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Seguin, TX Office Spaces for Lease

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Downtown Office Suites
Updated: Jul 28
Downtown Office Suites

217 S River Street, Seguin, TX 78155

$850/Mo
20,128 sqft 0.31 AC lot
20,128‑square‑foot office building on a 0.3059‑acre site
Multiple office suites with varied sizes and layouts
Each suite includes a private office and restroom
Located on the historic downtown square at 217 S River Street
Utilities included with a private business mailbox
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Updated Medical Office Condominium
Updated: Jun 19
Updated Medical Office Condominium

515 N King Street, Seguin, TX 78155

$2,285/Mo
1.27 AC lot
Medical office condominium available July 1, 2026
Updated interior with tile flooring
Near a hospital and established medical practices
COMM zoning on a 1.27‑acre parcel
Electric heating and cooling
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Medical Office Space
Medical Office Space

936 S Highway 123 Bypass, Seguin, TX 78155

$29 SF/Yr
13,026 sqft 1.00 AC lot

Flexible layout with private offices, exam rooms, and a dedicated waiting area.

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Flex Space with Roll-Up Door
Flex Space with Roll-Up Door

1419 Fleming Dr Warehouse 10, Seguin, TX 78155

$1,385/Mo
12,500 sqft

Zoned C, with a private restroom, enclosed office, open work area, and direct drive-up access.

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Flex Space With Warehouse Area
Flex Space With Warehouse Area

1012 Schriewer, Seguin, TX 78155

$4,500/Mo
16,555 sqft 2.61 AC lot

Combined office and industrial areas with a ramp entrance, concrete flooring, and public water and sewer service.

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Eight-Office Professional Suite
Eight-Office Professional Suite

3040 W Interstate 10 Expressway, Seguin, TX 78155

$3,800/Mo
2,442 sqft 0.87 AC lot

Professional office space with a conference room, central air, and direct access to IH 10.

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Updated Office Suites
Updated Office Suites

200-217 S River St, Seguin, TX 78155

$850/Mo
20,128 sqft

Private offices and restrooms are complemented by natural light, utilities, and a private business mailbox.

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Renovated Flex Space
Renovated Flex Space

1427 N Austin St, Seguin, TX 78155

$1,695/Mo
1,565 sqft

Open commercial space with hardwood floors, tall ceilings, large windows, and a gross lease structure.

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Adaptable Commercial Space For Rent
Adaptable Commercial Space For Rent

936 S Highway 123 Byp, Seguin, TX 78155

$29 SF/Yr
4,000 sqft 1.00 AC lot

Well-maintained Class B commercial building in high-traffic area.

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Versatile Flex Space in Seguin
Versatile Flex Space in Seguin

1012 Schriewer, Seguin, TX 78155

$4,500/Mo
16,555 sqft 2.61 AC lot

16,555 sq ft flex building on 2.61 acres.

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Office Suite with Private Office and Restroom
Office Suite with Private Office and Restroom

217 S River St 200, Seguin, TX 78155

$850/Mo

Luxury office suites offer a private office and restroom, with updated interiors and abundant natural light.

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Updated Office Unit with Reception Area
Updated Office Unit with Reception Area

100-128 S Moss St, Seguin, TX 78155

$2,100/Mo
11,200 sqft

Professional suite offers private offices, natural light, and recent interior improvements.

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Updated Medical Office Condominium
Updated Medical Office Condominium

515 N King St 108, Seguin, TX 78155

$2,285/Mo

Turnkey, freshly updated office condo available July 1, 2026, positioned for medical or other professional use near the hospital.

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Updated Professional Office Condominium
Updated Professional Office Condominium

108-515 N King St, Seguin, TX 78155

$2,285/Mo

Updated office condo available July 1, 2026, suited for medical or other professional office users.

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Open-Concept Live-Work Loft
Open-Concept Live-Work Loft

103 W Walnut St A, Seguin, TX 78155

$1,500/Mo
1,254 sqft

Upstairs workspace with flexible planning, central HVAC, supplemental window units, and strong natural light from expansive windows.

