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    Cape Girardeau, MO Commercial Real Estate for Sale

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    Saint Louis, MO Kansas City, MO Louis, MO
    58 results
    Updated Office Building For Sale
    $350,000
    4,000 SF

    Updated Office Building For Sale

    824 Independence Street, Cape Girardeau, MO 63703

    Well-maintained office building with high visibility and ample parking.

    • High daily traffic count on Independence
    • Excellent visibility
    • Ample on‑site parking
    • Well‑maintained and updated office building
    • Suitable for a variety of professional or service‑based businesses
    Updated: Mar 20
    View details
    Versatile Riverfront Commercial Property
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    450 N Main Street, Cape Girardeau, MO 63701

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    • Prime riverfront location directly on the Mississippi River.
    • High visibility and ideal location for downtown development and parking.
    • Versatile property suitable for office, restaurant, warehouse, or mixed‑use concepts.
    • Existing warehouse on the property.
    • Metal siding construction.
    Updated: Mar 12
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    Renovated Commercial Building in Cape Girardeau
    $239,900
    2,937 SF

    Renovated Commercial Building in Cape Girardeau

    Renovated commercial building with high visibility in a prime location.

    230 N Sprigg Street, Cape Girardeau, MO 63701
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    Versatile Commercial Space in Cape Girardeau
    $825,000
    0.17 Acres

    Versatile Commercial Space in Cape Girardeau

    Well-designed commercial space with banquet, dining, and bar areas.

    20 N Spanish Street, Cape Girardeau, MO 63701
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    Versatile Riverfront Commercial Property
    $475,000
    7,044 SF

    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main Street, Cape Girardeau, MO 63701
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    Versatile Commercial Building in Missouri
    $199,900
    0.57 Acres

    Versatile Commercial Building in Missouri

    Adaptable 1800 sq ft commercial building in Cape Girardeau.

    2357 Rust Avenue, Cape Girardeau, MO 63703
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    Versatile Commercial Property For Sale
    $295,000
    2,920 SF

    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Avenue, Cape Girardeau, MO 63701
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    Leased Office Building For Sale
    $500,000
    7,140 SF

    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Drive, Cape Girardeau, MO 63701
    View details
    Renovated 11-Bedroom Income Property
    $450,000
    4,548 SF

    Renovated 11-Bedroom Income Property

    Versatile, renovated 11-bedroom property in downtown Cape Girardeau.

    224 N Frederick Street, Cape Girardeau, MO 63701
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    Industrial Warehouse on 3.9 Acres
    $489,900
    3.90 Acres

    Industrial Warehouse on 3.9 Acres

    Industrial warehouse for sale in Cape Girardeau, Missouri.

    840 S Kingshighway, Cape Girardeau, MO 63703
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    Downtown Cape Girardeau Commercial Lot
    $450,000
    1.04 Acres

    Downtown Cape Girardeau Commercial Lot

    Prime commercial lot near casino, ideal for development.

    0 N Main Street, Cape Girardeau, MO 63701
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    Commercial Lot in High Growth Area
    $629,000
    3.00 Acres

    Commercial Lot in High Growth Area

    3-acre commercial lot in a high-growth area.

    367 S Broadview Street, Cape Girardeau, MO 63703
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    Ambulatory Surgery Center Investment Opportunity
    $8,050,000
    13,650 SF

    Ambulatory Surgery Center Investment Opportunity

    Single-tenant surgery center near St. Francis Medical Center for sale.

    3241 Percy Drive, Cape Girardeau, MO 63701
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    Cape Girardeau Commercial Land Opportunity
    $399,000
    10.20 Acres

    Cape Girardeau Commercial Land Opportunity

    7.5-acre commercial lot in Cape Girardeau, Missouri.

    0 Rear Commercial Street, Cape Girardeau, MO 63703
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    Commercial Condominiums in Historic Building
    $129,900
    4,300 SF

    Commercial Condominiums in Historic Building

    Four commercial condominiums in downtown Cape Girardeau.

    937 Broadway Street, Cape Girardeau, MO 63701
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    Downtown Office Building For Sale
    $899,900
    13,694 SF

    Downtown Office Building For Sale

    13,694 SF office building in historic downtown Cape Girardeau.

    18 N. Main, Cape Girardeau, MO 63701
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    Two-Level Office Building For Sale
    $815,000
    9,857 SF

    Two-Level Office Building For Sale

    9,857 SF office building with multiple offices and restrooms.

    10 Doctors Park, Cape Girardeau, MO 63703
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    Broadway Commercial Space with Apartment
    $280,000
    5,100 SF

    Broadway Commercial Space with Apartment

    Versatile investment opportunity with remodeled apartment and commercial space.

    520 Broadway Street, Cape Girardeau, MO 63701
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    Renovated Commercial Building on Sprigg
    $239,900
    2,937 SF

    Renovated Commercial Building on Sprigg

    Renovated commercial space with high visibility and income potential.

    230 N Sprigg Street, Cape Girardeau, MO 63701
    View details
    Historic Bar and Office Space
    $499,900
    4,630 SF

    Historic Bar and Office Space

    Downtown Cape Girardeau property featured in the movie Gone Girl.

    117 Themis Street, Cape Girardeau, MO 63701
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    Warehouse/Shop Building on 1.76 Acres
    $352,000
    3,310 SF

    Warehouse/Shop Building on 1.76 Acres

    3,310 SF warehouse/shop building with drive-through doors and ample space.

    5841 County Road 205, Cape Girardeau, MO 63701
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    Prime Retail Space in Cape
    Contact for pricing
    4,500 SF

    Prime Retail Space in Cape

    4,500 SF retail space in historic downtown Cape Girardeau.

    731 Broadway St, Cape Girardeau, MO 63701
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    Downtown Cape Girardeau Office/Flex Space
    Contact for pricing
    5,225 SF

    Downtown Cape Girardeau Office/Flex Space

    5,225 SF office/flex space in downtown Cape Girardeau.

    122 S. Spanish St., Cape Girardeau, MO 63701
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    Cape Girardeau Medical Office Building
    $270,000
    2,546 SF

    Cape Girardeau Medical Office Building

    2,546 SF medical office building in a thriving complex.

    62 Doctors Park, Cape Girardeau, MO 63703
    View details

    Cape Girardeau, MO Commercial Real Estate Investment Opportunities Market Analysis

    Explore 1573 commercial real estate for sale in Cape Girardeau, MO, showcased through 58 active listings on our real estate platform. These investment opportunities span a total of 8,086,304 square feet of properties for sale, with an estimated market value of $16,507,700.

    Sale prices for business properties in Cape Girardeau, MO start at $75,000, averaging $971,041, and reaching up to $8,050,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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