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Cape Girardeau, MO Office Properties & Spaces for Sale

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24 results
Updated Office Building For Sale
$350,000
4,000 SF

Updated Office Building For Sale

824 Independence Street, Cape Girardeau, MO 63703

Well-maintained office building with high visibility and ample parking.

  • High daily traffic count on Independence
  • Excellent visibility
  • Ample on‑site parking
  • Well‑maintained and updated office building
  • Suitable for a variety of professional or service‑based businesses
Updated: Mar 20
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Versatile Riverfront Commercial Property
$400,000
4,400 SF

Versatile Riverfront Commercial Property

450 N Main Street, Cape Girardeau, MO 63701

Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

  • Prime riverfront location directly on the Mississippi River.
  • High visibility and ideal location for downtown development and parking.
  • Versatile property suitable for office, restaurant, warehouse, or mixed‑use concepts.
  • Existing warehouse on the property.
  • Metal siding construction.
Updated: Mar 12
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Renovated Commercial Building in Cape Girardeau
$239,900
2,937 SF

Renovated Commercial Building in Cape Girardeau

Renovated commercial building with high visibility in a prime location.

230 N Sprigg Street, Cape Girardeau, MO 63701
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Versatile Riverfront Commercial Property
$475,000
7,044 SF

Versatile Riverfront Commercial Property

Flexible commercial space with riverfront location and development potential.

308 N Main Street, Cape Girardeau, MO 63701
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Versatile Commercial Property For Sale
$295,000
2,920 SF

Versatile Commercial Property For Sale

High-visibility commercial property with flexible layout and spacious attached warehouse.

225 Clark Avenue, Cape Girardeau, MO 63701
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Leased Office Building For Sale
$500,000
7,140 SF

Leased Office Building For Sale

Two-story office building with 21 units and parking.

2711 Thomas Drive, Cape Girardeau, MO 63701
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Renovated 11-Bedroom Income Property
$450,000
4,548 SF

Renovated 11-Bedroom Income Property

Versatile, renovated 11-bedroom property in downtown Cape Girardeau.

224 N Frederick Street, Cape Girardeau, MO 63701
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Downtown Office Building For Sale
$899,900
13,694 SF

Downtown Office Building For Sale

13,694 SF office building in historic downtown Cape Girardeau.

18 N. Main, Cape Girardeau, MO 63701
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Two-Level Office Building For Sale
$815,000
9,857 SF

Two-Level Office Building For Sale

9,857 SF office building with multiple offices and restrooms.

10 Doctors Park, Cape Girardeau, MO 63703
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Renovated Commercial Building on Sprigg
$239,900
2,937 SF

Renovated Commercial Building on Sprigg

Renovated commercial space with high visibility and income potential.

230 N Sprigg Street, Cape Girardeau, MO 63701
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Historic Bar and Office Space
$499,900
4,630 SF

Historic Bar and Office Space

Downtown Cape Girardeau property featured in the movie Gone Girl.

117 Themis Street, Cape Girardeau, MO 63701
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Downtown Cape Girardeau Office/Flex Space
Contact for pricing
5,225 SF

Downtown Cape Girardeau Office/Flex Space

5,225 SF office/flex space in downtown Cape Girardeau.

122 S. Spanish St., Cape Girardeau, MO 63701
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Cape Girardeau Medical Office Building
$270,000
2,546 SF

Cape Girardeau Medical Office Building

2,546 SF medical office building in a thriving complex.

62 Doctors Park, Cape Girardeau, MO 63703
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Cape Girardeau Commercial Space Available
Contact for pricing
1,250 SF

Cape Girardeau Commercial Space Available

Flexible commercial space for office, retail, or service businesses.

151 S Mount Auburn Rd, Cape Girardeau, MO 63703
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Prime Commercial Space on Mount Auburn
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1,660 SF

Prime Commercial Space on Mount Auburn

Versatile commercial space with parking and high visibility.

326 S. Mount Auburn, Cape Girardeau, MO 63703
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Retail/Office Space Near I-55
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Retail/Office Space Near I-55

Prime location near I-55 and West Park Mall.

3065 William, Cape Girardeau, MO 63703
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Prime Location Office Suites
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1,348 SF

Prime Location Office Suites

Excellent visibility office suites near I-55 and Highway 74.

440 S. Mount Auburn Road, Cape Girardeau, MO 63703
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Professional Office Complex For Sale
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Professional Office Complex For Sale

Professional office complex with parking near I-55, hotels, restaurants.

240-276 S. Mount Auburn Road, Cape Girardeau, MO 63703
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Warehouse Space in Central Cape
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50,000 SF

Warehouse Space in Central Cape

Up to 50,000 SF available with flexible space sizes.

334 N. Broadview, Cape Girardeau, MO 63701
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Versatile Commercial Building on 1.9 Acres
$2,900,000
13,458 SF

Versatile Commercial Building on 1.9 Acres

All-brick commercial building with abundant parking and multiple use opportunities.

1429 N Mount Auburn Road, Cape Girardeau, MO 63701
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High Traffic Retail/Office Space
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1,450 SF

High Traffic Retail/Office Space

Neighborhood center with high visibility and excellent tenant mix.

2500 - 2536 William, Cape Girardeau, MO 63703
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Commercial Land in Central Location
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Commercial Land in Central Location

1.2 acres suitable for retail or office development.

1749 Independence, Cape Girardeau, MO 63701
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Versatile Commercial Property For Sale
$295,000

Versatile Commercial Property For Sale

Commercial property with retail, office, and warehouse space.

225 Clark St, Cape Girardeau, MO 63701
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13,694 SF Single-Level Office Building
$899,900
13,694 SF

13,694 SF Single-Level Office Building

Single-level office building suitable for various uses and businesses.

18 Main St, Cape Girardeau, MO 63701
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Based on your search, we've compiled Potential Opportunities for your consideration. Besides 24 Active Listings in Cape Girardeau, MO, we suggest to view alternatives - similar 3 Off-Market properties to explore as potential leads.

Cape Girardeau, MO Office Properties & Spaces Investment Opportunities Market Analysis

Explore 27 office properties & spaces for sale in Cape Girardeau, MO, showcased through 24 active listings on our real estate platform. These investment opportunities span a total of 146,841 square feet of properties for sale, with an estimated market value of $2,709,900.

Sale prices for office spaces in Cape Girardeau, MO start at $239,900, averaging $387,128, and reaching up to $500,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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