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    Charleston County, SC Commercial Real Estate for Lease

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    Greenville, SC Columbia, SC Charleston, SC
    123 results
    Gregorie Ferry Landing
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    Mount Pleasant Retail Space Available
    $24 SF/Yr
    5,250 SF

    Mount Pleasant Retail Space Available

    543 Long Point Road, Mount Pleasant, SC 29464

    Retail space in prime Mount Pleasant location, available June 1, 2026.

    • Prime location in Mount Pleasant with high visibility and easy access near Long Point Road and Belle Hall Parkway.
    • Spacious 5,250 RSF layout offering flexibility for various business needs; suites can be leased together or separately.
    • Versatile space suitable for retail, office, or service‑oriented businesses.
    • Ample parking for tenants and customers.
    • Modern architecture and well‑maintained exterior with ultra‑high ceilings.
    Updated: Mar 5
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    Professional Office Space For Rent
    $895/Mo

    Professional Office Space For Rent

    845 Lowcountry Blvd, Mount Pleasant, SC 29464

    Prime location office building with walkable access to local favorites.

    • Prime location on Lowcountry Blvd with exceptional visibility and accessibility.
    • Free on‑site parking.
    • Walkable access to local favorites like Second State Coffee and Langdon’s Restaurant & Wine Bar.
    • Convenient access to Hwy 17.
    • Less than 10 minutes from downtown Charleston or the beach.
    Updated: Mar 7
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    Retail Space in Mt. Pleasant
    $28 SF/Yr
    3,689 SF

    Retail Space in Mt. Pleasant

    Retail space for lease in The Shoppes at Brickyard.

    2700 Brickyard Parkway, Mount Pleasant, SC 29466
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    Office Space Near Shopping Center
    $1,300/Mo

    Office Space Near Shopping Center

    Second-floor office space with natural light and free parking.

    1004 Anna Knapp Blvd, Mount Pleasant, SC 29464
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    Industrial Complex with Flexible Units
    $15 SF/Yr
    4,533 SF

    Industrial Complex with Flexible Units

    Multi-building industrial complex with modern construction and efficient layouts.

    4509 Savannah Highway, Ravenel, SC 29470
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    Class A Medical Office Building
    $28 SF/Yr
    14,084 SF

    Class A Medical Office Building

    Renovated medical/office building with ample parking in Mt. Pleasant.

    1200 Innovation Way, Mount Pleasant, SC 29466
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    Functional Space in Sea Island
    $12 SF/Yr
    2,710 SF

    Functional Space in Sea Island

    2,710 SF warehouse and office space for lease.

    3609 River Road, Johns Island, SC 29455
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    Mount Pleasant Office Space Available
    $895/Mo

    Mount Pleasant Office Space Available

    Office space for rent with parking, Wi-Fi, and conference room.

    845 Lowcountry Blvd, Mount Pleasant, SC 29464
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    Class A Office Condo
    $22 SF/Yr
    2,000 SF

    Class A Office Condo

    High-end office condo available for lease in Mt. Pleasant.

    505 Belle Hall Parkway, Mount Pleasant, SC 29464
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    Office Suite in Mt. Pleasant
    $30 SF/Yr
    1,245 SF

    Office Suite in Mt. Pleasant

    Office suite with private offices, reception, and conference room.

    782 Johnnie Dodds Boulevard #E, Mount Pleasant, SC 29464
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    Medical Office in Mt. Pleasant
    $34 SF/Yr
    60,809 SF

    Medical Office in Mt. Pleasant

    Medical office space available for sublease in Mt. Pleasant.

    1300 Hospital Dr, Mount Pleasant, SC 29464
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    Highway 17 North Development Site
    $40 SF/Yr
    8,250 SF

    Highway 17 North Development Site

    Land approved for retail/office development on Highway 17 North.

    3236 North Highway 17, Mount Pleasant, SC 29466
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    Mount Pleasant Office Space Available
    $28 SF/Yr
    352 SF

    Mount Pleasant Office Space Available

    Office space in a well-maintained park with included utilities.

    503 Wando Park Blvd, Mount Pleasant, SC
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    Mount Pleasant Office Space Available
    $26 SF/Yr
    2,227 SF

    Mount Pleasant Office Space Available

    Office space available for lease in Mount Pleasant, SC.

    1671 Belle Isle Avenue, Mount Pleasant, SC 29464
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    Retail Land Lease Opportunity
    $95,000 SF/Yr
    46,114 SF

    Retail Land Lease Opportunity

    Retail land for lease in Mount Pleasant's shopping district.

    1734 N Highway 17, Mount Pleasant, SC 29464
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    Flex Warehouse Space For Lease
    $18 SF/Yr
    19,600 SF

    Flex Warehouse Space For Lease

    Flex warehouse space for lease on Johns Island.

    636 Main Rd, Johns Island, SC 29455
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    Multi-Tenant Office Building
    $26 SF/Yr

    Multi-Tenant Office Building

    Move-in ready office suites with first-floor lobby access, plus a second-floor option, with convenient shared parking onsite.

    1124 Park West Boulevard, Mount Pleasant, SC 29466
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    New Office Building in Mount Pleasant
    $37 SF/Yr
    9,849 SF

    New Office Building in Mount Pleasant

    Newly constructed office building in desirable Mount Pleasant location.

    1681 Belle Isle Ave, Mount Pleasant, SC
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    Renovated Shopping Center on Hwy 17
    $32 SF/Yr
    103,036 SF

    Renovated Shopping Center on Hwy 17

    Highly visible, renovated shopping center with frontage on Hwy 17.

    627 Johnnie Dodds Blvd, Mount Pleasant, SC 29464
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    Single-Story Office in Wando Commons
    $24 SF/Yr
    2,263 SF

    Single-Story Office in Wando Commons

    Single-story office space with convenient access to major routes.

    498 Wando Park Blvd, Mount Pleasant, SC
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    Retail Space Near Ravenel Bridge
    Contact for pricing
    863 SF

    Retail Space Near Ravenel Bridge

    Retail space in Whole Foods anchored shopping center available for lease.

    855 Houston Northcutt Blvd, Mount Pleasant, SC 29464
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    Mount Pleasant Office Park Space
    Contact for pricing
    1,245 SF

    Mount Pleasant Office Park Space

    Office park with visibility, access, and nearby amenities for rent.

    782 Johnnie Dodds Boulevard, Mount Pleasant, SC 29464
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    Retail Space in Johns Island
    $15 SF/Yr
    1,200 SF

    Retail Space in Johns Island

    Retail space for lease in a bustling commercial district.

    3874 Savannah Hwy, Johns Island, SC
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    Charleston County, SC Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Charleston County, SC with 123 listings featured on our commercial real estate exchange. The current inventory includes 696,531 square feet of properties with an estimated lease value of $257,764.

    Estimated lease rates for Commercial real estate in Charleston County, SC begin at $1.00 SF/Yr, with an average of $4,157 /Mo and extend to $125,000.
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