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    Cape Girardeau, MO Office Properties & Spaces for Sale

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    Saint Louis, MO Kansas City, MO Louis, MO
    24 results
    Updated Office Building For Sale
    $350,000
    4,000 SF

    Updated Office Building For Sale

    824 Independence Street, Cape Girardeau, MO 63703

    Well-maintained office building with high visibility and ample parking.

    • High daily traffic count on Independence
    • Excellent visibility
    • Ample on‑site parking
    • Well‑maintained and updated office building
    • Suitable for a variety of professional or service‑based businesses
    Updated: Mar 20
    View details
    Versatile Riverfront Commercial Property
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    450 N Main Street, Cape Girardeau, MO 63701

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    • Prime riverfront location directly on the Mississippi River.
    • High visibility and ideal location for downtown development and parking.
    • Versatile property suitable for office, restaurant, warehouse, or mixed‑use concepts.
    • Existing warehouse on the property.
    • Metal siding construction.
    Updated: Mar 12
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    Renovated Commercial Building in Cape Girardeau
    $239,900
    2,937 SF

    Renovated Commercial Building in Cape Girardeau

    Renovated commercial building with high visibility in a prime location.

    230 N Sprigg Street, Cape Girardeau, MO 63701
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    Versatile Riverfront Commercial Property
    $475,000
    7,044 SF

    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main Street, Cape Girardeau, MO 63701
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    Versatile Commercial Property For Sale
    $295,000
    2,920 SF

    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Avenue, Cape Girardeau, MO 63701
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    Leased Office Building For Sale
    $500,000
    7,140 SF

    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Drive, Cape Girardeau, MO 63701
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    Renovated 11-Bedroom Income Property
    $450,000
    4,548 SF

    Renovated 11-Bedroom Income Property

    Versatile, renovated 11-bedroom property in downtown Cape Girardeau.

    224 N Frederick Street, Cape Girardeau, MO 63701
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    Downtown Office Building For Sale
    $899,900
    13,694 SF

    Downtown Office Building For Sale

    13,694 SF office building in historic downtown Cape Girardeau.

    18 N. Main, Cape Girardeau, MO 63701
    View details
    Two-Level Office Building For Sale
    $815,000
    9,857 SF

    Two-Level Office Building For Sale

    9,857 SF office building with multiple offices and restrooms.

    10 Doctors Park, Cape Girardeau, MO 63703
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    Renovated Commercial Building on Sprigg
    $239,900
    2,937 SF

    Renovated Commercial Building on Sprigg

    Renovated commercial space with high visibility and income potential.

    230 N Sprigg Street, Cape Girardeau, MO 63701
    View details
    Historic Bar and Office Space
    $499,900
    4,630 SF

    Historic Bar and Office Space

    Downtown Cape Girardeau property featured in the movie Gone Girl.

    117 Themis Street, Cape Girardeau, MO 63701
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    Downtown Cape Girardeau Office/Flex Space
    Contact for pricing
    5,225 SF

    Downtown Cape Girardeau Office/Flex Space

    5,225 SF office/flex space in downtown Cape Girardeau.

    122 S. Spanish St., Cape Girardeau, MO 63701
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    Cape Girardeau Medical Office Building
    $270,000
    2,546 SF

    Cape Girardeau Medical Office Building

    2,546 SF medical office building in a thriving complex.

    62 Doctors Park, Cape Girardeau, MO 63703
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    Cape Girardeau Commercial Space Available
    Contact for pricing
    1,250 SF

    Cape Girardeau Commercial Space Available

    Flexible commercial space for office, retail, or service businesses.

    151 S Mount Auburn Rd, Cape Girardeau, MO 63703
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    Prime Commercial Space on Mount Auburn
    Contact for pricing
    1,660 SF

    Prime Commercial Space on Mount Auburn

    Versatile commercial space with parking and high visibility.

    326 S. Mount Auburn, Cape Girardeau, MO 63703
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    Retail/Office Space Near I-55
    Contact for pricing

    Retail/Office Space Near I-55

    Prime location near I-55 and West Park Mall.

    3065 William, Cape Girardeau, MO 63703
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    Prime Location Office Suites
    Contact for pricing
    1,348 SF

    Prime Location Office Suites

    Excellent visibility office suites near I-55 and Highway 74.

    440 S. Mount Auburn Road, Cape Girardeau, MO 63703
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    Professional Office Complex For Sale
    Contact for pricing

    Professional Office Complex For Sale

    Professional office complex with parking near I-55, hotels, restaurants.

    240-276 S. Mount Auburn Road, Cape Girardeau, MO 63703
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    Warehouse Space in Central Cape
    Contact for pricing
    50,000 SF

    Warehouse Space in Central Cape

    Up to 50,000 SF available with flexible space sizes.

    334 N. Broadview, Cape Girardeau, MO 63701
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    Versatile Commercial Building on 1.9 Acres
    $2,900,000
    13,458 SF

    Versatile Commercial Building on 1.9 Acres

    All-brick commercial building with abundant parking and multiple use opportunities.

    1429 N Mount Auburn Road, Cape Girardeau, MO 63701
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    High Traffic Retail/Office Space
    Contact for pricing
    1,450 SF

    High Traffic Retail/Office Space

    Neighborhood center with high visibility and excellent tenant mix.

    2500 - 2536 William, Cape Girardeau, MO 63703
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    Commercial Land in Central Location
    Contact for pricing

    Commercial Land in Central Location

    1.2 acres suitable for retail or office development.

    1749 Independence, Cape Girardeau, MO 63701
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    Versatile Commercial Property For Sale
    $295,000

    Versatile Commercial Property For Sale

    Commercial property with retail, office, and warehouse space.

    225 Clark St, Cape Girardeau, MO 63701
    View details
    13,694 SF Single-Level Office Building
    $899,900
    13,694 SF

    13,694 SF Single-Level Office Building

    Single-level office building suitable for various uses and businesses.

    18 Main St, Cape Girardeau, MO 63701
    View details
    Based on your search, we've compiled Potential Opportunities for your consideration. Besides 24 Active Listings in Cape Girardeau, MO, we suggest to view alternatives - similar 3 Off-Market properties to explore as potential leads.

    Cape Girardeau, MO Office Properties & Spaces Investment Opportunities Market Analysis

    Explore 27 office properties & spaces for sale in Cape Girardeau, MO, showcased through 24 active listings on our real estate platform. These investment opportunities span a total of 146,841 square feet of properties for sale, with an estimated market value of $2,709,900.

    Sale prices for office spaces in Cape Girardeau, MO start at $239,900, averaging $387,128, and reaching up to $500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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