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    De Soto, MO

    De Soto, MO Commercial Real Estate for Lease

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    Park Hills, MO Festus, MO Leadington, MO Hillsboro, MO Crystal City, MO Farmington, MO Herculaneum, MO Cedar Hill, MO
    Open-Plan Storefront Space
    Updated: Aug 10
    Open-Plan Storefront Space

    200 S Main Street, De Soto, MO 63020

    $2,695/Mo
    0.14 AC lot
    Approximately 3,000+/- SF of commercial space
    Expansive storefront window line along Main Street
    Open interior layout with 3 half bathrooms
    Triple Net (NNN) lease structure
    Brick building constructed in 1910
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    Retail Space in Downtown DeSoto
    Updated: Jun 24, 2025
    Retail Space in Downtown DeSoto

    De Soto, MO

    Contact for pricing
    5,000 sqft 3.31 AC lot
    Convenient downtown location
    Great visibility
    Roll up doors on end cap
    North Main Street location
    High traffic volume (6,973 VPD)
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    Office Space with Road Visibility
    Office Space with Road Visibility

    2100 Rock Rd, De Soto, MO 63020

    Contact for pricing
    816 sqft

    Office space for lease with full access along Rock Road and strong passing traffic on Rock Road and Highway 21.

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    Office Space with High Visibility
    Office Space with High Visibility

    2100 Rock Rd, De Soto, MO 63020

    Contact for pricing
    288 sqft

    Office space with full access along Rock Road and strong passing traffic from Rock Road and Highway 21.

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    Retail Space with High-Traffic Frontage
    Retail Space with High-Traffic Frontage

    2100 Rock Rd, De Soto, MO 63020

    Contact for pricing
    1,550 sqft

    Retail space with full access along Rock Road and strong traffic exposure from Rock Road and Highway 21.

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    Based on your search, we've compiled 18 Potential Opportunities for your consideration. Besides 5 Active listings in De Soto, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 9 Properties for Sales.

    Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Freestanding Office Building
    Freestanding Office Building

    10639 Business 21, Hillsboro, MO 63050

    $2,700/Mo
    0.61 AC lot

    Flexible office layout with a kitchen, break area, and convenient access along Business 21.

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    Updated Office Suite
    Updated Office Suite

    130 Main Street, Festus, MO 63028

    $1,795/Mo
    0.14 AC lot

    Single-level commercial suite with private offices, reception space, a kitchen, restroom, and accessible entry.

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    Renovated Office Units
    Renovated Office Units

    1320 YMCA Drive, Festus, MO 63028

    Contact for pricing
    10,600 sqft 2.07 AC lot

    Flexible office workspace with updated building systems, ample parking, and convenient access to nearby restaurants and amenities.

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    Updated Office Units
    Updated Office Units

    118 4th St, Hillsboro, MO 63050

    $975/Mo

    Multiple office units feature refreshed HVAC and an updated main-level bathroom.

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    Similar Spaces for Sale in De Soto, MO

    Consider Similar Space for Sale. We found 9 Spaces matching your search parameters.

    Freestanding Church Building
    Freestanding Church Building

    13300 State Road Cc, De Soto, MO 63020

    $349,900
    2,400 sqft 0.91 AC lot

    Open sanctuary layout includes a kitchen, nursery, bathrooms, and paved and gravel parking.

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    Resort Property With Villa Accommodations
    Resort Property With Villa Accommodations

    De Soto, MO 63020

    $750,000
    92,779 sqft 327.23 AC lot

    Vacant resort campus combines lodging, recreation, dining, fitness, and event-oriented amenities in a residential-style setting.

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    Historic Brick Storefront Building
    Historic Brick Storefront Building

    400 S Main Street, De Soto, MO 63020

    $850,000
    0.14 AC lot

    Two storefront entrances create flexibility for operating one side and leasing the other.

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    Farm Property with Barn and Pasture
    Farm Property with Barn and Pasture

    14098 Charter Church Rd, De Soto, MO 63020

    $494,000
    1,400 sqft

    Pasture, wooded areas, and multiple supporting structures accompany the on-site house.

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    Historic Church Facility
    Historic Church Facility

    400 N 3rd Street, De Soto, MO 63020

    $214,000
    0.50 AC lot

    Restored sanctuary space includes an annex, fellowship hall, kitchen, and additional rooms.

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    Pasture Farm With Natural Spring
    Pasture Farm With Natural Spring

    13336 Mount Olive Rd, De Soto, MO 63020

    $611,090

    Fenced agricultural property with established utilities, water systems, storage, and open grazing areas.

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    Retail Space on Main Street
    Retail Space on Main Street

    400 - 420 North Main Street, De Soto, MO 63020

    Contact for pricing

    Retail space available for lease on North Main Street.

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    Retail and Office Space Available
    Retail and Office Space Available

    2100 - 2128 Rock Road, De Soto, MO 63020

    Contact for pricing

    Retail and office spaces for rent in De Soto.

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    Wooded Hunting Land With Electric
    Wooded Hunting Land With Electric

    Hill Side Dr, De Soto, MO 63020

    $314,900
    69.24 AC lot

    Agriculturally zoned acreage with mature hardwood forest and a cleared area suited to camping or other outdoor use.

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    De Soto, MO Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in De Soto, MO with 5 listings featured on our commercial real estate exchange. The current inventory includes 7,654 square feet of properties with an estimated lease value of $2,695.

    Estimated lease rates for Commercial real estate in De Soto, MO average $2,695/Mo.
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