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    Cape Girardeau, MO Commercial Real Estate for Sale

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    85 properties
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    Single-Tenant Medical Center
    Updated: Sep 14
    Single-Tenant Medical Center

    3241 Percy Drive, Cape Girardeau, MO 63701

    $8,050,000
    13,650 sqft 2.71 AC lot
    13,650 sq. ft. ambulatory surgery center on 2.708 acres
    Single‑tenant medical facility built in 2002
    Directly across from St. Francis Medical Center
    Two years remaining on current lease with 2% annual rental increases
    New state‑of‑the‑art HVAC system
    View details
    Mixed-Use Property with Bar & Grill
    Updated: Oct 9
    Mixed-Use Property with Bar & Grill

    10 S Spanish Street, Cape Girardeau, MO 63703

    $2,500,000
    0.65 AC lot
    Five properties included at 10 S Spanish St and 109, 115, 117, and 119 Independence St
    Combined property area of 0.647 acres
    Operating Library Bar & Grill included with the real estate
    Furnished 3‑bedroom, 2‑bath apartment currently occupied by extended‑stay tenants
    Two vacant commercial suites
    View details
    Renovated Mid-Century Office Building
    Renovated Mid-Century Office Building

    429 N Broadview Street, Cape Girardeau, MO 63701

    $1,690,000
    1.37 AC lot

    Updated workspace includes private offices, meeting rooms, shared work areas, and an event room with bar and projection screen.

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    See hot listings in Cape Girardeau

    Scored against comparables nationwide. These are worth a look.

    Scored against comparables nationwide. These are worth a look.

    Cap Rate available after sign in
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    Two-Storefront Retail Building
    Two-Storefront Retail Building

    26 North Spanish Street, Cape Girardeau, MO 63701

    $975,000
    10,850 sqft

    A 1.5-story layout in the CBD includes upper-floor space and a partial basement.

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    Equipped Sports Bar Property
    Equipped Sports Bar Property

    26 N Main Street, Cape Girardeau, MO 63701

    $750,000
    0.20 AC lot

    Sale includes the building, bar business, commercial kitchen, and entertainment equipment.

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    Renovated Office Building
    Renovated Office Building

    230 N Sprigg Street, Cape Girardeau, MO 63701

    $239,900
    2,937 sqft 0.25 AC lot

    Brick commercial property with central air, public utilities, and open-lot parking near downtown activity.

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    Restaurant Building with Banquet Space
    Restaurant Building with Banquet Space

    20 N Spanish Street, Cape Girardeau, MO 63701

    $799,000
    0.17 AC lot

    Versatile restaurant layout includes dining, banquet, bar, kitchen, and covered patio areas in downtown Cape Girardeau.

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    Renovated Mid-Century Office Building
    Renovated Mid-Century Office Building

    429 N Broadview Street, Cape Girardeau, MO 63701

    $1,690,000
    10,000 sqft

    Updated office building with multiple private offices, conference rooms, and an event space with bar and projection screen.

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    Corner Bar and Pub Building
    Corner Bar and Pub Building

    632 Broadway Street, Cape Girardeau, MO 63701

    $1,200,000
    0.36 AC lot

    Renovated kitchen, patio, and accessible exterior restrooms support food-and-beverage operations.

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    Brick Flex Space with Warehouse
    Brick Flex Space with Warehouse

    333 N Main Street, Cape Girardeau, MO 63701

    $425,000
    0.25 AC lot

    Brick commercial property combining warehouse capacity and finished offices in a downtown Cape Girardeau setting.

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    Retail Building with Drive-Through
    Retail Building with Drive-Through

    5 S Kingshighway, Cape Girardeau, MO 63703

    $1,650,000
    3,483 sqft 0.80 AC lot

    The C2-zoned site includes paved off-street parking and a drive-through window.

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    Historic Office Condominium Units
    Historic Office Condominium Units

    937 Broadway Street, Cape Girardeau, MO 63701

    $99,000
    4,300 sqft

    Multiple commercial condominium suites in a brick downtown building with central air, public water, and public sewer.

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    Warehouse with Open Interior
    Warehouse with Open Interior

    710 Southern Expressway, Cape Girardeau, MO 63703

    $475,000
    4.00 AC lot

    The property occupies approximately four acres and includes outdoor area and parking.

