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    South San Francisco, CA Office Spaces for Lease

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    Belmont, CA San Bruno, CA Brisbane, CA
    47 results
    CA, South San Francisco - Spaces Oyster Point
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    Corner Office Space Available
    $2 SF/Yr
    2,621 SF
    Corner Office Space Available

    1486 Huntington Avenue, South San Francisco, CA 94080

    Prominent corner office space near transportation and shopping.
    • Excellent Location: Just off Hwy 380 and El Camino Real
    • Walking distance (0.5 miles) to San Bruno BART and Tanforan Shopping Center
    • Adjacent to new Safeway development at Discovery Station
    • Prominent corner office on the 3rd floor
    • 3 Private Offices
    Updated: Mar 25
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    South San Francisco Office/Lab Sublease
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    22,365 SF
    South San Francisco Office/Lab Sublease

    651 Gateway Boulevard, South San Francisco, CA 94080

    Full floor office/lab space available for sublease through July 2029.
    • Full floor (± 22,365 RSF) divisible office/lab space available for sublease through July 2029.
    • Prominent location on Highway 101 corridor with easy access.
    • Free shuttle service to San Francisco Airport (10 minutes away).
    • Full‑building lab conversion with new laboratory infrastructure and robust MEP systems.
    • Brand new Class A exteriors, lobby, and lab warm shell core.
    Updated: Jan 27
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    South San Francisco Industrial Building
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    29,800 SF
    South San Francisco Industrial Building

    Freestanding industrial building with office/lab space for rent.

    250 Hillside Boulevard, South San Francisco, CA 94080

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    Oyster Point Flex/Lab Space
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    10,248 SF
    Oyster Point Flex/Lab Space

    30,140 SF flex/lab space available for lease.

    333 Oyster Point Blvd, South San Francisco, CA 94080

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    Functional Lab/Office Space Available
    Contact for pricing
    8,711 SF
    Functional Lab/Office Space Available

    Prime location, functional lab/office space near transportation.

    600 Gateway Blvd, South San Francisco, CA 94080

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    South San Francisco Flex Space
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    30,491 SF
    South San Francisco Flex Space

    Flex space available for rent in South San Francisco.

    400 E Jamie Ct, South San Francisco, CA 94080

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    Class A Lab & Office
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    34,988 SF
    Class A Lab & Office

    Sublease opportunity: 34,988 SF of Class A lab & office.

    131 Oyster Point Blvd, South San Francisco, CA 94080

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    South San Francisco Office Space
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    14,000 SF
    South San Francisco Office Space

    14,000 sqft office space available for rent.

    1487 Huntington Ave, South San Francisco, CA 94080

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    South San Francisco Office Space
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    40,606 SF
    South San Francisco Office Space

    Office building with 40,606 square feet available for rent.

    453-467 Forbes Blvd, South San Francisco, CA 94080

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    Plug & Play Office Sublease
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    29,711 SF
    Plug & Play Office Sublease

    Sublease available with premier finishes and included furniture.

    111 Oyster Point Blvd, South San Francisco, CA 94080

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    South San Francisco Office Space
    $2 SF/Yr
    1,694 SF
    South San Francisco Office Space

    Office space near transportation and airport in South San Francisco.

    220 S Spruce Ave, South San Francisco, CA

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    Office Space For Rent
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    Office Space For Rent

    Office space available for rent in South San Francisco.

    South San Francisco, CA 94080

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    Downtown Office Space Available
    $1.66 SF/Yr
    3,689 SF
    Downtown Office Space Available

    Office space in downtown core with multiple private rooms.

    301 Grand Ave, South San Francisco, CA

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    Life Science Campus for Rent
    Contact for pricing
    300,000 SF
    Life Science Campus for Rent

    Vibrant campus with amenities near Biotech Bay Area corridor.

    180 El Camino Real, South San Francisco, CA 94080

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    South San Francisco Commercial Space
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    South San Francisco Commercial Space

    Commercial space available for rent in South San Francisco.

    578 Eccles Avenue, South San Francisco, CA 94080

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    South San Francisco Warehouse Space
    $33,000 SF/Yr
    19,800 SF
    South San Francisco Warehouse Space

    19,800 SF warehouse space for rent in South San Francisco.

    253 E Harris Ave, South San Francisco, CA 94080

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    South San Francisco Office Space
    $2.00 SF/Yr
    29,470 SF
    South San Francisco Office Space

    LEED Gold certified office space with excellent transportation access.

    701 Gateway Blvd, South San Francisco, CA

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    South San Francisco Integrated Facility
    Contact for pricing
    30,000 SF
    South San Francisco Integrated Facility

    Integrated biology, tissue culture, chemistry, and vivarium labs for rent.

    285 East Grand Avenue, South San Francisco, CA 94080

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    South San Francisco Office Space
    $35 SF/Yr
    1,590 SF
    South San Francisco Office Space

    Office space available for lease in South San Francisco.

    201 Grand Ave, South San Francisco, CA

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    Office Space in South San Francisco
    Contact for pricing
    58,446 SF
    Office Space in South San Francisco

    58,446 SF office space available for lease.

    South San Francisco, CA 94080

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    South San Francisco Office Space
    Contact for pricing
    38,400 SF
    South San Francisco Office Space

    Office space available for lease in South San Francisco.

    1 & 2 Tower Place, South San Francisco, CA 94080

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    Class A Office Building
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    31,321 SF
    Class A Office Building

    Class A office building in South San Francisco life science market.

    6000 Shoreline Court, South San Francisco, CA 94080

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    South San Francisco Lab Space
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    19,817 SF
    South San Francisco Lab Space

    Class A lab and office space available for sublease.

    2 Tower Place, South San Francisco, CA 94080

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    South San Francisco, CA Office Spaces Leasing Opportunities Market Analysis

    Explore Office Spaces leasing options in South San Francisco, CA with 47 listings featured on our commercial real estate exchange. The current inventory includes 67,413 square feet of properties with an estimated lease value of $33,189.

    Estimated lease rates for Office Spaces in South San Francisco, CA begin at $0.80 SF/Yr, with an average of $3,318 /Mo and extend to $33,000.
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