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Location, type, price

De Soto, MO Commercial Real Estate for Sale

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Bonne Terre, MO French Village, MO Blackwell, MO Festus, MO Cadet, MO Desloge, MO Park Hills, MO Leadwood, MO

13 properties

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Mixed-Use Building with Apartment

Updated: Oct 21

Mixed-Use Building with Apartment

200 S Main Street, De Soto, MO 63020

$394,900

0.14 AC lot

Renovated upper‑level apartment leased through December 31, 2026
Separate rear area offers an additional space within the building
0.14‑acre lot on South Main Street in De Soto
Brick construction; built in 1910
Central air conditioning and forced‑air, natural gas heat

Historic Brick Storefront Building

Updated: Jun 29

Historic Brick Storefront Building

400 S Main Street, De Soto, MO 63020

$850,000

0.14 AC lot

1870‑built brick storefront building
Existing florist, gift shop, retail store, and branded‑item business
Inventory included with the purchase
Separate storefront entrances allow distinct use of each side
Open upper level with glass flooring section and lift elevator

Medical Office Building

Medical Office Building

126 S Main St, De Soto, MO 63020

$325,000

0.14 AC lot

The interior combines private work areas with a large open room, lab space, and two commercial restrooms.

Realmo Analytics Monitor Off-market properties and contact owners who are ready to sell. Many signals applied to make quality leads for you. Get Leads

Freestanding Church Building

Freestanding Church Building

13300 State Road Cc, De Soto, MO 63020

$349,900

2,400 sqft 0.91 AC lot

Open sanctuary layout includes a kitchen, nursery, bathrooms, and paved and gravel parking.

Historic Church Facility

Historic Church Facility

400 N 3rd Street, De Soto, MO 63020

$198,000

0.50 AC lot

Restored sanctuary space includes an annex, fellowship hall, kitchen, and additional rooms.

Wooded Hunting Land With Electric

Wooded Hunting Land With Electric

Hill Side Dr, De Soto, MO 63020

$314,900

69.24 AC lot

Agriculturally zoned acreage with mature hardwood forest and a cleared area suited to camping or other outdoor use.

Resort Property With Villa Accommodations

Resort Property With Villa Accommodations

De Soto, MO 63020

$750,000

92,779 sqft 327.23 AC lot

Vacant resort campus combines lodging, recreation, dining, fitness, and event-oriented amenities in a residential-style setting.

Farm Property with Barn and Pasture

Farm Property with Barn and Pasture

14098 Charter Church Rd, De Soto, MO 63020

$494,000

1,400 sqft

Pasture, wooded areas, and multiple supporting structures accompany the on-site house.

Pasture Farm With Natural Spring

Pasture Farm With Natural Spring

13336 Mount Olive Rd, De Soto, MO 63020

$611,090

Fenced agricultural property with established utilities, water systems, storage, and open grazing areas.

Farm

Farm

5295 State Road H, De Soto, MO 63020

$299,900

Agricultural land / Farmland

Retail Space on Main Street

Retail Space on Main Street

400 - 420 North Main Street, De Soto, MO 63020

Contact for pricing

Retail space available for lease on North Main Street.

Retail and Office Space Available

Retail and Office Space Available

2100 - 2128 Rock Road, De Soto, MO 63020

Contact for pricing

Retail and office spaces for rent in De Soto.

Land

Land

13942 Springdale Rd, De Soto, MO 63020

$300,000

Residential land & home lots

Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 13 Active listings in De Soto, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 59 Off-Market properties to explore as potential leads

Opportunities in Nearby Cities

Here are 4 Similar properties we found in Nearby Locations for your consideration.

Highway-Frontage Commercial Land

Highway-Frontage Commercial Land

2533 Highway 67, Festus, MO 63028

$345,000

137,214 sqft

Level commercial site near a signalized intersection with highway access and prominent roadside exposure.

Agricultural Land with Mature Timber

Agricultural Land with Mature Timber

3225 Carron Road, Festus, MO 63028

$520,000

40.12 AC lot

Agricultural acreage with public water and two access points to paved Carron Road.

Commercial Corner Development Site

Commercial Corner Development Site

902 Peach Tree Plaza Dr, Hillsboro, MO 63050

Contact for pricing

1 sqft

C2-zoned development land at Peach Tree Plaza with all utilities to the site and 11,618 combined vehicles daily.

Corner Commercial Land

Corner Commercial Land

10865 Business 21, Hillsboro, MO 63050

$350,000

0.98 AC lot

Commercial-zoned corner parcel near highways and a busy intersection.

Off-Market Properties in De Soto, MO

Consider similar Off-Market properties in De Soto, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

501 5th St

GARDEN APT, COURT APT (5+ UNITS)

501 5th St, De Soto, MO 63020-1516

Estimated value:

$270,000

0.46 AC lot

3305 Lemehl Rd

MOBILE HOME PARK, TRAILER PARK

3305 Lemehl Rd, De Soto, MO 63020-4539

Estimated value:

$70,000

15.00 AC lot

300 Main St

DISTRIBUTION WAREHOUSE

300 Main St, De Soto, MO 63020

Estimated value:

$265,000

0.21 AC lot

De Soto, MO 63020

DISTRIBUTION WAREHOUSE

De Soto, MO 63020

Estimated value:

$250,000

4,200 sqft 8.33 AC lot

1703 Rock Rd

MINI-WAREHOUSE, STORAGE

1703 Rock Rd, De Soto, MO 63020-1045

Estimated value:

$260,000

1,540 sqft 0.50 AC lot

De Soto, MO 63020

VACANT COMMERCIAL LAND

De Soto, MO 63020

Estimated value:

$270,000

0.22 AC lot

113 Easton St

DISTRIBUTION WAREHOUSE

113 Easton St, De Soto, MO 63020

Estimated value:

$245,000

6,400 sqft 0.14 AC lot

15737 State Rd T T

OFFICE/RESIDENTIAL (MIXED USE)

15737 State Rd T T, De Soto, MO 63020-5228

Estimated value:

$265,000

2,224 sqft 15.47 AC lot

De Soto, MO 63020

MANUFACTURING (LIGHT)

De Soto, MO 63020

Estimated value:

$300,000

0.04 AC lot

12548 Ware Rd

OFFICE/RESIDENTIAL (MIXED USE)

12548 Ware Rd, De Soto, MO 63020-5748

Estimated value:

$255,000

2,528 sqft 6.68 AC lot

12999 State Rte 21

AUTO REPAIR, GARAGE

12999 State Rte 21, De Soto, MO 63020-1000

Estimated value:

$290,000

3,200 sqft 0.19 AC lot

De Soto, MO Commercial Real Estate Market Trends and Statistics

Explore 72 commercial real estate for sale in De Soto, MO, showcased through 13 active listings on our real estate platform. These investment opportunities span a total of 96,579 square feet of properties for sale, with an estimated market value of $4,887,690.

Sale prices for business properties in De Soto, MO start at $198,000, averaging $444,335, and reaching up to $850,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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Demographics Overview

Population 20K

Population Growth (5Y) +1.8%

Median Household Income $65,908

College Educated 18.9%

High-Yield Neighborhoods for Investment

Identify De Soto submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

Neighborhood	Average Price
63020	$387.5K

Taxes & Financing

Average Loan-to-Value 65.0%

Listings Trend

New vs delisted commercial listings in St. Francois County

New Delisted

Total CRE Inventory on Market (SF)

How Realmo verifies these figures

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