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    De Soto, MO
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    De Soto, MO Commercial Real Estate for Sale

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    Bonne Terre, MO French Village, MO Cadet, MO
    7 results
    Historic Mixed-Use Commercial Property
    $219,000
    4,095 SF
    Historic Mixed-Use Commercial Property

    400 N 3rd Street, De Soto, MO 63020

    Unique 4,095 SF commercial property in downtown De Soto.
    • Unique 4,095 sq ft commercial property in the heart of downtown De Soto.
    • Historic 1866 schoolhouse/church with restored original sanctuary lighting and significant overall restoration.
    • Versatile layout with large fellowship hall, kitchen, and two additional rooms in the 1964 annex.
    • Two basements with egress access, providing ample storage space.
    • Corner lot location with adjacent vacant lot foundation for potential future use.
    Updated: Apr 14
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    De Soto Ranch with Acreage
    $850,000
    2,698 SF
    De Soto Ranch with Acreage

    3700 State Road V, De Soto, MO 63020

    34-acre ranch featuring a custom-built home and equestrian facilities.
    • 34+/- acres of usable land, fenced and cross‑fenced, suitable for horses or livestock with potential for division and future development.
    • 2,700 sq ft, 4‑bedroom, 3‑bath custom home built in 2021, featuring an open floor plan, vaulted ceilings, and fresh interior paint.
    • 40x60 barn with three stalls and additional space for equipment and tack.
    • Mudroom and laundry area with two washer/dryer hookups.
    • Year‑round creek and established trails for riding, hiking, or UTV use.
    Updated: May 24
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    De Soto Retail Business Opportunity
    $850,000
    15,500 SF
    De Soto Retail Business Opportunity

    Own a business and a piece of history!

    400 S Main Street, De Soto, MO 63020

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    De Soto Mixed-Use Opportunity
    $420,000
    5,000 SF
    De Soto Mixed-Use Opportunity

    Mixed-use property on Main Street with retail and residential potential.

    120 N Main Street, De Soto, MO 63020

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    68 Acres Near Highway Frontage
    $646,000
    67.94 Acres
    68 Acres Near Highway Frontage

    68 acres near school, shopping, and highway frontage.

    0 State Route 21, De Soto, MO 63020

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    Jefferson County Land with Lake
    $997,500
    2,000 SF
    Jefferson County Land with Lake

    100+ acre property with lake, timber, and home.

    2551 Yellow Rock W, De Soto, MO 63020

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    De Soto Commercial Property
    $115,000
    De Soto Commercial Property

    Commercial property for sale in De Soto, Missouri.

    112 W Kelley Street, De Soto, MO 63020

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    Based on your search, we've compiled 76 Potential Opportunities for your consideration. Besides 7 Active listings in De Soto, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 65 Off-Market properties to explore as potential leads

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Hillsboro Church with Conversion Potential
    $1,750,000
    5.00 Acres
    Hillsboro Church with Conversion Potential

    Church building on 5 acres, suitable for office conversion.

    4770 State Road B, Hillsboro, MO 63050

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    Commercial Land on Corner Lot
    $350,000
    0.98 Acres
    Commercial Land on Corner Lot

    Corner lot with high visibility near highways in Hillsboro, MO.

    10865 Business 21, Hillsboro, MO 63050

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    Auto Mechanic Shop For Sale
    $145,000
    1,800 SF
    Auto Mechanic Shop For Sale

    Auto mechanic building and shop with three drive-in bay doors.

    10045 Silver Springs Rd, Bonne Terre, MO

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    Bonne Terre Retail Opportunity
    $550,000
    8,200 SF
    Bonne Terre Retail Opportunity

    8,200 SF retail space for sale or lease.

