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    Bonne Terre, MO Blackwell, MO French Village, MO Cadet, MO Desloge, MO Fredericktown, MO Festus, MO Leadwood, MO
    Mixed-Use Retail and Office Building
    Updated: Dec 17, 2025
    Mixed-Use Retail and Office Building

    400 S Main Street, De Soto, MO 63020

    $850,000
    0.14 AC lot
    Brick building built in 1870 with public water service and electric heating and cooling
    Roof maintenance completed, with updated electrical, HVAC, and general maintenance noted
    Existing florist/gift shop/retail operations include branded item sales (family‑owned)
    Use one side of the building while renting the other side out; both areas have store‑front entrance access
    Inventory included with the purchase; seller will review the full building with the new buyer
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    Turn Any Listing Into an Investment Snapshot Owner equity, real caprate, demand score for every listing. Go To Analytics Center
    Based on your search, we've compiled 39 Potential Opportunities for your consideration. Besides 1 Active listings in De Soto, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 30 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Mixed-Use Building with Income Potential
    Mixed-Use Building with Income Potential

    105 N Division Street, Bonne Terre, MO 63628

    $550,000
    7,500 sqft

    Commercial building featuring apartments, storage units, and flexible space.

    View details
    Historic Vargos Mixed-Use Potential
    Historic Vargos Mixed-Use Potential

    702 Benham Street, Bonne Terre, MO 63628

    $275,000
    13,200 sqft 0.47 AC lot

    Historic building with mixed-use potential in Bonne Terre.

    View details
    Multi-Office Building with Generator
    Multi-Office Building with Generator

    405 Main Street Hills, Hillsboro, MO 63050

    $50,000
    9,810 sqft

    Office building with 24 offices, multiple restrooms, and a mobile generator plus 41 dedicated parking spaces.

    View details
    Commercial Property Near City Hall
    Commercial Property Near City Hall

    114 Main St, Hillsboro, MO 63050

    $426,900
    2,772 sqft 0.50 AC lot

    Updated commercial property with large lot near government buildings.

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land with Corner Location
    Commercial Land with Corner Location

    114 Main Street, Hillsboro, MO 63050

    $426,900
    2,772 sqft 0.51 AC lot

    Corner commercial lot includes a recently updated kitchen area and offers flexible space near downtown civic uses.

    View details
    Cleared Commercial Land Parcel
    Cleared Commercial Land Parcel

    St Francois Road, Bonne Terre, MO 63628

    $39,900
    0.33 AC lot

    Commercially zoned cleared lot with substantial road frontage on a main road for flexible development.

    View details
    High-Visibility Commercial Land Lot
    High-Visibility Commercial Land Lot

    3 Cedric Station, Cedar Hill, MO 63016

    $349,620
    0.99 AC lot

    Commercial-zoned lot with access from Highway 30 and strong nearby retail and civic activity.

    View details
    Commercial Building Lot with Highway Access
    Commercial Building Lot with Highway Access

    2 Cedric Station, Cedar Hill, MO 63016

    $291,740
    0.80 AC lot

    Build-to-suit commercial site near Highway 30, offering convenient access and visibility for retail, restaurant, or medical use.

    View details

    Off-Market Properties in De Soto, MO

    Consider similar Off-Market properties in De Soto, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    402 2nd St
    OFFICE (GENERAL)

    402 2nd St, De Soto, MO 63020-2007

    Value Estimation by Request
    0.11 AC lot
    View details
    112 Main St
    OFFICE (GENERAL)

    112 Main St, De Soto, MO 63020-2104

    Value Estimation by Request
    4,340 sqft 0.09 AC lot
    View details
    12417 State Rte 21
    OFFICE (GENERAL)

    12417 State Rte 21, De Soto, MO 63020-3317

    Value Estimation by Request
    6.45 AC lot
    View details
    200 Main St
    OFFICE (GENERAL)

    200 Main St, De Soto, MO 63020

    Value Estimation by Request
    1,614 sqft 0.14 AC lot
    View details
    12 Boyd St
    OFFICE (GENERAL)

