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    Seneca, SC Restaurants for Lease

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    Columbia, SC Greenville, SC Charleston, SC
    Retail Space Near Clemson University
    $21 SF/Yr
    43,000 SF

    Retail Space Near Clemson University

    1085 Old Clemson Highway, Seneca, SC 29672

    End-cap retail space with drive-thru potential near Clemson University.

    • High Traffic Location: 29,900 Vehicles Per Day (VPD) on Hwy. 123.
    • Proximity to Clemson University: Only 5 minutes away.
    • Located Between Two Major Lakes: Lake Keowee and Lake Hartwell.
    • End Cap Unit: ±1,200 SF Available for Lease.
    • Drive‑Thru Potential: Suite A offers drive‑thru possibilities.
    Updated: Nov 26, 2025
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    Restaurant Space Near Oconee Medical
    Contact for pricing
    16,000 SF

    Restaurant Space Near Oconee Medical

    201-273 Applewood Center Pl, Seneca, SC

    1,600 SF 2nd Gen Restaurant Space Available For Rent.

    • 1,600 SF 2nd Gen Restaurant Available
    • Located across the street from 169 bed Oconee Medical Center (Greenville Health System)
    • New 238 unit multifamily project under development adjacent to the center
    • 18,100 VPD on US‑76 / Sandifer Blvd. (just west of site)
    • Less than 10 miles from Clemson University
    Updated: May 21, 2024
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    Based on your search, we've compiled 15 Potential Opportunities for your consideration. Besides 2 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 5 Properties for Sales.

    Explore Restaurants for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Downtown Clemson Retail Space Available
    $2,800/Mo

    Downtown Clemson Retail Space Available

    Retail space in downtown Clemson, formerly a coffee shop.

    382 College Avenue, Clemson, SC 29631
    View details
    Adaptable Commercial Space Available
    Contact for pricing

    Adaptable Commercial Space Available

    Versatile commercial space suitable for various business types.

    441 Hwy 183, Piedmont, SC 29673
    View details
    Retail/Restaurant Space Near Clemson University
    Contact for pricing
    3,500 SF

    Retail/Restaurant Space Near Clemson University

    Retail/restaurant space with dedicated parking and lake access.

    894 Tiger Blvd, Clemson, SC
    View details
    Former Fast-Food Building For Rent
    Contact for pricing
    3,450 SF

    Former Fast-Food Building For Rent

    Former fast-food building with drive-thru near I-85.

    2 Kalyns Way, Piedmont, SC 29673
    View details

    Explore Similar Spaces for Sale in Seneca, SC

    Consider Similar Space for Sale. We found 5 Spaces matching your search parameters.

    Commercial Building in Seneca, SC
    $249,900
    0.23 Acres

    Commercial Building in Seneca, SC

    Commercial building with open floor plan suitable for various businesses.

    615 W N 1st Street, Seneca, SC 29678
    View details
    Turn-Key Restaurant Franchise Opportunity
    $1,900,000
    0.78 Acres

    Turn-Key Restaurant Franchise Opportunity

    Turn-key national franchise restaurant with real estate for sale.

    1053 By Pass 123 Bypass, Seneca, SC 29678
    View details
    Prime Commercial Acreage For Sale
    $3,500,000
    4.33 Acres

    Prime Commercial Acreage For Sale

    4.3 acres in Seneca, SC, ideal for retail or hospitality.

    1018 E. North 1st Street, Seneca, SC 29678
    View details
    Automotive Shop Near Lake Keowee
    $900,000

    Automotive Shop Near Lake Keowee

    10-bay automotive shop, redevelopment potential for fast food.

    445 By Pass 123, Seneca, SC 29678
    View details
    Established Hibachi Restaurant for Sale
    $219,000

    Established Hibachi Restaurant for Sale

    Turnkey Hibachi restaurant with existing lease and equipment included.

    1510 Blue Ridge Boulevard, Seneca, SC 29672
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Toccoa Commercial Lease Opportunity
    $1,500/Mo
    306 SF

    Toccoa Commercial Lease Opportunity

    Prime commercial location in Toccoa, GA for lease.

    655 S Pond Street, Toccoa, GA 30577
    View details
    Ellijay, GA Commercial Land
    $7,260/Mo

    Ellijay, GA Commercial Land

    4.74 acres of commercial land for lease in Ellijay.

    4.74AC Eller Road, Ellijay, GA 30540
    View details
    Ellijay, GA Commercial Land
    $17,424/Mo

    Ellijay, GA Commercial Land

    12.86 acres of commercial land for lease in Ellijay.

    12.86AC Highlands Hill Drive, Ellijay, GA 30540
    View details
    Commercial Land on Winfield Dunn
    $8,000/Mo

    Commercial Land on Winfield Dunn

    Prime commercial property with high traffic count available for lease.

    332 Old Douglas Dam Road, Sevierville, TN 37876
    View details

    Seneca, SC Restaurants Leasing Opportunities Market Analysis

    Explore Restaurants leasing options in Seneca, SC with 2 listings featured on our commercial real estate exchange. The current inventory includes 43,000 square feet of properties with an estimated lease value of $21 SF/Yr.

    Estimated lease rates for Restaurants in Seneca, SC begin at $21 SF/Yr, with an average of $21 SF/Yr and extend to $21 SF/Yr.
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