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    Seguin, TX Office Spaces for Lease

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    Downtown Office Suites
    Updated: Jul 28
    Downtown Office Suites

    217 S River Street, Seguin, TX 78155

    $850/Mo
    20,128 sqft 0.31 AC lot
    20,128‑square‑foot office building on a 0.3059‑acre site
    Multiple office suites with varied sizes and layouts
    Each suite includes a private office and restroom
    Located on the historic downtown square at 217 S River Street
    Utilities included with a private business mailbox
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    Office Units in Brick Building
    Updated: Apr 16
    Office Units in Brick Building

    314 N Austin Street, Seguin, TX 78155

    $800/Mo
    4,554 sqft 0.08 AC lot
    4,554‑square‑foot office property
    Building constructed in 1906
    COMM zoning
    Brick, block, glass, and concrete construction materials
    Tile and carpet flooring
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    Renovated Flex Space
    Renovated Flex Space

    1427 N Austin Street, Seguin, TX 78155

    $1,695/Mo
    1,565 sqft 0.08 AC lot

    1920s-era brick commercial space with an open layout, hardwood flooring, tall ceilings, and updated restrooms.

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    Flex Space with Roll-Up Door
    Flex Space with Roll-Up Door

    1419 Fleming Dr Warehouse 10, Seguin, TX 78155

    $1,335/Mo
    12,500 sqft

    Zoned C, with a private restroom, enclosed office, open work area, and direct drive-up access.

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    Updated Medical Office Condominium
    Updated Medical Office Condominium

    515 N King Street, Seguin, TX 78155

    $2,285/Mo
    1.27 AC lot

    Professional suite with tile flooring, electric heating and cooling, and driveway parking.

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    Medical Office Space
    Medical Office Space

    936 S Highway 123 Bypass, Seguin, TX 78155

    $30 SF/Yr
    13,026 sqft 1.00 AC lot

    Flexible layout with private offices, exam rooms, and a dedicated waiting area.

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    Flex Space With Warehouse Area
    Flex Space With Warehouse Area

    1012 Schriewer, Seguin, TX 78155

    $4,500/Mo
    16,555 sqft 2.61 AC lot

    Combined office and industrial areas with a ramp entrance, concrete flooring, and public water and sewer service.

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    Downtown Office Suites
    Downtown Office Suites

    217 S River St #200, Seguin, TX 78155

    $850/Mo
    20,128 sqft

    Updated workspaces provide private offices, restrooms, natural light, utilities, and a private business mailbox.

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    Two-Story Office Building
    Two-Story Office Building

    109 N River Street, Seguin, TX 78155

    $4,888/Mo
    4,250 sqft 0.25 AC lot

    Historic downtown office property with flexible rooms, display windows, multiple entrances, and patron parking.

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    Eight-Office Professional Suite
    Eight-Office Professional Suite

    3040 W Interstate 10 Expressway, Seguin, TX 78155

    $3,800/Mo
    2,442 sqft 0.87 AC lot

    Professional office space with a conference room, central air, and direct access to IH 10.

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    Downtown-Close Office Space
    Downtown-Close Office Space

    314 N Austin St, Seguin, TX 78155

    $800/Mo
    4,554 sqft

    Office space in a building near downtown Seguin, available for rent.

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    Adaptable Commercial Space For Rent
    Adaptable Commercial Space For Rent

    936 S Highway 123 Byp, Seguin, TX 78155

    $30 SF/Yr
    4,000 sqft 1.00 AC lot

    Well-maintained Class B commercial building in high-traffic area.

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    Versatile Flex Space in Seguin
    Versatile Flex Space in Seguin

    1012 Schriewer, Seguin, TX 78155

    $4,500/Mo
    16,555 sqft 2.61 AC lot

    16,555 sq ft flex building on 2.61 acres.

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    Office Suite with Private Office and Restroom
    Office Suite with Private Office and Restroom

    217 S River St 200, Seguin, TX 78155

    $850/Mo

    Luxury office suites offer a private office and restroom, with updated interiors and abundant natural light.

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    Renovated Flex Space
    Renovated Flex Space

    1427 N Austin St, Seguin, TX 78155

    $1,695/Mo
    1,565 sqft

    Open commercial space with hardwood floors, tall ceilings, large windows, and a gross lease structure.

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    Seguin Industrial Warehouse Space
    Seguin Industrial Warehouse Space

    299 Navarro Drive #1, Seguin, TX 78155

    $1,875/Mo
    1,500 sqft

    1500 sqft industrial warehouse with modern office space for lease.

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    Open-Concept Live-Work Loft
    Open-Concept Live-Work Loft

    103 W Walnut St A, Seguin, TX 78155

    $1,500/Mo
    1,254 sqft

    Upstairs workspace with flexible planning, central HVAC, supplemental window units, and strong natural light from expansive windows.

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    Updated Office Suites
    Updated Office Suites

    200-217 S River Street, Seguin, TX 78155

    $850/Mo

    Private offices and restrooms are complemented by natural light, utilities, and a private business mailbox.

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    Updated Medical Office Condominium
    Updated Medical Office Condominium

    515 N King St 108, Seguin, TX 78155

    $2,285/Mo

    Turnkey, freshly updated office condo available July 1, 2026, positioned for medical or other professional use near the hospital.

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    Updated Professional Office Condominium
    Updated Professional Office Condominium

    108-515 N King St, Seguin, TX 78155

    $2,285/Mo

    Updated office condo available July 1, 2026, suited for medical or other professional office users.

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    Renovated Office Suite with Reception
    Renovated Office Suite with Reception

    128 S Moss St, Seguin, TX 78155

    Contact for pricing
    1,400 sqft

    Renovated 1,400 SF office suite with a reception area, four private offices, and a coffee nook.

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    Medical Office Space For Rent
    Medical Office Space For Rent

    412 N King St, Seguin, TX 78155

    $1,500/Mo
    0.30 AC lot

    Move-in ready medical office space near Guadalupe Regional Medical Center.

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    Two-Story Office Building
    Two-Story Office Building

    A-109 N River St, Seguin, TX 78155

    $4,888/Mo
    4,250 sqft

    Downtown commercial space includes seven offices, flex rooms, and multiple customer-facing entrances.

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    Newly Renovated Office Space
    Newly Renovated Office Space

    1117 E Court St, Seguin, TX 78155

    Contact for pricing

    Newly renovated, move-in-ready office space on a high-visibility corridor in Seguin.

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    Seguin, TX Office Spaces Lease Rates & Market Statistics

    Explore 25 Office Spaces for lease in Seguin, TX on Realmo, a commercial real estate exchange covering the Seguin area. The current inventory totals 130,226 square feet of properties — an average of ~5,200 SF per listing.

    Asking lease rates for Office Spaces in Seguin start at $1.28 SF/Yr, average $12.40 SF/Yr, and reach $30 SF/Yr at the top of the market. That's a 23x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $12.40 SF/Yr is 48% below the Texas state average of $23.86 SF/Yr.

    Seguin accounts for 76% of the 33 office spaces currently available across Guadalupe County, where nearby markets include Schertz and Cibolo. By space type, the market includes 21 office units and 6 medical office space listings — office units typically offer the lowest entry point, while medical office space commands the highest rates.

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