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    De Soto, MO
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    De Soto, MO Storefront Properties for Sale

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    Bonne Terre, MO French Village, MO Cadet, MO
    De Soto Retail Business Opportunity
    $850,000
    15,500 SF
    De Soto Retail Business Opportunity

    400 S Main Street, De Soto, MO 63020

    Own a business and a piece of history!
    • Established, family‑owned business with included inventory and seller assistance during transition.
    • Dual storefronts offer the opportunity to operate a business while renting out the other side for additional income.
    • Large main office, great prep space, and an open upper level with unique features like a glass floor and lift elevator.
    • Recent maintenance includes roof work, updated electric, and HVAC improvements.
    • Historic brick building built in 1870.
    Updated: Dec 17, 2025
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    De Soto Mixed-Use Opportunity
    $420,000
    5,000 SF
    De Soto Mixed-Use Opportunity

    120 N Main Street, De Soto, MO 63020

    Mixed-use property on Main Street with retail and residential potential.
    • Over 5,000 sq ft of mixed‑use commercial and apartment space on Main Street.
    • Flexible main level space adaptable for office, retail, or additional apartment.
    • Apartment upstairs offers potential rental income.
    • Garage/storage area in the rear adds functionality.
    • Strong Main Street presence and excellent visibility.
    Updated: May 25
    View details
    Based on your search, we've compiled 10 Potential Opportunities for your consideration. Besides 2 Active listings in De Soto, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Commercial Building in Potosi, MO
    $569,900
    5,408 SF
    Commercial Building in Potosi, MO

    Commercial building with three units, leased for immediate income.

    326 E High Street, Potosi, MO 63664

    View details
    Retail Building in Historic Kimmswick
    $299,999
    1,444 SF
    Retail Building in Historic Kimmswick

    Commercial opportunity in the heart of historic Kimmswick, Missouri.

    101 Mill Street, Kimmswick, MO 63053

    View details
    Historic Victorian Retail/Trade Building
    $450,000
    0.19 Acres
    Historic Victorian Retail/Trade Building

    Victorian storefront with soaring ceilings, remodeled kitchen, and flexible layout for retail, hospitality, or live-work use.

    6025 Third Street, Kimmswick, MO 63052

    View details
    Retail Storefront with Parking
    $459,000
    2,181 SF
    Retail Storefront with Parking

    Retail building on a 2.01-acre lot with 25 parking spaces and equipment included, built in 2005.

    10022 Franklin Rd, Potosi, MO 63664

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Hillsboro Land Near City Hall
    $426,900
    2,772 SF
    Hillsboro Land Near City Hall

    Versatile half-acre lot in prime Hillsboro location.

    114 Main Street, Hillsboro, MO 63050

    View details
    Highway Frontage Commercial Land
    $84,900
    0.88 Acres
    Highway Frontage Commercial Land

    Prime commercial land with high visibility and easy access.

    4591 Highway W, House Springs, MO 63051

    View details
    Waterloo, IL Commercial Lots
    $250,000
    1.67 Acres
    Waterloo, IL Commercial Lots

    12 commercial lots available in Waterloo, Illinois, B-3 Central Business.

    0 Station Crossing Lot 6, Waterloo, IL 62298

    View details
    Waterloo Commercial Lots on Route 3
    $325,000
    2.00 Acres
    Waterloo Commercial Lots on Route 3

    Commercial lots available along IL Route 3 in Waterloo, IL.

    0 Station Crossing Lot 7, Waterloo, IL 62298

    View details

    De Soto, MO Storefront Properties Market Trends and Statistics

    Explore 2 storefront properties for sale in De Soto, MO on our real estate platform. These investment opportunities span a total of 20,500 square feet of properties for sale, with an estimated market value of $1,270,000.

    Sale prices for retail units in De Soto, MO start at $420,000, averaging $635,000, and reaching up to $850,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Storefront properties 2
    Auto shops 1
    Automotive properties 1

    Demographics Overview

    Population 20K
    Population Growth (5Y) +1.8%
    Median Household Income $65,908
    College Educated 18.9%

    High-Yield Neighborhoods for Investment

    Identify De Soto submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63020 $635K

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Total CRE Inventory on Market (SF)

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