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    Cape Girardeau, MO Commercial Real Estate for Lease

    15 results
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    Cape Girardeau Office Space Available
    Pending
    $5,500 / Mo
    7,000 SF

    Cape Girardeau Office Space Available

    340 S Broadview St, Cape Girardeau, MO 63703

    Well-maintained commercial property with ample space in a convenient location.

    • Over 7,000 square feet of usable space suitable for professional or medical use.
    • Highly visible and convenient location.
    • Ample on‑site parking for staff and visitors.
    • Two elevators for accessibility.
    • ADA compliance throughout the building.
    Updated: Dec 1, 2025
    View details
    Office Suite in Cape Girardeau
    $5,641 / Mo
    6,770 SF

    Office Suite in Cape Girardeau

    450 Siemers Dr, Cape Girardeau, MO 63701

    Office suite with high visibility and traffic in Cape Girardeau.

    • Turn‑key ready office suite
    • High visibility and high traffic location
    • Highway/Interstate frontage
    • Heating: Forced Air, Natural Gas, Solar
    • Cooling: Central Air, Electric
    Updated: Nov 14, 2025
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    Renovated Commercial Space For Lease
    $2,500 / Mo
    2,937 SF

    Renovated Commercial Space For Lease

    Renovated commercial space with high visibility in a prime location.

    230 N Sprigg St, Cape Girardeau, MO 63701
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    Retail Space Near West Park
    Contact for pricing
    7,908 SF

    Retail Space Near West Park

    Retail space in regional shopping hub with easy Interstate access.

    3047 William St, Cape Girardeau, MO 63703
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    Retail Space Near West Park
    Contact for pricing
    4,970 SF

    Retail Space Near West Park

    Retail space in regional shopping hub with high visibility.

    3036-3048 William St, Cape Girardeau, MO 63703
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    Retail Space Near West Park
    Contact for pricing
    1,595 SF

    Retail Space Near West Park

    Retail space available in regional shopping hub near West Park.

    240-250 S Silver Springs Rd, Cape Girardeau, MO 63703
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    Retail Space Near Interstate 55
    Contact for pricing
    10,800 SF

    Retail Space Near Interstate 55

    Retail space in regional shopping hub with interstate access.

    258 Siemers Dr, Cape Girardeau, MO 63701
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    Regional Shopping Center Near I-55
    Contact for pricing
    9,400 SF

    Regional Shopping Center Near I-55

    Regional shopping center with easy access to Interstate 55.

    155-157 Siemers Dr, Cape Girardeau, MO 63701
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    Prime Commercial Land For Lease
    Contact for pricing

    Prime Commercial Land For Lease

    0.47 acre commercial land for lease in Cape Girardeau.

    2148 William St, Cape Girardeau, MO 63703
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    Prime Commercial Land For Rent
    Contact for pricing

    Prime Commercial Land For Rent

    High-traffic commercial land available for rent near major retailers.

    210 S Silver Springs Rd, Cape Girardeau, MO 63703
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    Retail Space Near St. Francis
    Contact for pricing
    3,154 SF

    Retail Space Near St. Francis

    Retail space available across from St. Francis Medical Center.

    3049 Williams St, Cape Girardeau, MO
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    West Park Mall Medical Office Space
    Contact for pricing
    79,122 SF

    West Park Mall Medical Office Space

    Missouri medical office suites for lease

    3049 William St, Cape Girardeau, MO 63703
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    West Park Strip Center Retail Space
    Contact for pricing
    23,464 SF

    West Park Strip Center Retail Space

    High-traffic retail center; two spaces available.

    250 Silver Springs Rd, Cape Girardeau, MO 63703
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    Lambert Plaza Retail Space
    Contact for pricing
    46,692 SF

    Lambert Plaza Retail Space

    Cape Girardeau, MO Retail Opportunity

    155 Siemers Dr, Cape Girardeau, MO 63701
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    HubCo Coworking Office Space
    $36 SF/Yr
    8,200 SF

    HubCo Coworking Office Space

    Modern Cape Girardeau Office Suites

    1427 Thomas Dr, Cape Girardeau, MO 63701
    View details
    Based on your search, we've compiled 53 Potential Opportunities for your consideration. Besides 15 Active listings in Cape Girardeau, MO, we suggest exploring alternatives. Consider Similar 4 Spaces in Nearby Cities, and Similar 34 Properties for Sales.

