San Antonio, TX Medical Office Space for Lease

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146 properties

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Updated: Apr 3

Shell Medical Office Suite

13035 Nacogdoches Rd, San Antonio, TX 78217

$2,950/Mo

4,290 sqft

1,400 SF commercial office suite available on Nacogdoches Rd in Northeast San Antonio
Currently in shell condition, allowing tenants to customize the layout for their business needs
Zoned C‑2 / C‑3NA for medical office, med spa, therapy, insurance, wellness, and professional service uses
Adjacent to an established OBGYN practice, offering synergy for complementary businesses
Convenient access to Loop 410 and nearby residential neighborhoods for client and employee visibility

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Updated: Jun 10

Medical Office Suite with Private Offices

7418 John Smith Dr, San Antonio, TX

$1,990/Mo

1,250 sqft

Approximately 1,250 SF of medical office space
Five private offices with reception area
Storage room and private restroom
On‑site parking included
Medical Center location with access to IH‑10 and Loop 410

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Medical Office or Retail Suite

2-1036 E Borgfeld Dr, San Antonio, TX 78260

$4,000/Mo

1,200 sqft 0.65 AC lot

Approximately 1,500 sq-ft suite is available within a multi-tenant building, suited for medical office or retail use.

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Two-Story Medical Office Building

5902 Computer Dr, San Antonio, TX 78229

$790-$7,914/Mo

31,320 sqft 1.20 AC lot

Two-story medical office building on a 1.2-acre site with flexible suite sizes for a range of healthcare providers.

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Class A Medical Center Lease Space

6348 Prue Rd, San Antonio, TX 78240

$6,050/Mo

2,515 sqft 7.80 AC lot

Class A Oak Hollow Medical Center offers Phase One medical suites anchored by Christus Santa Rosa.

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Medical Office in Medical Center

21 Spurs Lane, San Antonio, TX 78240

$33 SF/Yr

6,646 sqft

Four-story medical office building in San Antonio's Medical Center.

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Medical Office Building Suites

9150 Huebner Rd, San Antonio, TX 78240

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3,472 sqft

Leased medical office building with a multi-practice tenant mix and recent long-term renewals.

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Renovated Medical Office Space

5430 Fredericksburg Rd, San Antonio, TX 78229

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2,678 sqft

Renovated medical office with flexible floor plans and upgraded mechanical systems.

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Front Office Suite with Reception

1445 Austin Hwy, San Antonio, TX 78209

$2,200/Mo

Well-appointed suite includes reception, four private offices, break room, and private restroom, with electricity, water, and sewer included.

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First-Floor Medical Office Suite

7810 Louis Pasteur Dr, San Antonio, TX 78229

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6,071 sqft

6,071 SF first-floor medical suite within a 12,730 SF medical office building with parking at the Medical Center entrance.

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Medical Office Space with Hospital Access

7950 Floyd Curl Dr, San Antonio, TX 78229

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2,224 sqft

Medical office space within a hospital campus offering connected access, parking, and on-site healthcare services.

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Freestanding Office Building

San Antonio, TX 78217

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1,554 sqft

Configured with individual rooms, reception space, and on-site parking for professional or medical occupancy.

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Medical Office Suite

7810 Louis Pasteur Drive, San Antonio, TX 78229

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6,071 sqft

First-floor medical suite with ample parking in a medical office building at the Medical Center entrance.

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Renovated Medical Office Building

5282-5284 Medical Dr, San Antonio, TX 78229

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1,723 sqft

Medical office space in a renovated multi-story facility with surface and covered parking options.

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Built-Out Lab Medical Suite

8122 Datapoint Drive, San Antonio, TX 78229

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3,032 sqft

Fully built-out laboratory and medical suite with specialized walk-in, ventilation, sprinkler protection, and emergency safety stations.

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Shopping Center

23535 W IH 10, San Antonio, TX 78256

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2,000 sqft

Well-established retail center built in 2004 with strong visibility between I-10 exit and entrance ramps.

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Medical Office Space with Monument Signage

325 E Sonterra Blvd, San Antonio, TX 78258

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2,259 sqft

Second-generation medical space with monument signage and access to Hwy 281 and Loop 1604.

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Class A Medical Office Space

3903 Wiseman Blvd, San Antonio, TX 78251

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779 sqft

Healthcare practices share access to imaging, laboratory services, covered patient drop-off, and free surface parking.

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Three-Story Medical Office Building

7390 Barlite Blvd, San Antonio, TX 78224

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584 sqft

Second-generation suites support customized medical office layouts with tenant improvement allowances.

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First-Floor Medical Office Space

4515 N Loop 1604 W, San Antonio, TX 78257

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2,434 sqft

Flexible shell space supports a customized medical or professional build-out within a multi-story office building.

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Medical Office Space with Monument Signage

255 E Sonterra Blvd, San Antonio, TX 78258

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1,823 sqft

Second-generation medical space near major hospitals with access to Hwy 281 and Loop 1604.

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New Medical Office Space

11153 Westwood Loop, San Antonio, TX 78253

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200 sqft

Newly constructed professional space with OCL zoning for office or medical use.

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Freestanding Medical Office Building

13431-13441 Blanco Rd, San Antonio, TX 78248

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8,000 sqft

Two-story medical facility with 12 patient rooms and administrative offices, built for immediate healthcare use.

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Move-In Ready Medical Clinic

19016 Stone Oak Pkwy, San Antonio, TX 78258

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1,911 sqft

Well-maintained medical clinic space with Class A elevated finishes near North Central Baptist Hospital.

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San Antonio, TX Medical Office Space Lease Rates & Market Statistics

Browse 146 Medical Office Space listings for lease in San Antonio, TX on Realmo, a commercial real estate marketplace serving the San Antonio area. The current inventory totals 684,495 square feet of properties — an average of ~4,700 SF per listing.

Medical Office Space lease rates in San Antonio range from $8.25 SF/Yr at the entry level to $40 SF/Yr at the top of the market, averaging $23.67 SF/Yr. That's a 5x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $23.67 SF/Yr is in line with the Texas state average.

Medical Office Space listings make up 21% of the 682 Office Spaces currently for lease in San Antonio, with asking rates averaging $23.67 SF/Yr — 11% above the citywide Office Spaces average of $21.42 SF/Yr. Tenants comparing options may also consider Office Units (337 listings) and Office buildings (221 listings) elsewhere in the San Antonio market.

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