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    Syracuse, NY
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    Syracuse, NY Medical Office Space for Sale

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    Jamesville, NY Camillus, NY Nedrow, NY Salina, NY East Syracuse, NY Fayetteville, NY Clay, NY Pompey, NY
    12 properties
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    Office Building with Split Layout
    Updated: Jul 16
    Office Building with Split Layout

    430 S Main St, Syracuse, NY 13212

    $549,900
    5,000 sqft 0.34 AC lot
    Well‑maintained 5,000 SF commercial office building on a 15,000 SF lot on S Main St in North Syracuse.
    Two distinct sides for flexible use: 2,900 SF right side fully built out as a professional office suite.
    Right‑side build‑out includes multiple private offices with soundproof insulation and two virtual‑conference‑capable conference rooms pre‑wired with CAT6 and electrical.
    2,100 SF left side is open shell space, ready for custom tenant or owner build‑out.
    Major systems updated: new furnaces and central air on both sides, new hot water tank, and upgraded electrical with new panels and CAT6 data cabling to every workspace.
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    This listing looks promising.

    Here's a quick look at some key insights for

    430 S Main St, Syracuse, NY

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    • Est. Cap Rate

      8.8%
      Above avg (5.9%)

    • Est. NOI

      $48K
      Annual

    • Price @ 7% Cap

      $687K
      Above asking
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    North Syracuse Medical Office Building
    Updated: May 19
    North Syracuse Medical Office Building

    105 N Main Street, Syracuse, NY 13212

    $400,000
    2,244 sqft 0.23 AC lot
    2,244 SF single‑story medical/professional office built in 1950, suited for exam rooms, retail, offices, and laboratory space.
    New roof installed in 2024, helping reduce near‑term capital expenditure risk.
    15 dedicated on‑site parking spaces for the 2,244 SF building (about 7 per 1,000 SF).
    Currently an established optometry practice in continuous professional use for 60+ years and operating at this location for 29 years.
    Zoned for medical and professional office use; single‑tenant, owner‑occupied building.
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    Single-Story Medical Office Building
    Single-Story Medical Office Building

    105 N Main Street, Syracuse, NY 13212

    $400,000
    2,244 sqft 0.23 AC lot

    Professional medical office with exam rooms, private offices, laboratory space, and dedicated on-site parking.

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    Multi-Story Office Building
    Multi-Story Office Building

    717 E Genesee Street, Syracuse, NY 13210

    Contact for pricing
    6,000 sqft

    Six-thousand-square-foot office building with private parking and renovated second-floor space.

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    Turn a Listing Into an Investment Snapshot Cap Rate, Potential NOI, Demand score for every listing. Go To Analytics Center
    Single-Story Office Building
    Single-Story Office Building

    4623 Onondaga Blvd, Syracuse, NY 13219

    Contact for pricing
    6,000 sqft

    Single-story office space on Syracuse’s West Side with separate front entrances, ample parking, and restrooms in contiguous suites.

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    Two-Story Medical Office Building
    Two-Story Medical Office Building

    2800 CT ST, Syracuse, NY 13208

    Contact for pricing
    4,538 sqft

    Vacant medical office property with separate upper- and lower-level layouts for healthcare and professional office operations.

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    One-Story Medical Office Building
    One-Story Medical Office Building

    5792 Widewaters Parkway, Syracuse, NY 13214

    Contact for pricing
    29,432 sqft

    One-story medical office building with upgraded lobby and suite finishes, offering a vacant move-in-ready space.

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    Freestanding Commercial Building on Erie
    Freestanding Commercial Building on Erie

    1810 Erie Blvd E, Syracuse, NY 13210

    Contact for pricing
    4,200 sqft

    4,200 SF commercial building on Erie Blvd available for sale.

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    Medical Office Investment Building
    Medical Office Investment Building

    2910 Court St, Syracuse, NY 13208

    Contact for pricing

    Multi-tenant medical office building leased to a medical tenant with 13 years remaining on a 15-year term.

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    Renovated Downtown Office Building
    Renovated Downtown Office Building

    423 James Street, Syracuse, NY 13203

    Contact for pricing

    Partially renovated office building suited for medical office or law firm use in downtown Syracuse.

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    ADA-Accessible Medical Office Building
    ADA-Accessible Medical Office Building

    5232 Witz Dr, N Syracuse, NY 13212

    Contact for pricing
    22,867 sqft

    Well-maintained two-story medical office building with basement, elevator, and ample onsite parking.

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    Multi-Tenant Office Building For Sale
    Multi-Tenant Office Building For Sale

    716 James St, Syracuse, NY 13203

    Contact for pricing
    15,200 sqft

    Stand-alone office building with ample parking and convenient access.

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    Based on your search, we've compiled 50 Potential Opportunities for your consideration. Besides 12 Active listings in Syracuse, NY, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 33 Off-Market properties to explore as potential leads, plus 1 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Free-Standing Medical Office Building
    Free-Standing Medical Office Building

    5844 Widewaters Pkwy, East Syracuse, NY 13057

    Contact for pricing
    3,812 sqft

    Free-standing 3,812 SF single-user medical office building with immediate access to key East Syracuse roadways.

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    Modern Class A Office Building
    Modern Class A Office Building

    5062 Brittonfield Pkwy, East Syracuse, NY

    Contact for pricing
    40,625 sqft 4.81 AC lot

    40,625 SF office building ideal for medical or conventional use.

