Cape Girardeau, MO Retail Properties & Spaces for Lease

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$2,500 /Mo

2,937 SF

Renovated Commercial Space For Lease

230 N Sprigg Street, Cape Girardeau, MO 63701

Renovated commercial space with high visibility in a prime location.

Prime location with high traffic and road frontage on N Sprigg St, offering excellent visibility in the Business District.
Almost 3000 sq ft of renovated space suitable for multiple offices or service providers.
Completely renovated with brand new A/C, roof, gutters, flooring, fixtures, bathrooms, kitchenette, and siding.
Significant rental income potential.
Located downtown, in the midst of exciting activities.

Updated: Jun 30, 2025

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$2,900 /Mo

Historic Art Deco Landmark Space

824 Broadway St, Cape Girardeau, MO 63701

Restored historic building in downtown Cape Girardeau's commercial district.

Prime downtown Broadway location in a revitalized historic landmark
Restored Art Deco architectural character with preserved marquee elements
High‑traffic location with excellent frontage and visibility
Flexible floor plans suitable for retail, office, or service providers
Strong walkability and proximity to shops, restaurants, and city amenities

Updated: Mar 5

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10,000 SF

New Development Retail Space Available

Prime lease space with high visibility and build-out allowance.

2510 Veterans Memorial Drive, Cape Girardeau, MO 63701

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2,300 SF

Prime Retail/Office Space Available

New 2,300 SF space ideal for retail or office.

3465 William, Cape Girardeau, MO 63703

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1,275 SF

Retail Storefront with Office Space

Downtown retail storefront with office space for rent.

221 Merriwether Street, Cape Girardeau, MO 63703

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10,800 SF

Retail Space Near Interstate 55

Retail space in regional shopping hub with interstate access.

258 Siemers Dr, Cape Girardeau, MO

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$12 SF/Yr

2,937 SF

Retail Space in Cape Girardeau

Retail space available for rent in Cape Girardeau, Missouri.

230 N Sprigg Street, Cape Girardeau, MO 63701

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3,154 SF

Retail Space Near St. Francis

Retail space available across from St. Francis Medical Center.

3049 Williams St, Cape Girardeau, MO

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Commercial Space For Lease

Commercial space available for lease at 3049 William St.

3049 William St, Cape Girardeau, MO 63703

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9,400 SF

Regional Shopping Center Near I-55

Regional shopping center with easy access to Interstate 55.

155-157 Siemers Dr, Cape Girardeau, MO

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7,908 SF

Retail Space Near West Park

Retail space in regional shopping hub with easy Interstate access.

3047 William St, Cape Girardeau, MO

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4,970 SF

Retail Space Near West Park

Retail space in regional shopping hub with high visibility.

3036-3048 William St, Cape Girardeau, MO

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1,595 SF

Retail Space Near West Park

Retail space available in regional shopping hub near West Park.

240-250 S Silver Springs Rd, Cape Girardeau, MO

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14,850 SF

Retail Space Available For Rent

Retail spaces available, ranging from 4,050 to 14,850 SqFt.

258 Siemers Drive, Cape Girardeau, MO 63701

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4,970 SF

Retail Space Available For Rent

Retail space available, offering 4,970 square feet.

3036 William Street, Cape Girardeau, MO 63701

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Commercial Space For Lease

Commercial space available for lease in Cape Girardeau, Missouri.

155 Siemers Dr, Cape Girardeau, MO 63701

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Based on your search, we've compiled 39 Potential Opportunities for your consideration. Besides 16 Active listings in Cape Girardeau, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 15 Properties for Sales.

Explore Retail properties & Spaces for Lease in Nearby Cities

Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

$1,000 /Mo

Professional Space Near Main Intersection

Prime location, high visibility, and flexible floor plan.

1226 Linn St, Suite D, Sikeston, MO 63801

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$1,950 /Mo

2,600 SF

New Office/Retail Center on Main

Prime location with excellent traffic and visibility.

600 N. Main Street, Sikeston, MO 63801

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$1,440 /Mo

Retail Space in High Traffic Area

Retail space in Jackson, MO with high visibility.

2931 E Jackson Boulevard, Jackson, MO 63755

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$1,440 /Mo

1,220 SF

Retail Space in High-Traffic Location

Retail space with signage, parking, and delivery entrance available for lease.

2931 E Jackson Blvd, Jackson, MO 63755

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Explore Similar Spaces for Sale in Cape Girardeau, MO

Consider Similar Space for Sale. We found 15 Spaces matching your search parameters.

