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    De Soto, MO Commercial Real Estate for Sale

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    Saint Louis, MO Kansas City, MO Louis, MO
    Historic Mixed-Use Commercial Property
    $219,000
    4,095 SF

    Historic Mixed-Use Commercial Property

    400 N 3rd Street, De Soto, MO 63020

    Unique 4,095 SF commercial property in downtown De Soto.

    • Unique 4,095 sq ft commercial property in the heart of downtown De Soto.
    • Historic 1866 schoolhouse/church with restored original sanctuary lighting and significant overall restoration.
    • Versatile layout with large fellowship hall, kitchen, and two additional rooms in the 1964 annex.
    • Two basements with egress access, providing ample storage space.
    • Corner lot location with adjacent vacant lot foundation for potential future use.
    Updated: Apr 14
    View details
    De Soto Retail Business Opportunity
    $850,000
    15,500 SF

    De Soto Retail Business Opportunity

    400 S Main Street, De Soto, MO 63020

    Own a business and a piece of history!

    • Established, family‑owned business with included inventory and seller assistance during transition.
    • Dual storefronts offer the opportunity to operate a business while renting out the other side for additional income.
    • Large main office, great prep space, and an open upper level with unique features like a glass floor and lift elevator.
    • Recent maintenance includes roof work, updated electric, and HVAC improvements.
    • Historic brick building built in 1870.
    Updated: Dec 17, 2025
    View details
    Farm with Modern Custom Home
    $899,000
    2,698 SF

    Farm with Modern Custom Home

    33-acre farm featuring a modern, custom-built home and barn.

    3700 State Road V, De Soto, MO 63020
    View details
    De Soto Commercial Property
    $115,000

    De Soto Commercial Property

    Commercial property for sale in De Soto, Missouri.

    112 W Kelley Street, De Soto, MO 63020
    View details
    Based on your search, we've compiled 365 Potential Opportunities for your consideration. Besides 4 Active listings in De Soto, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 357 Off-Market properties to explore as potential leads

    Explore Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Hillsboro Church with Conversion Potential
    $1,750,000
    5.00 Acres

    Hillsboro Church with Conversion Potential

    Church building on 5 acres, suitable for office conversion.

    4770 State Road B, Hillsboro, MO 63050
    View details
    Commercial Land on Corner Lot
    $350,000
    0.98 Acres

    Commercial Land on Corner Lot

    Corner lot with high visibility near highways in Hillsboro, MO.

    10865 Business 21, Hillsboro, MO 63050
    View details
    Auto Mechanic Shop For Sale
    $145,000
    1,800 SF

    Auto Mechanic Shop For Sale

    Auto mechanic building and shop with three drive-in bay doors.

    10045 Silver Springs Rd, Bonne Terre, MO
    View details
    Bonne Terre Retail Opportunity
    $550,000
    8,200 SF

    Bonne Terre Retail Opportunity

    8,200 SF retail space for sale or lease.

    7 Northwood Dr, Bonne Terre, MO
    View details

    Explore Off-Market Properties in De Soto, MO

    Consider similar Off-Market properties in De Soto, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    501 5th St

    501 5th St

    GARDEN APT, COURT APT (5+ UNITS) • 0.46 Acres
    Value Estimation by Request
    501 5th St, De Soto, MO 63020-1516
    View details
    3305 Lemehl Rd

    3305 Lemehl Rd

    MOBILE HOME PARK, TRAILER PARK • 15.00 Acres
    Value Estimation by Request
    3305 Lemehl Rd, De Soto, MO 63020-4539
    View details
    300 Main St

    300 Main St

    DISTRIBUTION WAREHOUSE • 0.21 Acres
    Value Estimation by Request
    300 Main St, De Soto, MO 63020
    View details
    De Soto, MO 63020

    De Soto, MO 63020

    DISTRIBUTION WAREHOUSE • 4,200 SF
    Value Estimation by Request
    De Soto, MO 63020
    View details
    1703 Rock Rd

    1703 Rock Rd

    MINI-WAREHOUSE, STORAGE • 1,540 SF
    Value Estimation by Request
    1703 Rock Rd, De Soto, MO 63020-1045
    View details
    De Soto, MO 63020

    De Soto, MO 63020

    VACANT COMMERCIAL LAND • 0.22 Acres
    Value Estimation by Request
    De Soto, MO 63020
    View details
    113 Easton St

    113 Easton St

    DISTRIBUTION WAREHOUSE • 6,400 SF
    Value Estimation by Request
    113 Easton St, De Soto, MO 63020
    View details
    15737 State Rd T T

    15737 State Rd T T

    OFFICE/RESIDENTIAL (MIXED USE) • 2,224 SF
    Value Estimation by Request
    15737 State Rd T T, De Soto, MO 63020-5228
    View details
    De Soto, MO 63020

    De Soto, MO 63020

    MANUFACTURING (LIGHT) • 0.04 Acres
    Value Estimation by Request
    De Soto, MO 63020
    View details
    12548 Ware Rd

    12548 Ware Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 2,528 SF
    Value Estimation by Request
    12548 Ware Rd, De Soto, MO 63020-5748
    View details
    12999 State Rte 21

    12999 State Rte 21

    AUTO REPAIR, GARAGE • 3,200 SF
    Value Estimation by Request
    12999 State Rte 21, De Soto, MO 63020-1000
    View details
    De Soto, MO 63020

    De Soto, MO 63020

    COMMERCIAL (GENERAL) • 0.37 Acres
    Value Estimation by Request
    De Soto, MO 63020
    View details
    124 Main St

    124 Main St

    COMMERCIAL (GENERAL) • 258 SF
    Value Estimation by Request
    124 Main St, De Soto, MO 63020-1709
    View details
    124 Main St

    124 Main St

    VACANT COMMERCIAL LAND • 0.01 Acres
    Value Estimation by Request
    124 Main St, De Soto, MO 63020-1709
    View details
    515 Amvets Dr

    515 Amvets Dr

    GARDEN APT, COURT APT (5+ UNITS) • 0.52 Acres
    Value Estimation by Request
    515 Amvets Dr, De Soto, MO 63020-2342
    View details
    12760 State Rte 21

    12760 State Rte 21

    AUTO REPAIR, GARAGE • 3,600 SF
    Value Estimation by Request
    12760 State Rte 21, De Soto, MO 63020-3313
    View details
    12521 State Rte 21

    12521 State Rte 21

    MINI-WAREHOUSE, STORAGE • 832 SF
    Value Estimation by Request
    12521 State Rte 21, De Soto, MO 63020-3316
    View details
    122 Main St

    122 Main St

    RETAIL STORES (PERSONAL SERVICES) • 4,263 SF
    Value Estimation by Request
    122 Main St, De Soto, MO 63020-1709
    View details
    13659 Klondike Rd

    13659 Klondike Rd

    AUTO REPAIR, GARAGE • 14.83 Acres
    Value Estimation by Request
    13659 Klondike Rd, De Soto, MO 63020-3668
    View details
    De Soto, MO 63020

    De Soto, MO 63020

    MOBILE HOME PARK, TRAILER PARK • 6.70 Acres
    Value Estimation by Request
    De Soto, MO 63020
    View details

    De Soto, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 361 commercial real estate for sale in De Soto, MO, showcased through 4 active listings on our real estate platform. These investment opportunities span a total of 1,501,404 square feet of properties for sale, with an estimated market value of $1,968,000.

    Sale prices for business properties in De Soto, MO start at $219,000, averaging $656,000, and reaching up to $899,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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