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    Medical Office Suite with Exam Rooms
    Medical Office Suite with Exam Rooms

    4000 Medical Center Drive, Fayetteville, NY 13066

    Contact for pricing
    1,200 sqft

    Suite includes four exam rooms, two private offices, reception/waiting area, and a private bathroom.

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    Medical Office Building with Elevator
    Medical Office Building with Elevator

    7085 E Genesee Street, Fayetteville, NY 13066

    Contact for pricing

    Well-maintained medical office building includes an elevator, ample parking, and multiple exam rooms.

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    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Land with Commercial Zoning Frontage
    Commercial Land with Commercial Zoning Frontage

    2931-39 State Route 49, West Monroe, NY 13167

    $1,490,000
    8,356 sqft 13.00 AC lot

    13-acre commercial development site zoned RES/COM, featuring a single-family home and multiple flex-style buildings.

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    Off-Market Properties in Syracuse, NY

    Consider similar Off-Market properties in Syracuse, NY. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    5008 Brittany Ln
    MEDICAL CLINIC

    5008 Brittany Ln, Syracuse, NY 13215

    $1,945,000
    Estimated value
    70,668 sqft 5.35 AC lot
    View details
    504 Delaware St Sabine St
    MEDICAL CLINIC

    504 Delaware St Sabine St, Syracuse, NY 13204

    $270,000
    Estimated value
    11,016 sqft 0.36 AC lot
    View details
    190 Intrepid Ln
    MEDICAL CLINIC

    190 Intrepid Ln, Syracuse, NY 13205-2545

    $4,055,000
    Estimated value
    16,624 sqft 1.40 AC lot
    View details
    161 Intrepid Ln
    MEDICAL CLINIC

    161 Intrepid Ln, Syracuse, NY 13205-2548

    $305,000
    Estimated value
    6,000 sqft 0.66 AC lot
    View details
    6227 Thompson Rd
    MEDICAL CLINIC

    6227 Thompson Rd, Syracuse, NY 13206-1405

    $335,000
    Estimated value
    3,600 sqft 1.01 AC lot
    View details
    813 Fay Rd
    MEDICAL CLINIC

    813 Fay Rd, Syracuse, NY 13219-3009

    $1,605,000
    Estimated value
    58,012 sqft 21.64 AC lot
    View details
    973 James St To Highland Ave
    MEDICAL CLINIC

    973 James St To Highland Ave, Syracuse, NY 13203

    $1,185,000
    Estimated value
    53,509 sqft 2.39 AC lot
    View details
    2112 Erie E Blvd
    MEDICAL CLINIC

    2112 Erie E Blvd, Syracuse, NY 13224-1041

    $435,000
    Estimated value
    15,511 sqft 1.14 AC lot
    View details
    5823 Widewaters Pkwy
    MEDICAL CLINIC

    5823 Widewaters Pkwy, Syracuse, NY 13214

    $1,140,000
    Estimated value
    64,476 sqft 7.00 AC lot
    View details
    626-72 Salina S To Clinton St
    MEDICAL CLINIC

    626-72 Salina S To Clinton St, Syracuse, NY 13202

    $1,185,000
    Estimated value
    79,763 sqft 2.59 AC lot
    View details
    228 Lafayette Rd
    MEDICAL CLINIC

    228 Lafayette Rd, Syracuse, NY 13205-2921

    $405,000
    Estimated value
    11,388 sqft 2.59 AC lot
    View details
    5792 Widewaters Pkwy
    MEDICAL CLINIC

    5792 Widewaters Pkwy, Syracuse, NY 13214-1847

    $420,000
    Estimated value
    15,128 sqft 5.13 AC lot
    View details

    Syracuse, NY Medical Office Space Market Trends and Statistics

    Explore 45 medical office space for sale in Syracuse, NY, showcased through 12 active listings on our real estate platform. These investment opportunities span a total of 97,725 square feet of properties for sale, with an estimated market value of $1,349,900.

    Sale prices for medical spaces in Syracuse, NY start at $400,000, averaging $449,966, and reaching up to $549,900 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Office Units 98
    Office buildings 60
    Medical Office Space 25
    Creative space 6
    Coworking space 2

    Demographics Overview

    Population 229K
    Population Growth (5Y) -0.9%
    Median Household Income $59,936
    College Educated 33.4%

    High-Yield Neighborhoods for Investment

    Identify Syracuse submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    13212 $499.9K

    Taxes & Financing

    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Onondaga County

    New Delisted

    Total CRE Inventory on Market (SF)

    Average Property Price per SF

    For-sale pricing trends across core commercial property types in Onondaga County

    Office

    Residential Income

    Property Size Breakdown

    The majority of commercial real estate listings in Syracuse fall within the 100,000+ square foot range.

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    Browse Medical Office Space for Sale Near Syracuse, NY

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    Most Searched ZIP Codes in Syracuse, NY

    • 13212
    • 13203
    • 13208
    • 13210
    • 13214
    • 13219

    Featured Syracuse Real Estate Agencies

    Realmo connects you with licensed Syracuse CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    SUTTON REAL ESTATE COMPANY LLC
    525 PLUM ST STE 100 Syracuse, NY
    Phone: 13154241111
    CBRE Syracuse
    Syracuse, NY 13204
    www.cbre.us/people-and-offices/affiliate-offices/syracuse
    Pemco Group,Inc.
    Syracuse, NY 13206
    pemcogroup.com/

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