Versatile Riverfront Commercial Property

$400,000

4,400 SF

Versatile Riverfront Commercial Property

Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

450 N Main Street, Cape Girardeau, MO 63701

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Renovated Commercial Building in Cape Girardeau

$239,900

2,937 SF

Renovated Commercial Building in Cape Girardeau

Renovated commercial building with high visibility in a prime location.

230 N Sprigg Street, Cape Girardeau, MO 63701

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$475,000

7,044 SF

Versatile Riverfront Commercial Property

Flexible commercial space with riverfront location and development potential.

308 N Main Street, Cape Girardeau, MO 63701

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Versatile Commercial Building in Missouri

$199,900

0.57 Acres

Versatile Commercial Building in Missouri

Adaptable 1800 sq ft commercial building in Cape Girardeau.

2357 Rust Avenue, Cape Girardeau, MO 63703

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$295,000

2,920 SF

Versatile Commercial Property For Sale

High-visibility commercial property with flexible layout and spacious attached warehouse.

225 Clark Avenue, Cape Girardeau, MO 63701

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Broadway Commercial Space with Apartment

$280,000

5,100 SF

Broadway Commercial Space with Apartment

Versatile investment opportunity with remodeled apartment and commercial space.

520 Broadway Street, Cape Girardeau, MO 63701

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$239,900

2,937 SF

Renovated Commercial Building on Sprigg

Renovated commercial space with high visibility and income potential.

230 N Sprigg Street, Cape Girardeau, MO 63701

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4,500 SF

Prime Retail Space in Cape

4,500 SF retail space in historic downtown Cape Girardeau.

731 Broadway St, Cape Girardeau, MO 63701

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Potential Development Sites for Consideration

Can't find the perfect fit? These Land listings present an alternative path: the potential to develop a property for your specific goals.

Important: These AI-suggestions are a starting point, not a guarantee of permitted use. All zoning, permitting, and land use information must be independently verified by you with the appropriate local authorities before making any commitments.

$2.00 SF/Yr

Prime Commercial Land in Paducah

8 acres of commercial real estate on Paducah's retail corridor.

5251 Hinkleville Road, Paducah, KY 42001

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$1,000 /Mo

Vacant Lot in Downtown Paducah

Vacant commercial lot for lease in downtown Paducah.

525 Broadway, Paducah, KY 42001

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$225,000

Vacant Land Near I-44

10.11 acres of vacant land with I-44 visibility.

800 S Highway, Fenton, MO 63026

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$5,000 /Mo

5,000 SF

Collinsville Commercial Space For Lease

Versatile commercial space in Collinsville, available immediately.

1902 Vandalia Street, Collinsville, IL 62234

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Cape Girardeau, MO Retail properties & Spaces Leasing Opportunities Market Analysis

Explore Retail properties & Spaces leasing options in Cape Girardeau, MO with 16 listings featured on our commercial real estate exchange. The current inventory includes 127,935,720 square feet of properties with an estimated lease value of $10 SF/Yr.

Estimated lease rates for Retail properties & Spaces in Cape Girardeau, MO begin at $10 SF/Yr, with an average of $10 SF/Yr and extend to $10 SF/Yr.

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Cape Girardeau, MO Retail Properties & Spaces for Lease

Renovated Commercial Space For Lease

Renovated commercial space with high visibility in a prime location.

Historic Art Deco Landmark Space

Restored historic building in downtown Cape Girardeau's commercial district.

New Development Retail Space Available

Prime Retail/Office Space Available

Retail Storefront with Office Space

Retail Space Near Interstate 55

Retail Space in Cape Girardeau

Retail Space Near St. Francis

Commercial Space For Lease

Regional Shopping Center Near I-55

Retail Space Near West Park

Retail Space Near West Park

Retail Space Near West Park

Retail Space Available For Rent

Retail Space Available For Rent

Commercial Space For Lease

Explore Retail properties & Spaces for Lease in Nearby Cities

Professional Space Near Main Intersection

New Office/Retail Center on Main

Retail Space in High Traffic Area

Retail Space in High-Traffic Location

Explore Similar Spaces for Sale in Cape Girardeau, MO

Versatile Riverfront Commercial Property

Renovated Commercial Building in Cape Girardeau

Versatile Riverfront Commercial Property

Versatile Commercial Building in Missouri

Versatile Commercial Property For Sale

Broadway Commercial Space with Apartment

Renovated Commercial Building on Sprigg

Prime Retail Space in Cape

Potential Development Sites for Consideration

Prime Commercial Land in Paducah

Vacant Lot in Downtown Paducah

Vacant Land Near I-44

Collinsville Commercial Space For Lease

Cape Girardeau, MO Retail properties & Spaces Leasing Opportunities Market Analysis

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