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    Cape Girardeau, MO
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    Cape Girardeau, MO Healthcare Properties for Sale

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    Mc Clure, IL Scott City, MO Jackson, MO
    Ambulatory Surgery Center Investment Opportunity
    $8,050,000
    13,650 SF
    Ambulatory Surgery Center Investment Opportunity

    3241 Percy Drive, Cape Girardeau, MO 63701

    Single-tenant surgery center near St. Francis Medical Center for sale.
    • 13,650 sq. ft. single‑tenant ambulatory surgery center.
    • Located directly across from St. Francis Medical Center (Level III trauma center).
    • Turnkey investment with 2 years remaining on the current lease and 2% annual rental increases.
    • New, state‑of‑the‑art HVAC system (valued at over $800,000).
    • Specializes in key medical areas (ENT, general surgery, gynecology, ophthalmology, orthopedics, retinal).
    Updated: Sep 9, 2025
    View details
    Versatile Commercial Building on 1.9 Acres
    $2,900,000
    13,458 SF
    Versatile Commercial Building on 1.9 Acres

    1429 N Mount Auburn Road, Cape Girardeau, MO 63701

    All-brick commercial building with abundant parking and multiple use opportunities.
    • Versatile commercial building suitable for multiple uses
    • Potential for dual income stream: owner‑occupy main level and lease lower level
    • Abundant parking with 70+ spaces and a large front entry canopy
    • Well‑maintained building with recent updates including remodeled interior
    • Equipped with a 2,000 lb capacity elevator
    Updated: Dec 7, 2024
    View details
    Based on your search, we've compiled 18 Potential Opportunities for your consideration. Besides 2 Active listings in Cape Girardeau, MO, we suggest exploring several alternatives: 4 properties in Nearby Cities, and similar 8 Off-Market properties to explore as potential leads, plus 4 Land Listings that present a potential for development.

    Opportunities in Nearby Cities

    Here are 4 Similar properties we found in Nearby Locations for your consideration.

    Versatile Building in Poplar Bluff
    $325,000
    12,351 SF
    Versatile Building in Poplar Bluff

    12351 SF building suitable for various purposes in Poplar Bluff.

    338 Hazel St, Poplar Bluff, MO 63901

    View details
    Versatile Commercial Building in Poplar Bluff
    $325,000
    12,351 SF
    Versatile Commercial Building in Poplar Bluff

    12,351 SF commercial building suitable for various uses.

    338 Hazel St, Poplar Bluff, MO 63901

    View details
    Paducah Ambulatory Surgery Center
    Contact for pricing
    21,236 SF
    Paducah Ambulatory Surgery Center

    21,236 SF ambulatory surgery center for sale.

    2831 Lone Oak Rd, Paducah, KY 42003

    View details
    Former Nursing Home in Paducah
    $275,000
    29,781 SF
    Former Nursing Home in Paducah

    29,781 sq ft commercial building for sale in Kentucky.

    3100 Clay Street, Paducah, KY 42001

    View details

    Potential Development Sites for Consideration

    Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

    Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

    Commercial Development Land Parcel
    $600,000
    1.97 Acres
    Commercial Development Land Parcel

    Nearly 2-acre parcel on James Sanders Blvd near Sam's Club and Jordan's Crossing, suited for retail or medical development.

    3620 James Sanders Blvd, Paducah, KY 42001

    View details
    Level Commercial Development Tract
    $1,475,000
    16.50 Acres
    Level Commercial Development Tract

    Level 16.5-acre commercial site with city utilities and direct access to Wayne Sullivan Drive.

    3020 Wayne Sullivan Drive, Paducah, KY 42003

    View details
    Commercial Land in Poplar Bluff
    $399,000
    6.64 Acres
    Commercial Land in Poplar Bluff

    6.64 acres of commercial land ready for development.

    3387 Kanell Boulevard, Poplar Bluff, MO 63901

    View details
    Fulton, KY Commercial Development Site
    $1,150,000
    33.60 Acres
    Fulton, KY Commercial Development Site

    33-acre commercial development site in Fulton, KY, near I-69.

    Myatt Road, Fulton, KY 42041

    View details

    Off-Market Properties in Cape Girardeau, MO

    Consider similar Off-Market properties in Cape Girardeau, MO. You may contact the owners directly to inquire about their potential intentions to sell. To help you make a strong first impression, we can assist by reaching out to these owners with compelling proposals created using our AI tool.

    430 Frederick St
    HOMES (RETIRED, NURSING)
    11,218 SF Lot: 0.16 Acres
    Value Estimation by Request

    430 Frederick St, Cape Girardeau, MO 63701-4835

    View details
    2906 Beaver Crk Dr
    HOMES (RETIRED, NURSING)
    6,721 SF Lot: 0.60 Acres
    Value Estimation by Request

    2906 Beaver Crk Dr, Cape Girardeau, MO 63701-1732

    View details
    2525 Boutin Dr
    HOMES (RETIRED, NURSING)
    26,911 SF Lot: 12.65 Acres
    Estimated value
    $575,000

    2525 Boutin Dr, Cape Girardeau, MO 63701-8551

    View details
    Silver Springs Rd
    Individual retail properties
    Lot: 4.56 Acres
    Value Estimation by Request
    Silver Springs Rd

    0 Silver Springs Rd, Cape Girardeau, MO 63703

    View details
    3049 William St
    Medical Office Space
    79,122 SF

    3049 William St, Cape Girardeau, MO 63703

    View details
    325 Sprigg St
    HOMES (RETIRED, NURSING)
    1,913 SF Lot: 0.66 Acres

    325 Sprigg St, Cape Girardeau, MO 63701-5531

    View details
    2001 Kingshighway St
    HOMES (RETIRED, NURSING)
    13,006 SF Lot: 10.30 Acres
    Value Estimation by Request

    2001 Kingshighway St, Cape Girardeau, MO 63701-2127

    View details
    2915 Cpe Lacroix Rd
    HOMES (RETIRED, NURSING)
    11,978 SF Lot: 4.49 Acres
    Value Estimation by Request

    2915 Cpe Lacroix Rd, Cape Girardeau, MO 63701-9766

    View details

    Cape Girardeau, MO Healthcare Properties Investment Opportunities Market Analysis

    Explore 10 healthcare properties for sale in Cape Girardeau, MO on our real estate platform. These investment opportunities span a total of 27,108 square feet of properties for sale, with an estimated market value of $10,950,000.

    Sale prices for medical real estate in Cape Girardeau, MO start at $2,900,000, averaging $5,475,000, and reaching up to $8,050,000 — offering options for a variety of budgets and business needs. Daily updated analytics ensure you stay ahead with the latest data and market trends.

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    Top Commercial Asset Segments

    Commercial property segments ranked by active listings on the market

    Medical centers 2
    Medical space 1

    Demographics Overview

    Population 47K
    Population Growth (5Y) +1.2%
    Median Household Income $62,338
    College Educated 29.0%

    High-Yield Neighborhoods for Investment

    Identify Cape Girardeau submarkets with the highest inventory density on the market and evaluate the average listing prices of real estate assets

    Neighborhood Average Price
    63701 $5.5M

    Taxes & Financing

    Tax Rate (average for all types) 5.29%
    Property Tax per SF $93.92 per SF
    Average Loan-to-Value 65.0%

    Listings Trend

    New vs delisted commercial listings in Cape Girardeau County

    New Delisted

    Total CRE Inventory on Market (SF)

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