Seneca, SC Office Units for Rent & Lease

Updated: Mar 28, 2025

Seneca Office Space For Lease

865 Old Clemson Highway, Seneca, SC 29678

$1,500/Mo

Suitable for various business types, including medical/dental offices.
Two levels with separate entrances and restrooms, offering flexible leasing options (entire building or individual floors).
Located in close proximity to Clemson and Seneca.
Lower level features 3 offices, conference room, and reception area (Lease: $1,750.00 NNN).
Upper level offers 5 offices and a reception area (Lease: $2,900.00 NNN).

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Updated: Apr 24

Main Corridor Office Suite

114 Nimmons Circle, Seneca, SC 29678

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1,500 sqft

+/- 1,500 SF bottom‑floor office space available for lease at 114 Nimmons Circle in Seneca
Multi‑tenant office building with co‑tenant Salvation Army Oconee Service Center upstairs
Suite layout includes multiple offices, conference room, reception area, 2 restrooms, and storage area
Direct access off By Pass 123 and Debra Street, with parking in front and existing signage
Located in Seneca city limits and zoned Highway Commercial (HC)

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Second-Floor Office Suite with Balcony

202-1510 Blue Ridge Blvd, Seneca, SC 29672

$3,000/Mo

Second-floor suite with five private offices, a kitchen area, and two private bathrooms, plus shared lobby access and a balcony.

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Based on your search, we've compiled 8 Potential Opportunities for your consideration. Besides 3 Active listings in Seneca, SC, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 1 Properties for Sales.

Office Units for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

Multi-Tenant Retail and Office Center

4120-4126 Clemson Blvd, Anderson, SC 29621

Contact for pricing

505 sqft

Affordable office and retail space in a 57,107 SF multi-tenant business community with onsite dining, signage, and ample parking.

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Retail or Office Suite

5823 Calhoun Memorial Highway, Easley, SC 29640

Contact for pricing

1,211 sqft

Suite 1A provides flexible retail or office space within a highly visible shopping center with ample parking.

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Multi-Tenant Office and Retail

4120-4126 Clemson Blvd, Anderson, SC 29621

Contact for pricing

2,373 sqft

Flexible leasing options in a multi-tenant business community with onsite restaurant, road signage, and ample parking.

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Easley Office Space Available

109 Fleetwood Dr, Easley, SC

Contact for pricing

3,422 sqft

Office space available for rent in Easley, South Carolina.

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Similar Spaces for Sale in Seneca, SC

Consider Similar Space for Sale. We found 1 Spaces matching your search parameters.

General Commercial Retail/Office Building

615 W N 1st Street, Seneca, SC 29678

$199,900

0.23 AC lot

Open floor plan with two bathrooms and a side storage building, zoned General Commercial in Seneca.

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