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    De Soto, MO Mixed-use Properties for Sale

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    Bonne Terre, MO French Village, MO Cadet, MO
    Historic Mixed-Use Commercial Property
    $219,000
    4,095 SF

    Historic Mixed-Use Commercial Property

    400 N 3rd Street, De Soto, MO 63020

    Unique 4,095 SF commercial property in downtown De Soto.

    • Unique 4,095 sq ft commercial property in the heart of downtown De Soto.
    • Historic 1866 schoolhouse/church with restored original sanctuary lighting and significant overall restoration.
    • Versatile layout with large fellowship hall, kitchen, and two additional rooms in the 1964 annex.
    • Two basements with egress access, providing ample storage space.
    • Corner lot location with adjacent vacant lot foundation for potential future use.
    Updated: Apr 14
    View details
    De Soto Mixed-Use Opportunity
    $420,000
    5,000 SF

    De Soto Mixed-Use Opportunity

    120 N Main Street, De Soto, MO 63020

    Mixed-use property on Main Street with retail and residential potential.

    • Over 5,000 sq ft of mixed‑use commercial and apartment space on Main Street.
    • Flexible main level space adaptable for office, retail, or additional apartment.
    • Apartment upstairs offers potential rental income.
    • Garage/storage area in the rear adds functionality.
    • Strong Main Street presence and excellent visibility.
    Updated: May 25
    View details
    Based on your search, we've compiled 34 Potential Opportunities for your consideration. Besides 2 Active listings in De Soto, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 24 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Versatile Commercial Property Near Highway
    $475,000
    2.30 Acres

    Versatile Commercial Property Near Highway

    Mixed-use property with income potential and highway visibility.

    3350 Highway O, Lot 2, Park Hills, MO 63601
    View details
    Adaptable Mixed-Use Building on Acreage
    $665,000
    8.00 Acres

    Adaptable Mixed-Use Building on Acreage

    12,000 sq ft building on 8 acres in High Ridge.

    3483 High Ridge Boulevard, High Ridge, MO 63049
    View details
    Versatile Commercial Property in Park Hills
    $600,000
    8,296 SF

    Versatile Commercial Property in Park Hills

    Expansive mixed-use property with high visibility and flexible layout.

    331 W Main Street, Park Hills, MO 63601
    View details
    Versatile Land with Existing Building
    $665,000
    12,000 SF

    Versatile Land with Existing Building

    8 acres with development potential and a 12,000 sqft building.

    3483 High Ridge Boulevard, High Ridge, MO 63049
    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Jefferson County Land Development Opportunity
    $1,350,000
    10.11 Acres

    Jefferson County Land Development Opportunity

    Over 10 acres prime for development with I-55 visibility.

    8703 Metropolitan Boulevard, Pevely, MO 63070
    View details
    Residential Development Opportunity in Fenton
    $5,483,000
    7.35 Acres

    Residential Development Opportunity in Fenton

    7.53-acre parcel for luxury residential development in high-demand location.

    000 Gravois Summit, Fenton, MO 63026
    View details
    Mixed-Use Building on S. Grand
    $219,900
    0.05 Acres

    Mixed-Use Building on S. Grand

    Mixed-use building with commercial space and residential unit.

    4135 S Grand, St, Louis, MO 63118
    View details
    Land on South Grand Boulevard
    $195,000
    0.12 Acres

    Land on South Grand Boulevard

    Mixed-use investment property with high visibility and traffic.

    3831 S Grand Boulevard, St, Louis, MO 63118
    View details

    Off-Market Properties in De Soto, MO

    Consider similar Off-Market properties in De Soto, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    15737 State Rd T T

    15737 State Rd T T

    OFFICE/RESIDENTIAL (MIXED USE) • 2,224 SF
    Value Estimation by Request
    15737 State Rd T T, De Soto, MO 63020-5228
    View details
    12548 Ware Rd

    12548 Ware Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 2,528 SF
    Value Estimation by Request
    12548 Ware Rd, De Soto, MO 63020-5748
    View details
    4549 State Rte 110

    4549 State Rte 110

    OFFICE/RESIDENTIAL (MIXED USE) • 1,584 SF
    Value Estimation by Request
    4549 State Rte 110, De Soto, MO 63020-3218
    View details
    3273 Stonehouse Rd

    3273 Stonehouse Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 2,269 SF
    Value Estimation by Request
    3273 Stonehouse Rd, De Soto, MO 63020-6801
    View details
    13909 State Rte 21

