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    Cape Girardeau, MO Office Properties & Spaces for Lease

    12 results
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    Cape Girardeau Office Space Available
    Pending
    $5,500 / Mo
    7,000 SF

    Cape Girardeau Office Space Available

    340 S Broadview St, Cape Girardeau, MO 63703

    Well-maintained commercial property with ample space in a convenient location.

    • Over 7,000 square feet of usable space suitable for professional or medical use.
    • Highly visible and convenient location.
    • Ample on‑site parking for staff and visitors.
    • Two elevators for accessibility.
    • ADA compliance throughout the building.
    Updated: Dec 1, 2025
    View details
    Office Suite in Cape Girardeau
    $5,641 / Mo
    6,770 SF

    Office Suite in Cape Girardeau

    450 Siemers Dr, Cape Girardeau, MO 63701

    Office suite with high visibility and traffic in Cape Girardeau.

    • Turn‑key ready office suite
    • High visibility and high traffic location
    • Highway/Interstate frontage
    • Heating: Forced Air, Natural Gas, Solar
    • Cooling: Central Air, Electric
    Updated: Nov 14, 2025
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    Renovated Commercial Space For Lease
    $2,500 / Mo
    2,937 SF

    Renovated Commercial Space For Lease

    Renovated commercial space with high visibility in a prime location.

    230 N Sprigg St, Cape Girardeau, MO 63701
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    600 SF Commercial Storage Space
    $400 / Mo

    600 SF Commercial Storage Space

    Commercial space ideal for off-site storage with drive-in door.

    2222 Kings Way Dr, Cape Girardeau, MO 63701
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    Remodeled Office Space with Amenities
    $850 / Mo

    Remodeled Office Space with Amenities

    Centrally located office space with modern finishes and included amenities.

    1427 Thomas Dr, Cape Girardeau, MO 63701
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    Historic Art Deco Landmark Space
    $2,900 / Mo

    Historic Art Deco Landmark Space

    Restored historic building in downtown Cape Girardeau's commercial district.

    824 Broadway St, Cape Girardeau, MO 63701
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    Remodeled Office Space with Amenities
    $850 / Mo

    Remodeled Office Space with Amenities

    Centrally located office space with modern finishes and included amenities.

    1427 Thomas Dr, Cape Girardeau, MO 63701
    View details
    Downtown Office Building For Lease
    $8,558 / Mo

    Downtown Office Building For Lease

    13,694 SF office building in historic downtown Cape Girardeau.

    18 N Main St, Cape Girardeau, MO 63701
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    Professional Office Building For Rent
    $1,100 / Mo

    Professional Office Building For Rent

    1,218 SF professional office building in good location.

    720 Forest Ave, Cape Girardeau, MO 63701
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    Prime Retail/Office Space Available
    Contact for pricing

    Prime Retail/Office Space Available

    New 2,300 SF space ideal for retail or office.

    3465 William St, Cape Girardeau, MO 63703
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    West Park Mall Medical Office Space
    Contact for pricing
    79,122 SF

    West Park Mall Medical Office Space

    Missouri medical office suites for lease

    3049 William St, Cape Girardeau, MO 63703
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    HubCo Coworking Office Space
    $36 SF/Yr
    8,200 SF

    HubCo Coworking Office Space

    Modern Cape Girardeau Office Suites

    1427 Thomas Dr, Cape Girardeau, MO 63701
    View details
    Based on your search, we've compiled 33 Potential Opportunities for your consideration. Besides 12 Active listings in Cape Girardeau, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 17 Properties for Sales.

    Explore Office properties & Spaces for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Anna Commercial Flex Space
    $13 SF/Yr
    2,900 SF

    Anna Commercial Flex Space

    Prime Anna location, 2,900 sq ft.

    1000 Leigh Ave, Anna, IL 62906
    View details
    Commercial Office Space in Anna, IL
    Contact for pricing

    Commercial Office Space in Anna, IL

    Office space available in the Wal-Mart Plaza area.

