

$1,200,000

3,648 sqft

Two-level property combines medical-office improvements with a separate residential apartment and flexible live-work potential.

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Shopping Center with Medical Office

6623 S Zarzamora St, San Antonio, TX 78211

Contact for pricing

39,759 sqft 2.01 AC lot

Multi-tenant retail property includes a fully built-out medical office suite and established retail surroundings.

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Medical Office Building with Flexible Suites

2 Spurs Lane, San Antonio, TX 78240

Contact for pricing

8,696 sqft

Two-story medical office property with existing clinical buildout and configurable suite options.

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Medical Office Space in Oak Hollow

6348 Prue Rd., San Antonio, TX 78240

Contact for pricing

2,515 sqft 7.80 AC lot

Medical office opportunity within a completed healthcare center with access to Prue Road, Babcock Road, and regional routes.

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Top-Floor Medical Office Condominium

1314 East Sonterra Boulevard, San Antonio, TX 78258

Contact for pricing

5,253 sqft

Class A medical-office condo on the building’s top floor within an established medical office park.

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Medical Office Space with Private Rooms

1302 S General Mcmullen Dr Unit 102, San Antonio, TX 78237

Contact for pricing

5,552 sqft

The suite includes private rooms with sinks, plus reception, storage, and a break area.

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Medical Office Space with Anchor Tenant

1036 E Borgfeld Dr Unit 2, San Antonio, TX 78260

Contact for pricing

1,200 sqft 0.65 AC lot

Two-tenant commercial building includes San Martin Orthodontics as the named anchor occupant.

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Medical Office Space at Legacy Oaks

5372 Fredericksburg Rd, San Antonio, TX 78229

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16,241 sqft

Renovated finishes and upgraded mechanical systems support medical office use.

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Medical Office Campus with Suites

4025 E Southcross Blvd, San Antonio, TX 78222

Contact for pricing

21,624 sqft 2.40 AC lot

Five one-story red brick office buildings totaling 12 suites, with most suites built out for medical office use.

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Medical Office Building

9631 Huebner Rd, San Antonio, TX 78240

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4,846 sqft

Established medical office property with a named clinic occupant and an absolute net lease structure.

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Single-Story Medical Office Space

2620 McCullough Avenue, San Antonio, TX 78212

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2,844 sqft 0.27 AC lot

Existing dermatopathology configuration with gated parking and direct access from McCullough Avenue.

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Medical Office Building

818 Lexington Ave, San Antonio, TX 78212

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7,421 sqft 0.94 AC lot

Fully leased healthcare property with two occupants under NNN lease structures near downtown San Antonio.

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Retail Space

11070 Shaenfield Rd, San Antonio, TX 78254

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1,632 sqft

Commercial space accommodates retail, restaurant, medical, office, and service-oriented uses.

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Medical Office Building with Garage

9465 Huebner Rd, San Antonio, TX 78240

Contact for pricing

8,111 sqft

Turnkey medical office building includes exam rooms, X-ray room, and conditioned attic space plus a 3-car garage.

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San Antonio, TX Medical Office Space Market Trends and Statistics

Explore 72 medical office space for sale in San Antonio, TX, showcased through 53 active listings on our real estate platform. These investment opportunities span a total of 459,840 square feet of properties for sale, with an estimated market value of $26,857,267.

Sale prices for medical spaces in San Antonio, TX start at $139,900, averaging $1,678,579, and reaching up to $6,900,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Top Commercial Asset Segments

Commercial property segments ranked by active listings on the market

Demographics Overview

Population 1.87M

Population Growth (5Y) +6.6%

Median Household Income $73,633

College Educated 29.7%

High-Yield Neighborhoods for Investment

Identify San Antonio submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
78237	$139.9K
78229	$162.5K
78240	$219.7K
78217	$227.5K
78221	$275K

Taxes & Financing

Tax Rate (average for all types) 2.26%

Property Tax per SF $27.36 per SF

Tax Rate vs County Average 0.01 pp below county avg

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in Bexar County

New Delisted

Total CRE Inventory on Market (SF)

Property Size Breakdown

The majority of commercial real estate listings in San Antonio fall within the 100,000+ square foot range.

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