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    Cape Girardeau, MO Commercial Real Estate for Sale

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    Mc Clure, IL Scott City, MO Jackson, MO
    66 results
    Warehouse with Showroom and Shop Space
    $700,000
    7,200 SF
    Warehouse with Showroom and Shop Space

    3082 County Road 620, Cape Girardeau, MO 63701

    Purchase a 7,200 SF warehouse with dedicated showroom, shop area, and framed upstairs space for flexible business or storage needs.
    • 7,200 SF warehouse with approx. 2,400 SF finished showroom/retail or office space and 3,600 SF shop area
    • Additional 1,200 SF upstairs area is framed and ready to be finished as living quarters, office space, or storage
    • Two large garage doors for convenient access and workflow
    • Central air and forced‑air heating
    • Metal siding exterior and concrete flooring
    Updated: Jun 5
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    Renovated Mid-Century Office Building
    $1,690,000
    15,831 SF
    Renovated Mid-Century Office Building

    429 N Broadview Street, Cape Girardeau, MO 63701

    Renovated 1960s office building with event space, overhead doors, and gated rear parking for flexible operations.
    • Mid‑century modern commercial building originally constructed for the Teamsters in 1962
    • Approximately 10,000 SF on the main level with private offices, conference rooms, and an executive office with private bathroom
    • Event and gathering space with a full bar and projection screen for meetings, presentations, and training
    • Concrete and steel frame construction with brick exterior and forced air heat plus central air
    • 4 overhead doors, 8 indoor parking spaces, and 55+ exterior parking spaces
    Updated: Jun 5
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    Updated Office Building For Sale
    $350,000
    4,000 SF
    Updated Office Building For Sale

    Well-maintained office building with high visibility and ample parking.

    824 Independence Street, Cape Girardeau, MO 63703

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    Versatile Riverfront Commercial Property
    $400,000
    4,400 SF
    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main Street, Cape Girardeau, MO 63701

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    Renovated Commercial Building in Cape Girardeau
    $239,900
    2,937 SF
    Renovated Commercial Building in Cape Girardeau

    Renovated commercial building with high visibility in a prime location.

    230 N Sprigg Street, Cape Girardeau, MO 63701

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    Versatile Commercial Space in Cape Girardeau
    $825,000
    0.17 Acres
    Versatile Commercial Space in Cape Girardeau

    Well-designed commercial space with banquet, dining, and bar areas.

    20 N Spanish Street, Cape Girardeau, MO 63701

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    Versatile Riverfront Commercial Property
    $475,000
    7,044 SF
    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main Street, Cape Girardeau, MO 63701

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    Versatile Commercial Building in Missouri
    $199,900
    0.57 Acres
    Versatile Commercial Building in Missouri

    Adaptable 1800 sq ft commercial building in Cape Girardeau.

    2357 Rust Avenue, Cape Girardeau, MO 63703

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    Flex Space Property with Heated Shop
    $999,900
    4,000 SF
    Flex Space Property with Heated Shop

    All-brick home with a heated three-bay workshop, apartment above, and additional bar and seating area for flexible use.

    241 County Road 226, Cape Girardeau, MO 63701

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    Versatile Commercial Property For Sale
    $295,000
    2,920 SF
    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Avenue, Cape Girardeau, MO 63701

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    Leased Office Building For Sale
    $500,000
    7,140 SF
    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Drive, Cape Girardeau, MO 63701

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    Industrial Warehouse on 3.9 Acres
    $489,900
    3.90 Acres
    Industrial Warehouse on 3.9 Acres

    Industrial warehouse for sale in Cape Girardeau, Missouri.

    840 S Kingshighway, Cape Girardeau, MO 63703

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    Downtown Cape Girardeau Commercial Lot
    $450,000
    1.04 Acres
    Downtown Cape Girardeau Commercial Lot

    Prime commercial lot near casino, ideal for development.

    0 N Main Street, Cape Girardeau, MO 63701

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    Commercial Lot in High Growth Area
    $629,000
    3.00 Acres
    Commercial Lot in High Growth Area

    3-acre commercial lot in a high-growth area.

    367 S Broadview Street, Cape Girardeau, MO 63703

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    Broadway Commercial Opportunity
    $1,200,000
    0.36 Acres
    Broadway Commercial Opportunity

    Commercial property on Broadway with high visibility and accessibility.

    632 Broadway Street, Cape Girardeau, MO 63701

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    Broadway Commercial Space with Apartment
    $280,000
    2,900 SF
    Broadway Commercial Space with Apartment

    Versatile commercial space with remodeled apartment in prime location.

    520 Broadway Street, Cape Girardeau, MO 63701

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    Ambulatory Surgery Center Investment Opportunity
    $8,050,000
    13,650 SF
    Ambulatory Surgery Center Investment Opportunity

    Single-tenant surgery center near St. Francis Medical Center for sale.

    3241 Percy Drive, Cape Girardeau, MO 63701

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    Two-Level Office Building For Sale
    $815,000
    9,857 SF
    Two-Level Office Building For Sale

    9,857 SF office building with multiple offices and restrooms.

    10 Doctors Park, Cape Girardeau, MO 63703

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    Warehouse/Shop Building on 1.76 Acres
    $352,000
    3,310 SF
    Warehouse/Shop Building on 1.76 Acres

    3,310 SF warehouse/shop building with drive-through doors and ample space.

    5841 County Road 205, Cape Girardeau, MO 63701

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    Downtown Office Building For Sale
    $899,900
    13,694 SF
    Downtown Office Building For Sale

    13,694 SF office building in historic downtown Cape Girardeau.

    18 N. Main, Cape Girardeau, MO 63701

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    Cape Girardeau Commercial Land Opportunity
    $389,000
    10.20 Acres
    Cape Girardeau Commercial Land Opportunity

    7.5-acre commercial lot in prime Cape Girardeau location.

    0 Rear Commercial Street, Cape Girardeau, MO 63703

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    Cape Girardeau Medical Office Building
    $270,000
    2,546 SF
    Cape Girardeau Medical Office Building

    2,546 SF medical office building in a thriving complex.

    62 Doctors Park, Cape Girardeau, MO 63703

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    12.88 Acres Timbered Building Lot
    $322,000
    12.88 Acres
    12.88 Acres Timbered Building Lot

    Unrestricted 12.88+/- acre timbered lot near Cape Girardeau.

    0 Old Sprigg Street Road (Tract# 3), Cape Girardeau, MO 63701

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    Renovated Commercial Building on Sprigg
    $239,900
    2,937 SF
    Renovated Commercial Building on Sprigg

    Renovated commercial space with high visibility and income potential.

    230 N Sprigg Street, Cape Girardeau, MO 63701

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    Cape Girardeau, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 72 commercial real estate for sale in Cape Girardeau, MO, showcased through 66 active listings on our real estate platform. These investment opportunities span a total of 141,285 square feet of properties for sale, with an estimated market value of $25,471,400.

    Sale prices for business properties in Cape Girardeau, MO start at $239,900, averaging $1,061,308, and reaching up to $8,050,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Demographics Overview

    Population 47K
    Population Growth (5Y) +1.2%
    Median Household Income $62,338
    College Educated 29.0%

    High-Yield Neighborhoods for Investment

    Identify Cape Girardeau submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    63703 $330.1K
    63701 $765.6K

    Taxes & Financing

    Tax Rate (average for all types) 5.29%
    Property Tax per SF $93.92 per sq ft
    Average Loan-to-Value 65.0%

    Listings Trend

    Total CRE Area on Market Trend

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