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Two-Story Office Building
Two-Story Office Building

A-109 N River St, Seguin, TX 78155

$4,888/Mo
4,250 sqft

Downtown commercial space includes seven offices, flex rooms, and multiple customer-facing entrances.

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Based on your search, we've compiled 38 Potential Opportunities for your consideration. Besides 16 Active listings in Seguin, TX, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 18 Properties for Sales.

Office Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

New Braunfels Office Space Available
New Braunfels Office Space Available

2021 State Highway 46 W, Ste 105, New Braunfels, TX 78132

$36 SF/Yr
2,629 sqft

Versatile office space in a high-growth New Braunfels location.

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Flex Space with Office Area
Flex Space with Office Area

3782 FM 725, New Braunfels, TX 78130

$2,000/Mo

Office and warehouse areas include a restroom, internet access, electricity, and parking.

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Office Space with Meeting Rooms
Office Space with Meeting Rooms

2027 W State Hwy 46, New Braunfels, TX 78132

Contact for pricing
7,553 sqft

Existing offices and shared work areas provide a flexible setting for professional operations.

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Versatile Commercial Leasing Opportunity
Versatile Commercial Leasing Opportunity

7049 FM 1044, Marion, TX 78124

Contact for pricing
9,000 sqft

Premier commercial complex with flexible build-out options and ample yard space.

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Similar Spaces for Sale in Seguin, TX

Consider Similar Space for Sale. We found 18 Spaces matching your search parameters.

Two-Story Mixed-Use Building
Two-Story Mixed-Use Building

111 E GONZALES ST, Seguin, TX 78155

$1,500,000
11,074 sqft

Historic commercial property with separately metered suites, private offices, storefronts, meeting areas, and retained architectural details.

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Two-Story Office Building with Roof Balcony
Two-Story Office Building with Roof Balcony

109 N River Street, Seguin, TX 78155

$969,000
6,554 sqft

Historic downtown setting with flexible office, shell, and support areas.

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Historic Downtown Seguin Commercial Portfolio
Historic Downtown Seguin Commercial Portfolio

200 E Court Street, 107, Seguin, TX 78155

$1,100,000
5,476 sqft

Retail and office spaces in historic downtown Seguin.

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Updated Medical Office Condominium
Updated Medical Office Condominium

515 N King St Ste 108, Seguin, TX 78155

$225,000
10,702 sqft

Fresh interior improvements support medical and other professional office uses in a hospital-area corridor.

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Mixed-Use Block Assemblage with Parking
Mixed-Use Block Assemblage with Parking

256 W Court, Seguin, TX 78155

$2,400,000
16,000 sqft

Mixed-use property with retail, office, warehouse, and parking.

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Updated Four-Office Professional Suite
Updated Four-Office Professional Suite

128 S Moss Unit 100, Seguin, TX 78155

Contact for pricing
11,200 sqft

Refreshed office unit with private workrooms, natural light, and a client-facing reception area.

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Medical Office Space With Exam Rooms
Medical Office Space With Exam Rooms

936 S Highway 123 Bypass, Seguin, TX 78155

Contact for pricing
13,026 sqft

Flexible medical-office layout includes private rooms and a dedicated waiting area for patient-facing operations.

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Multi-Building Flex Space
Multi-Building Flex Space

299 Navarro Dr, Seguin, TX 78155

Contact for pricing
16,500 sqft 3.12 AC lot

Office and warehouse improvements across multiple buildings, with divisible suites and additional land for future construction.

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Seguin, TX Office Spaces Lease Rates & Market Statistics

Explore 16 Office Spaces for lease in Seguin, TX on Realmo, a commercial real estate exchange covering the Seguin area. The current inventory totals 123,603 square feet of properties — an average of ~7,750 SF per listing.

Asking lease rates for Office Spaces in Seguin start at $1.33 SF/Yr, average $13.96 SF/Yr, and reach $29 SF/Yr at the top of the market. That's a 22x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $13.96 SF/Yr is 43% below the Texas state average of $24.40 SF/Yr.

Seguin accounts for 73% of the 22 office spaces currently available across Guadalupe County, where nearby markets include Schertz and Cibolo. By space type, the market includes 14 office units and 6 medical office space listings — office units typically offer the lowest entry point, while medical office space commands the highest rates.

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