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De Soto, MO

De Soto, MO Commercial Real Estate for Lease

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Bonne Terre, MO Desloge, MO Park Hills, MO Festus, MO Leadington, MO Potosi, MO Crystal City, MO Farmington, MO

Retail Space in Downtown DeSoto

Updated: Jun 24, 2025

Retail Space in Downtown DeSoto

De Soto, MO

Contact for pricing

5,000 sqft

Convenient downtown location
Great visibility
Roll up doors on end cap
North Main Street location
High traffic volume (6,973 VPD)

End Cap Strip Mall Space with Roll-Up Doors

Updated: Jun 24, 2025

End Cap Strip Mall Space with Roll-Up Doors

De Soto, MO 63020

Contact for pricing

646 sqft

End cap strip mall space with roll‑up doors
Traffic count on North Main Street: 6,973 VPD
Available retail space totaling 646 SF
Location: 400‑508 N Main St, DeSoto, MO 63020

Office Space with High Visibility

Office Space with High Visibility

2100 Rock Rd, De Soto, MO 63020

Contact for pricing

288 sqft

Office space with full access along Rock Road and strong passing traffic from Rock Road and Highway 21.

Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center

Retail Space with High-Traffic Frontage

Retail Space with High-Traffic Frontage

2100 Rock Rd, De Soto, MO 63020

Contact for pricing

1,550 sqft

Retail space with full access along Rock Road and strong traffic exposure from Rock Road and Highway 21.

Office Space with Road Visibility

Office Space with Road Visibility

2100 Rock Rd, De Soto, MO 63020

Contact for pricing

816 sqft

Office space for lease with full access along Rock Road and strong passing traffic on Rock Road and Highway 21.

Based on your search, we've compiled 15 Potential Opportunities for your consideration. Besides 5 Active listings in De Soto, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 6 Properties for Sales.

Commercial real estate for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Downtown Office-Retail Suite

Downtown Office-Retail Suite

130 Main Street, Festus, MO 63028

$1,795/Mo

Single-level suite with reception, three private offices, restroom, and full kitchen, with paved rear parking.

Regional Shopping Center Space Available

Regional Shopping Center Space Available

110-155 Twin City Mall, Crystal City, MO

Contact for pricing

5,115 sqft

Retail space available in regional shopping center with high visibility.

Former Restaurant with Drive-Thru

Former Restaurant with Drive-Thru

807 Lee Ave, Festus, MO 63028

Contact for pricing

3,136 sqft

3,136 SF former restaurant with drive-thru on 0.76 acres.

Regional Shopping Center with LED Pylon Sign

Regional Shopping Center with LED Pylon Sign

110-155 Twin City Mall, Crystal City, MO 63019

Contact for pricing

5,115 sqft

Regional shopping center with a new LED pylon sign and strong visibility along Hwy 61/67.

Similar Spaces for Sale in De Soto, MO

Consider Similar Space for Sale. We found 6 Spaces matching your search parameters.

Mixed-Use Retail and Office Building

Mixed-Use Retail and Office Building

400 S Main Street, De Soto, MO 63020

$850,000

0.14 AC lot

Updated retail and office building with multiple entrances and upstairs open area, including a glass floor section.

Agricultural Land with Brick Home

Agricultural Land with Brick Home

12621 Hyfield Rd, De Soto, MO 63020

$725,000

1,765 sqft

Cross-fenced farmland with pasture, woods, and an all-brick 3-bedroom home plus outbuilding.

Entire-Block Development Land

Entire-Block Development Land

4 Easton Street, De Soto, MO 63020

Contact for pricing

65,340 sqft

Large entire-block parcel with approximately 569 feet of frontage and 575 feet at the rear.

Retail Building

Retail Building

12939 State Highway 21, De Soto, MO 63020

Contact for pricing

60,000 sqft

Retail property offered for sale totaling 60,000 SF.

Retail Space on Main Street

Retail Space on Main Street

400 - 420 North Main Street, De Soto, MO 63020

Contact for pricing

Retail space available for lease on North Main Street.

Retail and Office Space Available

Retail and Office Space Available

2100 - 2128 Rock Road, De Soto, MO 63020

Contact for pricing

Retail and office spaces for rent in De Soto.

De Soto, MO Commercial real estate Market Trends and Statistics

Explore Commercial real estate leasing options in De Soto, MO with 5 listings featured on our commercial real estate exchange. The current inventory includes 8,300 square feet of properties.

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