Syracuse, NY Office Spaces for Rent & Lease

Updated: Aug 10

Retail Space with Central Air

4455A E Genesee Street, Syracuse, NY 13214

$1,300/Mo

14,760 sqft 0.86 AC lot

14,760‑square‑foot retail property on a 0.86‑acre parcel
Multiple listed use options, including retail, office, service, gallery, studio, and take‑out food service
Central air conditioning and natural gas forced‑air heating
Public water and public sewer
Built in 1963 with a flat roof

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Updated: Jul 25

Second-Floor Office Space

308 W Genesee Street, Syracuse, NY 13202

$10,000/Mo

11,220 sqft 0.42 AC lot

Entire second floor available with stairwell and roof access
11,220‑square‑foot property built in 1930
MX‑5 zoning in Syracuse
Open shell requiring full build‑out
Large windows provide substantial natural light

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Office Unit with Included Services

422 W Onondaga Street, Syracuse, NY 13202

$5,000/Mo

37,112 sqft 0.91 AC lot

Office sublease with utilities, parking, and property maintenance included.

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Creative Space With Roof Access

308 W Genesee St, Syracuse, NY 13202

$10,000/Mo

11,220 sqft

Second-floor shell space offers large windows, flexible build-out potential, and access to a rooftop outdoor area.

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Renovated Live-Work Space

480 S Salina Street, Syracuse, NY 13202

$1,850/Mo

Two-story unit combines residential areas with a substantial office area and includes in-unit laundry.

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Mixed-Use Building with Diner

3604 Court Street, Syracuse, NY 13206

Contact for pricing

5,351 sqft 0.41 AC lot

Includes a mechanic garage and one-bedroom apartment under the same roof.

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Creative Office/Retail Space

112 Wilkinson Street, Syracuse, NY 13204

$8 SF/Yr

12,500 sqft

Second-floor creative office and retail space offers natural light and a flexible blank-canvas layout.

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Furnished Office Units with Parking

580 South Salina Street, Syracuse, NY 13202

$11.67-$14 SF/Yr

3,600 sqft

CBD-zoned office premises with optional furniture, basement storage, and exterior signage opportunities.

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Office Unit with Outdoor Patio

Dewitt, NY 13057

$1,850/Mo

950 sqft

One-story professional office space with conference room access, shared restrooms, and convenient parking.

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Medical Office Space Available

792 North Main Street, North Syracuse, NY 13212

$18.50 SF/Yr

5,126 sqft

5,126 SF medical office suite for lease.

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Corner Office Unit

447 East Washington Street, Syracuse, NY 13202

$3,000/Mo

Ground-level commercial space combines an adaptable open area with separate private and public restrooms.

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Iconic Mixed-Use State Tower

109 South Warren Street, Syracuse, NY 13202

$18.50 SF/Yr

23,201 sqft

Mixed-use property with office, residential, and retail spaces available.

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Office Unit in Office Building

580-584 South Salina Street, Syracuse, NY 13202

Contact for pricing

3,600 sqft

Office floor near downtown transit, a regional STEAM school, and Salt City market.

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Medical Office Suite with Exam Rooms

3400 Vickery Road, Syracuse, NY 13212

Contact for pricing

4,196 sqft

Suite C offers a mix of open space, private offices, and exam rooms for healthcare use.

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Medical-Convertible Office Suite

6567 Kinne Rd, Syracuse, NY 13214

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8,400 sqft

Office space with multiple offices, conference rooms, and private bathrooms, supported by shared-building water for possible medical use.

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Flex Warehouse with Office

209 Factory Ave, Syracuse, NY 13208

Contact for pricing

6,615 sqft 0.27 AC lot

Flex facility includes 3,200 SF of Class A office space and 3,415 SF warehouse with two automatic overhead doors.

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Flex Space with Loading Docks

530 State Fair Blvd, Syracuse, NY 13204

Contact for pricing

15,000 sqft

Adaptable flex space with office area, three-phase power, dock access, and sprinkler protection.

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Office Suite with Large Window Lines

2804-2806 Court St, Syracuse, NY 13208

Contact for pricing

1,225 sqft

First-floor office space for lease with strong natural light and window lines in a two-floor layout.

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Second-Floor Office Suite

550 Westcott Street, Syracuse, NY 13210

Contact for pricing

1,300 sqft

Bright second-floor suite with front and rear windows, flexible layout, luxury vinyl flooring, and freshly painted interiors.

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Class A Office Park Space

301 Plainfield Road, Syracuse, NY

$18 SF/Yr

96,084 sqft

Class A office space available in Syracuse, New York.

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Syracuse Flex Space For Rent

4601 Nixon Park Drive, Syracuse, NY

$5.25 SF/Yr

62,000 sqft

Flex/industrial/office space near Route 175, Syracuse, NY.

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Class A Suburban Office Park

200 Salina Meadows Pkwy, Syracuse, NY

$18 SF/Yr

44,730 sqft

Class A office space for rent in Syracuse, New York.

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Class A Suburban Office Park

220 Salina Meadows Pkwy, Syracuse, NY

$18 SF/Yr

44,730 sqft

Class A office space for rent in Syracuse, New York.

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Class A Suburban Office Park

231 Salina Meadows Pkwy, Syracuse, NY

$18 SF/Yr

53,992 sqft

Class A office space available for rent in Syracuse, NY.

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Syracuse, NY Office Spaces Lease Rates & Market Statistics

Explore 59 Office Spaces for lease in Syracuse, NY on Realmo, a commercial real estate exchange covering the Syracuse area. The current inventory totals 674,886 square feet of properties — an average of ~11,450 SF per listing.

Office Spaces lease rates in Syracuse range from $1.06 SF/Yr at the entry level to $23.37 SF/Yr at the top of the market, averaging $13.37 SF/Yr. That's a 22x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $13.37 SF/Yr is 57% below the New York state average of $31.13 SF/Yr.

Syracuse accounts for 57% of the 103 office spaces currently available across Onondaga County, where nearby markets include Liverpool and East Syracuse. By space type, the market includes 42 office units, 14 office buildings and 6 medical office space listings — office units typically offer the lowest entry point, while office buildings command the highest rates.