    1000 Leigh Ave, Anna, IL 62906
    View details
    Professional Space Near Main Intersection
    $1,000 / Mo

    Professional Space Near Main Intersection

    Prime location, high visibility, and flexible floor plan.

    1226 Linn St, Sikeston, MO 63801
    View details
    Professional Space Near Main Intersection
    $2,000 / Mo

    Professional Space Near Main Intersection

    Prime location, high visibility, and flexible floor plan.

    1226 Linn St, Sikeston, MO 63801
    View details

    Explore Similar Spaces for Sale in Cape Girardeau, MO

    Consider Similar Space for Sale. We found 17 Spaces in Nearby Locations matching your search parameters.

    Versatile Riverfront Commercial Property
    Pending
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main St, Cape Girardeau, MO 63701
    View details
    Versatile Commercial Property For Sale
    $295,000
    2,920 SF

    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Ave, Cape Girardeau, MO 63701
    View details
    Cape Girardeau Commercial Property
    Pending
    $825,000
    7,000 SF

    Cape Girardeau Commercial Property

    Well-maintained commercial property with over 7,000 square feet.

    340 S Broadview St, Cape Girardeau, MO 63703
    View details
    Versatile Commercial Building in Cape
    $225,000
    0.57 Acres

    Versatile Commercial Building in Cape

    Adaptable 1800 sq ft commercial building in thriving Cape Girardeau.

    2357 Rust Ave, Cape Girardeau, MO 63703
    View details
    Cape Girardeau Mixed-Use Investment
    $489,900
    7,282 SF

    Cape Girardeau Mixed-Use Investment

    Leased commercial spaces with residential unit for income growth.

    1606 Independence St, Cape Girardeau, MO 63703
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    Renovated Downtown Commercial Property
    $500,000
    4,548 SF

    Renovated Downtown Commercial Property

    Versatile 11-bedroom property in downtown Cape Girardeau.

    224 N Frederick St, Cape Girardeau, MO 63701
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    Leased Office Building For Sale
    $500,000
    7,140 SF

    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Dr, Cape Girardeau, MO 63701
    View details
    Renovated Commercial Space in Cape Girardeau
    $239,900
    2,937 SF

    Renovated Commercial Space in Cape Girardeau

    Renovated commercial space with high potential in a prime location.

    230 N Sprigg St, Cape Girardeau, MO 63701
    View details
    Cape Girardeau Industrial Building For Sale
    Contact for pricing

    Cape Girardeau Industrial Building For Sale

    10,000 SF industrial building with office and warehouse space.

    2109 Rust Ave, Cape Girardeau, MO 63703
    View details
    Prime Location Office Suites
    Contact for pricing

    Prime Location Office Suites

    Excellent visibility office suites near I-55 and Highway 74.

    440 S Mount Auburn Rd, Cape Girardeau, MO 63703
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    Retail/Office Space Near I-55
    Contact for pricing

    Retail/Office Space Near I-55

    Prime location near I-55 and West Park Mall.

    3065 William St, Cape Girardeau, MO 63703
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    Cape Girardeau Commercial Space Available
    Contact for pricing

    Cape Girardeau Commercial Space Available

    Flexible commercial space for office, retail, or service businesses.

    151 S Mount Auburn Rd, Cape Girardeau, MO 63703
    View details

    Cape Girardeau, MO Office properties & Spaces Leasing Opportunities Market Analysis

    Explore Office properties & Spaces leasing options in Cape Girardeau, MO with 29 listings featured on our commercial real estate exchange. The current inventory includes 1,084,948,920 square feet of properties with an estimated lease value of $65 SF/Yr.

    Estimated lease rates for Office properties & Spaces in Cape Girardeau, MO begin at $9 SF/Yr, with an average of $16 SF/Yr and extend to $36 SF/Yr.
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    Most Searched ZIP Codes in Cape Girardeau, MO

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