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South San Francisco, CA Office Properties & Spaces for Lease

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45 results
CA, South San Francisco - Spaces Oyster Point
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CA, South San Francisco - Spaces Oyster Point

Workspaces, services and support to help you grow your business in CA, South San Francisco - Spaces Oyster Point

611 Gateway Blvd, South San Francisco, CA 94080
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Corner Office Space Available
$2 SF/Yr
2,621 SF

Corner Office Space Available

1486 Huntington Avenue, South San Francisco, CA 94080

Prominent corner office space near transportation and shopping.

  • Excellent Location: Just off Hwy 380 and El Camino Real
  • Walking distance (0.5 miles) to San Bruno BART and Tanforan Shopping Center
  • Adjacent to new Safeway development at Discovery Station
  • Prominent corner office on the 3rd floor
  • 3 Private Offices
Updated: Mar 25
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South San Francisco Office/Lab Sublease
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22,365 SF

South San Francisco Office/Lab Sublease

651 Gateway Boulevard, South San Francisco, CA 94080

Full floor office/lab space available for sublease through July 2029.

  • Full floor (± 22,365 RSF) divisible office/lab space available for sublease through July 2029.
  • Prominent location on Highway 101 corridor with easy access.
  • Free shuttle service to San Francisco Airport (10 minutes away).
  • Full‑building lab conversion with new laboratory infrastructure and robust MEP systems.
  • Brand new Class A exteriors, lobby, and lab warm shell core.
Updated: Jan 27
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South San Francisco Industrial Building
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29,800 SF

South San Francisco Industrial Building

Freestanding industrial building with office/lab space for rent.

250 Hillside Boulevard, South San Francisco, CA 94080
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Functional Lab/Office Space Available
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8,711 SF

Functional Lab/Office Space Available

Prime location, functional lab/office space near transportation.

600 Gateway Blvd, South San Francisco, CA 94080
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Oyster Point Flex/Lab Space
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10,248 SF

Oyster Point Flex/Lab Space

30,140 SF flex/lab space available for lease.

333 Oyster Point Blvd, South San Francisco, CA 94080
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Class A Lab & Office
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34,988 SF

Class A Lab & Office

Sublease opportunity: 34,988 SF of Class A lab & office.

131 Oyster Point Blvd, South San Francisco, CA 94080
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South San Francisco Flex Space
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30,491 SF

South San Francisco Flex Space

Flex space available for rent in South San Francisco.

400 E Jamie Ct, South San Francisco, CA 94080
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Life Science Campus for Rent
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300,000 SF

Life Science Campus for Rent

Vibrant campus with amenities near Biotech Bay Area corridor.

180 El Camino Real, South San Francisco, CA 94080
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South San Francisco Flex Space
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16,421 SF

South San Francisco Flex Space

Flex space with labs, vivarium, and convenient transit access.

225 Gateway Blvd, South San Francisco, CA
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South San Francisco Office Space
$2.00 SF/Yr
29,470 SF

South San Francisco Office Space

LEED Gold certified office space with excellent transportation access.

701 Gateway Blvd, South San Francisco, CA
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Plug & Play Office Sublease
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29,711 SF

Plug & Play Office Sublease

Sublease available with premier finishes and included furniture.

111 Oyster Point Blvd, South San Francisco, CA 94080
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South San Francisco Office Space
$2 SF/Yr
1,694 SF

South San Francisco Office Space

Office space near transportation and airport in South San Francisco.

220 S Spruce Ave, South San Francisco, CA
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Downtown Office Space Available
$1.66 SF/Yr
3,689 SF

Downtown Office Space Available

Office space in downtown core with multiple private rooms.

301 Grand Ave, South San Francisco, CA
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South San Francisco Integrated Facility
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30,000 SF

South San Francisco Integrated Facility

Integrated biology, tissue culture, chemistry, and vivarium labs for rent.

285 East Grand Avenue, South San Francisco, CA 94080
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Oyster Point Marina Plaza Suites
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Oyster Point Marina Plaza Suites

Office suites with flexible floor plans and bay views.

395 and 400 Oyster Point Boulevard, South San Francisco, CA 94080
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Class A Flex Sublease
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30,140 SF

Class A Flex Sublease

Flexible sublease with modern amenities and highway access.

333 Oyster Point Blvd, South San Francisco, CA
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Plug & Play Office Sublease
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29,711 SF

Plug & Play Office Sublease

Sublease available with premier finishes and furniture included.

111 Oyster Point Boulevard, South San Francisco, CA 94080
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South San Francisco Office Space
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979 SF

South San Francisco Office Space

Second floor office space available for rent in South San Francisco.

90 S Spruce Ave, South San Francisco, CA
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Class A Office Building
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31,321 SF

Class A Office Building

Class A office building in South San Francisco life science market.

6000 Shoreline Court, South San Francisco, CA 94080
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South San Francisco Lab Space
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19,817 SF

South San Francisco Lab Space

Class A lab and office space available for sublease.

2 Tower Place, South San Francisco, CA 94080
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South San Francisco Office Space
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73,216 SF

South San Francisco Office Space

Office space for rent in South San Francisco life science hub.

5000 Shoreline Court, South San Francisco, CA 94080
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South San Francisco Office/Lab Space
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85,140 SF

South San Francisco Office/Lab Space

Office and laboratory spaces in South San Francisco.

180 Kimball Way & 442 Littlefield Ave, South San Francisco, CA 94080
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South San Francisco Office Space
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107,175 SF

South San Francisco Office Space

Move-in ready office suites available in South San Francisco.

490 Forbes Boulevard, South San Francisco, CA 94080
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South San Francisco, CA Office properties & Spaces Leasing Opportunities Market Analysis

Explore Office properties & Spaces leasing options in South San Francisco, CA with 45 listings featured on our commercial real estate exchange. The current inventory includes 114,170,760 square feet of properties with an estimated lease value of $2 SF/Yr.

Estimated lease rates for Office properties & Spaces in South San Francisco, CA begin at $2 SF/Yr, with an average of $2 SF/Yr and extend to $2 SF/Yr.
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