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    Syracuse, NY
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    Syracuse, NY Office Buildings for Lease

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    Liverpool, NY Jamesville, NY East Syracuse, NY
    9 listings
    Iconic Mixed-Use State Tower
    $18 SF/Yr
    23,201 SF
    Iconic Mixed-Use State Tower

    109 South Warren Street, Syracuse, NY 13202

    Mixed-use property with office, residential, and retail spaces available.
    • Iconic 22‑story mixed‑use building in Hanover Square.
    • Multiple office spaces available, ranging from 529 to ±15,176 SF contiguous.
    • 61 high‑end residential units on floors 8‑21.
    • Convenient location near major employers and highway access.
    • Amenities include 24/7 lobby attendant, attached parking garage, and on‑site restaurant.
    Updated: Mar 25
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    Class A Office Space Available
    $20 SF/Yr
    7,054 SF
    Class A Office Space Available

    500 Plum Street, Syracuse, NY 13204

    Prestigious office building in historic Franklin Square, Syracuse.
    • Class A office building in historic Franklin Square.
    • Sweeping views of downtown, Onondaga Creek walk path, Onondaga Lake, and Inner Harbor.
    • Convenient access to I81 and downtown Syracuse.
    • Suite 310 available with 7,054 RSF.
    • 300‑car parking garage.
    Updated: Nov 22, 2025
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    Restored Office Building in Syracuse
    $18 SF/Yr
    15,000 SF
    Restored Office Building in Syracuse

    Restored office building with parking near Armory Square.

    358 W Jefferson St, Syracuse, NY

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    Downtown Syracuse Office Building
    Contact for pricing
    15,000 SF
    Downtown Syracuse Office Building

    15,163 SF office building in downtown Syracuse for lease.

    716 James Street, Syracuse, NY 13203

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    Renovated Office Building with Parking
    Contact for pricing
    6,300 SF
    Renovated Office Building with Parking

    Downtown office building with on-site parking and renovated interior.

    506 E Washington St, Syracuse, NY 13202

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    Class A Office Building
    $500/Mo
    14,887 SF
    Class A Office Building

    Four-story renovated office building with parking and creekwalk access.

    455 N Franklin St, Syracuse, NY

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    Renovated Office Space Available
    $19 SF/Yr
    Renovated Office Space Available

    Recently renovated office building with fitness center and on-site amenities.

    300 S State St, Syracuse, NY 13202

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    Landmark Mixed-Use Tower for Lease
    $20 SF/Yr
    200,000 SF
    Landmark Mixed-Use Tower for Lease

    Historic building with office, retail, and luxury apartment spaces.

    109 S Warren St, Syracuse, NY 13202

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    Class A Office Building Space
    $12 SF/Yr
    120,000 SF
    Class A Office Building Space

    Class A office building with on-site parking near Downtown.

    620 Erie Blvd W, Syracuse, NY 13204

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    Based on your search, we've compiled 26 Potential Opportunities for your consideration. Besides 9 Active listings in Syracuse, NY, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 9 Properties for Sales.

    Office buildings for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Class A Office Suites Available
    Contact for pricing
    7,092 SF
    Class A Office Suites Available

    Modern office suites with ample natural light near major highways.

    225 Greenfield Parkway, Liverpool, NY 13088

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    Collamer Office Building Space Available
    Contact for pricing
    1,175 SF
    Collamer Office Building Space Available

    Office spaces for rent in a well-maintained building.

    6670 Old Collamer Rd, E Syracuse, NY

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    Divisible Office Building with Garage
    Contact for pricing
    2,870 SF
    Divisible Office Building with Garage

    16,500 SF office building divisible into 2,000+ SF suites.

    1 Adler Dr, E Syracuse, NY

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    Class A Office Space Available
    $17 SF/Yr
    3,305 SF
    Class A Office Space Available

    Modern office suites with ample natural light and highway access.

    225 Greenfield Pkwy, Liverpool, NY 13088

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    Similar Spaces for Sale in Syracuse, NY

    Consider Similar Space for Sale. We found 9 Spaces matching your search parameters.

    Commercial Flex Building with Shop Area
    $358,000
    4,408 SF
    Commercial Flex Building with Shop Area

    Flex commercial/industrial building with dedicated front office space and a rear garage/loading setup.

    6730 Townline Road, Syracuse, NY 13211

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    610 Oak St, Syracuse
    $425,000
    6,755 SF
    610 Oak St, Syracuse

    Historic Firehouse Converted to Office Space

    610 Oak St, Syracuse, NY 13203

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    S Salina St Office Building
    $249,900
    2,562 SF
    S Salina St Office Building

    Office building on a major commercial thoroughfare, great investment.

    4709 S Salina St, Syracuse, NY

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    Downtown Syracuse Office Building
    $3,567,324
    26,000 SF
    Downtown Syracuse Office Building

    26,000 SF office building for sale in Syracuse.

    359 S Salina St, Syracuse, NY

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    Syracuse Office Building For Sale
    $1,950,000
    15,299 SF
    Syracuse Office Building For Sale

    Office building in Syracuse, NY, with ample parking.

    105 Twin Oaks Dr, Syracuse, NY

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    Multi-Tenant Office Building For Sale
    $990,000
    20,808 SF
    Multi-Tenant Office Building For Sale

    Multi-tenant office building with potential sale/leaseback opportunity.

    990 James St, Syracuse, NY 13203

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    North Syracuse Office/Medical Building
    Contact for pricing
    North Syracuse Office/Medical Building

    Two-story office building in North Syracuse, available for sale.

    5232 Witz Dr, Syracuse, NY 13212

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    James Street Office Building For Sale
    $695,000
    17,888 SF
    James Street Office Building For Sale

    High-visibility Syracuse office building with ample parking and renovated restrooms.

    750 James St, Syracuse, NY

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    Well-Maintained Two-Story Office Building
    $1,695,000
    22,867 SF
    Well-Maintained Two-Story Office Building

    Two-story office building with basement and excellent onsite parking.

    5232 Witz Dr, N Syracuse, NY

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Owner-Paid Build-to-Suit Office Space
    $17 SF/Yr
    Owner-Paid Build-to-Suit Office Space

    Flexible office lease with an owner-paid build-to-suit option for tenant customization in downtown Bellefonte.

    135 S ALLEGHENY Street, Bellefonte, PA 16823

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    Prime Asbury Avenue Location
    Contact for pricing
    1,800 SF
    Prime Asbury Avenue Location

    High-visibility commercial space with customizable build-out and roof deck.

    901 Asbury Avenue, Asbury Park, NJ 7712

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    Prime Land for Ground Lease
    Contact for pricing
    Prime Land for Ground Lease

    20,245 sq ft land in high-traffic retail corridor.

    550 William Floyd Parkway, Brookhaven, NY 11967

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    Prime Retail Corridor Land Lease
    $10,000/Mo
    Prime Retail Corridor Land Lease

    20,245 sq ft land for lease in Shirley, NY.

    550 William Floyd Pkwy, Shirley, NY 11967

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    Syracuse, NY Office buildings Leasing Opportunities Market Analysis

    Explore Office buildings leasing options in Syracuse, NY with 9 listings featured on our commercial real estate exchange. The current inventory includes 365,255 square feet of properties with an estimated lease value of $88 SF/Yr.

    Estimated lease rates for Office buildings in Syracuse, NY begin at $12 SF/Yr, with an average of $17 SF/Yr and extend to $20 SF/Yr.
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    Most Searched ZIP Codes in Syracuse, NY

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