    Explore Commercial real estate for Lease in Nearby Cities

    Here are 4 Similar Spaces we found in Nearby Locations for your consideration.

    Retail Space in High-Traffic Location
    $1,440 / Mo

    Retail Space in High-Traffic Location

    Retail space with signage, parking, and delivery entrance available for lease.

    2931 E Jackson Blvd, Jackson, MO 63755
    View details
    Retail Space in High Traffic Area
    $1,440 / Mo
    34,761 SF

    Retail Space in High Traffic Area

    Retail space in Jackson, MO with high visibility.

    2931 E Jackson Blvd, Jackson, MO 63755
    View details
    Anna Commercial Flex Space
    $13 SF/Yr
    2,900 SF

    Anna Commercial Flex Space

    Prime Anna location, 2,900 sq ft.

    1000 Leigh Ave, Anna, IL 62906
    View details
    Commercial Office Space in Anna, IL
    Contact for pricing

    Commercial Office Space in Anna, IL

    Office space available in the Wal-Mart Plaza area.

    1000 Leigh Ave, Anna, IL 62906
    View details

    Explore Similar Spaces for Sale in Cape Girardeau, MO

    Consider Similar Space for Sale. We found 34 Spaces in Nearby Locations matching your search parameters.

    Versatile Riverfront Commercial Property
    Pending
    $400,000
    4,400 SF

    Versatile Riverfront Commercial Property

    Prime riverfront property suitable for office, restaurant, warehouse, or mixed-use.

    450 N Main St, Cape Girardeau, MO 63701
    View details
    Versatile Commercial Space in Missouri
    $900,000
    7,396 SF

    Versatile Commercial Space in Missouri

    7,396 SF commercial building with banquet, dining, and bar areas.

    20 N Spanish St, Cape Girardeau, MO 63701
    View details
    Downtown Cape Girardeau Commercial Lot
    Pending
    $450,000
    1.04 Acres

    Downtown Cape Girardeau Commercial Lot

    Prime commercial lot near casino, ideal for development.

    N Main St, Cape Girardeau, MO 63701
    View details
    Versatile Commercial Property For Sale
    $295,000
    2,920 SF

    Versatile Commercial Property For Sale

    High-visibility commercial property with flexible layout and spacious attached warehouse.

    225 Clark Ave, Cape Girardeau, MO 63701
    View details
    Cape Girardeau Commercial Property
    Pending
    $825,000
    7,000 SF

    Cape Girardeau Commercial Property

    Well-maintained commercial property with over 7,000 square feet.

    340 S Broadview St, Cape Girardeau, MO 63703
    View details
    Renovated Downtown Commercial Property
    $500,000
    4,548 SF

    Renovated Downtown Commercial Property

    Versatile 11-bedroom property in downtown Cape Girardeau.

    224 N Frederick St, Cape Girardeau, MO 63701
    View details
    Cape Girardeau Mixed-Use Investment
    $489,900
    7,282 SF

    Cape Girardeau Mixed-Use Investment

    Leased commercial spaces with residential unit for income growth.

    1606 Independence St, Cape Girardeau, MO 63703
    View details
    Leased Office Building For Sale
    $500,000
    7,140 SF

    Leased Office Building For Sale

    Two-story office building with 21 units and parking.

    2711 Thomas Dr, Cape Girardeau, MO 63701
    View details
    Renovated Commercial Space in Cape Girardeau
    $239,900
    2,937 SF

    Renovated Commercial Space in Cape Girardeau

    Renovated commercial space with high potential in a prime location.

    230 N Sprigg St, Cape Girardeau, MO 63701
    View details

    Cape Girardeau, MO Commercial real estate Leasing Opportunities Market Analysis

    Explore Commercial real estate leasing options in Cape Girardeau, MO with 49 listings featured on our commercial real estate exchange. The current inventory includes 1,084,948,920 square feet of properties with an estimated lease value of $65 SF/Yr.

    Estimated lease rates for Commercial real estate in Cape Girardeau, MO begin at $9 SF/Yr, with an average of $16 SF/Yr and extend to $36 SF/Yr.
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