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    De Soto, MO

    De Soto, MO Commercial Real Estate for Lease

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    Bonne Terre, MO Park Hills, MO Festus, MO Leadington, MO Hillsboro, MO Crystal City, MO Farmington, MO Herculaneum, MO
    Open-Plan Storefront Space
    Triple net (NNN)
    Open-Plan Storefront Space

    200 S Main Street, De Soto, MO 63020

    $2,695/Mo
    Built 1910

    Main Street commercial space with extensive windows, natural light, three half bathrooms, and NNN lease structure.

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    Retail Space in Downtown DeSoto
    Retail Space in Downtown DeSoto

    De Soto, MO

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    5,000 sqft

    Retail space with great visibility and convenient downtown location.

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    Office Space with Road Visibility
    Office Space with Road Visibility

    2100 Rock Rd, De Soto, MO 63020

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    3–5 people  816 sqft

    Office space for lease with full access along Rock Road and strong passing traffic on Rock Road and Highway 21.

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    Office Space with High Visibility
    Office Space with High Visibility

    2100 Rock Rd, De Soto, MO 63020

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    288 sqft

    Office space with full access along Rock Road and strong passing traffic from Rock Road and Highway 21.

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    Retail Space with High-Traffic Frontage
    Retail Space with High-Traffic Frontage

    2100 Rock Rd, De Soto, MO 63020

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    1,550 sqft

    Retail space with full access along Rock Road and strong traffic exposure from Rock Road and Highway 21.

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    Based on your search, we've compiled 25 Potential Opportunities for your consideration. Besides 5 Active listings in De Soto, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 16 Properties for Sales.

    Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Renovated Office Units
    Renovated Office Units

    1320 YMCA Drive, Festus, MO 63028

    Contact for pricing
    42–70 people  10,600 sqft  2.07 acres

    Flexible office workspace with updated building systems, ample parking, and convenient access to nearby restaurants and amenities.

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    Freestanding Office Building
    Freestanding Office Building

    10639 Business 21, Hillsboro, MO 63050

    $2,300/Mo
    Built 1999

    Several offices, a kitchen and a restroom create a practical layout for commercial operations.

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    Updated Office Suite
    Updated Office Suite

    130 Main Street, Festus, MO 63028

    $1,795/Mo
    Built 1950  0.14 acres

    Single-level commercial suite with private offices, reception space, a kitchen, restroom, and accessible entry.

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    Freestanding Office Building
    Freestanding Office Building

    10639 Business 21, Hillsboro, MO 63050

    $2,300/Mo
    Built 1999  0.61 acres

    Flexible office layout with a kitchen, break area, and convenient access along Business 21.

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    Similar Spaces for Sale in De Soto, MO

    Consider Similar Space for Sale. We found 16 Spaces matching your search parameters.

    Freestanding Church Building
    Freestanding Church Building

    13300 State Road Cc, De Soto, MO 63020

    $349,900
    2,400 sqft 0.91 AC lot

    Open sanctuary layout includes a kitchen, nursery, bathrooms, and paved and gravel parking.

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    Resort Property With Villa Accommodations
    Resort Property With Villa Accommodations

    De Soto, MO 63020

    $750,000
    92,779 sqft 327.23 AC lot

    Vacant resort campus combines lodging, recreation, dining, fitness, and event-oriented amenities in a residential-style setting.

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    Mixed-Use Building with Apartment
    Mixed-Use Building with Apartment

    200 S Main Street, De Soto, MO 63020

    $394,900
    0.14 AC lot

    An upper-level residence is leased through December 31, 2026, alongside commercial space and a distinct rear area.

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    Historic Brick Storefront Building
    Historic Brick Storefront Building

    400 S Main Street, De Soto, MO 63020

    $850,000
    0.14 AC lot

    Two storefront entrances create flexibility for operating one side and leasing the other.

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    Medical Office Building
    Medical Office Building

    126 S Main St, De Soto, MO 63020

    $325,000
    0.14 AC lot

    The interior combines private work areas with a large open room, lab space, and two commercial restrooms.

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    Historic Church Facility
    Historic Church Facility

    400 N 3rd Street, De Soto, MO 63020

    $198,000
    0.50 AC lot

    Restored sanctuary space includes an annex, fellowship hall, kitchen, and additional rooms.

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    Church Facility with Annex
    Church Facility with Annex

    400 N 3rd Street, De Soto, MO 63020

    $198,000
    4,095 sqft

    A restored sanctuary layout includes fellowship space, a kitchen, auxiliary rooms and two basements with exterior access.

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    Medical Office with Flexible Layout
    Medical Office with Flexible Layout

    126 S Main St, De Soto, MO 63020

    $325,000

    The interior combines reception and waiting areas with a large open room and space for as many as eight offices.

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    Equestrian Property with Indoor Arena
    Equestrian Property with Indoor Arena

    12950 Palmer Lane, De Soto, MO 63020

    $725,000

    Horse facilities include a multi-stall barn, fenced pastures, covered storage, and space for riding and training.

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    Cross-Fenced Farmland
    Cross-Fenced Farmland

    0000 Hyfield Road, De Soto, MO 63020

    $540,000

    Mostly open, level pasture includes scattered woods and an older barn near the property edge.

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    Pasture Farm With Natural Spring
    Pasture Farm With Natural Spring

    13336 Mount Olive Rd, De Soto, MO 63020

    $611,090

    Fenced agricultural property with established utilities, water systems, storage, and open grazing areas.

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    Farm
    Farm

    5295 State Road H, De Soto, MO 63020

    $299,900

    Agricultural land / Farmland

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    Retail Space on Main Street
    Retail Space on Main Street

    400 - 420 North Main Street, De Soto, MO 63020

    Contact for pricing

    Retail space available for lease on North Main Street.

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    Wooded Hunting Land With Electric
    Wooded Hunting Land With Electric

    Hill Side Dr, De Soto, MO 63020

    $314,900
    69.24 AC lot

    Agriculturally zoned acreage with mature hardwood forest and a cleared area suited to camping or other outdoor use.

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    Retail and Office Space Available
    Retail and Office Space Available

    2100 - 2128 Rock Road, De Soto, MO 63020

    Contact for pricing

    Retail and office spaces for rent in De Soto.

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    Land
    Land

    13942 Springdale Rd, De Soto, MO 63020

    $300,000

    Residential land & home lots

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    De Soto, MO Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in De Soto, MO with 5 listings featured on our commercial real estate exchange. The current inventory includes 7,654 square feet of properties with an estimated lease value of $2,695.

    Estimated lease rates for Commercial real estate in De Soto, MO average $2,695/Mo.
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    • 63020

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    Heartland Realty
    50 Jefferson Square Valles Mines, MO 63020
    Phone: (636) 337-0600
    www.heartlandhomesrealty.com
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