North Syracuse, NY Office Spaces for Rent & Lease

Updated: Aug 10

Retail Space with Central Air

4455A E Genesee Street, Syracuse, NY 13214

$1,300/Mo

14,760 sqft 0.86 AC lot

14,760‑square‑foot retail property on a 0.86‑acre parcel
Multiple listed use options, including retail, office, service, gallery, studio, and take‑out food service
Central air conditioning and natural gas forced‑air heating
Public water and public sewer
Built in 1963 with a flat roof

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Updated: Aug 11

Mixed-Use Building with Diner

3604 Court Street, Syracuse, NY 13206

Contact for pricing

5,351 sqft 0.41 AC lot

5,351‑square‑foot mixed‑use building on 0.408 acres
Operational diner with a month‑to‑month lease
Auto mechanic garage currently vacant
One‑bedroom apartment included in the building
C2 zoning with public sewer

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Furnished Office Units with Parking

580 South Salina Street, Syracuse, NY 13202

Modified gross

$11.67-$14 SF/Yr

14–24 people 3,600 sqft

Highway access MX-5

CBD-zoned office premises with optional furniture, basement storage, and exterior signage opportunities.

4.7/1,000 SF parking Furnished Exterior signage opportunities Free on-site parking

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Creative Space With Roof Access

308 W Genesee St, Syracuse, NY 13202

$10,000/Mo

44–74 people 11,220 sqft Built 1930 Floor 2

Second-floor shell space offers large windows, flexible build-out potential, and access to a rooftop outdoor area.

Roof access

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Medical Office Space Available

792 North Main Street, North Syracuse, NY 13212

$18.50 SF/Yr

5,126 sqft

5,126 SF medical office suite for lease.

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Iconic Mixed-Use State Tower

109 South Warren Street, Syracuse, NY 13202

$18.50 SF/Yr

23,201 sqft

Mixed-use property with office, residential, and retail spaces available.

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Corner Office Unit

447 East Washington Street, Syracuse, NY 13202

$2,750/Mo

Built 1950 Floor 1

Public transit

Ground-level commercial space combines an adaptable open area with separate private and public restrooms.

Private restroom facilities Public restroom facilities

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Medical Office Suite with Exam Rooms

3400 Vickery Road, Syracuse, NY 13212

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Multi-tenant 4,196 sqft

Suite C offers a mix of open space, private offices, and exam rooms for healthcare use.

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Office Units

2500 Brewerton Rd, Syracuse, NY 13211

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14–24 people 1 space 3,600 sqft

Highway access

Office space is available for lease at the Brewerton Road address.

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Medical-Convertible Office Suite

6567 Kinne Rd, Syracuse, NY 13214

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33–56 people 8,400 sqft

Office space with multiple offices, conference rooms, and private bathrooms, supported by shared-building water for possible medical use.

40 parking spaces Conference rooms Private bathrooms

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Office Suite with Large Window Lines

2804-2806 Court St, Syracuse, NY 13208

Modified gross

Contact for pricing

4–8 people 1 space 1,225 sqft Floor 1

Highway access

First-floor office space for lease with strong natural light and window lines in a two-floor layout.

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Syracuse Flex Space For Rent

4601 Nixon Park Drive, Syracuse, NY

$5.25 SF/Yr

62,000 sqft

Flex/industrial/office space near Route 175, Syracuse, NY.

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Class A Suburban Office Park

200 Salina Meadows Pkwy, Syracuse, NY

$18 SF/Yr

178–298 people 44,730 sqft

Class A office space for rent in Syracuse, New York.

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Office Building with Fenced Yard

2030 Erie Blvd East, Syracuse, NY 13224

$4,000/Mo

Built 1960

Commercial zoning, on-site camera surveillance, and dedicated parking complement the office property.

Fenced-in yard Security cameras

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Office Units Near Interstate Access

1045 James St, Syracuse, NY 13203

Contact for pricing

14–24 people 3,600 sqft

Highway access + Road access

Office space is positioned near restaurants, retail shops, banks, and hotels.

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Downtown Syracuse Office Building

716 James Street, Syracuse, NY 13203

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60–100 people 15,000 sqft

15,163 SF office building in downtown Syracuse for lease.

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First-Floor Office Suite

2804 Court Street, Syracuse, NY 13206

$12 SF/Yr

Highway access

First-level office space with a private restroom and multiple offices, featuring windows in nearly every room.

Private restroom

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Class A Office Suite

6702 Buckley Rd, Syracuse, NY 13212

Modified gross Class A

Contact for pricing

7–11 people 1 space 1,760 sqft Built 2011

Highway access

Well-maintained, newly built-out office suite with perimeter offices, waiting/reception, break room, and double conference room.

Double conference room Waiting/reception area Break room

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Flex Warehouse with Office

209 Factory Ave, Syracuse, NY 13208

Contact for pricing

6,615 sqft

Flex facility includes 3,200 SF of Class A office space and 3,415 SF warehouse with two automatic overhead doors.

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Renovated Office Space For Lease

207 Pine St, Syracuse, NY 13210

$1,250/Mo

Built 1989 0.75 acres

Recently renovated office space available for lease in convenient location.

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Office Building with Large Yard

6331 E Molloy Rd, Dewitt, NY 13057

$3,376/Mo

Built 1989 1.1 acres

5,064 SF office building with yard for rent.

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Class A Office Space Available

500 Plum Street, Syracuse, NY 13204

$20 SF/Yr

28–47 people 7,054 sqft

Prestigious office building in historic Franklin Square, Syracuse.

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Turnkey Medical Office Space Available

127-29 Seeley Rd, Syracuse, NY 13224

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3,000 sqft Built 1964

Professionally renovated medical office with suites, kitchen, and ample parking.

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Four-Story Brick Mixed-Use Building

329 West Fayette Street, Syracuse, NY 13202

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31,000 sqft building Built 1888 4-story brick

Office and retail space is arranged across four floors, with elevator service and gated on-site parking.

Elevator Heating Air conditioning

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North Syracuse, NY Office Spaces Lease Rates & Market Statistics

Browse 52 Office Spaces for lease in North Syracuse, NY on Realmo, a commercial real estate marketplace serving the North Syracuse area. The current inventory totals 399,398 square feet of properties — an average of ~7,700 SF per listing.

Office Spaces lease rates in North Syracuse range from $1.06 SF/Yr at the entry level to $20 SF/Yr at the top of the market, averaging $13.81 SF/Yr. That's a 19x spread between entry-level and premium space, making side-by-side comparison of asking rents and lease terms essential. The local average of $13.81 SF/Yr is 56% below the New York state average of $31.56 SF/Yr.

North Syracuse accounts for 53% of the 98 office spaces currently available across Onondaga County, where nearby markets include Syracuse and Liverpool. By space type, the market includes 36 office units, 14 office buildings and 6 medical office space listings — office units typically offer the lowest entry point, while office buildings command the highest rates.