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    Guadalupe County, TX Office Spaces for Lease

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    Downtown Office Suites
    Updated: Jul 28
    Downtown Office Suites

    217 S River Street, Seguin, TX 78155

    $850/Mo
    20,128 sqft 0.31 AC lot
    20,128‑square‑foot office building on a 0.3059‑acre site
    Multiple office suites with varied sizes and layouts
    Each suite includes a private office and restroom
    Located on the historic downtown square at 217 S River Street
    Utilities included with a private business mailbox
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    Office Space with Central HVAC
    Updated: Aug 18
    Office Space with Central HVAC

    310 Pfeil Road, Cibolo, TX 78108

    $4,000/Mo
    2,147 sqft 0.79 AC lot
    2,147 square feet of office space on 0.79 acres
    C‑2 zoning
    Masonry construction dating to 1952
    Central heating and central air conditioning
    Public water and public sewer
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    Office Units in Brick Building
    Office Units in Brick Building

    314 N Austin Street, Seguin, TX 78155

    $800/Mo
    4,554 sqft 0.08 AC lot

    Commercially zoned space near downtown Seguin with tile and carpet flooring.

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    Flex Space with Roll-Up Door
    Flex Space with Roll-Up Door

    1419 Fleming Dr Warehouse 10, Seguin, TX 78155

    $1,335/Mo
    12,500 sqft

    Zoned C, with a private restroom, enclosed office, open work area, and direct drive-up access.

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    Renovated Flex Space
    Renovated Flex Space

    1427 N Austin Street, Seguin, TX 78155

    $1,695/Mo
    1,565 sqft 0.08 AC lot

    1920s-era brick commercial space with an open layout, hardwood flooring, tall ceilings, and updated restrooms.

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    Updated Medical Office Condominium
    Updated Medical Office Condominium

    515 N King Street, Seguin, TX 78155

    $2,285/Mo
    1.27 AC lot

    Professional suite with tile flooring, electric heating and cooling, and driveway parking.

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    Medical Office Space
    Medical Office Space

    936 S Highway 123 Bypass, Seguin, TX 78155

    $29 SF/Yr
    13,026 sqft 1.00 AC lot

    Flexible layout with private offices, exam rooms, and a dedicated waiting area.

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    Updated Office Suites
    Updated Office Suites

    200-217 S River St, Seguin, TX 78155

    $850/Mo
    20,128 sqft

    Private offices and restrooms are complemented by natural light, utilities, and a private business mailbox.

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    Flex Space With Warehouse Area
    Flex Space With Warehouse Area

    1012 Schriewer, Seguin, TX 78155

    $4,500/Mo
    16,555 sqft 2.61 AC lot

    Combined office and industrial areas with a ramp entrance, concrete flooring, and public water and sewer service.

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    Eight-Office Professional Suite
    Eight-Office Professional Suite

    3040 W Interstate 10 Expressway, Seguin, TX 78155

    $3,800/Mo
    2,442 sqft 0.87 AC lot

    Professional office space with a conference room, central air, and direct access to IH 10.

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    Renovated Flex Space
    Renovated Flex Space

    1427 N Austin St, Seguin, TX 78155

    $1,695/Mo
    1,565 sqft

    Open commercial space with hardwood floors, tall ceilings, large windows, and a gross lease structure.

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    Two-Story Office Building
    Two-Story Office Building

    109 N River Street, Seguin, TX 78155

    $4,888/Mo
    4,250 sqft 0.25 AC lot

    Historic downtown office property with flexible rooms, display windows, multiple entrances, and patron parking.

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    Adaptable Commercial Space For Rent
    Adaptable Commercial Space For Rent

    936 S Highway 123 Byp, Seguin, TX 78155

    $29 SF/Yr
    4,000 sqft 1.00 AC lot

    Well-maintained Class B commercial building in high-traffic area.

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    Versatile Flex Space in Seguin
    Versatile Flex Space in Seguin

    1012 Schriewer, Seguin, TX 78155

    $4,500/Mo
    16,555 sqft 2.61 AC lot

    16,555 sq ft flex building on 2.61 acres.

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    Office Suite with Private Office and Restroom
    Office Suite with Private Office and Restroom

    217 S River St 200, Seguin, TX 78155

    $850/Mo

    Luxury office suites offer a private office and restroom, with updated interiors and abundant natural light.

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    Flexible Office Unit
    Flexible Office Unit

    310 Pfeil Rd, Cibolo, TX 78108

    $4,000/Mo

    Commercial space with an adaptable layout for office, retail, daycare, or professional service use, subject to zoning and permitting.

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    Updated Medical Office Condominium
    Updated Medical Office Condominium

    515 N King St 108, Seguin, TX 78155

    $2,285/Mo

    Turnkey, freshly updated office condo available July 1, 2026, positioned for medical or other professional use near the hospital.

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    Updated Professional Office Condominium
    Updated Professional Office Condominium

    108-515 N King St, Seguin, TX 78155

    $2,285/Mo

    Updated office condo available July 1, 2026, suited for medical or other professional office users.

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    Open-Concept Live-Work Loft
    Open-Concept Live-Work Loft

    103 W Walnut St A, Seguin, TX 78155

    $1,500/Mo
    1,254 sqft

    Upstairs workspace with flexible planning, central HVAC, supplemental window units, and strong natural light from expansive windows.

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    Medical Office Space
    Medical Office Space

    16977 Interstate 35 N, Schertz, TX 78154

    Contact for pricing
    2,347 sqft

    Space is offered under a sublease arrangement.

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    Medical Office Space For Rent
    Medical Office Space For Rent

    412 N King St, Seguin, TX 78155

    $1,500/Mo
    0.30 AC lot

    Move-in ready medical office space near Guadalupe Regional Medical Center.

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    Versatile Commercial Leasing Opportunity
    Versatile Commercial Leasing Opportunity

    7049 FM 1044, Marion, TX 78124

    Contact for pricing
    9,000 sqft

    Premier commercial complex with flexible build-out options and ample yard space.

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    Schertz Medical Center Office Space
    Schertz Medical Center Office Space

    3701 FM3009, Schertz, TX

    Contact for pricing
    1,250 sqft 9.00 AC lot

    New medical development in a rapidly growing area.

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    Two-Story Office Building
    Two-Story Office Building

    A-109 N River St, Seguin, TX 78155

    $4,888/Mo
    4,250 sqft

    Downtown commercial space includes seven offices, flex rooms, and multiple customer-facing entrances.

    View details

    Guadalupe County, TX Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Guadalupe County, TX with 25 listings featured on our commercial real estate exchange. The current inventory includes 140,510 square feet of properties with an estimated lease value of $176.89.

    Estimated lease rates for Office Spaces in Guadalupe County, TX begin at $1.28 SF/Yr, with an average of $13.61 SF/Yr and extend to $29 SF/Yr.
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    Featured Guadalupe County Real Estate Agencies

    Realmo connects you with licensed Guadalupe County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Simmonds Real Estate Inc
    17331 IH-35 North, Ste 103 Schertz, TX 78154
    Phone: 12106519300
    www.roycerealestate.com

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