    13909 State Rte 21

    OFFICE/RESIDENTIAL (MIXED USE) • 2.69 Acres
    Value Estimation by Request
    13909 State Rte 21, De Soto, MO 63020-4360
    View details
    5307 State Rd P P

    5307 State Rd P P

    OFFICE/RESIDENTIAL (MIXED USE) • 4.32 Acres
    Value Estimation by Request
    5307 State Rd P P, De Soto, MO 63020
    View details
    3195 Oakvale Rd

    3195 Oakvale Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 1,000 SF
    Value Estimation by Request
    3195 Oakvale Rd, De Soto, MO 63020-5216
    View details
    118 2nd St

    118 2nd St

    OFFICE/RESIDENTIAL (MIXED USE) • 8,262 SF
    Value Estimation
    $530,000
    118 2nd St, De Soto, MO 63020-1701
    View details
    4076 Athena School Rd

    4076 Athena School Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 4.46 Acres
    Value Estimation by Request
    4076 Athena School Rd, De Soto, MO 63020-4580
    View details
    13219 State Rd Cc

    13219 State Rd Cc

    OFFICE/RESIDENTIAL (MIXED USE) • 1,326 SF
    Value Estimation by Request
    13219 State Rd Cc, De Soto, MO 63020-4695
    View details
    3136 Fountain City Rd

    3136 Fountain City Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 1,200 SF
    Value Estimation by Request
    3136 Fountain City Rd, De Soto, MO 63020-4542
    View details
    2905 Oakvale Rd

    2905 Oakvale Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 1,740 SF
    Value Estimation by Request
    2905 Oakvale Rd, De Soto, MO 63020-5218
    View details
    12862 Lone Oak Ln

    12862 Lone Oak Ln

    OFFICE/RESIDENTIAL (MIXED USE) • 672 SF
    Value Estimation by Request
    12862 Lone Oak Ln, De Soto, MO 63020-3539
    View details
    4824 State Rd V V

    4824 State Rd V V

    OFFICE/RESIDENTIAL (MIXED USE) • 864 SF
    Value Estimation by Request
    4824 State Rd V V, De Soto, MO 63020
    View details
    1951 Skyline Dr

    1951 Skyline Dr

    OFFICE/RESIDENTIAL (MIXED USE) • 1,071 SF
    Value Estimation by Request
    1951 Skyline Dr, De Soto, MO 63020-2627
    View details
    15165 Dickinson Rd

    15165 Dickinson Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 546 SF
    Value Estimation by Request
    15165 Dickinson Rd, De Soto, MO 63020-6125
    View details
    4024 Fountain City Rd

    4024 Fountain City Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 1,220 SF
    Value Estimation by Request
    4024 Fountain City Rd, De Soto, MO 63020-3428
    View details
    12249 Hyfield Rd

    12249 Hyfield Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 1,156 SF
    Value Estimation by Request
    12249 Hyfield Rd, De Soto, MO 63020-3158
    View details
    12528 Hyfield Rd

    12528 Hyfield Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 836 SF
    Value Estimation by Request
    12528 Hyfield Rd, De Soto, MO 63020-3166
    View details
    3960 Greenhouse Rd

    3960 Greenhouse Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 1,152 SF
    Value Estimation by Request
    3960 Greenhouse Rd, De Soto, MO 63020-3431
    View details
    3268 Fountain City Rd

    3268 Fountain City Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 8.57 Acres
    Value Estimation by Request
    3268 Fountain City Rd, De Soto, MO 63020-4546
    View details
    1156 Berry Dairy Rd

    1156 Berry Dairy Rd

    OFFICE/RESIDENTIAL (MIXED USE) • 1,248 SF
    Value Estimation by Request
    1156 Berry Dairy Rd, De Soto, MO 63020
    View details

    De Soto, MO Mixed-Use Properties Investment Opportunities Market Analysis

    Explore 26 mixed-use properties for sale in De Soto, MO on our real estate platform. These investment opportunities span a total of 9,095 square feet of properties for sale, with an estimated market value of $639,000.

    Sale prices for multi use buildings in De Soto, MO start at $219,000, averaging $319,500, and reaching up to $420,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Demographics Overview

    Population 20K
    Population Growth (5Y) +1.8%
    Median Household Income $65,908
    College Educated 18.9%

    High-Yield Neighborhoods for Strategic Investment

    Identify De Soto submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    63020 $219K

    Taxes & Financing

    Average Loan-to-Value 65.0%

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