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    Two-Level Office Building For Sale
    Two-Level Office Building For Sale

    10 Doctors Park, Cape Girardeau, MO 63703

    $815,000
    9,857 sqft 0.44 AC lot

    9,857 SF office building with multiple offices and restrooms.

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    Brick Storefront Property
    Brick Storefront Property

    525 Broadway Street, Cape Girardeau, MO 63701

    $189,000
    0.10 AC lot

    Downtown commercial building with flexible unfinished interior space and rear service access.

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    Corner Conventional Restaurant Property
    Corner Conventional Restaurant Property

    45 S Kingshighway, Cape Girardeau, MO 63703

    $2,500,000
    0.85 AC lot

    Established restaurant property with highway and interstate frontage, public water, and an on-site parking lot.

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    13,694 SF Single-Level Office Building
    13,694 SF Single-Level Office Building

    18 N Main St, Cape Girardeau, MO 63701

    $899,900
    13,674 sqft

    Single-level office building suitable for various uses and businesses.

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    C-2 Commercial Land with Existing Structure
    C-2 Commercial Land with Existing Structure

    1931 N Kingshighway Street, Cape Girardeau, MO 63701

    $459,000
    0.80 AC lot

    Highway commercial zoning supports renovation, repurposing, or redevelopment of the existing structure.

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    Downtown Office Building For Sale
    Downtown Office Building For Sale

    18 N. Main, Cape Girardeau, MO 63701

    $899,900
    13,694 sqft

    13,694 SF office building in historic downtown Cape Girardeau.

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    Flex Space with Showroom
    Flex Space with Showroom

    3082 County Road 620, Cape Girardeau, MO 63701

    $650,000
    1.37 AC lot

    Versatile commercial facility combining customer-facing space, industrial work areas, and unfinished expansion capacity.

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    Cape Girardeau Medical Office Building
    Cape Girardeau Medical Office Building

    62 Doctors Park, Cape Girardeau, MO 63703

    $270,000
    2,546 sqft 0.43 AC lot

    2,546 SF medical office building in a thriving complex.

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    Commercial Corner Land
    Commercial Corner Land

    502 N Silver Springs Road, Cape Girardeau, MO 63701

    $229,000
    2.36 AC lot

    Commercially zoned corner parcel near shopping, medical facilities, the mall, and established businesses.

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    Freestanding Single-Tenant Restaurant
    Freestanding Single-Tenant Restaurant

    2406 William Street, Cape Girardeau, MO 63703

    Contact for pricing
    5,030 sqft 1.01 AC lot

    Freestanding single-tenant restaurant on an absolute NNN lease structure with a brand-new 10-year term.

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    Commercial Development Land
    Commercial Development Land

    367 S Broadview Street, Cape Girardeau, MO 63703

    $629,000
    3.00 AC lot

    Commercial-zoned land with water available for future development.

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    Cape Girardeau, MO Commercial Real Estate Market Trends and Statistics

    Explore 85 commercial real estate for sale in Cape Girardeau, MO, showcased through 85 active listings on our real estate platform. These investment opportunities span a total of 332,589 square feet of properties for sale, with an estimated market value of $60,405,430.

    Sale prices for business properties in Cape Girardeau, MO start at $92,500, averaging $1,118,619, and reaching up to $8,050,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

    Cape Girardeau, MO CRE market trends — vacancy, lease rates and price per SF, updated monthly
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    Demographics Overview

    Population 47K
    Population Growth (5Y) +1.2%
    Median Household Income $62,338
    College Educated 29.0%

    High-Yield Neighborhoods for Investment

    Identify Cape Girardeau submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63703 $493.7K
    63701 $802.5K

    Taxes & Financing

    Tax Rate (average for all types) 5.29%
    Property Tax per SF $93.92 per SF
    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Cape Girardeau County

    New Delisted

    Total CRE Inventory on Market (SF)

    How Realmo verifies these figures

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    Most Searched ZIP Codes in Cape Girardeau, MO

    • 63701
    • 63703
    • 63755

    Featured Cape Girardeau Real Estate Agencies

    Realmo connects you with licensed Cape Girardeau CRE brokers providing property specifications, local market pricing, and commercial transaction underwriting support.

    Edge Realty
    2511 Independence St, Ste 100 Cape Girardeau, MO 63703
    Phone: (573) 335-8111
    www.capeareahomes.com
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