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    De Soto, MO Retail Properties & Spaces for Sale

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    Saint Louis, MO Kansas City, MO Louis, MO
    De Soto Retail Business Opportunity
    $850,000
    15,500 SF

    De Soto Retail Business Opportunity

    400 S Main Street, De Soto, MO 63020

    Own a business and a piece of history!

    • Established, family‑owned business with included inventory and seller assistance during transition.
    • Dual storefronts offer the opportunity to operate a business while renting out the other side for additional income.
    • Large main office, great prep space, and an open upper level with unique features like a glass floor and lift elevator.
    • Recent maintenance includes roof work, updated electric, and HVAC improvements.
    • Historic brick building built in 1870.
    Updated: Dec 17, 2025
    View details
    De Soto Commercial Property
    $115,000

    De Soto Commercial Property

    112 W Kelley Street, De Soto, MO 63020

    Commercial property for sale in De Soto, Missouri.

    • Located in De Soto, MO
    • GPS Address provided: 423 S 2nd St. De Soto, MO. 63020
    • Heating: Electric, Forced Air
    • Cooling: Electric, Window Unit(s)
    • Year Built: 1920
    Updated: Aug 19, 2025
    View details
    Based on your search, we've compiled 146 Potential Opportunities for your consideration. Besides 2 Active listings in De Soto, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 136 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Hillsboro Retail with Highway Frontage
    $299,000
    0.27 Acres

    Hillsboro Retail with Highway Frontage

    Retail property in Hillsboro with highway frontage and recent updates.

    10550 Business 21, Hillsboro, MO 63050
    View details
    Auto Mechanic Shop For Sale
    $145,000
    1,800 SF

    Auto Mechanic Shop For Sale

    Auto mechanic building and shop with three drive-in bay doors.

    10045 Silver Springs Rd, Bonne Terre, MO
    View details
    Bonne Terre Retail Opportunity
    $550,000
    8,200 SF

    Bonne Terre Retail Opportunity

    8,200 SF retail space for sale or lease.

    7 Northwood Dr, Bonne Terre, MO
    View details
    Commercial Property Near City Hall
    $426,900
    2,772 SF

    Commercial Property Near City Hall

    Updated commercial property with large lot near government buildings.

    114 Main St, Hillsboro, MO 63050
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land on Corner Lot
    $350,000
    0.98 Acres

    Commercial Land on Corner Lot

    Corner lot with high visibility near highways in Hillsboro, MO.

    10865 Business 21, Hillsboro, MO 63050
    View details
    Hillsboro Land Near City Hall
    $426,900
    2,772 SF

    Hillsboro Land Near City Hall

    Versatile half-acre lot in prime Hillsboro location.

    114 Main Street, Hillsboro, MO 63050
    View details
    Commercial Land on Truman Boulevard
    $250,000

    Commercial Land on Truman Boulevard

    0.32 acre commercial land with high visibility.

    520 S Truman Boulevard, Festus, MO 63028
    View details
    Commercial Lot on Highway 30
    $84,900
    1.56 Acres

    Commercial Lot on Highway 30

    1.54 acre commercial lot with highway visibility.

    7095 Old Hwy 30, Cedar Hill, MO 63016
    View details

    Explore Off-Market Properties in De Soto, MO

    Consider similar Off-Market properties in De Soto, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    12999 State Rte 21

    12999 State Rte 21

    AUTO REPAIR, GARAGE • 3,200 SF
    Value Estimation by Request
    12999 State Rte 21, De Soto, MO 63020-1000
    View details
    12760 State Rte 21

    12760 State Rte 21

    AUTO REPAIR, GARAGE • 3,600 SF
    Value Estimation by Request
    12760 State Rte 21, De Soto, MO 63020-3313
    View details
    122 Main St

    122 Main St

    RETAIL STORES (PERSONAL SERVICES) • 4,263 SF
    Value Estimation by Request
    122 Main St, De Soto, MO 63020-1709
    View details
    13659 Klondike Rd

    13659 Klondike Rd

    AUTO REPAIR, GARAGE • 14.83 Acres
    Value Estimation by Request
    13659 Klondike Rd, De Soto, MO 63020-3668
    View details
    13220 Timberwood Ln