    7 Northwood Dr, Bonne Terre, MO

    View details

    Off-Market Properties in De Soto, MO

    Consider similar Off-Market properties in De Soto, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    501 5th St
    GARDEN APT, COURT APT (5+ UNITS)
    Lot: 0.46 Acres
    Value Estimation by Request

    501 5th St, De Soto, MO 63020-1516

    View details
    3305 Lemehl Rd
    MOBILE HOME PARK, TRAILER PARK
    Lot: 15.00 Acres
    Value Estimation by Request

    3305 Lemehl Rd, De Soto, MO 63020-4539

    View details
    300 Main St
    DISTRIBUTION WAREHOUSE
    Lot: 0.21 Acres
    Value Estimation by Request

    300 Main St, De Soto, MO 63020

    View details
    De Soto, MO 63020
    DISTRIBUTION WAREHOUSE
    4,200 SF Lot: 8.33 Acres
    Value Estimation by Request

    De Soto, MO 63020

    View details
    1703 Rock Rd
    MINI-WAREHOUSE, STORAGE
    1,540 SF Lot: 0.50 Acres
    Value Estimation by Request

    1703 Rock Rd, De Soto, MO 63020-1045

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    De Soto, MO 63020
    VACANT COMMERCIAL LAND
    Lot: 0.22 Acres
    Value Estimation by Request

    De Soto, MO 63020

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    113 Easton St
    DISTRIBUTION WAREHOUSE
    6,400 SF Lot: 0.14 Acres
    Value Estimation by Request

    113 Easton St, De Soto, MO 63020

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    15737 State Rd T T
    OFFICE/RESIDENTIAL (MIXED USE)
    2,224 SF Lot: 15.47 Acres
    Value Estimation by Request

    15737 State Rd T T, De Soto, MO 63020-5228

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    De Soto, MO 63020
    MANUFACTURING (LIGHT)
    Lot: 0.04 Acres
    Value Estimation by Request

    De Soto, MO 63020

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    12548 Ware Rd
    OFFICE/RESIDENTIAL (MIXED USE)
    2,528 SF Lot: 6.68 Acres
    Value Estimation by Request

    12548 Ware Rd, De Soto, MO 63020-5748

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    12999 State Rte 21
    AUTO REPAIR, GARAGE
    3,200 SF Lot: 0.19 Acres
    Value Estimation by Request

    12999 State Rte 21, De Soto, MO 63020-1000

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    De Soto, MO 63020
    COMMERCIAL (GENERAL)
    Lot: 0.37 Acres
    Value Estimation by Request

    De Soto, MO 63020

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    124 Main St
    COMMERCIAL (GENERAL)
    258 SF Lot: 0.01 Acres
    Value Estimation by Request

    124 Main St, De Soto, MO 63020-1709

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    124 Main St
    VACANT COMMERCIAL LAND
    Lot: 0.01 Acres
    Value Estimation by Request

    124 Main St, De Soto, MO 63020-1709

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    515 Amvets Dr
    GARDEN APT, COURT APT (5+ UNITS)
    Lot: 0.52 Acres
    Value Estimation by Request

    515 Amvets Dr, De Soto, MO 63020-2342

    View details
    12760 State Rte 21
    AUTO REPAIR, GARAGE
    3,600 SF Lot: 1.00 Acre
    Value Estimation by Request

    12760 State Rte 21, De Soto, MO 63020-3313

    View details
    12521 State Rte 21
    MINI-WAREHOUSE, STORAGE
    832 SF Lot: 10.40 Acres
    Value Estimation by Request

    12521 State Rte 21, De Soto, MO 63020-3316

    View details

    De Soto, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 72 commercial real estate for sale in De Soto, MO, showcased through 7 active listings on our real estate platform. These investment opportunities span a total of 29,293 square feet of properties for sale, with an estimated market value of $3,336,500.

    Sale prices for business properties in De Soto, MO start at $219,000, averaging $667,300, and reaching up to $997,500 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Demographics Overview

    Population 20K
    Population Growth (5Y) +1.8%
    Median Household Income $65,908
    College Educated 18.9%

    High-Yield Neighborhoods for Investment

    Identify De Soto submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    63020 $585.4K

    Taxes & Financing

    Average Loan-to-Value 65.0%

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