Cape Girardeau, MO Commercial real estate for Rent & Lease

Updated: Nov 14, 2025

Turn-Key Office Suite

450 Siemers Drive, Cape Girardeau, MO 63701

$5,642/Mo

6,770 sqft

Office suite with solar heating, forced air heating, and natural gas
Central air and electric cooling
Driveway parking
Year built 1991
Utilities include cable available; served by public water and public sewer

View details

Updated: Jul 1, 2025

Renovated Office Building with Road Frontage

230 N Sprigg Street, Cape Girardeau, MO 63701

$2,500/Mo

2,937 sqft

Massive building with brick construction and flat roof
Offered for sale or lease with road frontage on N Sprigg St
Almost 3,000 sq ft of renovated space
BRAND NEW A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, siding, and newly tuckpointed
Utilities include public water and public sewer; forced air heating

View details

Specialty Commercial Space

401 S West End Boulevard, Cape Girardeau, MO 63703

$1,250/Mo

Specialty property available for lease at 401 S West End Boulevard in Cape Girardeau, MO 63703.

View details

Retail Building with Drive-Through Window

5 S Kingshighway, Cape Girardeau, MO 63703

$8,707/Mo

3,483 sqft

Drive-through retail building with off-street paved parking on C2-zoned land, adjacent to major retailers.

View details

Versatile Commercial Space on Kingshighway

500 N Kingshighway St, Cape Girardeau, MO 63701

$3,650/Mo

3,500 sqft

3,500 SF commercial property suitable for retail, office, or service.

View details

Professional Office Building For Rent

720 Forest Ave, Cape Girardeau, MO 63701

$1,100/Mo

1,218 sqft

1,218 SF professional office building in good location.

View details

Downtown Office Building For Lease

18 N. Main, Cape Girardeau, MO 63701

$8,558/Mo

13,694 sqft

13,694 SF office building in historic downtown Cape Girardeau.

View details

Remodeled Office Space with Amenities

1427 Thomas Dr, Cape Girardeau, MO 63701

$850/Mo

275 sqft

Centrally located office space with modern finishes and included amenities.

View details

Remodeled Office Space with Amenities

1427 Thomas Dr, Cape Girardeau, MO 63701

$850/Mo

279 sqft

Centrally located office space with modern finishes and included amenities.

View details

Mixed-Use Commercial Space Available

2117 Broadway St. Suite B, Cape Girardeau, MO 63701

$1,900/Mo

2,400 sqft

Versatile storefront and warehouse space in downtown Cape Girardeau.

View details

Second-Floor Office Suite

2b-301 Broadway St, Cape Girardeau, MO 63701

$2,600/Mo

1,250 sqft

Second-floor office suite with reception, private office, conference space, and an open area for flexible work setups.

View details

Retail and Office Storefront

211 Merriwether St, Cape Girardeau, MO 63703

$1,000/Mo

1,300 sqft

Flexible 1,300 SF storefront layout with retail frontage and included office spaces, suited for mixed-use operations.

View details

Cape Girardeau Warehouse Space Available

45 N Broadview St - Middle, Cape Girardeau, MO 63701

$3,000/Mo

5,100 sqft

Versatile warehouse space with high ceilings and ample parking.

View details

Versatile Warehouse Space Available

45 N Broadview St - Front, Cape Girardeau, MO 63701

$6,000/Mo

9,600 sqft

9600 sf warehouse with high ceilings, shared loading dock.

View details

Office Space for Lease

2027 Broadway Street, Cape Girardeau, MO 63701

$1,958/Mo

Office space available for lease at 2027 Broadway Street in Cape Girardeau.

View details

Flex Space with Off-Street Parking

213 Clark Street, Cape Girardeau, MO 63701

$1,500/Mo

Flexible 1,172 SF flex space in an M-1 district, suited for day care, office, or professional service use.

View details

New Development Retail Space Available

2510 Veterans Memorial Drive, Cape Girardeau, MO 63701

Contact for pricing

10,000 sqft

Prime lease space with high visibility and build-out allowance.

View details

Prime Retail/Office Space Available

3465 William, Cape Girardeau, MO 63703

Contact for pricing

2,300 sqft

New 2,300 SF space ideal for retail or office.

View details

Restaurant-Ready Office/Retail Suite

820 N Sprigg St, Cape Girardeau, MO 63701

Contact for pricing

3,000 sqft

Suite 1 offers an open layout and existing restaurant infrastructure with street visibility across from Towers Hall.

View details

Retail Storefront with Office Space

221 Merriwether Street, Cape Girardeau, MO 63703

Contact for pricing

1,275 sqft

Downtown retail storefront with office space for rent.

View details

Warehouse with Drive-In Dock

211 N Spring Avenue C, Cape Girardeau, MO 63701

$6 SF/Yr

13,875 sqft

13,875 SF warehouse with office and drive-in dock.

View details

Retail Space in Cape Girardeau

230 N Sprigg Street, Cape Girardeau, MO 63701

$2,500/Mo

2,937 sqft

Retail space available for rent in Cape Girardeau, Missouri.

View details

Office Space with Reception Area

Cape Girardeau, MO 63701

$1,000/Mo

1,200 sqft

Office space featuring reception, offices, kitchen, and bathroom.

View details

Prime Commercial Land For Lease

2148 William St, Cape Girardeau, MO

Contact for pricing

0.47 acre commercial land for lease in Cape Girardeau.

View details