    13220 Timberwood Ln

    RETAIL STORES (PERSONAL SERVICES) • 1,300 SF
    Value Estimation by Request
    13220 Timberwood Ln, De Soto, MO 63020-6701
    View details
    3771 Flucom Rd

    3771 Flucom Rd

    AUTO REPAIR, GARAGE • 2,400 SF
    Value Estimation by Request
    3771 Flucom Rd, De Soto, MO 63020-3512
    View details
    1 Jefferson Sq

    1 Jefferson Sq

    RESTAURANT • 0.30 Acres
    Value Estimation by Request
    1 Jefferson Sq, De Soto, MO 63020-1031
    View details
    1801 Rock Rd

    1801 Rock Rd

    AUTO REPAIR, GARAGE • 2,880 SF
    Value Estimation by Request
    1801 Rock Rd, De Soto, MO 63020-1047
    View details
    5215 Us Hwy 67

    5215 Us Hwy 67

    AUTO REPAIR, GARAGE • 1.05 Acres
    Value Estimation by Request
    5215 Us Hwy 67, De Soto, MO 63020-4921
    View details
    13000 State Rte 21

    13000 State Rte 21

    AUTO REPAIR, GARAGE • 1.02 Acres
    Value Estimation by Request
    13000 State Rte 21, De Soto, MO 63020-1088
    View details
    600 Main St

    600 Main St

    RETAIL STORES (PERSONAL SERVICES) • 0.07 Acres
    Value Estimation by Request
    600 Main St, De Soto, MO 63020-2206
    View details
    106 Main St

    106 Main St

    RESTAURANT • 3,165 SF
    Value Estimation by Request
    106 Main St, De Soto, MO 63020-2104
    View details
    610 Main St

    610 Main St

    RETAIL STORES (PERSONAL SERVICES) • 4,888 SF
    Value Estimation by Request
    610 Main St, De Soto, MO 63020-2206
    View details
    304 Main St

    304 Main St

    RETAIL STORES (PERSONAL SERVICES) • 0.07 Acres
    Value Estimation by Request
    304 Main St, De Soto, MO 63020-2106
    View details
    118 Main St

    118 Main St

    RETAIL STORES (PERSONAL SERVICES) • 12,950 SF
    Value Estimation by Request
    118 Main St, De Soto, MO 63020-2104
    View details
    2186 Hillview Dr

    2186 Hillview Dr

    AUTO REPAIR, GARAGE • 1,576 SF
    Value Estimation by Request
    2186 Hillview Dr, De Soto, MO 63020-3707
    View details
    500 Main St

    500 Main St

    RETAIL STORES (PERSONAL SERVICES) • 6,364 SF
    Value Estimation by Request
    500 Main St, De Soto, MO 63020-2204
    View details
    530 2nd St

    530 2nd St

    RESTAURANT • 4,500 SF
    Value Estimation by Request
    530 2nd St, De Soto, MO 63020-1503
    View details
    13201 State Rd Jj

    13201 State Rd Jj

    AUTO REPAIR, GARAGE • 3,080 SF
    Value Estimation by Request
    13201 State Rd Jj, De Soto, MO 63020-4948
    View details
    13000 Fox Farm Rd

    13000 Fox Farm Rd

    AUTO REPAIR, GARAGE • 784 SF
    Value Estimation by Request
    13000 Fox Farm Rd, De Soto, MO 63020-4422
    View details
    308 Main St

    308 Main St

    RETAIL STORES (PERSONAL SERVICES) • 0.10 Acres
    Value Estimation by Request
    308 Main St, De Soto, MO 63020-2106
    View details
    12949 State Rte 21

    12949 State Rte 21

    RETAIL STORES (PERSONAL SERVICES) • 1.30 Acres
    Value Estimation by Request
    12949 State Rte 21, De Soto, MO 63020-1078
    View details

    De Soto, MO Retail Properties & Spaces Investment Opportunities Market Analysis

    Explore 138 retail properties & spaces for sale in De Soto, MO on our real estate platform. These investment opportunities span a total of 15,500 square feet of properties for sale, with an estimated market value of $850,000.

    Sale prices for stores in De Soto, MO start at $850,000, averaging $850,000, and reaching up to $850,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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