Advertise
    Texas
    Office

    Guadalupe County, TX Office Spaces for Lease

    Notify Me
    List
    Map
    Dallas, TX Austin, TX Houston, TX San Antonio, TX Fort Worth, TX El Paso, TX Mcallen, TX Lubbock, TX
    22 properties
    Sort:
    Downtown Office Suites
    Updated: Jul 28
    Downtown Office Suites

    217 S River Street, Seguin, TX 78155

    $850/Mo
    20,128 sqft 0.31 AC lot
    20,128‑square‑foot office building on a 0.3059‑acre site
    Multiple office suites with varied sizes and layouts
    Each suite includes a private office and restroom
    Located on the historic downtown square at 217 S River Street
    Utilities included with a private business mailbox
    View details
    Updated Medical Office Condominium
    Updated: Jun 19
    Updated Medical Office Condominium

    515 N King Street, Seguin, TX 78155

    $2,285/Mo
    1.27 AC lot
    Medical office condominium available July 1, 2026
    Updated interior with tile flooring
    Near a hospital and established medical practices
    COMM zoning on a 1.27‑acre parcel
    Electric heating and cooling
    View details
    Ground-Floor Office Units
    Ground-Floor Office Units

    936 S Highway 123 Bypass, Seguin, TX 78155

    $29 SF/Yr
    52–86 people  13,026 sqft  Built 2010  1 acre

    Flexible commercial space can accommodate office, medical, retail, and service uses, subject to applicable approvals.

    View details
    Flex Space with Roll-Up Door
    Flex Space with Roll-Up Door

    1419 Fleming Dr Warehouse 10, Seguin, TX 78155

    $1,385/Mo
    12,500 sqft  Built 1985

    Zoned C, with a private restroom, enclosed office, open work area, and direct drive-up access.

    View details
    Flex Space With Warehouse Area
    Flex Space With Warehouse Area

    1012 Schriewer, Seguin, TX 78155

    $4,500/Mo
    16,555 sqft  Built 1987
    Highway access  Road access

    Combined office and industrial areas with a ramp entrance, concrete flooring, and public water and sewer service.

    40 parking spaces
    View details
    Eight-Office Professional Suite
    Eight-Office Professional Suite

    3040 W Interstate 10 Expressway, Seguin, TX 78155

    $3,800/Mo
    9–16 people  2,442 sqft  Built 1995  0.87 acres
    8 private offices  1 meeting room  Highway access

    Professional office space with a conference room, central air, and direct access to IH 10.

    View details
    Office Suites with Private Restrooms
    Office Suites with Private Restrooms

    217 S River St #200, Seguin, TX 78155

    $850/Mo
    80–134 people  20,128 sqft  Built 1920

    Each workspace includes a dedicated office, restroom, utilities, and a private business mailbox.

    Abundant natural light  Updated interiors  Private mailbox
    View details
    Updated Office Suites
    Updated Office Suites

    200-217 S River St, Seguin, TX 78155

    $850/Mo
    80–134 people  20,128 sqft
    1 private office

    Private offices and restrooms are complemented by natural light, utilities, and a private business mailbox.

    Private mailbox
    View details
    Adaptable Commercial Space For Rent
    Adaptable Commercial Space For Rent

    936 S Highway 123 Byp, Seguin, TX 78155

    $29 SF/Yr
    4,000 sqft  Built 2010  1 acre

    Well-maintained Class B commercial building in high-traffic area.

    View details
    Renovated Flex Space
    Renovated Flex Space

    1427 N Austin St, Seguin, TX 78155

    Gross
    $1,695/Mo
    1,565 sqft  3-phase  Built 1925

    Open commercial space with hardwood floors, tall ceilings, large windows, and a gross lease structure.

    Utilities to site  Original hardwood floors  Large Windows  Tall Ceilings
    View details
    Versatile Flex Space in Seguin
    Versatile Flex Space in Seguin

    1012 Schriewer, Seguin, TX 78155

    $4,500/Mo
    16,555 sqft  Built 1987

    16,555 sq ft flex building on 2.61 acres.

    View details
    Office Suite with Private Office and Restroom
    Office Suite with Private Office and Restroom

    217 S River St 200, Seguin, TX 78155

    $850/Mo
    Built 1920

    Luxury office suites offer a private office and restroom, with updated interiors and abundant natural light.

    Natural light  Private mailbox
    View details
    Updated Office Unit with Reception Area
    Updated Office Unit with Reception Area

    100-128 S Moss St, Seguin, TX 78155

    $2,100/Mo
    44–74 people  11,200 sqft
    4 private offices

    Professional suite offers private offices, natural light, and recent interior improvements.

