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    Cape Girardeau, MO
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    Cape Girardeau, MO Office Spaces for Sale

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    Mc Clure, IL Scott City, MO Jackson, MO
    26 results
    Warehouse with Showroom and Shop Space
    $700,000
    7,200 SF
    Warehouse with Showroom and Shop Space

    3082 County Road 620, Cape Girardeau, MO 63701

    Purchase a 7,200 SF warehouse with dedicated showroom, shop area, and framed upstairs space for flexible business or storage needs.
    • 7,200 SF warehouse with approx. 2,400 SF finished showroom/retail or office space and 3,600 SF shop area
    • Additional 1,200 SF upstairs area is framed and ready to be finished as living quarters, office space, or storage
    • Two large garage doors for convenient access and workflow
    • Central air and forced‑air heating
    • Metal siding exterior and concrete flooring
    Updated: Jun 5
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    Renovated Mid-Century Office Building
    $1,690,000
    15,831 SF
    Renovated Mid-Century Office Building

    429 N Broadview Street, Cape Girardeau, MO 63701

    Renovated 1960s office building with event space, overhead doors, and gated rear parking for flexible operations.
    • Mid‑century modern commercial building originally constructed for the Teamsters in 1962
    • Approximately 10,000 SF on the main level with private offices, conference rooms, and an executive office with private bathroom
    • Event and gathering space with a full bar and projection screen for meetings, presentations, and training
    • Concrete and steel frame construction with brick exterior and forced air heat plus central air
    • 4 overhead doors, 8 indoor parking spaces, and 55+ exterior parking spaces
    Updated: Jun 5
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    Updated Office Building For Sale
    $350,000
    4,000 SF
    Updated Office Building For Sale

    Well-maintained office building with high visibility and ample parking.

    824 Independence Street, Cape Girardeau, MO 63703

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    Versatile Riverfront Commercial Property
    $400,000
    4,400 SF
    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main Street, Cape Girardeau, MO 63701

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    Renovated Commercial Building in Cape Girardeau
    $239,900
    2,937 SF
    Renovated Commercial Building in Cape Girardeau

    Renovated commercial building with high visibility in a prime location.

    230 N Sprigg Street, Cape Girardeau, MO 63701

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    Versatile Riverfront Commercial Property
    $475,000
    7,044 SF
    Versatile Riverfront Commercial Property

    Flexible commercial space with riverfront location and development potential.

    308 N Main Street, Cape Girardeau, MO 63701

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    Flex Space Property with Heated Shop
    $999,900
    4,000 SF
    Flex Space Property with Heated Shop

    All-brick home with a heated three-bay workshop, apartment above, and additional bar and seating area for flexible use.

    241 County Road 226, Cape Girardeau, MO 63701

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    Versatile Commercial Property For Sale
    $295,000
    2,920 SF
    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Avenue, Cape Girardeau, MO 63701

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    Leased Office Building For Sale
    $500,000
    7,140 SF
    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Drive, Cape Girardeau, MO 63701

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    Two-Level Office Building For Sale
    $815,000
    9,857 SF
    Two-Level Office Building For Sale

    9,857 SF office building with multiple offices and restrooms.

    10 Doctors Park, Cape Girardeau, MO 63703

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    Downtown Office Building For Sale
    $899,900
    13,694 SF
    Downtown Office Building For Sale

    13,694 SF office building in historic downtown Cape Girardeau.

    18 N. Main, Cape Girardeau, MO 63701

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    Cape Girardeau Medical Office Building
    $270,000
    2,546 SF
    Cape Girardeau Medical Office Building

    2,546 SF medical office building in a thriving complex.

    62 Doctors Park, Cape Girardeau, MO 63703

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    Renovated Commercial Building on Sprigg
    $239,900
    2,937 SF
    Renovated Commercial Building on Sprigg

    Renovated commercial space with high visibility and income potential.

