San Antonio, TX Medical Office Space for sale

San Antonio Freestanding Commercial Building

$275,000

2,898 SF

San Antonio Freestanding Commercial Building

114 West Vestal Place, San Antonio, TX 78221

Versatile commercial building in San Antonio's Southside, ideal for customization.

High‑intensity C‑3 NA zoning allows for a wide range of high‑traffic commercial uses.
Freestanding ±2,898 SF building offers a versatile footprint.
Prime opportunity for a "value‑add" investor or business owner to customize the space.
Located in the heart of San Antonio’s Southside.
Existing professional office configuration includes reception/waiting area, multiple private offices, and a central hallway.

Updated: Mar 5

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$1,350,000

3,990 SF

Historic Office Building For Sale

118 E Ashby Pl, San Antonio, TX 78212

1915 property ideal for law firm or professional services.

Prime central location with convenient access to Downtown and major corridors.
Beautifully preserved 1915 property with timeless character.
Ideal for law firm, professional services, medical, or owner‑user.
Features a welcoming reception area with original fireplace, high ceilings, rich wood trim, and abundant natural light.
Includes impressive conference room, full kitchen, and multiple restrooms.

Updated: Feb 23

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Medical/Physical Therapy Building For Sale

$699,000

6,012 SF

Medical/Physical Therapy Building For Sale

6,012 SF medical/physical therapy building with ample parking.

3326-3328 E Southcross Blvd, San Antonio, TX

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25,040 SF

Freestanding Office Building on I-10

25,040 SF office building with IH-10 frontage.

6222 W INTERSTATE 10, San Antonio, TX 78201

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$1,800,000

4,428 SF

San Antonio Mixed-Use Property For Sale

Mixed-use property with parking and development potential near stadium.

234 San Pedro, San Antonio, TX 78205

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27,494 SF

Medical Office Space in San Antonio

Prime medical/office space in San Antonio's Medical Center area.

5107 Medical Dr, San Antonio, TX

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5,253 SF

Medical Office in Stone Oak

5,253 SF condominium in the Villages on Sonterra Office Park.

San Antonio, TX 78258

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$205,000

968 SF

Move-in Ready Office Space

968 SF office space with plumbing and ample parking.

7300 Blanco Rd, San Antonio, TX

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Versatile Space in High-Traffic Location

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2,630 SF

Versatile Space in High-Traffic Location

Adaptable office, retail, or medical space with customization options.

11800-1866 Wurzbach Rd, San Antonio, TX

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2,065 SF

High-Quality Medical Office Space

Move-in ready medical office near Downtown and the Pearl.

San Antonio, TX 78215

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$895,000

4,200 SF

Turnkey Surgery Center Condo

Surgery center condo near San Antonio's medical corridor.

7272 Wurzbach Rd, San Antonio, TX 78240

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$4,950,000

37,708 SF

Medical Office Building For Sale

37,708 SF multi-tenant medical office building in San Antonio.

1123 N Main Ave, San Antonio, TX 78205

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$2,065,313

6,022 SF

Medical Imaging Center & Office

Medical imaging center and office space for sale.

11923 Culebra Rd, San Antonio, TX 78253

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$880,000

2,340 SF

Medical Office Near Baptist Hospital

Medical office space for sale near Baptist Hospital.

530 Lexington, San Antonio, TX 78215

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6,834 SF

Prime Office Space Available

Office space for rent in a premier location.

3602 Paesanos Pkwy, San Antonio, TX

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Medical Office Building in Medical Center

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12,012 SF

Medical Office Building in Medical Center

Two-story, 12,012 SF medical office building in San Antonio.

4775 Hamilton Wolfe Rd, San Antonio, TX

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6,245 SF

San Antonio Commercial Office Building

6,245 sqft office building in Central San Antonio.

5415 Lost Ln, San Antonio, TX

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7,000 SF

Retail Center Near Medical Center

7,000 SF multi-tenant retail center near San Antonio Medical Center.

6423 Babcock Rd, San Antonio, TX

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Medical Office Condo Investment

Medical office condo near South Texas Medical Center.

4903 Golden Quail, San Antonio, TX 78240

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7,930 SF

Medical Office Space For Sale

Class A medical office space in a new office park.

5250 Rogers Rd, San Antonio, TX

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Medical Office Near Stone Oak

Medical office space for sale near Methodist Stone Oak Hospital.

116 Gallery Cir, San Antonio, TX 78258

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$359,000

1,825 SF

Medical Office Space Available

Prime medical center location with multiple offices and restrooms.

9386 Huebner Rd 108, San Antonio, TX 78240

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$4,799,958

9,853 SF

Westover Hills Area Medical Office

Medical office building in the Westover Hills area.

9139 Westover Hills Blvd, San Antonio, TX

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$230,000

San Pedro Avenue Investment Opportunity

Renewed urban location, convenient access, and redevelopment potential.

234 San Pedro Avenue, San Antonio, TX 78205

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San Antonio, TX Medical Office Space Investment Opportunities Market Analysis

Explore 72 medical office space for sale in San Antonio, TX, showcased through 27 active listings on our real estate platform. These investment opportunities span a total of 80,244 square feet of properties for sale, with an estimated market value of $18,278,271.

Sale prices for medical spaces in San Antonio, TX start at $205,000, averaging $1,661,661, and reaching up to $4,950,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

Neighborhood	Average Price
78221	$275K
78240	$627K
78215	$880K
78212	$1.4M
78253	$2.1M

Neighborhood

Average Price

78221

$275K

78240

$627K

78215

$880K

78212

$1.4M

78253

$2.1M