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De Soto, MO

De Soto, MO Commercial Real Estate for Sale

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Bonne Terre, MO Blackwell, MO French Village, MO Cadet, MO Desloge, MO Fredericktown, MO Festus, MO Leadwood, MO

Mixed-Use Retail and Office Building

Updated: Dec 17, 2025

Mixed-Use Retail and Office Building

400 S Main Street, De Soto, MO 63020

$850,000

0.14 AC lot

Brick building built in 1870 with public water service and electric heating and cooling
Roof maintenance completed, with updated electrical, HVAC, and general maintenance noted
Existing florist/gift shop/retail operations include branded item sales (family‑owned)
Use one side of the building while renting the other side out; both areas have store‑front entrance access
Inventory included with the purchase; seller will review the full building with the new buyer

As-Is Corner Lot Development Site

Updated: Mar 6

As-Is Corner Lot Development Site

3055 Thompson Road, De Soto, MO 63020

Contact for pricing

223,462 sqft

As‑is 2‑story property with CMU foundation and walls
3‑car attached garage; no fire damage reported in the garage area
2000‑gallon septic system with clean inspection as of October 2025
Well on site
Inground saltwater pool with concrete decking, pool cover, and pool thermal cover (pool and systems have no fire damage)

Retail Building

Retail Building

12939 State Highway 21, De Soto, MO 63020

Contact for pricing

60,000 sqft

Retail property offered for sale totaling 60,000 SF.

Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center

Retail Space on Main Street

Retail Space on Main Street

400 - 420 North Main Street, De Soto, MO 63020

Contact for pricing

Retail space available for lease on North Main Street.

Retail and Office Space Available

Retail and Office Space Available

2100 - 2128 Rock Road, De Soto, MO 63020

Contact for pricing

Retail and office spaces for rent in De Soto.

Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 5 Active listings in De Soto, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 67 Off-Market properties to explore as potential leads

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Corner Commercial Development Lot

Corner Commercial Development Lot

10865 Business 21, Hillsboro, MO 63050

$350,000

0.98 AC lot

Nearly one-acre corner site on a busy intersection, offering strong visibility for a future commercial use.

Corner Commercial Development Land

Corner Commercial Development Land

905 Peach Tree Plaza Dr, Hillsboro, MO 63050

Contact for pricing

0.79 AC lot

Multi-lot C2 land at a high-traffic corner with all utilities available to support retail and service uses.

Commercial Land with Highway Frontage

Commercial Land with Highway Frontage

11730 Cloverleaf Dr, Festus, MO 63028

Contact for pricing

6.80 AC lot

6.8± acres in the city limits with substantial outer-road frontage and prominent Highway 67 visibility.

53 Acres Near Festus

53 Acres Near Festus

2351 Buck Creek Road, Festus, MO 63028

$2,000,000

53.80 AC lot

53 acres of land with frontage on Hwy A.

Off-Market Properties in De Soto, MO

Consider similar Off-Market properties in De Soto, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

GARDEN APT, COURT APT (5+ UNITS)

501 5th St, De Soto, MO 63020-1516

Value Estimation by Request

0.46 AC lot

MOBILE HOME PARK, TRAILER PARK

3305 Lemehl Rd, De Soto, MO 63020-4539

Value Estimation by Request

15.00 AC lot

DISTRIBUTION WAREHOUSE

300 Main St, De Soto, MO 63020

Value Estimation by Request

0.21 AC lot

De Soto, MO 63020

DISTRIBUTION WAREHOUSE

De Soto, MO 63020

Value Estimation by Request

4,200 sqft 8.33 AC lot

MINI-WAREHOUSE, STORAGE

1703 Rock Rd, De Soto, MO 63020-1045

Value Estimation by Request

1,540 sqft 0.50 AC lot

De Soto, MO 63020

VACANT COMMERCIAL LAND

De Soto, MO 63020

Value Estimation by Request

0.22 AC lot

DISTRIBUTION WAREHOUSE

113 Easton St, De Soto, MO 63020

Value Estimation by Request

6,400 sqft 0.14 AC lot

15737 State Rd T T

OFFICE/RESIDENTIAL (MIXED USE)

15737 State Rd T T, De Soto, MO 63020-5228

Value Estimation by Request

2,224 sqft 15.47 AC lot

De Soto, MO 63020

MANUFACTURING (LIGHT)

De Soto, MO 63020

Value Estimation by Request

0.04 AC lot

OFFICE/RESIDENTIAL (MIXED USE)

12548 Ware Rd, De Soto, MO 63020-5748

Value Estimation by Request

2,528 sqft 6.68 AC lot

12999 State Rte 21

AUTO REPAIR, GARAGE

12999 State Rte 21, De Soto, MO 63020-1000

Value Estimation by Request

3,200 sqft 0.19 AC lot

De Soto, MO 63020

COMMERCIAL (GENERAL)

De Soto, MO 63020

Value Estimation by Request

0.37 AC lot

COMMERCIAL (GENERAL)

124 Main St, De Soto, MO 63020-1709

Value Estimation by Request

258 sqft 0.01 AC lot

VACANT COMMERCIAL LAND

124 Main St, De Soto, MO 63020-1709

Value Estimation by Request

0.01 AC lot

GARDEN APT, COURT APT (5+ UNITS)

515 Amvets Dr, De Soto, MO 63020-2342

Value Estimation by Request

0.52 AC lot

12760 State Rte 21

AUTO REPAIR, GARAGE

12760 State Rte 21, De Soto, MO 63020-3313

Value Estimation by Request

3,600 sqft 1.00 AC lot

12521 State Rte 21

MINI-WAREHOUSE, STORAGE

12521 State Rte 21, De Soto, MO 63020-3316

Value Estimation by Request

832 sqft 10.40 AC lot

RETAIL STORES (PERSONAL SERVICES)

122 Main St, De Soto, MO 63020-1709

Value Estimation by Request

4,263 sqft 0.06 AC lot

13659 Klondike Rd

AUTO REPAIR, GARAGE

13659 Klondike Rd, De Soto, MO 63020-3668

Value Estimation by Request

14.83 AC lot

De Soto, MO Commercial Real Estate Market Trends and Statistics

Explore 72 commercial real estate for sale in De Soto, MO, showcased through 5 active listings on our real estate platform. These investment opportunities span a total of 283,462 square feet of properties for sale, with an estimated market value of $850,000.

Sale prices for business properties in De Soto, MO start at $0.00, averaging $170,000, and reaching up to $850,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Demographics Overview

Population 20K

Population Growth (5Y) +1.8%

Median Household Income $65,908

College Educated 18.9%

High-Yield Neighborhoods for Investment

Identify De Soto submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
63020	$654.2K

Taxes & Financing

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in St. Francois County

New Delisted

Total CRE Inventory on Market (SF)

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