    230 N Sprigg Street, Cape Girardeau, MO 63701

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    Historic Bar and Office Space
    $499,900
    4,630 SF
    Historic Bar and Office Space

    Downtown Cape Girardeau property featured in the movie Gone Girl.

    117 Themis Street, Cape Girardeau, MO 63701

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    Retail/Office Space Near I-55
    Contact for pricing
    5.13 Acres
    Retail/Office Space Near I-55

    Prime location near I-55 and West Park Mall.

    3065 William, Cape Girardeau, MO 63703

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    Downtown Cape Girardeau Office/Flex Space
    Contact for pricing
    5,225 SF
    Downtown Cape Girardeau Office/Flex Space

    5,225 SF office/flex space in downtown Cape Girardeau.

    122 S. Spanish St., Cape Girardeau, MO 63701

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    Professional Office Complex For Sale
    Contact for pricing
    6.78 Acres
    Professional Office Complex For Sale

    Professional office complex with parking near I-55, hotels, restaurants.

    240-276 S. Mount Auburn Road, Cape Girardeau, MO 63703

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    Cape Girardeau Commercial Space Available
    Contact for pricing
    1,250 SF
    Cape Girardeau Commercial Space Available

    Flexible commercial space for office, retail, or service businesses.

    151 S Mount Auburn Rd, Cape Girardeau, MO 63703

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    Prime Commercial Space on Mount Auburn
    Contact for pricing
    1,660 SF
    Prime Commercial Space on Mount Auburn

    Versatile commercial space with parking and high visibility.

    326 S. Mount Auburn, Cape Girardeau, MO 63703

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    Prime Location Office Suites
    Contact for pricing
    1,348 SF
    Prime Location Office Suites

    Excellent visibility office suites near I-55 and Highway 74.

    440 S. Mount Auburn Road, Cape Girardeau, MO 63703

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    Warehouse Space in Central Cape
    Contact for pricing
    50,000 SF
    Warehouse Space in Central Cape

    Up to 50,000 SF available with flexible space sizes.

    334 N. Broadview, Cape Girardeau, MO 63701

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    High Traffic Retail/Office Space
    Contact for pricing
    1,450 SF
    High Traffic Retail/Office Space

    Neighborhood center with high visibility and excellent tenant mix.

    2500 - 2536 William, Cape Girardeau, MO 63703

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    Commercial Land in Central Location
    Contact for pricing
    1.20 Acres
    Commercial Land in Central Location

    1.2 acres suitable for retail or office development.

    1749 Independence, Cape Girardeau, MO 63701

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    Versatile Commercial Building on 1.9 Acres
    $2,900,000
    13,458 SF
    Versatile Commercial Building on 1.9 Acres

    All-brick commercial building with abundant parking and multiple use opportunities.

    1429 N Mount Auburn Road, Cape Girardeau, MO 63701

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    Cape Girardeau, MO Office Spaces Investment Opportunities Market Analysis

    Explore 29 office spaces for sale in Cape Girardeau, MO, showcased through 26 active listings on our real estate platform. These investment opportunities span a total of 112,288 square feet of properties for sale, with an estimated market value of $11,174,500.

    Sale prices for office spaces in Cape Girardeau, MO start at $239,900, averaging $744,966, and reaching up to $2,900,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

    List
    Map

    Top Commercial Asset Segments

    Office Units 27
    Office buildings 10
    Medical Office Space 3
    Coworking space 2

    Demographics Overview

    Population 47K
    Population Growth (5Y) +1.2%
    Median Household Income $62,338
    College Educated 29.0%

    High-Yield Neighborhoods for Investment

    Identify Cape Girardeau submarkets with the highest inventory density on the market and evaluate the median listing prices of real estate assets

    Neighborhood Average Price
    63703 $179.4K
    63701 $588K

    Taxes & Financing

    Tax Rate (average for all types) 5.29%
    Property Tax per SF $93.92 per sq ft
    Average Loan-to-Value 65.0%

    Listings Trend

    Total CRE Area on Market Trend

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