    Natural light  Reception/waiting area
    View details
    Updated Medical Office Condominium
    Updated Medical Office Condominium

    515 N King St 108, Seguin, TX 78155

    $2,285/Mo
    Built 1991

    Turnkey, freshly updated office condo available July 1, 2026, positioned for medical or other professional use near the hospital.

    View details
    Updated Professional Office Condominium
    Updated Professional Office Condominium

    108-515 N King St, Seguin, TX 78155

    $2,285/Mo

    Updated office condo available July 1, 2026, suited for medical or other professional office users.

    View details
    Open-Concept Live-Work Loft
    Open-Concept Live-Work Loft

    103 W Walnut St A, Seguin, TX 78155

    $1,500/Mo
    5–8 people  1,254 sqft  Built 1906

    Upstairs workspace with flexible planning, central HVAC, supplemental window units, and strong natural light from expansive windows.

    View details
    Medical Office Condominium
    Medical Office Condominium

    515 N King Street #108, Seguin, TX 78155

    $2,285/Mo
    Built 1991

    Updated interior space accommodates medical or other professional office users.

    60 parking spaces
    View details
    Medical Office Space
    Medical Office Space

    16977 Interstate 35 N, Schertz, TX 78154

    Contact for pricing
    2,347 sqft

    Space is offered under a sublease arrangement.

    View details
    Versatile Commercial Leasing Opportunity
    Versatile Commercial Leasing Opportunity

    7049 FM 1044, Marion, TX 78124

    Contact for pricing
    9,000 sqft

    Premier commercial complex with flexible build-out options and ample yard space.

    View details
    Corner Office Units
    Corner Office Units

    3 Commercial Place, Schertz, TX 78154

    Contact for pricing

    The office complex has entry points on both sides and parking for staff and visitors.

    View details
    Schertz Medical Center Office Space
    Schertz Medical Center Office Space

    3701 FM3009, Schertz, TX

    Triple net (NNN)
    Contact for pricing
    1,250 sqft  9 acres

    New medical development in a rapidly growing area.

    View details
    Two-Story Office Building
    Two-Story Office Building

    A-109 N River St, Seguin, TX 78155

    $4,888/Mo
    17–28 people  4,250 sqft  2-story  decorative masonry
    7 private offices

    Downtown commercial space includes seven offices, flex rooms, and multiple customer-facing entrances.

    Covered awning  Large display windows  Front reception area  Breakroom
    View details
    22 active listings match your search: Office for lease in Guadalupe County, TX. Based on your search, we've also compiled 26 Potential Opportunities for your consideration: 26 properties for sale.

    Similar Spaces for Sale in Guadalupe County, TX

    Consider Similar Space for Sale. We found 26 Spaces matching your search parameters.

    Mixed-Use Property with Office Building
    Mixed-Use Property with Office Building

    3925 LINNE RD, Seguin, TX 78155

    $949,777
    4,800 sqft 10.00 AC lot

    Office space, two residences, storage buildings, and substantial on-site utility infrastructure support a range of property operations.

    View details
    Two-Story Mixed-Use Building
    Two-Story Mixed-Use Building

    111 E GONZALES ST, Seguin, TX 78155

    $1,500,000
    11,074 sqft

    Historic commercial property with separately metered suites, private offices, storefronts, meeting areas, and retained architectural details.

    View details

    Guadalupe County, TX Office Spaces Market Trends and Statistics

    Explore Office Spaces leasing options in Guadalupe County, TX with 22 listings featured on our commercial real estate exchange. The current inventory includes 156,328 square feet of properties with an estimated lease value of $125.67.

    Estimated lease rates for Office Spaces in Guadalupe County, TX begin at $1.33 SF/Yr, with an average of $13.96 SF/Yr and extend to $29 SF/Yr.
    List
    Map

    Office Spaces by market

    Browse Office Spaces for Lease Near Guadalupe, TX

    Popular Categories

    Featured Guadalupe County Real Estate Agencies

    Realmo connects you with licensed Guadalupe County CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Vantage Real Estate Group, LLC
    664 N Hwy 123 Bypass, #1 Seguin, TX 78155
    Phone: (210) 240-5990
    www.vantagerealestategroup.net
    Simmonds Real Estate Inc
    17331 IH-35 North, Ste 103 Schertz, TX 78154
    Phone: (210) 651-9300
    www.roycerealestate.com
    Wayne Wilton Windle, Broker
    226 Elm Street Seguin, TX
    Phone: (915) 203-6361
    Why this one?
    Saved

    Select Neighborhood

    Google sign-in failed. Please try again or use another login method.
    Sign Up Successful!
    You now have access to more from Realmo!