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N Syracuse, NY Office Spaces for Lease

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53 properties
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Retail Space with Central Air
Retail Space with Central Air

4455A E Genesee Street, Syracuse, NY 13214

Gross
$1,300/Mo
14,760 sqft  Built 1963

Commercial space accommodates retail, service, office, gallery, studio, and take-out food operations.

10 parking spaces
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Mixed-Use Building with Diner
Mixed-Use Building with Diner

3604 Court Street, Syracuse, NY 13206

Contact for pricing
5,351 sqft  Built 1958  0.41 acres

Includes a mechanic garage and one-bedroom apartment under the same roof.

10 parking spaces
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Furnished Office Units with Parking
Furnished Office Units with Parking

580 South Salina Street, Syracuse, NY 13202

Modified gross
$11.67-$14 SF/Yr
14–24 people  3,600 sqft
Highway access  MX-5

CBD-zoned office premises with optional furniture, basement storage, and exterior signage opportunities.

4.7/1,000 SF parking  Furnished  Exterior signage opportunities  Free on-site parking
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Creative Space With Roof Access
Creative Space With Roof Access

308 W Genesee St, Syracuse, NY 13202

$10,000/Mo
44–74 people  11,220 sqft  Built 1930

Second-floor shell space offers large windows, flexible build-out potential, and access to a rooftop outdoor area.

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Creative Office/Retail Space
Creative Office/Retail Space

112 Wilkinson Street, Syracuse, NY 13204

Triple net (NNN)
$8 SF/Yr
50–83 people  12,500 sqft

Second-floor creative office and retail space offers natural light and a flexible blank-canvas layout.

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Office Unit with Outdoor Patio
Office Unit with Outdoor Patio

Dewitt, NY 13057

Gross
$1,850/Mo
3–6 people  950 sqft  Built 1988

One-story professional office space with conference room access, shared restrooms, and convenient parking.

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Medical Office Space Available
Medical Office Space Available

792 North Main Street, North Syracuse, NY 13212

$18.50 SF/Yr
5,126 sqft

5,126 SF medical office suite for lease.

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Iconic Mixed-Use State Tower
Iconic Mixed-Use State Tower

109 South Warren Street, Syracuse, NY 13202

$18.50 SF/Yr
23,201 sqft

Mixed-use property with office, residential, and retail spaces available.

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Corner Office Unit
Corner Office Unit

447 East Washington Street, Syracuse, NY 13202

$2,750/Mo
Built 1950  Floor 1
Public transit

Ground-level commercial space combines an adaptable open area with separate private and public restrooms.

Private restroom facilities  Public restroom facilities
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Medical Office Suite with Exam Rooms
Medical Office Suite with Exam Rooms

3400 Vickery Road, Syracuse, NY 13212

Contact for pricing
Multi-tenant  4,196 sqft

Suite C offers a mix of open space, private offices, and exam rooms for healthcare use.

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Medical-Convertible Office Suite
Medical-Convertible Office Suite

6567 Kinne Rd, Syracuse, NY 13214

Contact for pricing
33–56 people  8,400 sqft

Office space with multiple offices, conference rooms, and private bathrooms, supported by shared-building water for possible medical use.

40 parking spaces  Conference rooms  Private bathrooms
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Second-Floor Office Suite
Second-Floor Office Suite

550 Westcott Street, Syracuse, NY 13210

Contact for pricing
5–8 people  1,300 sqft

Bright second-floor suite with front and rear windows, flexible layout, luxury vinyl flooring, and freshly painted interiors.

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Syracuse Flex Space For Rent
Syracuse Flex Space For Rent

4601 Nixon Park Drive, Syracuse, NY

$5.25 SF/Yr
62,000 sqft

Flex/industrial/office space near Route 175, Syracuse, NY.

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Class A Suburban Office Park
Class A Suburban Office Park

200 Salina Meadows Pkwy, Syracuse, NY

$18 SF/Yr
178–298 people  44,730 sqft

Class A office space for rent in Syracuse, New York.

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Office Building with Fenced Yard
Office Building with Fenced Yard

2030 Erie Blvd East, Syracuse, NY 13224

$4,000/Mo
Built 1960

Commercial zoning, on-site camera surveillance, and dedicated parking complement the office property.

Fenced-in yard  Security cameras
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Class A Suburban Office Park
Class A Suburban Office Park

231 Salina Meadows Pkwy, Syracuse, NY

$18 SF/Yr
215–359 people  53,992 sqft

Class A office space available for rent in Syracuse, NY.

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Office Units Near Interstate Access
Office Units Near Interstate Access

1045 James St, Syracuse, NY 13203

Contact for pricing
14–24 people  3,600 sqft

Office space is positioned near restaurants, retail shops, banks, and hotels.

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Downtown Syracuse Office Building
Downtown Syracuse Office Building

716 James Street, Syracuse, NY 13203

Contact for pricing
60–100 people  15,000 sqft

15,163 SF office building in downtown Syracuse for lease.

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First-Floor Office Suite
First-Floor Office Suite

2804 Court Street, Syracuse, NY 13206

$12 SF/Yr
Highway access

First-level office space with a private restroom and multiple offices, featuring windows in nearly every room.

Private restroom
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Flex Warehouse with Office
Flex Warehouse with Office

209 Factory Ave, Syracuse, NY 13208

Contact for pricing
6,615 sqft

Flex facility includes 3,200 SF of Class A office space and 3,415 SF warehouse with two automatic overhead doors.

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Office Suite with Large Window Lines
Office Suite with Large Window Lines

2804-2806 Court St, Syracuse, NY 13208

Modified gross
Contact for pricing
4–8 people  1 space  1,225 sqft  Floor 1
Highway access

First-floor office space for lease with strong natural light and window lines in a two-floor layout.

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Renovated Office Space For Lease
Renovated Office Space For Lease

207 Pine St, Syracuse, NY 13210

$1,250/Mo
Built 1989  0.75 acres

Recently renovated office space available for lease in convenient location.

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Office Building with Large Yard
Office Building with Large Yard

6331 E Molloy Rd, Dewitt, NY 13057

$3,376/Mo
Built 1989  1.1 acres

5,064 SF office building with yard for rent.

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Turnkey Medical Office Space Available
Turnkey Medical Office Space Available

127-29 Seeley Rd, Syracuse, NY 13224

Contact for pricing
3,000 sqft  Built 1964

Professionally renovated medical office with suites, kitchen, and ample parking.

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N Syracuse, NY Office Spaces Lease Rates & Market Statistics

Explore 53 Office Spaces for lease in N Syracuse, NY on Realmo, a commercial real estate exchange covering the N Syracuse area. The current inventory totals 467,140 square feet of properties — an average of ~8,800 SF per listing.

Office Spaces lease rates in N Syracuse range from $1.06 SF/Yr at the entry level to $23.37 SF/Yr at the top of the market, averaging $14.08 SF/Yr. That's a 22x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $14.08 SF/Yr is 54% below the New York state average of $30.69 SF/Yr.

N Syracuse accounts for 52% of the 101 office spaces currently available across Onondaga County, where nearby markets include Syracuse and Liverpool. By space type, the market includes 38 office units, 13 office buildings and 6 medical office space listings — office units typically offer the lowest entry point, while office buildings command the highest rates.

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