    12 Boyd St, De Soto, MO 63020-1748

    Value Estimation by Request
    0.09 AC lot
    View details
    702 Main St
    OFFICE (GENERAL)

    702 Main St, De Soto, MO 63020-1450

    Value Estimation by Request
    2,118 sqft 0.22 AC lot
    View details
    600 Main St
    OFFICE (GENERAL)

    600 Main St, De Soto, MO 63020-1449

    Value Estimation by Request
    1,240 sqft 0.25 AC lot
    View details
    1830 Rock Rd
    OFFICE (GENERAL)

    1830 Rock Rd, De Soto, MO 63020-1048

    Value Estimation by Request
    1,316 sqft 1.98 AC lot
    View details
    120 Boyd St
    OFFICE (GENERAL)

    120 Boyd St, De Soto, MO 63020-1702

    Value Estimation by Request
    0.20 AC lot
    View details
    704 Main St
    OFFICE (GENERAL)

    704 Main St, De Soto, MO 63020-1450

    Value Estimation by Request
    2,282 sqft 0.65 AC lot
    View details
    112 Clement St
    OFFICE (GENERAL)

    112 Clement St, De Soto, MO 63020-2102

    Value Estimation by Request
    0.22 AC lot
    View details
    215 Main St
    OFFICE (GENERAL)

    215 Main St, De Soto, MO 63020-2140

    Value Estimation by Request
    1,978 sqft 0.06 AC lot
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    414 Main St
    OFFICE (GENERAL)

    414 Main St, De Soto, MO 63020-2210

    Value Estimation by Request
    0.07 AC lot
    View details
    490 Main St
    OFFICE (GENERAL)

    490 Main St, De Soto, MO 63020-1538

    Value Estimation by Request
    960 sqft 0.39 AC lot
    View details
    3219 State Rd V V
    OFFICE (GENERAL)

    3219 State Rd V V, De Soto, MO 63020

    Value Estimation by Request
    1,422 sqft 15.36 AC lot
    View details
    112 Main St
    OFFICE (GENERAL)

    112 Main St, De Soto, MO 63020-1709

    Value Estimation by Request
    0.09 AC lot
    View details
    204 Main St
    OFFICE (GENERAL)

    204 Main St, De Soto, MO 63020-2105

    Value Estimation by Request
    3,350 sqft 0.14 AC lot
    View details
    111 Pratt St
    OFFICE (GENERAL)

    111 Pratt St, De Soto, MO 63020-2107

    Value Estimation by Request
    0.04 AC lot
    View details
    126 Main St
    OFFICE (GENERAL)

    126 Main St, De Soto, MO 63020-2104

    Value Estimation by Request
    4,625 sqft 0.14 AC lot
    View details
    127 Pratt St
    OFFICE (GENERAL)

    127 Pratt St, De Soto, MO 63020-2107

    Value Estimation by Request
    0.04 AC lot
    View details
    306 Main St
    OFFICE (GENERAL)

    306 Main St, De Soto, MO 63020-2106

    Value Estimation by Request
    2,164 sqft 0.05 AC lot
    View details
    115 Easton St
    OFFICE (GENERAL)

    115 Easton St, De Soto, MO 63020-1705

    Value Estimation by Request
    2,500 sqft 0.10 AC lot
    View details
    1900 Rock Rd
    OFFICE (GENERAL)

    1900 Rock Rd, De Soto, MO 63020-1050

    Value Estimation by Request
    2.41 AC lot
    View details

    De Soto, MO Office Spaces Market Trends and Statistics

    Explore 31 office spaces for sale in De Soto, MO on our real estate platform. These investment opportunities span a total of 0 square feet of properties for sale, with an estimated market value of $850,000.

    Sale prices for office spaces in De Soto, MO start at $850,000, averaging $850,000, and reaching up to $850,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 1

    Demographics Overview

    Population 20K
    Population Growth (5Y) +1.8%
    Median Household Income $65,908
    College Educated 18.9%

    High-Yield Neighborhoods for Investment

    Identify De Soto submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63020 $850K

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in St. Francois County

    New Delisted

    Total CRE Inventory on Market (SF)

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