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    Cape Girardeau, MO

    Cape Girardeau, MO Commercial Real Estate for Lease

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    Scott City, MO Jackson, MO
    52 properties
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    Renovated Downtown Storefront Property
    Updated: Jul 11
    Renovated Downtown Storefront Property

    230 N Sprigg Street, Cape Girardeau, MO 63701

    $2,500/Mo
    2,937 sqft 0.25 AC lot
    2937 square feet of renovated commercial space
    Renovations include A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, siding, and tuckpointing
    Brick construction with a flat roof
    Forced‑air heating and central air with electric cooling
    Open parking lot and road frontage on N Sprigg Street
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    Office Units with Highway Frontage
    Updated: Nov 14, 2025
    Office Units with Highway Frontage

    450 Siemers Drive, Cape Girardeau, MO 63701

    $5,642/Mo
    6,770 sqft
    6,770 square feet of office space
    Built in 1991
    Business park setting with highway and interstate frontage
    Central air conditioning with electric, natural gas, and forced‑air heating
    Driveway parking available
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    Second-Floor Office Suite
    Second-Floor Office Suite

    2027 Broadway Street, Cape Girardeau, MO 63701

    $1,958/Mo
    2.70 AC lot

    Updated second-floor suite with seven private offices, open work area, and secure 24/7 badge access.

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    Retail Building with Drive-Through Window
    Retail Building with Drive-Through Window

    5 S Kingshighway, Cape Girardeau, MO 63703

    $8,707/Mo
    3,483 sqft 0.80 AC lot

    Drive-through retail building with off-street paved parking on C2-zoned land, adjacent to major retailers.

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    Flexible Office Unit
    Flexible Office Unit

    1469 N Kingshighway Street, Cape Girardeau, MO 63701

    $1,128/Mo

    Commercial space with a private bathroom and owner-approved build-to-suit options.

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    Retail Space with Salon Layout
    Retail Space with Salon Layout

    1461 N Kingshighway Street, Cape Girardeau, MO 63701

    $2,255/Mo
    0.80 AC lot

    Adaptable commercial suite with reception space, multiple stations, shampoo bowls, and in-unit bathroom facilities.

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    Specialty Commercial Space
    Specialty Commercial Space

    401 S West End Boulevard, Cape Girardeau, MO 63703

    $1,250/Mo
    0.15 AC lot

    Specialty property available for lease at 401 S West End Boulevard in Cape Girardeau, MO 63703.

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    Sprinklered Storefront Space
    Sprinklered Storefront Space

    731 Broadway St, Cape Girardeau, MO 63701

    $3,000/Mo
    4,500 sqft

    Flexible commercial layout with full sprinkler protection and multiple restrooms.

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    Office Unit with Private Offices
    Office Unit with Private Offices

    C-1020 N Kingshighway Street, Cape Girardeau, MO 63701

    $1,200/Mo
    1,050 sqft

    Flexible suite layout includes reception, open workspace, break room, and private restroom.

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    Retail Suite with Pylon Signage
    Retail Suite with Pylon Signage

    3065 William St Unit 305, Cape Girardeau, MO 63703

    $1,190/Mo
    976 sqft

    Flexible commercial suite with on-site signage and access to nearby retail, office, hospitality, and dining uses.

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    Office Suite with Private Offices
    Office Suite with Private Offices

    1020 N. Kingshighway, Suite C, Cape Girardeau, MO 63701

    $1,200/Mo
    1,050 sqft

    Flexible commercial suite with reception, work areas, natural light, parking, and signage options for office or service-oriented use.

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    Flexible Restaurant/Retail/Office Suite
    Flexible Restaurant/Retail/Office Suite

    820 N Sprigg St - Suites 3-4, Cape Girardeau, MO 63701

    $18 SF/Yr
    3,000 sqft

    Versatile suites with existing restaurant infrastructure, positioned across from Towers Hall for high student traffic.

