San Mateo, CA Commercial Real Estate for Sale

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Updated: Jun 19, 2025

New Medical/Dental Condo For Sale

420 Peninsula Avenue #3, San Mateo, CA 94401

$1,499,000

4,000 sqft

Prime location on the San Mateo/Burlingame border in a high‑traffic area.
Turnkey medical/dental condo ready for immediate occupancy.
Three fully plumbed operatories ready for equipment installation.
Newly constructed in 2019 with high‑quality materials and finishes.
ADA‑compliant access and wheelchair lift.

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This listing looks promising.

Here's a quick look at some key insights for

420 Peninsula Avenue #3, SAN MATEO, CA 94401

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Est. Cap Rate

5.2%
NOI ÷ price
Est. NOI

$78K
Annual
Mortgage

$800K
Sep 2017
Last Sold

Apr 2004
$1.2M

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Updated: Jun 5

Corner Flex Office/Warehouse

101 E 25th Ave, San Mateo, CA 94403

$2,800,000

3,850 sqft 0.26 AC lot

11,500 SF lot with a total of 3,850 SF renovated office and warehouse/storage space
Includes detached unit with restroom, shower, and employee lockers
Approximately 23 parking spaces with security gates
Corner parcel located on 25th and Palm Ave
Building signage available

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Two-Unit Retail Building with Mezzanine

168-170 W 25th Ave, San Mateo, CA 94403

$2,000,000

2,837 sqft

Two ground-floor retail units with added mezzanine space and rear parking offer flexible options for retailers and service users.

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Industrial Auto Shop Building

84 E 21st Ave, San Mateo, CA 94403

$1,300,000

2,032 sqft

Industrial building with a new rollup door and paint booth, suited for automotive and light industrial operations.

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Flex Space with Second-Floor Office

83 E 21st Ave, San Mateo, CA 94403

$2,750,000

6,911 sqft

Flex-style layout with ground storage/shop space, second-floor office amenities, and on-site parking for multiple vehicles.

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San Mateo Retail Investment Opportunity

15 - 17 37th Avenue, San Mateo, CA 94403

$1,612,903

3,238 sqft

Retail space leased to national veterinary network near El Camino.

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Downtown Retail Storefront

67 East Fourth Avenue, San Mateo, CA 94401

$1,495,000

817 sqft

High-profile retail location near shopping and public transit in San Mateo.

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Restaurant Property with Highway Access

1901 S Norfolk St, San Mateo, CA

$2,300,000

1,372 sqft 0.30 AC lot

Restaurant property with outdoor seating and convenient highway access.

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Retail Buildings in Downtown San Mateo

233-235 Baldwin Avenue, San Mateo, CA

$2,888,000

5,486 sqft 0.18 AC lot

Two retail buildings in prime downtown location near Caltrain.

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San Mateo Office Space Available

65-71 E 3rd Ave, San Mateo, CA

$9,900,000

5,051 sqft 0.13 AC lot

Second floor office space with elevator, conference room, and skylights.

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San Mateo Flex Space For Sale

1731 Leslie St, San Mateo, CA 94402

$3,000,000

4,300 sqft 0.30 AC lot

Flex space property featuring office, shop, and warehouse areas.

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Specialty Commercial Property

871 Woodside Way, San Mateo, CA 94401

$1,880,000

2,242 sqft

For-sale specialty commercial property in San Mateo, CA, listed at $1,880,000.

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Retail Space in San Mateo

709 S B St, San Mateo, CA 94401

Contact for pricing

5,005 sqft

Retail space available in San Mateo, California.

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San Mateo Office Building Investment

630 N San Mateo Dr, San Mateo, CA

$12,750,000

17,398 sqft 0.60 AC lot

Fully leased San Mateo office building with long-term tenant.

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San Mateo Office Building

1 Baywood Ave, San Mateo, CA 94402

Contact for pricing

10,960 sqft

Office building with 10,960 square feet of space.

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San Mateo Mixed-Use Investment

22 - 26 25th Avenue, San Mateo, CA 94403

$1,995,000

2,870 sqft

Fully leased mixed-use building in high-traffic San Mateo location.

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Versatile Building Near Caltrain

422-426 Peninsula Ave, San Mateo, CA 94401

$1,999,999

Adaptable building suitable for office, school, medical, or residential use.

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San Mateo Multifamily Investment Opportunity

1101 Tilton Avenue, San Mateo, CA 94401

$5,500,000

7,756 sqft

Well-maintained 12-unit apartment building in desirable San Mateo location.

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For-Sale Office Building

216 N San Mateo Drive, San Mateo, CA 94401

$2,400,000

Office building available for sale at 216 N San Mateo Drive, suited for owner-occupiers or office users.

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San Mateo Investment Property

310 Baldwin Ave, San Mateo, CA

Contact for pricing

27,000 sqft 0.25 AC lot

Rare investment opportunity with future development potential in San Mateo.

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Medical/Dental Condo Suite

420 Peninsula Avenue 2, San Mateo, CA 94401

$3,000,000

Newly built medical/dental condo includes a waiting room, front desk area, and three operatories with ADA restroom and lift access.

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Rare San Mateo Land Parcel

2075 S Norfolk Street, San Mateo, CA 94403

$7,500,000

9,150 sqft 1.25 AC lot

Undeveloped 54,256 sqft lot in San Mateo County.

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Turnkey Restaurant Opportunity For Sale

127 W 25 Avenue, San Mateo, CA 94403

$99,000

1,250 sqft

Remodeled taqueria/Mexican restaurant with furniture, fixtures, and equipment included.

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Office Building with 13,727 SF

2301 Flores Street, San Mateo, CA 94403

Contact for pricing

13,727 sqft

Office building offered for sale with 13,727 SF available.

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Based on your search, we've compiled Potential Opportunities for your consideration. Besides 24 Active Listings in San Mateo, CA, we suggest to view alternatives - similar 48 Off-Market properties to explore as potential leads.

San Mateo, CA Commercial Real Estate Market Trends and Statistics

Explore 72 commercial real estate for sale in San Mateo, CA, showcased through 24 active listings on our real estate platform. These investment opportunities span a total of 80,560 square feet of properties for sale, with an estimated market value of $61,268,903.

Sale prices for business properties in San Mateo, CA start at $99,000, averaging $3,604,053, and reaching up to $12,750,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Demographics Overview

Population 141K

Population Growth (5Y) -1.2%

Median Household Income $165,615

College Educated 74.2%

High-Yield Neighborhoods for Investment

Identify San Mateo submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
94401	$2.4M
94403	$3M
94402	$3.9M

Taxes & Financing

Tax Rate (average for all types) 1.30%

Property Tax per SF $7.54 per SF

Tax Rate vs County Average 0.17 pp above county avg

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in San Mateo County

New Delisted

Total CRE Inventory on Market (SF)

Average Property Price per SF

For-sale pricing trends across core commercial property types in San Mateo County

Retail

Residential Income

Property Size Breakdown

The majority of commercial real estate listings in San Mateo fall within the 100,000+ square foot range.

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