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    Flexible Office Units with Private Entrances
    Flexible Office Units with Private Entrances

    106 Farrar Drive, Cape Girardeau, MO 63703

    $2,500/Mo
    2,580 sqft

    Adaptable office suites offer open workspace, private offices, and a dedicated breakroom.

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    Executive Office Suite
    Executive Office Suite

    2a-301 Broadway St, Cape Girardeau, MO 63701

    $5,633/Mo
    2,600 sqft

    Second-floor workspace with private offices, reception, breakroom, and two restrooms.

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    Storefront Retail Space
    Storefront Retail Space

    1606 Independence St, Cape Girardeau, MO 63703

    $975/Mo
    875 sqft

    Flexible commercial suite with an open layout, natural light, storefront exposure, and a private restroom.

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    Versatile Commercial Space on Kingshighway
    Versatile Commercial Space on Kingshighway

    500 N Kingshighway St, Cape Girardeau, MO 63701

    $3,650/Mo
    3,500 sqft

    3,500 SF commercial property suitable for retail, office, or service.

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    Second-Floor Office Suite
    Second-Floor Office Suite

    2b-301 Broadway St, Cape Girardeau, MO 63701

    $2,600/Mo
    1,250 sqft

    Second-floor office suite with reception, private office, conference space, and an open area for flexible work setups.

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    Downtown Office Building For Lease
    Downtown Office Building For Lease

    18 N. Main, Cape Girardeau, MO 63701

    $8,558/Mo
    13,694 sqft

    13,694 SF office building in historic downtown Cape Girardeau.

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    Retail Suite with Parking
    Retail Suite with Parking

    2500 William St, Cape Girardeau, MO 63703

    $1,650/Mo
    1,400 sqft

    Suite 2534 offers 1,400 SF in a tenant-mixed center with off-street parking and signage opportunities.

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    Flex Warehouse with Office
    Flex Warehouse with Office

    2285 Sacajawea Lane, Cape Girardeau, MO 63701

    $3,250/Mo
    4,576 sqft

    Flex facility features heated warehouse/shop space, office buildout, mezzanine, and four drive-in overhead doors.

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    Mixed-Use Commercial Space Available
    Mixed-Use Commercial Space Available

    2117 Broadway St. Suite B, Cape Girardeau, MO 63701

    $1,900/Mo
    2,400 sqft

    Versatile storefront and warehouse space in downtown Cape Girardeau.

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    Corner Executive Office Unit
    Corner Executive Office Unit

    301 Broadway St, Cape Girardeau, MO 63701

    $26 SF/Yr
    2,600 sqft

    Second-floor corner suite with private offices, reception, breakroom, and two restrooms.

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    Retail Space Near Interstate Exit
    Retail Space Near Interstate Exit

    102-3465 William St, Cape Girardeau, MO 63703

    $4,791/Mo
    2,300 sqft

    Commercial lease space with a customizable layout for multiple uses near Route K.

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    Remodeled Office Space with Amenities
    Remodeled Office Space with Amenities

    1427 Thomas Dr, Cape Girardeau, MO 63701

    $850/Mo per office
    275 sqft

    Centrally located office space with modern finishes and included amenities.

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    Cape Girardeau, MO Commercial real estate Market Trends and Statistics

    Explore Commercial real estate leasing options in Cape Girardeau, MO with 52 listings featured on our commercial real estate exchange. The current inventory includes 184,435 square feet of properties with an estimated lease value of $329.47.

    Estimated lease rates for Commercial real estate in Cape Girardeau, MO begin at $6 SF/Yr, with an average of $14.32 SF/Yr and extend to $30 SF/Yr.
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    Most Searched ZIP Codes in Cape Girardeau, MO

    • 63701
    • 63703

    Featured Cape Girardeau Real Estate Agencies

    Realmo connects you with licensed Cape Girardeau CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Edge Realty
    2511 Independence St, Ste 100 Cape Girardeau, MO 63703
    Phone: 15733358111
    www.capeareahomes.com

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